Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.341.750.500 [Categoria DeCS]
Referências encontradas : 135 [refinar]
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[PMID]:29233135
[Au] Autor:Helsen K; Acharya KP; Brunet J; Cousins SAO; Decocq G; Hermy M; Kolb A; Lemke IH; Lenoir J; Plue J; Verheyen K; De Frenne P; Graae BJ
[Ad] Endereço:Department of Biology, Norwegian University of Science and Technology, Høgskoleringen 5, 7034, Trondheim, Norway. kenny.helsen@ntnu.no.
[Ti] Título:Biotic and abiotic drivers of intraspecific trait variation within plant populations of three herbaceous plant species along a latitudinal gradient.
[So] Source:BMC Ecol;17(1):38, 2017 Dec 12.
[Is] ISSN:1472-6785
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The importance of intraspecific trait variation (ITV) is increasingly acknowledged among plant ecologists. However, our understanding of what drives ITV between individual plants (ITV ) at the population level is still limited. Contrasting theoretical hypotheses state that ITV can be either suppressed (stress-reduced plasticity hypothesis) or enhanced (stress-induced variability hypothesis) under high abiotic stress. Similarly, other hypotheses predict either suppressed (niche packing hypothesis) or enhanced ITV (individual variation hypothesis) under high niche packing in species rich communities. In this study we assess the relative effects of both abiotic and biotic niche effects on ITV of four functional traits (leaf area, specific leaf area, plant height and seed mass), for three herbaceous plant species across a 2300 km long gradient in Europe. The study species were the slow colonizing Anemone nemorosa, a species with intermediate colonization rates, Milium effusum, and the fast colonizing, non-native Impatiens glandulifera. RESULTS: Climatic stress consistently increased ITV across species and traits. Soil nutrient stress, on the other hand, reduced ITV for A. nemorosa and I. glandulifera, but had a reversed effect for M. effusum. We furthermore observed a reversed effect of high niche packing on ITV for the fast colonizing non-native I. glandulifera (increased ITV ), as compared to the slow colonizing native A. nemorosa and M. effusum (reduced ITV ). Additionally, ITV in the fast colonizing species tended to be highest for the vegetative traits plant height and leaf area, but lowest for the measured generative trait seed mass. CONCLUSIONS: This study shows that stress can both reduce and increase ITV , seemingly supporting both the stress-reduced plasticity and stress-induced variability hypotheses. Similarly, niche packing effects on ITV supported both the niche packing hypothesis and the individual variation hypothesis. These results clearly illustrates the importance of simultaneously evaluating both abiotic and biotic factors on ITV . This study adds to the growing realization that within-population trait variation should not be ignored and can provide valuable ecological insights.
[Mh] Termos MeSH primário: Anemone/fisiologia
Impatiens/fisiologia
Fenótipo
Dispersão Vegetal
Poaceae/fisiologia
[Mh] Termos MeSH secundário: Anemone/genética
Anemone/crescimento & desenvolvimento
Meio Ambiente
Europa (Continente)
Impatiens/genética
Impatiens/crescimento & desenvolvimento
Espécies Introduzidas
Poaceae/genética
Poaceae/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1186/s12898-017-0151-y


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[PMID]:28165740
[Au] Autor:Kim CS; Bae M; Oh J; Subedi L; Suh WS; Choi SZ; Son MW; Kim SY; Choi SU; Oh DC; Lee KR
[Ad] Endereço:Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 16419, Republic of Korea.
[Ti] Título:Anti-Neurodegenerative Biflavonoid Glycosides from Impatiens balsamina.
[So] Source:J Nat Prod;80(2):471-478, 2017 Feb 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Four biflavonoid glycosides, balsamisides A-D (1-4), and nine known compounds (5-13) were obtained from the white petals of Impatiens balsamina. The 2D structures of the purified phytochemicals were established using conventional NMR techniques in addition to the new long-range HSQMBC NMR experiment. Acid hydrolysis followed by experimental and quantum-mechanics-based ECD data analysis permitted full configurational assignment of the purified metabolites. Compounds 1-13 were assessed for their potential to impede the generation of nitric oxide in lipopolysaccharide-stimulated BV2 cells. They were also investigated for potential neuroprotective activity using C6 cells and cytotoxicity against some human tumor cell lines, but were inactive (IC > 10 µM) against all the cell lines.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Biflavonoides/isolamento & purificação
Biflavonoides/farmacologia
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Impatiens/química
Fármacos Neuroprotetores/isolamento & purificação
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Algoritmos
Animais
Anti-Inflamatórios não Esteroides/química
Biflavonoides/química
Glicosídeos/química
Seres Humanos
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Fármacos Neuroprotetores/química
Óxido Nítrico/biossíntese
Ressonância Magnética Nuclear Biomolecular
República da Coreia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Biflavonoids); 0 (Glycosides); 0 (Lipopolysaccharides); 0 (Neuroprotective Agents); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00981


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[PMID]:27377752
[Au] Autor:Lai HY; Lam CM; Wang WZ; Ji YJ
[Ad] Endereço:Department of Post-Modern Agriculture, MingDao University, No. 369, Wenhua Rd., Peetow, Changhua County, 52345, Taiwan. soil.lai@mdu.edu.tw.
[Ti] Título:Cadmium Uptake by Cuttings of Impatiens walleriana in Response to Different Cadmium Concentrations and Growth Periods.
[So] Source:Bull Environ Contam Toxicol;98(3):317-322, 2017 Mar.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Impatiens walleriana (I. walleriana), a potential cadmium (Cd) hyperaccumulator, can propagate by cuttings, which are less expensive to grow than seedlings. Different growth periods for cuttings, however, may lead to different physiological characteristics. In this study, I. walleriana cuttings were hydroponically grown in Cd-containing solutions (1.0-10.0 µM) for various growth periods (10-60 days). Experimental results showed that the Cd treatments had negative effects on growth compared to the controls that were not spiked with Cd. The extension of the growth period promoted most of the growth exhibitions of I. walleriana, except for SPAD readings for cuttings grown in the 5.0 and 10.0 µM solutions. The accumulation of Cd also increased over time, except in the roots of the cuttings grown in the 5.0 and 10.0 µM solutions. The subcellular distribution and chemical forms of Cd showed that I. walleriana developed better tolerance and detoxification capacities in the cuttings grown in the 5.0 and 10.0 µM solutions than in the cuttings grown in the other two Cd treatments.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Cádmio/toxicidade
Impatiens/crescimento & desenvolvimento
Impatiens/metabolismo
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Hidroponia
Impatiens/efeitos dos fármacos
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/metabolismo
Poluentes do Solo/metabolismo
Poluentes do Solo/toxicidade
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-016-1874-8


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[PMID]:27789379
[Au] Autor:Srivilai J; Rabgay K; Khorana N; Waranuch N; Nuengchamnong N; Ingkaninan K
[Ad] Endereço:Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
[Ti] Título:A new label-free screen for steroid 5α-reductase inhibitors using LC-MS.
[So] Source:Steroids;116:67-75, 2016 Dec.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Steroid 5α-reductase (S5αR) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (DHT) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne. The method for screening for S5αR inhibition is key in finding new antagonists. In this study, the label-free S5αR inhibitory assay using LC-MS was developed. S5αR type 1 enzyme was obtained from LNCaP prostate cancer cells. The enzymatic assay was optimised for enzyme-substrate (testosterone) concentration, NADPH-cofactor concentration, solvent tolerance, enzyme activity stability and incubation time. The developed assay was validated by measuring the signal to background ratio (S/B), the signal to noise ratio (S/N), the signal window (SW) and the zeta factor Z' in accordance with published bioassay guidelines. The enzymatic reaction was performed in 96-well plates and DHT formation was determined by LC-MS. S/B, S/N, SW and Z' factor were well above acceptable criteria and the reproducibility was good using Z' factor other 3days and further validated by dutasteride and finasteride inhibition. The method was successfully applied to quantify S5αR inhibitory activity of some Thai herbal extracts. Two plant extracts, Impatiens balsamina L. and Curcuma longa L. showed IC at 5.4±0.2 and 9.0±1.2µgmL and are therefore promising sources of new S5αR inhibitors. The assay has high selectability and reproducibility and suited to medium throughput screening required by phytochemistry.
[Mh] Termos MeSH primário: 3-Oxo-5-alfa-Esteroide 4-Desidrogenase/metabolismo
Inibidores de 5-alfa Redutase/farmacologia
Cromatografia Líquida/métodos
Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Inibidores de 5-alfa Redutase/química
Linhagem Celular Tumoral
Curcuma/química
Di-Hidrotestosterona/metabolismo
Ensaios Enzimáticos
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Seres Humanos
Impatiens/química
Masculino
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5-alpha Reductase Inhibitors); 0 (Enzyme Inhibitors); 0 (Plant Extracts); 08J2K08A3Y (Dihydrotestosterone); EC 1.3.99.5 (3-Oxo-5-alpha-Steroid 4-Dehydrogenase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161031
[St] Status:MEDLINE


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[PMID]:27598111
[Au] Autor:Szewczyk K; Kalemba D; Komsta L; Nowak R
[Ad] Endereço:Department of Pharmaceutical Botany, Medical University of Lublin, Chodzki 1 St., 20-093 Lublin, Poland. k.szewczyk@umlub.pl.
[Ti] Título:Comparison of the Essential Oil Composition of Selected Impatiens Species and Its Antioxidant Activities.
[So] Source:Molecules;21(9), 2016 Sep 01.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present paper describes the chemical composition of the essential oils obtained by hydrodistillation from four Impatiens species, Impatiens glandulifera Royle, I. parviflora DC., I. balsamina L. and I. noli-tangere L. The GC and GC-MS methods resulted in identification of 226 volatile compounds comprising from 61.7%-88.2% of the total amount. The essential oils differed significantly in their composition. Fifteen compounds were shared among the essential oils of all investigated Impatiens species. The majority of these constituents was linalool (0.7%-15.1%), hexanal (0.2%-5.3%) and benzaldehyde (0.1%-10.2%). Moreover, the antioxidant activity of the essential oils was investigated using different methods. The chemical composition of the essential oils and its antioxidant evaluation are reported for the first time from the investigated taxon.
[Mh] Termos MeSH primário: Antioxidantes/química
Impatiens/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Especificidade da Espécie
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oils, Volatile)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


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[PMID]:27135814
[Au] Autor:Chua LS
[Ad] Endereço:Metabolites Profiling Laboratory, Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310, UTM Skudai, Johor Bahru, Johor, Malaysia; Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, UTM Skudai, Johor Bahru, Johor, Malaysia. Electronic address: chualeesuan@utm.my.
[Ti] Título:Untargeted MS-based small metabolite identification from the plant leaves and stems of Impatiens balsamina.
[So] Source:Plant Physiol Biochem;106:16-22, 2016 Sep.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The identification of plant metabolites is very important for the understanding of plant physiology including plant growth, development and defense mechanism, particularly for herbal medicinal plants. The metabolite profile could possibly be used for future drug discovery since the pharmacological activities of the indigenous herbs have been proven for centuries. An untargeted mass spectrometric approach was used to identify metabolites from the leaves and stems of Impatiens balsamina using LC-DAD-MS/MS. The putative compounds are mostly from the groups of phenolic, organic and amino acids which are essential for plant growth and as intermediates for other compounds. Alanine appeared to be the main amino acid in the plant because many alanine derived metabolites were detected. There are also several secondary metabolites from the groups of benzopyrones, benzofuranones, naphthoquinones, alkaloids and flavonoids. The widely reported bioactive components such as kaempferol, quercetin and their glycosylated, lawsone and its derivatives were detected in this study. The results also revealed that aqueous methanol could extract flavonoids better than water, and mostly, flavonoids were detected from the leaf samples. The score plots of component analysis show that there is a minor variance in the metabolite profiles of water and aqueous methanolic extracts with 21.5 and 30.5% of the total variance for the first principal component at the positive and negative ion modes, respectively.
[Mh] Termos MeSH primário: Impatiens/metabolismo
Espectrometria de Massas/métodos
Metaboloma
Folhas de Planta/metabolismo
Caules de Planta/metabolismo
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Flavonoides/análise
Metanol/química
Fenóis/análise
Extratos Vegetais/química
Análise de Componente Principal
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 059QF0KO0R (Water); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE


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[PMID]:26751603
[Au] Autor:Vieira MN; Winterhalter P; Jerz G
[Ad] Endereço:Institute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstrasse 20, 38106, Braunschweig, Germany.
[Ti] Título:Flavonoids from the flowers of Impatiens glandulifera Royle isolated by high performance countercurrent chromatography.
[So] Source:Phytochem Anal;27(2):116-25, 2016 Mar-Apr.
[Is] ISSN:1099-1565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Impatiens glandulifera Royle (Balsaminaceae) is an annual herb from the Himalaya region, currently widespread along European river systems and one of the most important neophyte invading plants in Germany. Exploring the effects of allelopathic plant chemicals is important for the understanding of its ecological impacts in the process of suppression of indigenous plant species. OBJECTIVE: To investigate the chemical composition of Impatiens glandulifera flowers (IGFs) using high performance countercurrent chromatography (HPCCC). METHODS: The flowers of Impatiens glandulifera were manually separated and extracted with ethanol. LC-ESI-MS/MS was used to characterise the crude extract of IGF. The various flavonoids detected were isolated by HPCCC using of methyl tert-butyl ether-acetonitrile-water (2:2:3, v/v/v). The combination of the data provided by preparative ESI-MS/MS metabolite profiling, LC-ESI-MS/MS, UV-vis and 1D/2D-NMR spectroscopic analysis was used to elucidate the structures of the isolated compounds. RESULTS: HPCCC runs led to the direct isolation of pure dihydromyricetin (ampelopsin), eriodictyol-7-O-glucoside, kaempferol-3-O-glucoside (astragalin) and kaempferol-3-O-6"-malonyl-glucoside, as well as the pre-purification of kaempferol-3-O-rhamno-rhamnosyldiglucoside, quercetin-3-O-galactoside (hyperoside), quercetin and kaempferol in a single step. CONCLUSION: This is the first report on the flavonoid composition of the species Impatiens glandulifera. The developed protocol was successfully used to isolate the main flavonoids from the crude extract of IGFs. This combined HPCCC and HPLC procedure could be applied to the fast fractionation and recovery of flavonoid derivatives of other plant extracts.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Distribuição Contracorrente/métodos
Flavonoides/isolamento & purificação
Flores/química
Impatiens/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Espectrometria de Massas/métodos
Extratos Vegetais/química
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160112
[St] Status:MEDLINE
[do] DOI:10.1002/pca.2606


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[PMID]:26732071
[Au] Autor:Cimmino A; Mathieu V; Evidente M; Ferderin M; Moreno Y Banuls L; Masi M; De Carvalho A; Kiss R; Evidente A
[Ad] Endereço:Dipartimento di Scienze Chimiche, Universita' di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cintia 4, 80126 Napoli, Italy.
[Ti] Título:Glanduliferins A and B, two new glucosylated steroids from Impatiens glandulifera, with in vitro growth inhibitory activity in human cancer cells.
[So] Source:Fitoterapia;109:138-45, 2016 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Impatiens glandulifera has been imported from Himalaya in Europe and is considered as an invasive alien plant whose spreading arouses increasing interest among scientific literature. Via anti-cancer bioguiding, two new glucosylated steroids, named glanduliferins A and B, were isolated from the dried stem of I. glandulifera plants, together with the well-known α-spinasterol and 2-methoxy-1,4-naphthoquinone, which are also isolated from roots and leaves. They were characterized as 17-(2-hydroxy-2-pentamethylcyclopropyl-ethyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopents[a]phenathren-3-O-(4-O-acetyl)-α-D-glucopyranoside and 17-(4-ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopents[a]phenathren-3-O-(6-O-acetyl)-ß-D-glucopyranoside using various NMR and HRESIMS techniques and chemical methods. In vitro determination of the growth inhibitory activity of the four isolated compounds using the MTT colorimetric assay revealed mean IC50 growth inhibitory value of ~30 µM for glanduliferin A while glanduliferin B and α-spinasterol were poorly active till 100 µM. 2-methoxy-1,4-naphthoquinone revealed to be active in the single micromolar digit range as previously described. Quantitative videomicroscopy analyses of the effects of glanduliferins A and B suggested cytostatic rather than cytotoxic activity in U373 glioblastoma (GBM) cells.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Impatiens/química
Saponinas/farmacologia
Esteroides/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Seres Humanos
Estrutura Molecular
Naftoquinonas/isolamento & purificação
Caules de Planta/química
Saponinas/isolamento & purificação
Esteroides/isolamento & purificação
Estigmasterol/análogos & derivados
Estigmasterol/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Naphthoquinones); 0 (Saponins); 0 (Steroids); 0 (glanduliferin A); 0 (glanduliferin B); 0LG993QX1A (spinasterol); 2348-82-5 (2-methoxy-1,4-naphthoquinone); 99WUK5D0Y8 (Stigmasterol)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160301
[Lr] Data última revisão:
160301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE


  9 / 135 MEDLINE  
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[PMID]:26247535
[Au] Autor:Lai HY; Cai MC
[Ad] Endereço:a Department of Post-Modern Agriculture , MingDao University , Peetow, Changhua County , Taiwan.
[Ti] Título:Effects of extended growth periods on subcellular distribution, chemical forms, and the translocation of cadmium in Impatiens walleriana.
[So] Source:Int J Phytoremediation;18(3):228-34, 2016.
[Is] ISSN:1549-7879
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Impatiens walleriana plants accumulate sufficiently high concentrations of cadmium (Cd) for this species to be considered a potential Cd hyperaccumulator. Rooted cuttings were grown hydroponically for 25 and 50 days in solutions spiked with various Cd concentrations. The subcellular distribution and chemical forms of Cd in different organs were analyzed, and its upward translocation was also assessed. The plants accumulated large amounts of Cd; the Cd concentration in the roots and shoots reached 120-1900 and 60-1600 mg/kg, respectively. Regardless of the growth period, the Cd accumulated in the roots was primarily compartmentalized in the soluble fraction or ethanol and deionized water extractable chemical forms with high migration abilities. Translocation to the shoots was followed by an association of Cd mainly in the cell wall or with pectate and protein. The roots' Cd showed a high migration capacity for predicting the shoots' Cd concentrations. Different exposure periods significantly affected the subcellular distribution of Cd in the stems, and thus the upward translocation.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Impatiens/crescimento & desenvolvimento
Impatiens/metabolismo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Cádmio/química
Impatiens/química
Modelos Biológicos
Estrutura Molecular
Folhas de Planta/química
Folhas de Planta/metabolismo
Raízes de Plantas/química
Raízes de Plantas/metabolismo
Poluentes do Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Soil Pollutants); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150807
[St] Status:MEDLINE
[do] DOI:10.1080/15226514.2015.1073677


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[PMID]:26181315
[Au] Autor:Grabowska K; Podolak I; Galanty A; Zaluski D; Makowska-Was J; Sobolewska D; Janeczko Z; Zmudzki P
[Ad] Endereço:a Department of Pharmacognosy , Pharmaceutical Faculty, Medical College, Jagiellonian University , Medyczna 9, 30-688 Cracow , Poland.
[Ti] Título:In vitro anti-denaturation and anti-hyaluronidase activities of extracts and galactolipids from leaves of Impatiens parviflora DC.
[So] Source:Nat Prod Res;30(10):1219-23, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The in vitro anti-denaturation and anti-hyaluronidase activities of Impatiens parviflora extracts and isolated galactolipids (MGDG-1, DGDG-1) were investigated. This is the first report on these compounds in I. parviflora. All extracts showed anti-hyaluronidase activity, but only methanolic extract from fresh leaves exhibited significant activity against heat-induced denaturation of BSA in a dose-dependent manner. At 500 µg/mL, the extract and the reference drug showed 79.05% and 99.81% inhibition of protein denaturation, respectively. These results indicate that fresh leaves of I. parviflora may be beneficial in inflammatory conditions, especially those associated with protein denaturation, such as rheumatoid arthritis. The study revealed that only MGDG-1 showed weak activity in anti-denaturation assay but both galactolipids were potent inhibitors of hyaluronidase. MGDG-1 completely inhibited the enzyme activity at the concentration of 127.9 µg/mL. These results indicate the potential of galactolipids in the treatment of diseases associated with the loss of hyaluronic acid.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Galactolipídeos/farmacologia
Hialuronoglucosaminidase/antagonistas & inibidores
Impatiens/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/isolamento & purificação
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/farmacologia
Galactolipídeos/isolamento & purificação
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Enzyme Inhibitors); 0 (Galactolipids); 0 (Plant Extracts); EC 3.2.1.35 (Hyaluronoglucosaminidase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150717
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1049175



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