Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.328.750 [Categoria DeCS]
Referências encontradas : 52 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 6 ir para página                

  1 / 52 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28217981
[Au] Autor:Abdullah FO; Hussain FHS; Mannucci B; Lappano R; Tosi S; Maggiolini M; Vidari G
[Ad] Endereço:Department of Chemistry, College of Science, Salahaddin University - Kirkuk Road, Erbil, Iraq.
[Ti] Título:Composition, Antifungal and Antiproliferative Activities of the Hydrodistilled Oils from Leaves and Flower Heads of Pterocephalus nestorianus Nábelek.
[So] Source:Chem Biodivers;14(7), 2017 Jul.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This article reports the first study of the chemical composition, and antifungal and antiproliferative properties of the volatile extracts obtained by hydrodistillation of the flower heads and leaves of the traditional Kurdish medicinal plant Pterocephalus nestorianus Nábelek, collected in the wild. A total of 55 constituents, 43 of the flower heads' oil (PFO) and 46 of the leaves' oil (PLO), respectively, were identified by GC/MS, constituting 99.68% and 99.04% of the two oils, respectively. The oils were obtained in 0.15% and 0.10% yields (w/w), respectively, on air-dried vegetable material. The prevalent constituents of the PFO were α-terpineol (2.41%), α-linalool (6.42%), 6,10,14-trimethylpentadecan-2-one (2.59%), myristic acid (24.65%), and lauric acid (50.44%), while the major components of PLO were (E)-hex-2-enal (2.26%), (E)-hex-2-en-1-ol (2.04), myristic acid (34.03%), and lauric acid (50.35%). The two oils showed significant inhibitory and fungicidal activities against the medically important fungi Candida albicans, Candida tropicalis, Microsporum canis, and Trichophyton mentagrophytes, with minimum inhibitory concentration ranging from 0.7 to 3.3 mg/ml and minimum fungicidal concentration varying from 1.4 to 6.6 mg/ml. The antiproliferative activity of the two oils was assayed against one normal and six human tumor cell lines. Both oils showed selective cytotoxic activity, with IC values ranging from 1.4 to 3.3 µg/ml.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Caprifoliaceae/química
[Mh] Termos MeSH secundário: Antifúngicos/química
Antifúngicos/farmacologia
Antineoplásicos Fitogênicos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Flores/química
Fungos/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Concentração Inibidora 50
Testes de Sensibilidade Microbiana
Óleos Voláteis/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Oils, Volatile)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700009


  2 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28215418
[Au] Autor:Top H; Sarikahya NB; Nalbantsoy A; Kirmizigul S
[Ad] Endereço:Department of Chemistry, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey.
[Ti] Título:Immunomodulatory, hemolytic properties and cytotoxic activity potent of triterpenoid saponins from Cephalaria balansae.
[So] Source:Phytochemistry;137:139-147, 2017 May.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigations on n-butanol extract of Cephalaria balansae Raus. (Caprifoliaceae) led to the isolation of four previously undescribed triterpenoid saponins based on hederagenin type aglycone, namely, balansoides A-D, along with ten known compounds. Their structures were proposed based on 1D and 2D NMR spectroscopic data, HRESIMS analysis and chemical evidence as 3-O-α-L-rhamnopyranosyl-(1 â†’ 3)-ß-D-xylopyranosyl-(1 â†’ 3)-α-L-rhamnopyranosyl-(1 â†’ 2)-α-L-arabinopyranosyl hederagenin, 3-O-α-L-rhamnopyranosyl-(1 â†’ 3)-ß-D-xylopyranosyl-(1 â†’ 3)-α-L-rhamnopyranosyl-(1 â†’ 2)-α-L-arabinopyranosyl hederagenin 28-O-ß-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl-(1 â†’ 3)-ß-D-xylopyranosyl-(1 â†’ 3)-α-L-rhamnopyranosyl-(1 â†’ 2)-α-L-arabinopyranosyl hederagenin 28-O-ß-D-galactopyranosyl-(1 â†’ 6)-ß-D-glucopyranosyl ester and 3-O-α-L-rhamnopyranosyl-(1 â†’ 3)-ß-D-xylopyranosyl-(1 â†’ 3)-α-L-rhamnopyranosyl-(1 â†’ 2)-α-L-arabinopyranosyl hederagenin 28-O-ß-D-glucopyranosyl-(1 â†’ 6)-ß-D-glucopyranosyl ester. The four saponins were evaluated for their potential cytotoxic activity against HEK-293, A-549, HeLa cells and for hemolytic properties on human blood cells. Balansoide A displayed significant inhibitory effects on cancerous A-549 and HeLa cells, and non-cancerous HEK-293 cells with IC values of 12, 15 and 8 µM, respectively. Balansoides A-D together with n-butanol extract exhibited considerable hemolysis in human erythrocyte cells. Immunomodulatory properties of balansoides A-D were also evaluated in activated whole blood cells by PMA plus ionomycin. While balansoides A-C increased IL-1ß concentration with values of 1004.47, 991.57 and 966.50 pg/ml, only balansoide B augmented a slight IFN-γ secretion with value of 5219.14 pg/ml. None of the compounds changed IL-2 levels significantly.
