Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.328.750.388 [Categoria DeCS]
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[PMID]:29223813
[Au] Autor:Zhou Y; Tang RC
[Ad] Endereço:National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, 199 Renai Road, Suzhou 215123, China.
[Ti] Título:Facile and eco-friendly fabrication of AgNPs coated silk for antibacterial and antioxidant textiles using honeysuckle extract.
[So] Source:J Photochem Photobiol B;178:463-471, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Recently, there is a growing trend towards the functionalization of silk through nanotechnology for the prevention of fiber damage from microbial attack and the enhancement of hygienic aspects. Considering sustainable development and environmental protection, the eco-friendly fabrication of silver nanoparticles (AgNPs)-modified silk using natural extracts has currently become a hot research area. This study presents a facile strategy for the fabrication of colorful and multifunctional silk fabric using biogenic AgNPs prepared by honeysuckle extract as natural reductant and stabilizing agents. The influences of pH and reactant concentrations on the AgNPs synthesis were investigated. The color characteristics and functionalities of AgNPs treated silk were evaluated. The results revealed that the particle size of AgNPs decreased with increasing pH. The diameter of AgNPs decreased with increasing amount of honeysuckle extract and reducing amount of silver nitrate. The transmission electron microscopy image showed that the AgNPs were spherical in shape with a narrow size distribution. The treated silk showed excellent antibacterial activities against E. coli and S. aureus, and certain antioxidant activity. Both of the antibacterial and antioxidant activities were well maintained even after 30 washing cycles. This work provides a sustainable and eco-friendly approach to the fabrication of AgNPs coated silk for colorful and long-term multifunctional textiles using honeysuckle extract.
[Mh] Termos MeSH primário: Antibacterianos/química
Antioxidantes/química
Lonicera/química
Nanopartículas Metálicas/química
Seda/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Escherichia coli/efeitos dos fármacos
Química Verde
Concentração de Íons de Hidrogênio
Lonicera/metabolismo
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Transmissão
Tamanho da Partícula
Extratos Vegetais/química
Prata/química
Staphylococcus aureus/efeitos dos fármacos
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Silk); 3M4G523W1G (Silver)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


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[PMID]:28573848
[Au] Autor:Wu S; Yano S; Chen J; Hisanaga A; Sakao K; He X; He J; Hou DX
[Ad] Endereço:Core Research Program 1515, Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, Hunan Agricultural University , Changsha, Hunan 410128, China.
[Ti] Título:Polyphenols from Lonicera caerulea L. Berry Inhibit LPS-Induced Inflammation through Dual Modulation of Inflammatory and Antioxidant Mediators.
[So] Source:J Agric Food Chem;65(25):5133-5141, 2017 Jun 28.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lonicera caerulea L. berry polyphenols (LCBP) are considered as major components for bioactivity. This study aimed to clarify the molecular mechanisms by monitoring inflammatory and antioxidant mediator actions in lipopolysaccharide (LPS)-induced mouse paw edema and macrophage cell model. LCBP significantly attenuated LPS-induced paw edema (3.0 ± 0.1 to 2.8 ± 0.1 mm, P < 0.05) and reduced (P < 0.05) serum levels of monocyte chemotactic protein-1 (MCP-1, 100.9 ± 2.3 to 58.3 ± 14.5 ng/mL), interleukin (IL)-10 (1596.1 ± 424.3 to 709.7 ± 65.7 pg/mL), macrophage inflammatory protein (MIP)-1α (1761.9 ± 208.3 to 1369.1 ± 56.4 pg/mL), IL-6 (1262.8 ± 71.7 to 499.0 ± 67.1 pg/mL), IL-4 (93.3 ± 25.7 to 50.7 ± 12.5 pg/mL), IL-12(p-70) (580.4 ± 132.0 to 315.2 ± 35.1 pg/mL), and tumor necrosis factor-α (TNF-α, 2045.5 ± 264.9 to 1270.7 ± 158.6 pg/mL). Cell signaling analysis revealed that LCBP inhibited transforming growth factor ß activated kinase-1 (TAK1)-mediated mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways, and enhanced the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and manganese-dependent superoxide dismutase (MnSOD) in earlier response. Moreover, cyanidin 3-glucoside (C3G) and (-)-epicatechin (EC), two major components of LCBP, directly bound to TAK1. These data demonstrated that LCBP might inhibit LPS-induced inflammation by modulating both inflammatory and antioxidant mediators.
