Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.339.485.577 [Categoria DeCS]
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  1 / 28 MEDLINE  
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[PMID]:28353397
[Au] Autor:Mngadi S; Moodley R; Jonnalagadda SB
[Ad] Endereço:a School of Chemistry and Physics , University of KwaZulu-Natal , Westville campus, Chiltern Hills , Durban , South Africa.
[Ti] Título:Elemental composition and nutritional value of the edible fruits of coastal red-milkwood (Mimusops caffra) and impact of soil quality on their chemical characteristics.
[So] Source:J Environ Sci Health B;52(7):435-445, 2017 Jul 03.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the elemental distribution of essential and toxic elements in the soil and fruits of the indigenous plant species, Mimusops caffra, from ten sites along the KwaZulu-Natal east coast was investigated using inductively coupled plasma-optical emission spectrometry. This was done to determine the nutritional value of the fruits as well as to evaluate the impact of soil quality on elemental uptake by the plant. The elemental concentrations in the fruits (in descending order) were found to be K > Na > Ca > Mg > Si > Al > Fe > Zn > Mn > Ni > Cr > Cu > Pb > Mo > Sb > As > Se > V > Cd > Co. The results show that approximately 10 g of fruit would contribute more than 85% towards the recommended dietary allowance for Fe and Si for most adults. The proximate chemical composition revealed the fruits to contain approximately 84% moisture, 4.7% ash, 6.9% protein, 1.7% oil and 2.7% carbohydrates. The study indicates that the fruits of this indigenous plant species are a good source of essential elements with low levels of potentially toxic elements (Pb, As and Cd) which makes the plant a good indigenous food source especially for vulnerable communities that need food security.
[Mh] Termos MeSH primário: Frutas/química
Mimusops/química
Valor Nutritivo
Solo/química
[Mh] Termos MeSH secundário: Contaminação de Alimentos
Metais/análise
Poluentes do Solo/análise
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2017.1301753


  2 / 28 MEDLINE  
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[PMID]:27489141
[Au] Autor:Singh N; Singh SK
[Ad] Endereço:Department of Zoology, Banaras Hindu University, Varanasi, India.
[Ti] Título:Aqueous fruit extract of Mimusops elengi causes reversible suppression of spermatogenesis and fertility in male mice.
[So] Source:Andrologia;48(7):807-16, 2016 Sep.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Antifertility efficacy of oral administration of aqueous fruit extract of Mimusops elengi (200, 400 and 600 mg kg(-1) body weight/day for 35 days) was evaluated in Parkes strain male mice. Various reproductive end points such as histopathology, sperm parameters, testosterone level, haematology, serum biochemistry and fertility indices were assessed; activities of 3ß- and 17ß-hydroxysteroid dehydrogenases, and immunoblot expressions of StAR and P450scc in the testis were also assessed. Histologically, testes in Mimusops-treated mice showed nonuniform and diverse degenerative changes in the seminiferous tubules; both affected and normal tubules were observed in the same sections of testis. The treatment had adverse effects on testicular hydroxysteroid dehydrogenases and StAR and P450scc, serum level of testosterone and on motility, viability and number of spermatozoa in cauda epididymis. However, serum levels of alanine aminotransferase, aspartate aminotransferase and creatinine, and haematological parameters were not affected by the treatment. Also, libido was not affected in treated males, but their fertility was markedly suppressed. By 56 days of treatment withdrawal, the alterations caused in the above parameters recovered to control levels, suggesting that Mimusops treatment causes reversible suppression of spermatogenesis and fertility in Parkes mice. Further, there were no detectable signs of toxicity in treated males.