[Mh] Termos MeSH primário: Caprifoliaceae/química
Saponinas/química
Triterpenos/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Eritrócitos/efeitos dos fármacos
Células HEK293
Hemólise
Seres Humanos
Fatores Imunológicos/química
Fatores Imunológicos/isolamento & purificação
Estrutura Molecular
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Saponinas/isolamento & purificação
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes); 0 (balansoide A)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


  3 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27937009
[Au] Autor:Shen XF; Zeng Y; Li JC; Tang C; Zhang Y; Meng XL
[Ad] Endereço:a College of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , Sichuan , China.
[Ti] Título:The anti-arthritic activity of total glycosides from Pterocephalus hookeri, a traditional Tibetan herbal medicine.
[So] Source:Pharm Biol;55(1):560-570, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Pterocephalus hookeri (C. B. Clarke) Hock., a traditional Tibetan herbal medicine rich in glycosides, has been used to treat several diseases including rheumatoid arthritis. OBJECTIVE: To evaluate the anti-arthritic activity of total glycosides from P. hookeri, and its possible mechanisms of action. MATERIALS AND METHODS: Anti-arthritic activity of total glycosides from P. hookeri (oral administration for 30 days at 14-56 mg/kg) was evaluated using paw swelling, arthritis scores and histopathological measurement in adjuvant-induced arthritis (AA) Sprague-Dawley rats. The NF-κB p65 expression in synovial tissues, and serum superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) levels was measured in AA rats, respectively. Further assessment of anti-inflammatory and analgesic activities of these glycosides were carried out using inflammation and hyperalgesia models induced by xylene, carrageenan, agar and acetic acid, respectively. RESULTS: Total glycosides (56 mg/kg) decreased the paw swelling (38.0%, p < 0.01), arthritis scores (25.3%, p < 0.01) and synovial inflammation in AA rats. The glycosides significantly (p < 0.05-0.01) attenuated the inflammation induced by xylene, carrageenan, acetic acid and agar, increased the pain threshold in acetic acid-induced writhing in mice and mechanical stimuli-induced hyperalgia in AA rats. The glycosides (14, 28, 56 mg/kg) also suppressed the NF-κB p65 expression (33.1-78.2%, p < 0.05-0.01), reduced MDA (21.3-35.9%, p < 0.01) and NO (20.3-32.4%, p < 0.05-0.01) levels, respectively, enhanced the SOD activity (7.8%, p < 0.05) at 56 mg/kg in AA rats. DISCUSSION AND CONCLUSION: Our findings confirmed the anti-arthritic property of the total glycosides from P. hookeri, which may be attributed to its inhibition on NF-κB signalling and oxidative stress.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Artrite Experimental/tratamento farmacológico
Caprifoliaceae/química
Glicosídeos/farmacologia
Articulações/efeitos dos fármacos
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Artrite Experimental/induzido quimicamente
Artrite Experimental/metabolismo
Artrite Experimental/patologia
Comportamento Animal/efeitos dos fármacos
Biomarcadores/sangue
Relação Dose-Resposta a Droga
Edema/induzido quimicamente
Edema/prevenção & controle
Feminino
Adjuvante de Freund
Glicosídeos/isolamento & purificação
Hiperalgesia/induzido quimicamente
Hiperalgesia/fisiopatologia
Hiperalgesia/prevenção & controle
Mediadores da Inflamação/sangue
Articulações/metabolismo
Articulações/patologia
Masculino
Malondialdeído/sangue
Medicina Tradicional Tibetana
Camundongos
Óxido Nítrico/sangue
Limiar da Dor/efeitos dos fármacos
Fitoterapia
Preparações de Plantas/isolamento & purificação
Plantas Medicinais
Ratos Sprague-Dawley
Superóxido Dismutase/sangue
Fatores de Tempo
Fator de Transcrição RelA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Glycosides); 0 (Inflammation Mediators); 0 (Plant Preparations); 0 (Rela protein, rat); 0 (Transcription Factor RelA); 31C4KY9ESH (Nitric Oxide); 4Y8F71G49Q (Malondialdehyde); 9007-81-2 (Freund's Adjuvant); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  4 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27615893
[Au] Autor:Gagné RJ
[Ad] Endereço:Systematic Entomology Laboratory, Agricultural Research Service, U.S. Department of Agriculture, c/o Smithsonian Institution MRC-168, P.O. Box 37012, Washington, DC 20013-7012, USA.; Email: raymond.gagne@ars.usda.gov.