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Edema/tratamento farmacológico
Mediadores da Inflamação/administração & dosagem
Lonicera/química
Extratos Vegetais/administração & dosagem
Polifenóis/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Quimiocina CCL2/genética
Quimiocina CCL2/imunologia
Edema/genética
Edema/imunologia
Frutas/química
Seres Humanos
Mediadores da Inflamação/isolamento & purificação
Interleucina-12/genética
Interleucina-12/imunologia
Interleucina-4/genética
Interleucina-4/imunologia
Interleucina-6/genética
Interleucina-6/imunologia
Lipopolissacarídeos/efeitos adversos
Lipopolissacarídeos/imunologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Proteínas Quinases Ativadas por Mitógeno/genética
Proteínas Quinases Ativadas por Mitógeno/imunologia
NF-kappa B/genética
NF-kappa B/imunologia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Polifenóis/química
Polifenóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Chemokine CCL2); 0 (Inflammation Mediators); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Polyphenols); 187348-17-0 (Interleukin-12); 207137-56-2 (Interleukin-4); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01599


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[PMID]:28425933
[Au] Autor:Zhou W; Yin A; Shan J; Wang S; Cai B; Di L
[Ad] Endereço:College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhouwei19860506@163.com.
[Ti] Título:Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide via Integral Pharmacokinetics.
[So] Source:Molecules;22(4), 2017 Apr 20.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present study, the rationality for the antiviral effect (H1N1 virus) of (FLJ, named JinYinHua)-Fructus forsythiae (FF, named LianQiao) herb couple preparations improved by chito-oligosaccharide (COS) was investigated. We found that the improvement of antiviral activity for four preparations attributed to the enhancement of bioavailability for the FLJ-FF herb couple in vivo, and that caffeic acid derivatives are the most important type of components for antiviral activity. The anti-Influenza virus activity-half maximal inhibitory concentration (IC ), not area under concentration (AUC) was considered as the weighting factor for integrating the pharmacokinetics of caffeic acid derivatives. It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significantly by COS, an absorption enhancer based on tight junction. The results indicated that the antiviral activity in four preparations improved by COS was mainly attributed to the integral absorption enhancement of caffeic acid derivatives.
[Mh] Termos MeSH primário: Antivirais/química
Antivirais/farmacologia
Forsythia/química
Lonicera/química
Oligossacarídeos/química
Oligossacarídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antivirais/farmacocinética
Disponibilidade Biológica
Ácidos Cafeicos/química
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cães
Monitoramento de Medicamentos
Vírus da Influenza A Subtipo H1N1/efeitos dos fármacos
Concentração Inibidora 50
Absorção Intestinal/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Oligossacarídeos/farmacocinética
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Caffeic Acids); 0 (Oligosaccharides); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE


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[PMID]:28417913
[Au] Autor:Ma Q; Liang D; Song S; Yu Q; Shi C; Xing X; Luo JB
[Ad] Endereço:School of Traditional Chinese Medical Science, Southern Medical University, Guangzhou 510515, China. 13268268214@163.com.
[Ti] Título:Comparative Study on the Antivirus Activity of Shuang-Huang-Lian Injectable Powder and Its Bioactive Compound Mixture against Human Adenovirus III In Vitro.
