Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.341.875 [Categoria DeCS]
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  1 / 21 MEDLINE  
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[PMID]:28359198
[Au] Autor:Liu Y; Cai Y; He C; Chen M; Li H
[Ad] Endereço:* Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China.
[Ti] Título:Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review.
[So] Source:Am J Chin Med;45(3):423-441, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of apoptosis and autophagy, the disruption of the cell cycle, the inhibition of invasion and metastasis, and anti-angiogenesis. Plumbagin inhibits the growth of cancer cells mainly through the modulation of the signals of PI3K/Akt/mTOR, AMPK, Ras, and so on. The pharmaceutical applications of plumbagin combined with nanocarriers to achieve better therapeutic efficiency are discussed in this review Among them, liposomes, nanoparticles, microspheres, micelles, and nisosomes are used in cancer treatment. The anticancer study of plumbagin in vivo is also summarized in this review. On the whole, we aim to review the research progress of plumbagin both in pharmacological and pharmaceutical filed, which may provide some reference for further research of plumbagin.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos
Naftoquinonas/farmacologia
Naftoquinonas/uso terapêutico
Neoplasias/tratamento farmacológico
Fitoterapia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP
Animais
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Droseraceae/química
Ebenaceae/química
Genes ras
Seres Humanos
Técnicas In Vitro
Camundongos
Naftoquinonas/isolamento & purificação
Neoplasias/genética
Neoplasias/patologia
Fosfatidilinositol 3-Quinase/metabolismo
Plumbaginaceae/química
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/genética
Serina-Treonina Quinases TOR/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Naphthoquinones); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.137 (Phosphatidylinositol 3-Kinase); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.31 (AMP-Activated Protein Kinases); YAS4TBQ4OQ (plumbagin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500264


  2 / 21 MEDLINE  
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[PMID]:28089738
[Au] Autor:Woldemedhin B; Nedi T; Shibeshi W; Sisay M
[Ad] Endereço:Department of Pharmacology, College of Medicine and Health Sciences, Dilla University, Ethiopia.
[Ti] Título:Evaluation of the diuretic activity of the aqueous and 80% methanol extracts of the root of Euclea divinorum Hiern (Ebenaceae) in Sprague Dawley rats.
[So] Source:J Ethnopharmacol;202:114-121, 2017 Apr 18.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diuretics are drugs that increase the formation of urine and are important for the treatment of various diseases including hypertension and edema. The root decoction of Euclea divinorum has been used as a diuretic agent in the traditional medicine. Therefore, this study was aimed to evaluate the diuretic activity of the crude extracts of the roots of Euclea divinorum in Sprague Dawley rats. METHODS: The aqueous extract (AE) and 80% methanol extract (80ME) of the plant were prepared using decoction and maceration, respectively. Vehicle (distilled water, 10ml/kg), standard drug (hydrochlorothiazide, 10mg/kg) and three doses (100mg/kg, 200mg/kg and 400mg/kg) of the AE and 80ME were given to male rats by oral gavage. Parameters like urine volume (for 5h), electrolyte concentration and pH were measured (at 5 h) and analyzed. Data were analyzed using one way analysis of variance (ANOVA) followed by Tukey post hoc test. Linear regression was also applied to show the dose dependency nature of the diuretic effect. RESULTS: The result indicated that the 80ME of the plant significantly (p<0.05) produced diuresis at 200mg/kg and 400mg/kg. Furthermore, the AE produced significant diuresis (p<0.05) at all doses. With regard to the electrolyte excretion, the AE produced significant natriuresis and kaliuresis at all tested doses (p<0.001), while the 80ME showed significant natriuresis and kaliuresis at 200mg/kg (p<0.01) and 400mg/kg (p<0.001). Preliminary phytochemical screening revealed the presence of secondary metabolites, including saponins, flavonoids, glycosides, steroids, tannins and terpinoids in both extracts. These constituents might be responsible for the diuretic activity of Euclea divinorum. Both extracts were also found to be safe at 2000mg/kg on the acute toxicity study. CONCLUSION: This finding provides a scientific support for the acclaimed traditional use of the roots of Euclea divinorum as a diuretic agent.