[Ti] Título:Three new genera and three new species of Nearctic Lasiopteridi (Diptera: Cecidomyiidae: Cecidomyiinae) from Asteraceae and Caprifoliaceae, and the tribe Rhopalomyiini subsumed under Oligotrophini.
[So] Source:Zootaxa;4158(3):403-18, 2016 Aug 30.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Three new Nearctic genera of gall midges (Diptera: Cecidomyiidae), each with a new species, are described: Helianthecis Gagné for Helianthecis capitum Gagné, new species, that lives in flower heads of Helianthus spp. (Asteraceae) from North Dakota to Texas; Lonicerae Gagné for Lonicerae russoi Gagné, new species, and Lonicerae lonicera (Felt), new combination, that form bud galls on Lonicera spp. (Caprifoliaceae) in California; and Chiosperma Gagné for Chiosperma turgidum Gagné, new species, that forms a bud gall on Symphoricarpos albus (L.) S.F. Blake (Caprifoliaceae) in Washington. The three new genera belong to the supertribe Lasiopteridi and are placed in the tribe Oligotrophini. The tribes Oligotrophini and Rhopalomyiini are combined.
[Mh] Termos MeSH primário: Asteraceae/parasitologia
Caprifoliaceae/parasitologia
Chironomidae/classificação
[Mh] Termos MeSH secundário: Distribuição Animal
Estruturas Animais/anatomia & histologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Tamanho Corporal
Chironomidae/anatomia & histologia
Chironomidae/crescimento & desenvolvimento
Feminino
Masculino
Tamanho do Órgão
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4158.3.6


  5 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27425632
[Au] Autor:Resetnik I; Frajman B; Schönswetter P
[Ad] Endereço:Faculty of Science, University of Zagreb, Marulicev trg 20/II, HR-10000 Zagreb, Croatia.
[Ti] Título:Heteroploid Knautia drymeia includes K. gussonei and cannot be separated into diagnosable subspecies.
[So] Source:Am J Bot;103(7):1300-13, 2016 07.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Knautia drymeia is a morphologically variable, diploid and tetraploid temperate forest understory species distributed in southeastern Europe and adjacent areas. The species is an excellent system to explore the influence of polypoidy on taxonomic delineations, the role of hybridization among genetically distant populations in polyploid evolution, and the impact of glacial refugia on the evolution of polyploids. METHODS: Amplified fragment length polymorphism fingerprinting and multivariate analyses of morphological characters were performed on 57 populations spanning the distribution area of K. drymeia. K-means clustering, comparison of in-silico tetraploids and observed tetraploids, and a phylogeographic analysis using relaxed random walks were used to explore the genetic structure within the diploids, to infer the origin of the tetraploids and to reconstruct range expansion through time. Further, we contrasted the morphology and genetic groups with current taxonomy and evaluated the status of the tetraploid Apennine endemic K. gussonei and the intraspecific taxa of K. drymeia. KEY RESULTS: The genetic structure was strongly geographically correlated and yielded four genetic groups; K. gussonei was inseparable from K. drymeia. Distributions of diploid lineages are suggestive of glacial refugia in the northwesternmost and southeastern Balkan Peninsula. Polyploids originated at least two times, as autopolyploids and probably additionally also as allopolyploids. Morphological divergence corresponded with neither genetic groups nor current taxonomy. CONCLUSIONS: Genetic and morphometric data confirmed neither divergence of K. gussonei nor recognition of subspecies within K. drymeia. We therefore propose treating K. drymeia as a morphologically and genetically variable species without infraspecific taxa.