[Mh] Termos MeSH primário: Fertilidade/efeitos dos fármacos
Frutas/química
Mimusops/química
Extratos Vegetais/farmacologia
Espermatogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: 17-Hidroxiesteroide Desidrogenases/metabolismo
3-Hidroxiesteroide Desidrogenases/metabolismo
Animais
Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo
Masculino
Camundongos
Fosfoproteínas/metabolismo
Túbulos Seminíferos/patologia
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Testículo/patologia
Testosterona/sangue
Testosterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphoproteins); 0 (Plant Extracts); 0 (steroidogenic acute regulatory protein); 3XMK78S47O (Testosterone); EC 1.1.- (17-Hydroxysteroid Dehydrogenases); EC 1.1.- (3-Hydroxysteroid Dehydrogenases); EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE
[do] DOI:10.1111/and.12516


  3 / 28 MEDLINE  
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[PMID]:26515133
[Au] Autor:Dube ZP; Mashela PW; Mathabatha RV
[Ad] Endereço:Department of Plant Production, Soil Science and Agricultural Engineering, University of Limpopo, Sovenga, South Africa.
[Ti] Título:Mediterranean fruit fly on Mimusops zeyheri indigenous to South Africa: a threat to the horticulture industry.
[So] Source:Pest Manag Sci;72(8):1517-20, 2016 Aug.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Claims abound that the Transvaal red milkwood, Mimusops zeyheri, indigenous to areas with tropical and subtropical commercial fruit trees and fruiting vegetables in South Africa, is relatively pest free owing to its copious concentrations of latex in the above-ground organs. On account of observed fruit fly damage symptoms, a study was conducted to determine whether M. zeyheri was a host to the notorious quarantined Mediterranean fruit fly (Ceratitis capitata). RESULTS: Fruit samples were kept for 16-21 days in plastic pots containing moist steam-pasteurised growing medium with tops covered with a mesh sheath capable of retaining emerging flies. Microscopic diagnosis of the trapped flies suggested that the morphological characteristics were congruent with those of C. capitata, which was confirmed through cytochrome c oxidase I (COI) gene sequence alignment with a 100% bootstrap value and 99% confidence probability when compared with those from the National Centre for Biotechnology Information database. CONCLUSION: This study demonstrated that M. zeyheri is a host of C. capitata. Therefore, C. capitata from infestation reservoirs of M. zeyheri fruit trees could be a major threat to the tropical and subtropical fruit industries in South Africa owing to the fruit-bearing nature of the new host. © 2015 Society of Chemical Industry.
[Mh] Termos MeSH primário: Ceratitis capitata/genética
Mimusops
[Mh] Termos MeSH secundário: Animais
Ceratitis capitata/anatomia & histologia
Ceratitis capitata/classificação
Código de Barras de DNA Taxonômico
Frutas
Alinhamento de Sequência
Análise de Sequência de DNA
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151031
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4179


  4 / 28 MEDLINE  
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[PMID]:26300364
[Au] Autor:Subramaniam J; Murugan K; Panneerselvam C; Kovendan K; Madhiyazhagan P; Kumar PM; Dinesh D; Chandramohan B; Suresh U; Nicoletti M; Higuchi A; Hwang JS; Kumar S; Alarfaj AA; Munusamy MA; Messing RH; Benelli G
[Ad] Endereço:Division of Entomology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
[Ti] Título:Eco-friendly control of malaria and arbovirus vectors using the mosquitofish Gambusia affinis and ultra-low dosages of Mimusops elengi-synthesized silver nanoparticles: towards an integrative approach?