[Mh] Termos MeSH primário: Diuréticos/farmacologia
Ebenaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Diuréticos/toxicidade
Relação Dose-Resposta a Droga
Ebenaceae/toxicidade
Eletrólitos/análise
Eletrólitos/urina
Feminino
Masculino
Metanol
Natriurese/efeitos dos fármacos
Extratos Vegetais/análise
Extratos Vegetais/toxicidade
Raízes de Plantas/química
Potássio/urina
Ratos
Ratos Sprague-Dawley
Solventes
Urodinâmica/efeitos dos fármacos
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); 0 (Electrolytes); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); RWP5GA015D (Potassium); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


  3 / 21 MEDLINE  
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[PMID]:27305512
[Au] Autor:Sales-Peres SH; Xavier CN; Mapengo MA; Forim MR; Silva Mde F; Sales-Peres A
[Ad] Endereço:Universidade de São Paulo, Universidade de São Paulo, Bauru School of Dentistry, Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru SP , Brazil, Universidade de São Paulo - USP, Bauru School of Dentistry, Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru,
[Ti] Título:Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regions.
[So] Source:Braz Oral Res;30(1), 2016 Jun 14.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study evaluated the effect of Euclea natalensis gel on the reduction of erosive wear with or without abrasion, in enamel and dentin. During two five-day experimental crossover phases, volunteers (n = 10) wore palatal devices containing human enamel and dentin blocks (E = 8 and D = 8). The gel was applied in a thin layer in the experimental group, and was not applied in the control group. In the intraoral phase, volunteers used the palatal appliance for 12 h before the gel treatment, and were instructed to start the erosive challenges 6 h after the gel application. Erosion was performed with Coca-Cola® (for 5 min) 4 times/day. The appliance was then put back into the mouth and was brushed after 30 minutes. After intraoral exposure, the appliances were removed and the specimens were analyzed using profilometry (mean ± SD, µm). The Euclea natalensis gel caused less wear in enamel in the experimental group (EROS = 12.86 ± 1.75 µm; EROS + ABRAS = 12.13 ± 2.12 µm) than in the control group (EROS = 14.12 ± 7.66 µm; EROS + ABRAS = 16.29 ± 10.72 µm); however, the groups did not differ from each other significantly. A statistically significant value was found for erosion and eros + abrasion in dentin (p = 0.001). Euclea natalensis may play a role in the prevention of dentin loss under mild erosive and abrasive conditions. A clinical trial is required to confirm these promising results in a clinical situation.
[Mh] Termos MeSH primário: Esmalte Dentário/efeitos dos fármacos
Dentina/efeitos dos fármacos
Ebenaceae/química
Abrasão Dentária/prevenção & controle
Erosão Dentária/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Análise de Variância
Bebidas Gaseificadas
Géis
Testes de Dureza
Seres Humanos
Reprodutibilidade dos Testes
Salivação
Estatísticas não Paramétricas
Propriedades de Superfície/efeitos dos fármacos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gels)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE


  4 / 21 MEDLINE  
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[PMID]:27050961
[Au] Autor:Imir N; Aydemir E; Simsek E; Gokturk RS; Yesilada E; Fiskin K
[Ad] Endereço:Department of Biology Education, Akdeniz University, Antalya, Turkey.
[Ti] Título:Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells.