[So] Source:Viruses;9(4), 2017 Apr 12.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Shuang-Huang-Lian injectable powder (SHL)-a classical purified herbal preparation extracted from , , and -has been used against human adenovirus III (HAdV3) for many years. The combination herb and its major bioactive compounds, including chlorogenic acid, baicalin, and forsythia glycosides A, are effective inhibitors of the virus. However, no comprehensive studies are available on the antiviral effects of SHL against HAdV3. Moreover, it remains unclear whether the mixture of chlorogenic acid, baicalin, and forsythia glycosides A (CBF) has enhanced antiviral activity compared with SHL. Therefore, a comparative study was performed to investigate the combination which is promising for further antiviral drug development. To evaluate their antivirus activity in parallel, the combination ratio and dose of CBF were controlled and consistent with SHL. First, the fingerprint and the ratio of CBF in SHL were determined by high performance liquid chromatography. Then, a plaque reduction assay, reverse transcription polymerase chain reaction (PCR), real-time polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay (ELISA) were used to explore its therapeutic effects on viral infection and replication, respectively. The results showed that SHL and CBF inhibited dose- and time-dependently HAdV3-induced plaque formation in A549 and HEp-2 cells. SHL was more effective than CBF when supplemented prior to and after viral inoculation. SHL prevented viral attachment, internalization, and replication at high concentration and decreased viral levels within and out of cells at non-toxic concentrations in both cell types. Moreover, the expression of tumor necrosis factor alpha (TNF)-α, interleukin (IL)-1ß, and IL-6 was lower and the expression of interferon (IFN)-γ was higher in both cell types treated with SHL than with CBF. In conclusion, SHL is much more effective and slightly less toxic than CBF.
[Mh] Termos MeSH primário: Adenovírus Humanos/efeitos dos fármacos
Antivirais/farmacologia
Misturas Complexas/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adenovírus Humanos/fisiologia
Antivirais/química
Antivirais/isolamento & purificação
Linhagem Celular
Cromatografia Líquida de Alta Pressão
Misturas Complexas/química
Misturas Complexas/isolamento & purificação
Citocinas/antagonistas & inibidores
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Ensaio de Imunoadsorção Enzimática
Forsythia/química
Seres Humanos
Lonicera/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Scutellaria baicalensis/química
Carga Viral
Ensaio de Placa Viral
Ligação Viral/efeitos dos fármacos
Internalização do Vírus/efeitos dos fármacos
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Complex Mixtures); 0 (Cytokines); 0 (Drugs, Chinese Herbal); 0 (Plant Extracts); 0 (shuang-huang-lian)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170521
[Lr] Data última revisão:
170521
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28369447
[Au] Autor:Mahon MB; Campbell KU; Crist TO
[Ad] Endereço:Department of Biology, Miami University, 700 E High St, 212 Pearson Hall, Oxford, OH 45056 (mahonmb@miamioh.edu; kaitlin.campbell@uncp.edu; cristto@miamioh.edu).
[Ti] Título:Effectiveness of Winkler Litter Extraction and Pitfall Traps in Sampling Ant Communities and Functional Groups in a Temperate Forest.
[So] Source:Environ Entomol;46(3):470-479, 2017 06 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Selection of proper sampling methods for measuring a community of interest is essential whether the study goals are to conduct a species inventory, environmental monitoring, or a manipulative experiment. Insect diversity studies often employ multiple collection methods at the expense of researcher time and funding. Ants (Formicidae) are widely used in environmental monitoring owing to their sensitivity to ecosystem changes. When sampling ant communities, two passive techniques are recommended in combination: pitfall traps and Winkler litter extraction. These recommendations are often based on studies from highly diverse tropical regions or when a species inventory is the goal. Studies in temperate regions often focus on measuring consistent community response along gradients of disturbance or among management regimes; therefore, multiple sampling methods may be unnecessary. We compared the effectiveness of pitfalls and Winkler litter extraction in an eastern temperate forest for measuring ant species richness, composition, and occurrence of ant functional groups in response to experimental manipulations of two key forest ecosystem drivers, white-tailed deer and an invasive shrub (Amur honeysuckle). We found no significant effect of sampling method on the outcome of the ecological experiment; however, we found differences between the two sampling methods in the resulting ant species richness and functional group occurrence. Litter samples approximated the overall combined species richness and composition, but pitfalls were better at sampling large-bodied (Camponotus) species. We conclude that employing both methods is essential only for species inventories or monitoring ants in the Cold-climate Specialists functional group.
[Mh] Termos MeSH primário: Formigas/fisiologia
Biodiversidade
Conservação dos Recursos Naturais
Entomologia/métodos
[Mh] Termos MeSH secundário: Animais
Cervos/fisiologia
Lonicera/fisiologia
Ohio
Densidade Demográfica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx061


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[PMID]:28320974
[Au] Autor:Wang Y; Xue J; Jin H; Ma S
[Ad] Endereço:Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College.