[Mh] Termos MeSH primário: Caprifoliaceae/classificação
Ploidias
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Evolução Biológica
Caprifoliaceae/genética
Diploide
Genética Populacional
Filogeografia
Poliploidia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1500506


  6 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26880798
[Au] Autor:Lee H; Woo ER; Lee DG
[Ad] Endereço:School of Life Sciences, BK 21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daehak-ro 80, Buk-gu, Daegu 702-701, Republic of Korea.
[Ti] Título:(-)-Nortrachelogenin from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans.
[So] Source:FEMS Yeast Res;16(3), 2016 May.
[Is] ISSN:1567-1364
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study analyzes the antifungal properties of (-)-nortrachelogenin and elucidates its mode of action against pathogenic fungi. We performed susceptibility tests against several pathogenic fungi and verified the absence of hemolysis against human erythrocytes. Its antifungal activity increased reactive oxygen species (ROS) in response to intracellular stress and increased concentrations of both intracellular and extracellular trehalose without causing hemolysis. In addition, a cell wall regeneration study indicated its action on the cytoplasmic membrane. A cell surface study using 3,3(')-dipropylthiacarbocyanine iodide [DiSC3(5)] and 1,6-diphenyl-1,3,5-hexatriene (DPH) demonstrated dissipation of the cytoplasmic membrane at high concentrations. Our study revealed a disturbance in the membrane at higher concentrations and externalization of phosphatidylserine in a dose-dependent manner, affecting other intracellular responses. Furthermore, we investigated the late stage of apoptosis using TUNEL and 4('),6-diamidino-2-phenylindole (DAPI) assays. (-)-Nortrachelogenin-treated cells underwent apoptosis which was triggered by mitochondrial dysfunction via depolarization of the mitochondrial membrane, release of cytochrome c and calcium ion signaling, resulting in the activation of metacaspases. Different concentrations of (-)-nortrachelogenin induced membrane disruption and caspase-dependent apoptosis.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Apoptose
Candida albicans/efeitos dos fármacos
Candida albicans/fisiologia
Furanos/farmacologia
Lignanas/farmacologia
Viabilidade Microbiana/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antifúngicos/isolamento & purificação
Antifúngicos/toxicidade
Caprifoliaceae/química
Membrana Celular/efeitos dos fármacos
Membrana Celular/fisiologia
Eritrócitos/efeitos dos fármacos
Furanos/isolamento & purificação
Furanos/toxicidade
Hemólise
Seres Humanos
Lignanas/isolamento & purificação
Lignanas/toxicidade
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Furans); 0 (Lignans); 5HG1T9G09U (nortrachelogenin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160217
[St] Status:MEDLINE


  7 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26880432
[Au] Autor:Vukicevic DR; Stevanovic DD; Gencic MS; Blagojevic PD; Radulovic NS
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, S. Markovica 69, RS-34000 Kragujevac.
[Ti] Título:Essential-Oil Constituents and Alkanes of Cephalaria ambrosioides Roem. & Schult. (Family Caprifoliaceae, Subfamily Dipsacaceae) and (Chemo)taxonomic Discernment of the Subfamilies Dipsacaceae and Morinaceae.
[So] Source:Chem Biodivers;13(2):198-209, 2016 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Herein, the results of the first study of the volatile and alkane profiles of Cephalaria ambrosioides Roem. & Schult. (Caprifoliaceae, subfamily Dipsacaceae) were reported. The GC-FID and GC/MS analyses of the essential oils hydrodistilled from leaves and stems (CA1) and flowers (CA2) of C. ambrosioides allowed the identification of 284 different components. The main compounds of the studied oil samples were palmitic acid (24.3 and 32.5% for CA1 and CA2, resp.), hexahydrofarnesyl acetone (1.4 and 10.8% for CA1 and CA2, resp.), (Z)-hex-3-en-1-ol (7.0 and <0.1% for CA1 and CA2, resp.), and linoleic acid (1.9 and 6.5% for CA1 and CA2, resp.). Essential-oil compositional data of selected plant species belonging to the Dipsacaceae (15) and Morinaceae (2) subfamilies were used to resolve taxonomical ambiguities regarding the genus Cephalaria and its infrageneric relations, especially concerning the subfamily Morinaceae (formerly a genus within Dipsacaceae). The results of multivariate statistical analyses (25 different essential-oil samples) supported the exclusion of Morina species from the Dipsacaceae subfamily. The relative abundances of alkanes from n-, iso-, and anteiso-series followed a (distorted) Gaussian-like distribution and suggested that the biosyntheses of n- and branched alkanes in C. ambrosioides are possibly not controlled by the same elongase. Also, the obtained results suggested that there was a difference in the biosynthesis/accumulation of alkanes in the vegetative and reproductive parts of C. ambrosioides.