[So] Source:Environ Sci Pollut Res Int;22(24):20067-83, 2015 Dec.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Mosquito-borne diseases represent a deadly threat for millions of people worldwide. However, the use of synthetic insecticides to control Culicidae may lead to high operational costs and adverse non-target effects. Plant-borne compounds have been proposed for rapid extracellular synthesis of mosquitocidal nanoparticles. Their impact against biological control agents of mosquito larval populations has been poorly studied. We synthesized silver nanoparticles (AgNP) using the aqueous leaf extract of Mimusops elengi as a reducing and stabilizing agent. The formation of AgNP was studied using different biophysical methods, including UV-vis spectrophotometry, TEM, XRD, EDX and FTIR. Low doses of AgNP showed larvicidal and pupicidal toxicity against the malaria vector Anopheles stephensi and the arbovirus vector Aedes albopictus. AgNP LC50 against A. stephensi ranged from 12.53 (I instar larvae) to 23.55 ppm (pupae); LC50 against A. albopictus ranged from 11.72 ppm (I) to 21.46 ppm (pupae). In the field, the application of M. elengi extract and AgNP (10 × LC50) led to 100 % larval reduction after 72 h. In adulticidal experiments, AgNP showed LC50 of 13.7 ppm for A. stephensi and 14.7 ppm for A. albopictus. The predation efficiency of Gambusia affinis against A. stephensi and A. albopictus III instar larvae was 86.2 and 81.7 %, respectively. In AgNP-contaminated environments, predation was 93.7 and 88.6 %, respectively. This research demonstrates that M. elengi-synthesized AgNP may be employed at ultra-low doses to reduce larval populations of malaria and arbovirus vectors, without detrimental effects on predation rates of mosquito natural enemies, such as larvivorous fishes.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Anopheles/efeitos dos fármacos
Controle de Mosquitos
Prata/farmacologia
[Mh] Termos MeSH secundário: Animais
Infecções por Arbovirus/prevenção & controle
Ciprinodontiformes/fisiologia
Feminino
Insetos Vetores
Inseticidas/farmacologia
Larva/efeitos dos fármacos
Malária/prevenção & controle
Nanopartículas Metálicas/química
Mimusops/química
Extratos Vegetais/química
Folhas de Planta/química
Comportamento Predatório
Pupa/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Insecticides); 0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150825
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-015-5253-5


  5 / 28 MEDLINE  
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[PMID]:26223420
[Au] Autor:Schlickmann F; Mota da Silva L; Boeing T; Bordignon Somensi L; de Moura Burci L; Santin JR; Filho VC; Faloni de Andrade S
[Ad] Endereço:Postgraduate Program in Pharmaceutical Sciences (PPGCF), Universidade do Vale do Itajaí (UNIVALI), Rua Uruguai, 458, Centro, 88302-202, Itajaí, SC, Brazil.
[Ti] Título:Gastroprotective bio-guiding study of fruits from Mimusops balata.
[So] Source:Naunyn Schmiedebergs Arch Pharmacol;388(11):1187-200, 2015 Nov.
[Is] ISSN:1432-1912
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Mimusops spp. is used as plant-based antiulcer drugs in Indian traditional medicine. In this study, a bio-guiding study of methanolic extracts of Mimusops balata edible fruits was performed to identify an antiulcer gastric compound. The gastric lesions induced by HCl/ethanol in mice were significantly improved by methanolic extract from seed (MESe, 300 mg/kg), but not by methanolic extract from peel (MEPe, 300 mg/kg) or pulp (MEPu, 300 mg/kg), when compared to the vehicle group. Treatment with MESe also decreased gastric ulceration induced by indomethacin. The antiulcerogenic activity of MESe appears to involve the maintainance of GSH levels, reduction of LPO content, inhibition of neutrophil migration (as evidenced by a decrease in the MPO activity) and a potent free radical scavenger activity (IC50 = 3.4 µg/ml). Moreover, MESe decrease the gastric volume, pH, total acidity, and pepsin activity in the gastric juice. Exceptionally, MESe showed a high content of phenolic compound, identified by layer chromatography and Folin-Ciocalteu reagent. Considering the better pharmacological and phytochemical profile, MESe was successively partitioned and resulted in isolation and identification of a constituent, the flavonoid taxifolin, identified by spectroscopic methods ((1)H, (13)C NMR, and HPLC). Taxifolin also inhibited the ulcerogenic effect of HCl/ethanol at a low dose of 1.14 mg/kg and inhibited in vitro H+/K(+)-ATPase activity by 41% at a concentration of 100 µg/ml. Taken together, these results evidenced the gastroprotective potential of fruits from M. balata and showed that this effect is exclusive to the seeds.
[Mh] Termos MeSH primário: Antiulcerosos/uso terapêutico
Depuradores de Radicais Livres/uso terapêutico
Frutas/química
Mimusops
Extratos Vegetais/uso terapêutico
Úlcera Gástrica/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antiulcerosos/farmacologia
Etanol
Feminino
Depuradores de Radicais Livres/farmacologia
Glutationa/metabolismo
ATPase Trocadora de Hidrogênio-Potássio/metabolismo
Ácido Clorídrico
Indometacina
Peróxidos Lipídicos/metabolismo
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/farmacologia
Piloro/cirurgia
Ratos Wistar
Estômago/efeitos dos fármacos
Estômago/metabolismo
Estômago/patologia
Úlcera Gástrica/induzido quimicamente
Úlcera Gástrica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Free Radical Scavengers); 0 (Lipid Peroxides); 0 (Plant Extracts); 3K9958V90M (Ethanol); EC 3.6.3.10 (H(+)-K(+)-Exchanging ATPase); GAN16C9B8O (Glutathione); QTT17582CB (Hydrochloric Acid); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE
[do] DOI:10.1007/s00210-015-1156-8


  6 / 28 MEDLINE  
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[PMID]:24759779
[Au] Autor:Kiran Kumar HA; Mandal BK; Mohan Kumar K; Maddinedi Sb; Sai Kumar T; Madhiyazhagan P; Ghosh AR
[Ad] Endereço:Trace Elements Speciation Research Laboratory, Environmental and Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, India.
[Ti] Título:Antimicrobial and antioxidant activities of Mimusops elengi seed extract mediated isotropic silver nanoparticles.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;130:13-8, 2014 Sep 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study reports the use of Mimusops elengi (M. elengi) fruit extract for the synthesis of silver nanoparticles (Ag NPs). The synthesized Ag NPs was initially noticed through visual color change from yellow to reddish brown and further confirmed by surface plasmonic resonance (SPR) band at 429 nm using UV-Visible spectroscopy. Morphology and size of Ag NPs was determined by Transmission Electron Microscopy (TEM) analysis. X-ray Diffraction (XRD) study revealed crystalline nature of Ag NPs. The prolonged stability of Ag NPs was due to capping of oxidized polyphenols which was established by Fourier Transform Infrared Spectroscopy (FTIR) study. The polyphenols present in M. elengi fruit extract was analyzed by High Pressure Liquid Chromatography (HPLC) and the results revealed the presence of ascorbic acid, gallic acid, pyrogallol and resorcinol. In order to study the role of these polyphenols in reducing Ag+ ions to Ag NPs, analyses of extracts before reduction and after reduction were carried out. In addition, the synthesized Ag NPs were tested for antibacterial and antioxidant activities against Staphylococcus aureus (S. Aureus) and Escherichia coli (E. coli). Ag NPs showed good antimicrobial activity against both gram positive (S. aureus) and gram negative (E. coli) bacteria. It also showed good antioxidant activity as compared to ascorbic acid as standard antioxidant.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Antioxidantes/química
Mimusops/química
Extratos Vegetais/química
Sementes/química
Prata/química
[Mh] Termos MeSH secundário: Ácido Ascórbico/química
Cromatografia Líquida de Alta Pressão
Escherichia coli/efeitos dos fármacos
Ácido Gálico/química
Íons/química
Nanopartículas Metálicas/química
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Transmissão
Pirogalol/química
Resorcinóis/química
Espectroscopia de Infravermelho com Transformada de Fourier
Staphylococcus aureus/efeitos dos fármacos
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Ions); 0 (Plant Extracts); 0 (Resorcinols); 01Y4A2QXY0 (Pyrogallol); 3M4G523W1G (Silver); 632XD903SP (Gallic Acid); PQ6CK8PD0R (Ascorbic Acid); YUL4LO94HK (resorcinol)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140602
[Lr] Data última revisão:
140602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140425
[St] Status:MEDLINE


  7 / 28 MEDLINE  
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[PMID]:24033292
[Au] Autor:Suedee A; Tewtrakul S; Panichayupakaranant P
[Ad] Endereço:Department of Pharmacognosy and Pharmaceutical Botany and.
[Ti] Título:Anti-HIV-1 integrase activity of Mimusops elengi leaf extracts.
[So] Source:Pharm Biol;52(1):58-61, 2014 Jan.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Integrase (IN) is one of the three human immunodeficiency virus type 1 (HIV-1) enzymes that, together with a reverse transcriptase and protease, allow the virus to reproduce itself after infecting the host cells. Any new knowledge on inhibitors of this enzyme could provide essential clues for the development of anti-HIV drugs. OBJECTIVE: To evaluate the anti-HIV-1 IN activity of some Thai medicinal plant extracts, and to isolate the active compounds from the extract that possessed the strongest anti-HIV-1 IN activity. MATERIALS AND METHODS: Ethanol extracts of eight Thai medicinal plants (10-100 µg/mL) were evaluated for their inhibitory effect against HIV-1 IN. An extract of Mimusops elengi L. (Sapotaceae) leaves that possessed the strongest anti-HIV-1 IN activity was fractionated to isolate the active compounds by an anti-HIV-1 IN assay-guided isolation process. RESULTS AND DISCUSSION: The leaf extract from M. elengi had the strongest anti-HIV-1 IN activity with an IC50 value of 62.1 µg/mL. A bioassay-guided isolation of the active compounds from M. elengi leaf extract resulted in the isolation of active compounds, identified as a mixture of gallocatechin and epigallocatechin. This mixture of gallocatechin and epigallocatechin showed satisfactory anti-HIV-1 IN activity with an IC50 value of 35.0 µM. A flavanol glycoside, mearnsitrin was also isolated but was inactive at a concentration of 100 µM.
[Mh] Termos MeSH primário: Inibidores de Integrase de HIV/farmacologia
Integrase de HIV/efeitos dos fármacos
Mimusops/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Bioensaio
Catequina/análogos & derivados
Catequina/isolamento & purificação
Catequina/farmacologia
Relação Dose-Resposta a Droga
Integrase de HIV/metabolismo
Inibidores de Integrase de HIV/administração & dosagem
Concentração Inibidora 50
Oxazinas/isolamento & purificação
Oxazinas/farmacologia
Extratos Vegetais/administração & dosagem
Plantas Medicinais/química
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HIV Integrase Inhibitors); 0 (Oxazines); 0 (Plant Extracts); 0 (p31 integrase protein, Human immunodeficiency virus 1); 7Z197MG6QL (gallocatechol); 8R1V1STN48 (Catechin); 8S1S2GY38K (gallocyanine); EC 2.7.7.- (HIV Integrase)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130917
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.810649


  8 / 28 MEDLINE  
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[PMID]:24108397
[Au] Autor:Simelane MB; Shonhai A; Shode FO; Smith P; Singh M; Opoku AR
[Ad] Endereço:Department of Biochemistry & Microbiology, University of Zululand, Private Bag X1001, KwaDlangezwa 3886, South Africa. simelanembc@gmail.com.
[Ti] Título:Anti-plasmodial activity of some Zulu medicinal plants and of some triterpenes isolated from them.
[So] Source:Molecules;18(10):12313-23, 2013 Oct 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mimusops caffra E. Mey. ex A.DC and Mimusops obtusifolia Lam (both members of the Sapotaceae family), and Hypoxis colchicifolia Bak (family Hypoxidaceae) are used by traditional healers in Zululand to manage malaria. Anti-plasmodial investigation of the crude extracts and some triterpenes isolated from the plants showed activity against a chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10). Among the crude extracts the leaves of M. caffra exhibited the highest activity, with an IC50 of 2.14 µg/mL. The pentacyclic tritepenoid ursolic acid (1), isolated from the leaves of M. caffra was the most active compound (IC50 6.8 µg/mL) as compared to taraxerol (2) and sawamilletin (3) isolated from the stem bark of M. obtusifolia (IC50 > 100). Chemical modification of the ursolic acid (1) to 3ß-acetylursolic acid (4) greatly enhanced its anti-plasmodial activity. Compound 4 reduced parasitaemia against Plasmodium berghei by 94.01% in in vivo studies in mice. The cytotoxicity of 3ß-acetylursolic acid (IC50) to two human cell lines (HEK293 and HepG2) was 366.00 µg/mL and 566.09 µg/mL, respectively. The results validate the use of these plants in folk medicine.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Malária/tratamento farmacológico
Mimusops/química
Extratos Vegetais/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antimaláricos/isolamento & purificação
Antimaláricos/uso terapêutico
Sobrevivência Celular/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos
Feminino
Células HEK293
Células Hep G2
Seres Humanos
Concentração Inibidora 50
Masculino
Medicina Tradicional
Camundongos
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Folhas de Planta/química
Plantas Medicinais/química
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
Triterpenos/isolamento & purificação
Triterpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 0 (Triterpenes)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:131010
[Lr] Data última revisão:
131010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131011
[St] Status:MEDLINE
[do] DOI:10.3390/molecules181012313


  9 / 28 MEDLINE  
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[PMID]:23563291
[Au] Autor:Prakash P; Gnanaprakasam P; Emmanuel R; Arokiyaraj S; Saravanan M
[Ad] Endereço:Department of Chemistry, Thiagarajar College, Madurai, Tamil Nadu 625009, India.
[Ti] Título:Green synthesis of silver nanoparticles from leaf extract of Mimusops elengi, Linn. for enhanced antibacterial activity against multi drug resistant clinical isolates.
[So] Source:Colloids Surf B Biointerfaces;108:255-9, 2013 Aug 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Green synthesis of metallic silver nanoparticles has attracted nowadays and alternative to physical and chemical approaches. In the present study, silver nanoparticles (AgNPs) were synthesized from leaf extract of Mimusops elengi, L. at room temperature. Formation of stable AgNPs at 1mM concentrations of silver nitrate (AgNO3) typically gave spherical shape particles with diameter range from 55 to 83nm. The kinetic properties of particle formation were proportional to the effect of concentration of AgNO3 solution. In order to identify the compounds responsible for the bioreduction of Ag(+) ion and the stabilization of AgNPs produced, the functional group present in Mimusops elengi, L. leaf extract was investigated using FTIR. The formation of nanoparticle was confirmed using the surface plasmon resonance band shown in UV-vis spectrophotometer. The topography and morphology of the particles were determined using scanning electron microscopy. The crystalline nature of nanoparticles was confirmed from the XRD pattern. Furthermore these green synthesized AgNPs were found to show higher antimicrobial efficacy against multi drug resistant clinical isolates.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Nanopartículas Metálicas/química
Mimusops/química
Extratos Vegetais/química
Folhas de Planta/química
Prata/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla
Química Verde
Seres Humanos
Cinética
Klebsiella pneumoniae/efeitos dos fármacos
Klebsiella pneumoniae/crescimento & desenvolvimento
Klebsiella pneumoniae/isolamento & purificação
Micrococcus luteus/efeitos dos fármacos
Micrococcus luteus/crescimento & desenvolvimento
Micrococcus luteus/isolamento & purificação
Oxirredução
Tamanho da Partícula
Espectroscopia de Infravermelho com Transformada de Fourier
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/crescimento & desenvolvimento
Staphylococcus aureus/isolamento & purificação
Ressonância de Plasmônio de Superfície
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130409
[St] Status:MEDLINE


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[PMID]:23570006
[Au] Autor:Gami B; Pathak S; Parabia M
[Ad] Endereço:Ipcowala Santram Institute of Biotechnology and Emerging Sciences, Cross Road- Dharmaj, Darmaj-388430, Gujarat - India.
[Ti] Título:Ethnobotanical, phytochemical and pharmacological review of Mimusops elengi Linn.
[So] Source:Asian Pac J Trop Biomed;2(9):743-8, 2012 Sep.
[Is] ISSN:2221-1691
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Mimusops elengi is Indian native plant and is used for a long time in the history of the medicine. Plant was well studied in majority of the world because of its high potential medicinal value. Traditionally all different part of this plant, namely leaf, root, fruit, seed, bark and flower are used to cure various kinds of disorders. Information compiled here will be useful to improve the present investigation of several health care research regarding the Mimusops elengi.
[Mh] Termos MeSH primário: Mimusops/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130410
[St] Status:MEDLINE
[do] DOI:10.1016/S2221-1691(12)60221-4



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