[Ti] Título:Dissipation of Flonicamid in Honeysuckle and Its Transfer during Brewing Process.
[So] Source:Chem Pharm Bull (Tokyo);65(5):492-497, 2017 May 01.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The dissipation of flonicamid in Honeysuckle and transfer pattern from Honeysuckle to its tea infusion were investigated. Flonicamid was applied on Honeysuckle crop at two dosages, 60 g of active gradient per hectare (g a.i. hm ) and 180 g a.i. hm (recommended and triple the recommended) in Fenqiu, Henan Province in 2015 and 2016. Gas Chromatography-Electron Capture Detector (GC-ECD) detection methods were developed for the analysis of flonicamid residues in honeysuckles and its infusion. The recoveries in both honeysuckles and its infusion ranged from 81.5 to 101.7% with relative standard deviations (RSDs) of 3.2-9.1%. The dissipations of flonicamid in Honeysuckle were found to follow the first order kinetics with half-life ranging between 2.8 and 3.2 d. After recommended dose pesticide application, contents of flonicamid residues were lower than theoretical maximum residue limit (tMRL). Flonicamid residues can easily transfer from Honeysuckle to its tea infusion and transfer rates of flonicamid decrease with the brewing temperature reduction or the brewing times increase. These results are helpful to establish maximum residue limit and develop guidance on the appropriate and secure use of flonicamid in Honeysuckle.
[Mh] Termos MeSH primário: Contaminação de Alimentos/análise
Lonicera/química
Niacinamida/análogos & derivados
Praguicidas/análise
Chá/química
[Mh] Termos MeSH secundário: Técnicas de Química Analítica
Lonicera/metabolismo
Niacinamida/análise
Niacinamida/metabolismo
Praguicidas/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticides); 0 (Tea); 25X51I8RD4 (Niacinamide); 9500W2Z53J (flonicamid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c16-01015


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[PMID]:28302120
[Au] Autor:Bol S; Caspers J; Buckingham L; Anderson-Shelton GD; Ridgway C; Buffington CA; Schulz S; Bunnik EM
[Ad] Endereço:Cowboy Cat Ranch, Mico, TX, 78056, USA. bol@cowboycatranch.org.
[Ti] Título:Responsiveness of cats (Felidae) to silver vine (Actinidia polygama), Tatarian honeysuckle (Lonicera tatarica), valerian (Valeriana officinalis) and catnip (Nepeta cataria).
[So] Source:BMC Vet Res;13(1):70, 2017 Mar 16.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Olfactory stimulation is an often overlooked method of environmental enrichment for cats in captivity. The best known example of olfactory enrichment is the use of catnip, a plant that can cause an apparently euphoric reaction in domestic cats and most of the Pantherinae. It has long been known that some domestic cats and most tigers do not respond to catnip. Although many anecdotes exist of other plants with similar effects, data are lacking about the number of cats that respond to these plants, and if cats that do not respond to catnip respond to any of them. Furthermore, much is still unknown about which chemicals in these plants cause this response. METHODS: We tested catnip, silver vine, Tatarian honeysuckle and valerian root on 100 domestic cats and observed their response. Each cat was offered all four plant materials and a control, multiple times. Catnip and silver vine also were offered to nine tigers. The plant materials were analyzed by gas chromatography coupled with mass spectrometry to quantify concentrations of compounds believed to exert stimulating effects on cats. RESULTS: Nearly all domestic cats responded positively to olfactory enrichment. In agreement with previous studies, one out of every three cats did not respond to catnip. Almost 80% of the domestic cats responded to silver vine and about 50% to Tatarian honeysuckle and valerian root. Although cats predominantly responded to fruit galls of the silver vine plant, some also responded positively to its wood. Of the cats that did not respond to catnip, almost 75% did respond to silver vine and about one out of three to Tatarian honeysuckle. Unlike domestic cats, tigers were either not interested in silver vine or responded disapprovingly. The amount of nepetalactone was highest in catnip and only present at marginal levels in the other plants. Silver vine contained the highest concentrations of all other compounds tested. CONCLUSIONS: Olfactory enrichment for cats may have great potential. Silver vine powder from dried fruit galls and catnip were most popular among domestic cats. Silver vine and Tatarian honeysuckle appear to be good alternatives to catnip for domestic cats that do not respond to catnip.