[Mh] Termos MeSH primário: Alcanos/análise
Caprifoliaceae/química
Dipsacaceae/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Flores/química
Cromatografia Gasosa-Espectrometria de Massas
Folhas de Planta/química
Caules de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkanes); 0 (Oils, Volatile)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160217
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500050


  8 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26805449
[Au] Autor:Rezgui A; Mitaine-Offer AC; Miyamoto T; Tanaka C; Delemasure S; Dutartre P; Lacaille-Dubois MA
[Ad] Endereço:Laboratoire de Pharmacognosie, EA 4267, FDE, Université de Bourgogne Franche-Comté, UFR Sciences de Santé, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
[Ti] Título:Oleanolic acid and hederagenin glycosides from Weigela stelzneri.
[So] Source:Phytochemistry;123:40-7, 2016 Mar.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four previously undescribed and one known oleanolic acid glycosides were isolated from the roots of Weigela stelzneri, and one previously undescribed and three known hederagenin glycosides were isolated from the leaves. Their structures were elucidated mainly by 2D NMR spectroscopic analysis and mass spectrometry as 3-O-ß-D-glucopyranosyl-(1 → 2)-[ß-D-xylopyranosyl-(1 → 4)]-ß-D-xylopyranosyl-(1 → 4)-ß-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyloleanolic acid, 3-O-ß-D-glucopyranosyl-(1 → 2)-[ß-D-xylopyranosyl-(1 → 4)]-ß-D-xylopyranosyl-(1 → 4)-ß-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-ß-D-xylopyranosyloleanolic acid, 3-O-ß-D-glucopyranosyl-(1 → 2)-[ß-D-glucopyranosyl-(1 → 4)]-ß-D-xylopyranosyl-(1 → 4)-ß-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-ß-D-xylopyranosyloleanolic acid, 3-O-ß-D-glucopyranosyl-(1 → 2)-[ß-D-xylopyranosyl-(1 → 4)]-ß-D-xylopyranosyl-(1 → 4)-ß-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyloleanolic acid 28-O-ß-D-glucopyranosyl-(1 → 6)-ß-D-glucopyranosyl ester, and 3-O-ß-D-glucopyranosyl-(1 → 2)-α-L-arabinopyranosylhederagenin 28-O-ß-D-xylopyranosyl-(1 → 6)-[α-L-rhamnopyranosyl-(1 → 2)]-ß-D-glucopyranosyl ester. The majority of the isolated compounds were evaluated for their cytotoxicity against two tumor cell lines (SW480 and EMT-6), and for their anti-inflammatory activity. The compounds 3-O-ß-D-glucopyranosyl-(1 → 2)-[ß-D-xylopyranosyl-(1 → 4)]-ß-D-xylopyranosyl-(1 → 4)-ß-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyloleanolic acid and 3-O-ß-D-glucopyranosyl-(1 → 2)-[ß-D-xylopyranosyl-(1 → 4)]-ß-D-xylopyranosyl-(1 → 4)-ß-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-ß-D-xylopyranosyloleanolic acid exhibited the strongest cytotoxicity on both cancer cell lines. They revealed a 50% significant inhibitory effect of the IL-1ß production by PBMCs stimulated with LPS at a concentration inducing a very low toxicity of 23% and 28%, respectively.
[Mh] Termos MeSH primário: Caprifoliaceae/química
Glicosídeos/isolamento & purificação
Ácido Oleanólico/isolamento & purificação
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Glicosídeos/química
Glicosídeos/farmacologia
Interleucina-1beta/análise
Interleucina-1beta/efeitos dos fármacos
Interleucina-1beta/metabolismo
Lipopolissacarídeos/farmacologia
Ressonância Magnética Nuclear Biomolecular
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/química
Ácido Oleanólico/farmacologia
Folhas de Planta/química
Raízes de Plantas/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Interleukin-1beta); 0 (Lipopolysaccharides); 6SMK8R7TGJ (Oleanolic Acid); RQF57J8212 (hederagenin)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE


  9 / 52 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26182989
[Au] Autor:Frajman B; Resetnik I; Weiss-Schneeweiss H; Ehrendorfer F; Schönswetter P
[Ad] Endereço:Institute of Botany, University of Innsbruck, Sternwartestraße 15, A-6020, Innsbruck, Austria.