[So] Source:Genet Mol Res;15(1), 2016 Mar 18.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:We aimed to determine the cytotoxic and immunomodulatory effects of hydroalcoholic extracts of the roots and aerial parts of Ebenus boissieri (EB) on breast cancer MDA-MB231 cells and the non-cancerous human embryonic kidney cell line, 293T. Cell viability was determined by MTT assay, trypan blue exclusion, and Live/Dead Viability/Cytotoxicity assay. Apoptosis was evaluated by measuring the activity of caspase-2, 3, 6, 8, and 9. Tumor necrosis factor (TNF)-α and interferon (IFN)-g release was assayed by ELISA, and protein expression of caspase-3, TNF-a, and IFN-g was determined by western blot. The results of this study revealed that MDA-MB231 cell viability was reduced in a dose-dependent manner by the aerial and root extract of EB at 72 h with a half-maximal inhibitory concentration (IC50) of 41.1 ± 2.76 and 65 ± 1.09 µg/mL, respectively. In contrast, neither the aerial nor the root extracts of this plant inhibited the proliferation of 293T cells at doses up to 1000 µg/mL. There was a time-dependent increase in caspase activity, especially caspase-3 and caspase-9. The levels of TNF-aand IFN-g significantly increased in MDA-MB231 cells treated with aerial extract. In conclusion, the extracts of EB induced apoptosis in breast cancer cells by altering the levels of caspases, TNF-a, and IFN-g. The components and precise modes of action of EB have not yet been determined. However, potential antitumor and immunomodulatory activity was observed along with selectivity against cancer cells in vitro, suggesting that hydroalcoholic extracts of this plant are worthy of additional study.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias da Mama/metabolismo
Ebenaceae/química
Fatores Imunológicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Células HEK293
Seres Humanos
Interferon gama/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15017766


  5 / 21 MEDLINE  
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[PMID]:26936478
[Au] Autor:Macuvele DL; Sithole GZ; Cesca K; Macuvele SL; Matsinhe JV
[Ad] Endereço:Department of Chemistry, Universidade Pedagógica-Branch of Niassa, Lichinga, Mozambique. lusitaneom24@gmail.com.
[Ti] Título:Aqueous extracts of Mozambican plants as alternative and environmentally safe acid-base indicators.
[So] Source:Environ Sci Pollut Res Int;23(12):11639-44, 2016 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Indicators are substances that change color as the pH of the medium. Many of these substances are dyes of synthetic origin. The mulala plant (Euclea natalensis), which roots are commonly used by rural communities for their oral hygiene, and roseira (Hibiscus rosa-sinensis), an ornamental plant, are abundant in Mozambique. Currently, synthetic acid-base indicators are most commonly used but have environmental implications and, on the other hand, are expensive products, so the demand for natural indicators started. This study investigated the applicability of aqueous extracts of H. rosa-sinensis and E. natalensis as acid-base indicators. Ground on this work, the extracts can be used as acid-base indicators. On the basis of the absorption spectroscopy in both the UV-Vis region and previous studies, it was possible to preliminarily pinpoint anthocyanins and naphthoquinones as responsible for the shifting of colors depending on the pH range of aqueous extracts of H. rosa-sinensis and E. natalensis. These natural indicators are easily accessible, inexpensive, easy to extract, environmentally safe, and locally available.
[Mh] Termos MeSH primário: Ebenaceae/química
Hibiscus/química
Indicadores e Reagentes/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antocianinas/análise
Antocianinas/química
Concentração de Íons de Hidrogênio
Moçambique
Naftoquinonas/análise
Naftoquinonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Indicators and Reagents); 0 (Naphthoquinones); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160304
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6284-2


  6 / 21 MEDLINE  
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[PMID]:24026439
[Au] Autor:Brillouet JM; Romieu C; Schoefs B; Solymosi K; Cheynier V; Fulcrand H; Verdeil JL; Conéjéro G
[Ad] Endereço:UMR SPO INRA/SupAgro/UM I.
[Ti] Título:The tannosome is an organelle forming condensed tannins in the chlorophyllous organs of Tracheophyta.