[Mh] Termos MeSH primário: Actinidia
Felidae/fisiologia
Lonicera
Nepeta
Valeriana
[Mh] Termos MeSH secundário: Actinidia/química
Fatores Etários
Animais
Comportamento Animal
Gatos
Ciclopentanos
Feminino
Lonicera/química
Lynx/fisiologia
Masculino
Nepeta/química
Feromônios
Pironas
Olfato
Tigres
Valeriana/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopentanes); 0 (Pheromones); 0 (Pyrones); 21651-62-7 (nepetalactone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-0987-6


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[PMID]:28273885
[Au] Autor:Kucharska AZ; Sokól-Letowska A; Oszmianski J; Piórecki N; Fecka I
[Ad] Endereço:Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wroclaw University of Environmental and Life Science, Chelmonskiego 37, 51-630 Wroclaw, Poland. alicja.kucharska@upwr.edu.pl.
[Ti] Título:Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.).
[So] Source:Molecules;22(3), 2017 Mar 05.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Iridoid and polyphenol profiles of 30 different honeysuckle berry cultivars and genotypes were studied. Compounds were identified by ultra-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UPLC-ESI-qTOF-MS/MS) in positive and negative ion modes and quantified by HPLC-PDA. The 50 identified compounds included 15 iridoids, 6 anthocyanins, 9 flavonols, 2 flavanonols (dihydroflavonols), 5 flavones, 6 flavan-3-ols, and 7 phenolic acids. 8- -Loganic acid, pentosyl-loganic acid, taxifolin 7- -dihexoside, and taxifolin 7- -hexoside were identified in honeysuckle berries for the first time. Iridoids and anthocyanins were the major groups of bioactive compounds of honeysuckle constituents. The total content of quantified iridoids and anthocyanins was between 128.42 mg/100 g fresh weight (fw) ('Dlinnoplodnaya') and 372 mg/100 g fw ('Kuvshinovidnaya') and between 150.04 mg/100 g fw ('Karina') and 653.95 mg/100 g fw ('Amur'), respectively. Among iridoids, loganic acid was the dominant compound, and it represented between 22% and 73% of the total amount of quantified iridoids in honeysuckle berry. A very strong correlation was observed between the antioxidant potential and the quantity of anthocyanins. High content of iridoids in honeysuckle berries can complement antioxidant properties of phenolic compounds.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Frutas/química
Iridoides/química
Lonicera/química
Fenóis/química
Exsudatos de Plantas/química
Exsudatos de Plantas/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Radicais Livres/antagonistas & inibidores
Compostos Fitoquímicos/química
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radicals); 0 (Iridoids); 0 (Phenols); 0 (Phytochemicals); 0 (Plant Exudates)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:28260397
[Au] Autor:Liu R; Lai K; Xiao Y; Ren J
[Ad] Endereço:a School of Medicine and Nursing, Chengdu University , Chengdu , China.
[Ti] Título:Comparative pharmacokinetics of chlorogenic acid in beagles after oral administrations of single compound, the extracts of Lonicera japanica, and the mixture of chlorogenic acid, baicalin, and Forsythia suspense.