[Ti] Título:Cytotype diversity and genome size variation in Knautia (Caprifoliaceae, Dipsacoideae).
[So] Source:BMC Evol Biol;15:140, 2015 Jul 17.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Polyploidisation is one of the most important mechanisms in the evolution of angiosperms. As in many other genera, formation of polyploids has significantly contributed to diversification and radiation of Knautia (Caprifoliaceae, Dipsacoideae). Comprehensive studies of fine- and broad-scale patterns of ploidy and genome size (GS) variation are, however, still limited to relatively few genera and little is known about the geographic distribution of ploidy levels within these genera. Here, we explore ploidy and GS variation in Knautia based on a near-complete taxonomic and comprehensive geographic sampling. RESULTS: Genome size is a reliable indicator of ploidy level in Knautia, even if monoploid genome downsizing is observed in the polyploid cytotypes. Twenty-four species studied are diploid, 16 tetraploid and two hexaploid, whereas ten species possess two, and two species possess three ploidy levels. Di- and tetraploids are distributed across most of the distribution area of Knautia, while hexaploids were sampled in the Balkan and Iberian Peninsulas and the Alps. CONCLUSIONS: We show that the frequency of polyploidisation is unevenly distributed in Knautia both in a geographic and phylogenetic context. Monoploid GS varies considerably among three evolutionary lineages (sections) of Knautia, but also within sections Trichera and Tricheroides, as well as within some of the species. Although the exact causes of this variation remain elusive, we demonstrate that monoploid GS increases significantly towards the limits of the genus' distribution.
[Mh] Termos MeSH primário: Caprifoliaceae/genética
Poliploidia
[Mh] Termos MeSH secundário: Evolução Biológica
Caprifoliaceae/classificação
Caprifoliaceae/citologia
Cromossomos de Plantas
Tamanho do Genoma
Magnoliopsida/citologia
Magnoliopsida/genética
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1511
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-015-0425-y


  10 / 52 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:26107217
[Au] Autor:Al-Taweel AM; Perveen S; Fawzy GA; Ibrahim TA; Khan A; Mehmood R
[Ad] Endereço:Department of Pharmacognosy, College of Pharmacy, King Saud University. Riyadh, Kingdom of Saudi Arabia E-mail : ataweel@hotmail.com.
[Ti] Título:Cytotoxicity Assessment of Six Different Extracts of Abelia triflora leaves on A-549 Human Lung Adenocarcinoma Cells.
[So] Source:Asian Pac J Cancer Prev;16(11):4641-5, 2015.
[Is] ISSN:2476-762X
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:The present investigation was designed to assess the anticancer activity of six different leaf extracts (ethyl acetate, methanol, chloroform, petroleum ether, n-butanol, and water soluble) of Abelia triflora on A-549 human lung adenocarcinoma epithelial cells. A-549 cells were exposed to 10-1000 µg/ml concentrations of the leaf extracts of A. triflorafor 24 h and then percentage cell viability was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyl tetrazolium bromide (MTT) assay. The results showed that leaf extracts of A. triflora significantly reduced the viability of A-549 cells in a concentration-dependent manner. Decrease was recorded as 31% with ethyl acetate, 36% with methanol, 46% with chloroform, 54% with petroleum ether, 62% with n-butanol, and 63% with water soluble extracts at 1000 µg/ml each. Among the various plant extracts, ethyl acetate extract showed the highest decrease in the percentage cell viability, followed by methanol, chloroform, petroleum ether, n-butanol, and water soluble extracts. Our results demonstrated preliminary screening of anticancer activity of different soluble extracts of A. triflora extracts against A-549 cells, which can be further used for the development of a potential therapeutic anticancer agents.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Apoptose/efeitos dos fármacos
Caprifoliaceae/química
Neoplasias Pulmonares/patologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
Solventes/química
[Mh] Termos MeSH secundário: Adenocarcinoma/tratamento farmacológico
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Solvents)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150625
[St] Status:MEDLINE



página 1 de 6 ir para página                
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde