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Pesquisa : B01.650.940.800.575.912.250.341 [Categoria DeCS]
Referências encontradas : 159 [refinar]
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[PMID]:29229392
[Au] Autor:Zhou A; Sun H; Feng S; Zhou M; Gong S; Wang J; Zhang S
[Ad] Endereço:College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China. Electronic address: aiminzhou@neau.edu.cn.
[Ti] Título:A novel cold-regulated gene from Phlox subulata, PsCor413im1, enhances low temperature tolerance in Arabidopsis.
[So] Source:Biochem Biophys Res Commun;495(2):1688-1694, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Low temperature stress adversely affects plant growth, development, and crop productivity. Analysis of the function of genes in the response of plants to low temperature stress is essential for understanding the mechanism of chilling and freezing tolerance. In this study, PsCor413im1, a novel cold-regulated gene isolated from Phlox subulata, was transferred to Arabidopsis to investigate its function under low temperature stress. Real-time quantitative PCR analysis revealed that PsCor413im1 expression was induced by cold and abscisic acid. Subcellular localization revealed that PsCor413im1-GFP fusion protein was localized to the periphery of the chloroplast, consistent with the localization of chloroplast inner membrane protein AtCor413im1, indicating that PsCor413im1 is a chloroplast membrane protein. Furthermore, the N-terminal of PsCor413im1 was determined to be necessary for its localization. Compared to the wild-type plants, transgenic plants showed higher germination and survival rates under cold and freezing stress. Moreover, the expression of AtCor15 in transgenic plants was higher than that in the wild-type plants under cold stress. Taken together, our results suggest that the overexpression of PsCor413im1 enhances low temperature tolerance in Arabidopsis.
[Mh] Termos MeSH primário: Aclimatação/genética
Arabidopsis/genética
Ericales/genética
Genes de Plantas
[Mh] Termos MeSH secundário: Aclimatação/fisiologia
Sequência de Aminoácidos
Arabidopsis/crescimento & desenvolvimento
Arabidopsis/fisiologia
Proteínas de Arabidopsis/genética
Proteínas de Arabidopsis/metabolismo
Temperatura Baixa
Ericales/fisiologia
Técnicas de Transferência de Genes
Filogenia
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Plantas Geneticamente Modificadas
Proteínas Recombinantes de Fusão/genética
Proteínas Recombinantes de Fusão/metabolismo
Homologia de Sequência de Aminoácidos
Frações Subcelulares/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Plant Proteins); 0 (Recombinant Fusion Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:29346406
[Au] Autor:Aleza K; Villamor GB; Nyarko BK; Wala K; Akpagana K
[Ad] Endereço:West African Science Service Centre for Climate Change and Adapted Land Use (WASCAL) Graduate Research Programme, School of Agriculture, Department of Soil Science, University of Cape Coast, Ghana.
[Ti] Título:Shea (Vitellaria paradoxa Gaertn C. F.) fruit yield assessment and management by farm households in the Atacora district of Benin.
[So] Source:PLoS One;13(1):e0190234, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitellaria paradoxa (Gaertn C. F.), or shea tree, remains one of the most valuable trees for farmers in the Atacora district of northern Benin, where rural communities depend on shea products for both food and income. To optimize productivity and management of shea agroforestry systems, or "parklands," accurate and up-to-date data are needed. For this purpose, we monitored120 fruiting shea trees for two years under three land-use scenarios and different soil groups in Atacora, coupled with a farm household survey to elicit information on decision making and management practices. To examine the local pattern of shea tree productivity and relationships between morphological factors and yields, we used a randomized branch sampling method and applied a regression analysis to build a shea yield model based on dendrometric, soil and land-use variables. We also compared potential shea yields based on farm household socio-economic characteristics and management practices derived from the survey data. Soil and land-use variables were the most important determinants of shea fruit yield. In terms of land use, shea trees growing on farmland plots exhibited the highest yields (i.e., fruit quantity and mass) while trees growing on Lixisols performed better than those of the other soil group. Contrary to our expectations, dendrometric parameters had weak relationships with fruit yield regardless of land-use and soil group. There is an inter-annual variability in fruit yield in both soil groups and land-use type. In addition to observed inter-annual yield variability, there was a high degree of variability in production among individual shea trees. Furthermore, household socioeconomic characteristics such as road accessibility, landholding size, and gross annual income influence shea fruit yield. The use of fallow areas is an important land management practice in the study area that influences both conservation and shea yield.
[Mh] Termos MeSH primário: Ericales
Fazendas
[Mh] Termos MeSH secundário: Benin
Características da Família
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190234


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[PMID]:28413191
[Au] Autor:Guedes AMM; Antoniassi R; Galdeano MC; Grimaldi R; Carvalho MG; Wilhelm AE; Marangoni AG
[Ad] Endereço:Embrapa Agroindústria de Alimentos, Avenida das Américas.
[Ti] Título:Length-scale Specific Crystalline Structural Changes Induced by Molecular Randomization of Pequi Oil.
[So] Source:J Oleo Sci;66(5):469-478, 2017 May 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Pequi fruit (Caryocar brasiliense Camb) is considered important since its pulp has a high content of oil and carotenoids. The oil's triacylglycerols (TAGs) contain mainly oleic (~57%) and palmitic (~36%) fatty acids, distributed primarily among POO, POP/PPO, and OOO TAGs. It displays a tendency to fractionate upon storage and has a relatively low melting temperature (SFC of 4% at 25°C). Pequi oil was modified through chemical interesterification, which increased the PPP content to ~6%. This caused a flattening in the SFC-temperature profile, raising the end of melt temperature significantly (SFC of 4% at 39°C). The interesterified oil does not fractionate and is thermally stable up to 40°C, with an SFC-temperature profile resembling that of roll-in shortening (SFC of 31% at 16°C) despite containing high amounts of oleic acid. Crystallization and melting behavior changed. Crystal packing became more disorganized as evidenced by a significant decrease in crystalline domain size in the [001] direction from 42.3 nm to 32.1 nm. Polymorphism remained of the triclinic (ß) subcell type but polytypism changed from the 3L to the 2L type. Polarized light microscopy demonstrated that interesterification dramatically decreased crystal size, consistent with a higher rate of nucleation in the material. Moreover, the dramatic improvement in physical stability and functionality was not accompanied by a significant decrease in total carotenoid content (~390 mg/kg).
[Mh] Termos MeSH primário: Ericales
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Carotenoides/análise
Fenômenos Químicos
Cristalização
Esterificação
Ácido Oleico/análise
Ácido Palmítico/análise
Tamanho da Partícula
Temperatura de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 2UMI9U37CP (Oleic Acid); 2V16EO95H1 (Palmitic Acid); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16192


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[PMID]:28193408
[Au] Autor:Leão DP; Franca AS; Oliveira LS; Bastos R; Coimbra MA
[Ad] Endereço:PPGCA/Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil. Electronic address: danielapleao@gmail.com.
[Ti] Título:Physicochemical characterization, antioxidant capacity, total phenolic and proanthocyanidin content of flours prepared from pequi (Caryocar brasilense Camb.) fruit by-products.
[So] Source:Food Chem;225:146-153, 2017 Jun 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The potential of pequi by-products as substrates for the production of flours rich in antioxidant dietary fibers was evaluated. Dietary fiber contents ranged from 39.8 to 43.3g/100g with pectic polysaccharide fraction constituted of rhamnogalacturonans and hemicellulose fraction consisted of arabinogalactans, xylans and glucomannans. Total polyphenols, non-extractable proanthocyanidins (NEPA) and carotenoid contents of the flours were determined (respectively, 15.5-17.4g GAE/100g, 215.54-346.84mg/100g and 2116.52-3499.03µg/100g). The antioxidant capacities of pequi by-product flours (986.94-1154.42µM TE/g ABTS; 44.43-48.02g/g DPPH; and 3027.31-3216.27µmol Fe SO /g FRAP) were found to be exceptionally higher than those of fruits and fruits by-products reported in the literature. Exocarp removal promoted no significant changes in the technological properties of the flour, except for color. Results showed promising prospects for future exploitation of pequi peel as a potential source of dietary fiber and natural antioxidants.
[Mh] Termos MeSH primário: Ericales/química
Farinha/análise
Frutas/química
Polifenóis/análise
Proantocianidinas/análise
[Mh] Termos MeSH secundário: Antioxidantes/análise
Carotenoides/análise
Fibras na Dieta/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Dietary Fiber); 0 (Polyphenols); 0 (Proanthocyanidins); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


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[PMID]:28179001
[Au] Autor:Oliveira LG; Moreno LG; Melo DS; Costa-Pereira LV; Carvalho MM; Silva PH; Alves AM; Magalhães FC; Dias-Peixoto MF; Esteves EA
[Ad] Endereço:Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia (SBFis) - Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM, Rodovia MGT 367 - Km 583, n° 5000, Alto da Jacuba, Diamantina, MG, Brazil, CEP: 39100-000.
[Ti] Título:Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats.
[So] Source:Lipids Health Dis;16(1):37, 2017 Feb 08.
[Is] ISSN:1476-511X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Caryocar brasiliense (pequi) oil is high in monounsaturated fat acids (MUFA), especially oleic, and in carotenoids, which have been associated with protection against cardiovascular disease. However, this food is poorly studied in this context, especially in the cardiac function. Therefore, we investigated the effects of a long-term intake of pequi oil in systemic cardiovascular risk factors and in the ex vivo cardiac function of rats. METHODS: Previously, we determined fatty acids and carotenoids in pequi oil. Next, male rats were divided in C - control group feed a standard diet, and PO - pequi oil group fed the same diet added pequi oil (+2.25 g.100 g ). After 15 weeks, plasma lipids, glucose, insulin, blood pressure, heart rate, hepatic lipids were accessed and visceral fat pads were harvested. Hearts were used for the ex vivo cardiac function, histologic assays, SERCA2a and phospholanban (PLB) determinations. RESULTS: In agreement with scientific data, pequi oil had expressive amounts MUFA, especially oleic acid, and carotenoids. Hepatic triglycerides (TG) were reduced by pequi oil intake (p < 0.05). All others cardiovascular risk factors were not changed. The intrinsic heart rate was lower in PO group (p < 0.05). SERCA2a content was higher in this group (p < 0.05), without affecting PLB. Also, SERCA2a/PLB ratio increased in PO group (p < 0.05). CONCLUSION: Pequi oil intake improved cardiac function ex vivo, despite no significant changes in systemic cardiovascular risk factors. The higher lipid offer in pequi oil diet, its composition in oleic acid and carotenoids could be related to those effects.
[Mh] Termos MeSH primário: Proteínas de Ligação ao Cálcio/genética
Gorduras Insaturadas na Dieta/administração & dosagem
Ericales/química
Frequência Cardíaca/efeitos dos fármacos
Óleos Vegetais/administração & dosagem
ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Pressão Sanguínea/efeitos dos fármacos
Proteínas de Ligação ao Cálcio/metabolismo
Carotenoides/sangue
Gorduras Insaturadas na Dieta/metabolismo
Ácidos Graxos Monoinsaturados/metabolismo
Frutas/química
Expressão Gênica
Coração/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Ácido Oleico/metabolismo
Técnicas de Cultura de Órgãos
Óleos Vegetais/metabolismo
Ratos
Ratos Wistar
ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Calcium-Binding Proteins); 0 (Dietary Fats, Unsaturated); 0 (Fatty Acids, Monounsaturated); 0 (Plant Oils); 0 (phospholamban); 2UMI9U37CP (Oleic Acid); 36-88-4 (Carotenoids); EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1186/s12944-017-0422-9


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[PMID]:28159258
[Au] Autor:de Mendonça KS; Corrêa JL; Junqueira JR; Cirillo MA; Figueira FV; Carvalho EE
[Ad] Endereço:Universidade Federal de Lavras, Department of Food Science, 37200-000 Lavras, MG, Brazil. Electronic address: keamendonca@msn.com.
[Ti] Título:Influences of convective and vacuum drying on the quality attributes of osmo-dried pequi (Caryocar brasiliense Camb.) slices.
[So] Source:Food Chem;224:212-218, 2017 Jun 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pequi is a fruit from Brazilian Cerrado. Despite its ascorbic acid and carotenoid contents, consumption of pequi is restricted to its region of origin. The goal of this work was to study drying of pequi slices (convective or vacuum drying at 40°C and 60°C) preceded or not preceded by osmotic pretreatment (sucrose solution concentrations of 40% and 60%). It was found that osmotic dehydration pretreatment substantially decreased the moisture content, duration of the drying process, and the volumetric ratio of the dried product. However, it also promoted leaching of bioactive constituents, such as ascorbic acid and carotenoids. Vacuum and low temperature drying without osmotic pretreatment were preferable because the ascorbic acid and carotenoids were retained, rehydration coefficients were higher and there were minimal volume and color changes.
[Mh] Termos MeSH primário: Ericales/química
[Mh] Termos MeSH secundário: Ácido Ascórbico/análise
Carotenoides/análise
Dessecação
Osmose
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
36-88-4 (Carotenoids); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28105565
[Au] Autor:da Silva RR; Gomes LJ; Albuquerque UP
[Ad] Endereço:Centro de Ciências Agrárias, Área de Engenharia Florestal, Universidade Federal de Alagoas, BR-104 Norte, Km 85, s/n, Mata do Rolo, 57100-000, Rio Largo, Alagoas, Brazil.
[Ti] Título:What are the socioeconomic implications of the value chain of biodiversity products? A case study in Northeastern Brazil.
[So] Source:Environ Monit Assess;189(2):64, 2017 Feb.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The trade in biodiversity products has gained increasing importance in conservation and livelihood strategies. The aim of this study is to describe and analyze the socioeconomic aspects and dynamics of the production and commercialization of two important products of Brazilian biodiversity from the fruits of Caryocar coriaceum Wittm. and Dimorphandra gardneriana Tul. Interviews were conducted with who were involved in the various stages of value chains. Data were analyzed under an analytical/descriptive approach. It was found that the two value chains under study, although they share the same production environment and workforce, are different models of the commercial appropriation of the forest environment: one is related to local traditions, whereas the other seeks to meet an industry-related demand originating from a multinational pharmaceutical company. Harvesters become highly dependent on the trends imposed by these markets. Thus, it is clear that promoting these products as a conservation strategy requires an understanding of how their value chains arise, are established, and operate.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/economia
Monitoramento Ambiental
Ericales
Etnobotânica
Fabaceae
Frutas/economia
[Mh] Termos MeSH secundário: Biodiversidade
Brasil
Florestas
Seres Humanos
Modelos Teóricos
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5772-2


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[PMID]:27871896
[Au] Autor:de Lacerda Neto LJ; Ramos AG; Santos Sales V; de Souza SD; Dos Santos AT; de Oliveira LR; Kerntopf MR; de Albuquerque TR; Coutinho HD; Quintans-Júnior LJ; Wanderley AG; de Menezes IR
[Ad] Endereço:Chemical-Biology Department, Regional University of Cariri - URCA, Cel. Antonio Luis 1161, Crato, CE, Brazil.
[Ti] Título:Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
[So] Source:Chem Biol Interact;261:56-62, 2017 Jan 05.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:This work aimed to determine the chemical fingerprint of hydroethanolic extract of leaves of Caryocar coriaceum (HELCC) and the gastroprotective activity. The chemical fingerprint of HELCC was analyzed by HPLC-DAD, to quantify total phenols and flavonoids were carried out by Folin-Ciocalteu reagent and aluminum chloride assay, while in vitro antioxidant activity was evaluated by the DPPH method. The methods used to determine pharmacological activity were: gastroprotective screening test in classical models of induced acute and chronic gastric lesions and physical barrier test. Further assays were performed to demonstrate the involvement of NO, prostaglandins, ATP-dependent potassium channels, TRPV, noradrenergic α2 receptors, histamines, and opioids. The DPPH method demonstrated the antioxidant activity of the extract, in vitro, explained by the presence of polyphenols and flavonoids. Oral administration of the extract, previously dissolved in deionized water, at a dose of 100 mg/kg decreased the lesions induced by indomethacin, acidified ethanol, ethanol and acetic acid by 75.0, 72.8, 69.4 and 86.2% respectively. It was demonstrated that opioid receptors, α -adrenergic receptors and primary afferent neurons sensitive to capsaicin were involved in the mechanism of gastric protection, in addition to the contribution of NO and prostaglandins. The results show that extract is a promising candidate for the treatment of gastric ulcers.
[Mh] Termos MeSH primário: Ericales/química
Etanol/química
Extratos Vegetais/uso terapêutico
Folhas de Planta/química
Substâncias Protetoras/uso terapêutico
Úlcera Gástrica/tratamento farmacológico
Água/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Capsaicina/análogos & derivados
Capsaicina/farmacologia
Capsaicina/uso terapêutico
Cromatografia Líquida de Alta Pressão
Doença Crônica
Modelos Animais de Doenças
Feminino
Flavonoides/análise
Motilidade Gastrointestinal
Glibureto/farmacologia
Glibureto/uso terapêutico
Histamina/farmacologia
Histamina/uso terapêutico
Indometacina
Masculino
Camundongos
Muco/efeitos dos fármacos
NG-Nitroarginina Metil Éster/farmacologia
NG-Nitroarginina Metil Éster/uso terapêutico
Naloxona/farmacologia
Naloxona/uso terapêutico
Fenóis/análise
Fitoterapia
Extratos Vegetais/farmacologia
Úlcera Gástrica/patologia
Ioimbina/farmacologia
Ioimbina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Protective Agents); 059QF0KO0R (Water); 2Y49VWD90Q (Yohimbine); 36B82AMQ7N (Naloxone); 3K9958V90M (Ethanol); 820484N8I3 (Histamine); LFW48MY844 (capsazepine); S07O44R1ZM (Capsaicin); SX6K58TVWC (Glyburide); V55S2QJN2X (NG-Nitroarginine Methyl Ester); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


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[PMID]:27639543
[Au] Autor:Traesel GK; Menegati SE; Dos Santos AC; Carvalho Souza RI; Villas Boas GR; Justi PN; Kassuya CA; Sanjinez Argandoña EJ; Oesterreich SA
[Ad] Endereço:Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil. Electronic address: giselitraesel@gmail.com.
[Ti] Título:Oral acute and subchronic toxicity studies of the oil extracted from pequi (Caryocar brasiliense, Camb.) pulp in rats.
[So] Source:Food Chem Toxicol;97:224-231, 2016 Nov.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Caryocar brasiliense (pequi) is a Brazilian fruit of important geographic distribution and of broad popular use for nutritional purposes. This study aimed to evaluate the toxicological potential of pequi through the acute and subchronic toxicity tests. For the acute toxicity test, female Wistar rats received, orally, a single dose of 2000 mg/kg/bw of pequi oil and were observed for 14 days. In subchronic toxicity test, Wistar male and female rats received, orally, repeated doses of 125, 250, 500 or 1000 mg/kg/bw of the oil, being treated and observed for 28 days. In the acute toxicity test, no changes as well as no mortality were observed, indicating that the LD is higher than 2000 mg/kg/bw. In the subchronic toxicity test, the tested doses produced no significant changes in behavioral, physiological, biochemical or histopathologic parameters in animals. Some hematological abnormalities were found after subchronic exposure and need to be clarified. These results demonstrate the low toxicity of acute and subchronic to the oil of pequi in rats. However, additional studies are required in order to verify if the hematological abnormalities have any relation to the oil exposure and also provide sufficient safety evidence for the use of the oil in humans.
[Mh] Termos MeSH primário: Ericales/química
Extratos Vegetais/toxicidade
Óleos Vegetais/toxicidade
Testes de Toxicidade Aguda/métodos
Testes de Toxicidade Subcrônica/métodos
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Ácidos Graxos/metabolismo
Feminino
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160919
[St] Status:MEDLINE


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[PMID]:27321275
[Au] Autor:de Figueiredo PRL; Oliveira IB; Neto JBS; de Oliveira JA; Ribeiro LB; de Barros Viana GS; Rocha TM; Leal LKAM; Kerntopf MR; Felipe CFB; Coutinho HDM; de Alencar Menezes IR
[Ad] Endereço:Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
[Ti] Título:Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro.
[So] Source:J Ethnopharmacol;191:87-94, 2016 Sep 15.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significant reduction in total serum cholesterol and triglycerides, and an increase in HDL-C. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Dislipidemias/tratamento farmacológico
Ericales/química
Hipolipemiantes/farmacologia
Inflamação/prevenção & controle
Lipídeos/sangue
Extratos Vegetais/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Biomarcadores/sangue
Carragenina
Células Cultivadas
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Dislipidemias/sangue
Dislipidemias/induzido quimicamente
Frutas/química
Seres Humanos
Hipolipemiantes/isolamento & purificação
Inflamação/induzido quimicamente
Neutrófilos/efeitos dos fármacos
Neutrófilos/metabolismo
Peroxidase/metabolismo
Fitoterapia
Extratos Vegetais/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Plantas Medicinais
Polietilenoglicóis
Ratos Wistar
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Hypolipidemic Agents); 0 (Lipids); 0 (Plant Extracts); 0 (Plant Oils); 30IQX730WE (Polyethylene Glycols); 9000-07-1 (Carrageenan); EC 1.11.1.7 (Peroxidase); Y27PUL9H56 (tyloxapol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE



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