[So] Source:Pharm Biol;55(1):1234-1238, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Chlorogenic acid (ChA) is the major compound in Shuang-Huang-Lian (SHL), which is mainly composed of ChA, baicalin, and Forsythia suspense Thunb Vahl. OBJECTIVE: The effects of co-existing compounds in SHL and Lonicera japanica Thunb on the absorption of ChA was investigated. MATERIALS AND METHODS: According to 3 × 3 Latin-square test, ChA alone, the extracts of Lonicera japanica, or the mixture of ChA, baicalin and Forsythia suspense (ChA effective doses is 60 mg/kg) was separately given to six beagles for seven days. The oral pharmacokinetic parameters of ChA in plasma, urine and faeces were quantified by HPLC/UV and analyzed. RESULTS: The pharmacokinetic parameters of ChA alone, the extracts of Lonicera japanica, and the mixture of ChA, baicalin, and Forsythia suspense were as followed: C (2.350 ± 0.483, 1.655 ± 0.576, 2.332 ± 0.606 µg/mL), AUC (6.324 ± 1.853, 4.216 ± 1.886, 6.074 ± 1.473 µg·h/mL), t (0.911 ± 0.187, 1.204 ± 0.309, 1.094 ± 0.193 h), and T (1.861 ± 0.499, 1.000 ± 0.459, 1.833 ± 0.279 h). Accumulative fraction excretion of ChA in urine were 0.73 ± 0.55, 1.25 ± 1.23, 1.05 ± 0.96%, while that in faeces were 0.68 ± 0.94, 0.19 ± 0.40, and 1.76 ± 3.57%. DISCUSSION AND CONCLUSION: Co-existing compounds in SHL have no effect on the absorption of ChA, while the concomitant compounds in Lonicera japanica could decrease that of ChA. ChA in Beagles might have high biological transformation.
[Mh] Termos MeSH primário: Ácido Clorogênico/farmacocinética
Flavonoides/farmacocinética
Forsythia
Lonicera
Extratos Vegetais/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Ácido Clorogênico/administração & dosagem
Cães
Combinação de Medicamentos
Feminino
Flavonoides/administração & dosagem
Masculino
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Flavonoids); 0 (Plant Extracts); 318ADP12RI (Chlorogenic Acid); 347Q89U4M5 (baicalin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1296002


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[PMID]:28254571
[Au] Autor:Su D; Li S; Zhang W; Wang J; Wang J; Lv M
[Ad] Endereço:Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, People's Republic of China.
[Ti] Título:Structural elucidation of a polysaccharide from Lonicera japonica flowers, and its neuroprotective effect on cerebral ischemia-reperfusion injury in rat.
[So] Source:Int J Biol Macromol;99:350-357, 2017 Jun.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A water-soluble polysaccharide, LJPB2, was purified from Lonicera japonica flowers. The present study was aimed to illustrate its structural features and its neuroprotective effect via anti-oxidant activity on focal ischemia/reperfusion (I/R) injury in rat brain. Via chemical and spectral methods, LJPB2, a polysaccharide with molecular weight of 8.9×10 Da, was composed of arabinose, mannose, glucose, and galactose, in a molar ratio of 1.8: 1.0: 3.6: 3.7. In addition, the linkage analysis revealed that it mainly contained 1, 4, 6-linked mannose, 1, 4-linked glucose and 1, 4-linked galactose, with a highly branched structure of araban and terminal glucose. LJPB2 exhibited a strong capacity of scavenging DPPH free radical in vitro. Moreover, in vivo assay using a commonly used cerebral I/R model demonstrated that LJPB2 could significantly improve the neurological deficit scores and infract volume. In addition, LJPB2 remarkably reduced the MDA level and NO production, and elevated the SOD and GSH-Px enzyme activities in the rat brain tissues. These results certainly indicated that LJPB2 had a distinct neuroprotective effect related to its strong antioxidant capacity in the cerebral ischemia/reperfusion injury.
[Mh] Termos MeSH primário: Isquemia Encefálica/complicações
Flores/química
Lonicera/química
Polissacarídeos/química
Polissacarídeos/farmacologia
Traumatismo por Reperfusão/complicações
Traumatismo por Reperfusão/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Compostos de Bifenilo/química
Glutationa/metabolismo
Masculino
Malondialdeído/metabolismo
Monossacarídeos/análise
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/isolamento & purificação
Fármacos Neuroprotetores/farmacologia
Fármacos Neuroprotetores/uso terapêutico
Óxido Nítrico/metabolismo
Picratos/química
Polissacarídeos/isolamento & purificação
Polissacarídeos/uso terapêutico
Ratos
Traumatismo por Reperfusão/metabolismo
Traumatismo por Reperfusão/fisiopatologia
Superóxido Dismutase/metabolismo
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Monosaccharides); 0 (Neuroprotective Agents); 0 (Picrates); 0 (Polysaccharides); 059QF0KO0R (Water); 31C4KY9ESH (Nitric Oxide); 4Y8F71G49Q (Malondialdehyde); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE



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