[So] Source:Ann Bot;112(6):1003-14, 2013 Oct.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Condensed tannins (also called proanthocyanidins) are widespread polymers of catechins and are essential for the defence mechanisms of vascular plants (Tracheophyta). A large body of evidence argues for the synthesis of monomeric epicatechin on the cytosolic face of the endoplasmic reticulum and its transport to the vacuole, although the site of its polymerization into tannins remains to be elucidated. The aim of the study was to re-examine the cellular frame of tannin polymerization in various representatives of the Tracheophyta. METHODS: Light microscopy epifluorescence, confocal microscopy, transmission electron microscopy (TEM), chemical analysis of tannins following cell fractionation, and immunocytochemistry were used as independent methods on tannin-rich samples from various organs from Cycadophyta, Ginkgophyta, Equisetophyta, Pteridophyta, Coniferophyta and Magnoliophyta. Tissues were fixed in a caffeine-glutaraldehyde mixture and examined by TEM. Other fresh samples were incubated with primary antibodies against proteins from both chloroplastic envelopes and a thylakoidal chlorophyll-carrying protein; they were also incubated with gelatin-Oregon Green, a fluorescent marker of condensed tannins. Coupled spectral analyses of chlorophyll and tannins were carried out by confocal microscopy on fresh tissues and tannin-rich accretions obtained through cell fractionation; chemical analyses of tannins and chlorophylls were also performed on the accretions. KEY RESULTS AND CONCLUSIONS: The presence of the three different chloroplast membranes inside vacuolar accretions that constitute the typical form of tannin storage in vascular plants was established in fresh tissues as well as in purified organelles, using several independent methods. Tannins are polymerized in a new chloroplast-derived organelle, the tannosome. These are formed by pearling of the thylakoids into 30 nm spheres, which are then encapsulated in a tannosome shuttle formed by budding from the chloroplast and bound by a membrane resulting from the fusion of both chloroplast envelopes. The shuttle conveys numerous tannosomes through the cytoplasm towards the vacuole in which it is then incorporated by invagination of the tonoplast. Finally, shuttles bound by a portion of tonoplast aggregate into tannin accretions which are stored in the vacuole. Polymerization of tannins occurs inside the tannosome regardless of the compartment being crossed. A complete sequence of events apparently valid in all studied Tracheophyta is described.
[Mh] Termos MeSH primário: Organelas/ultraestrutura
Proantocianidinas/metabolismo
Traqueófitas/metabolismo
[Mh] Termos MeSH secundário: Animais
Catequina/metabolismo
Membrana Celular/metabolismo
Membrana Celular/ultraestrutura
Clorofila/metabolismo
Cloroplastos/química
Cloroplastos/metabolismo
Cloroplastos/ultraestrutura
Cromatografia Líquida de Alta Pressão
Ebenaceae/química
Ebenaceae/metabolismo
Ebenaceae/ultraestrutura
Frutas/química
Frutas/metabolismo
Frutas/ultraestrutura
Ginkgo biloba/química
Ginkgo biloba/metabolismo
Ginkgo biloba/ultraestrutura
Microscopia Confocal
Microscopia Eletrônica de Transmissão
Modelos Biológicos
Organelas/química
Organelas/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Folhas de Planta/ultraestrutura
Polimerização
Proantocianidinas/química
Proantocianidinas/isolamento & purificação
Traqueófitas/química
Traqueófitas/ultraestrutura
Vacúolos/química
Vacúolos/metabolismo
Vacúolos/ultraestrutura
Vitis/química
Vitis/metabolismo
Vitis/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proanthocyanidins); 1406-65-1 (Chlorophyll); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130913
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mct168


  7 / 21 MEDLINE  
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[PMID]:23228914
[Au] Autor:Feyissa T; Asres K; Engidawork E
[Ad] Endereço:Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Ethiopia.
[Ti] Título:Renoprotective effects of the crude extract and solvent fractions of the leaves of Euclea divinorum Hierns against gentamicin-induced nephrotoxicity in rats.
[So] Source:J Ethnopharmacol;145(3):758-66, 2013 Feb 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Euclea divinorum Hierns (Ebenaceae) is used in Ethiopian folklore medicine to treat scabies, inflammation of the skin, eczema, abdominal pain, gonorrhea, and kidney problems. However, the claim has not been scientifically validated. AIM OF THE STUDY: To assess the renoprotective effects of the crude extract and solvent fractions of E. divinorum leaves against gentamicin-induced nephrotoxicity in rats. MATERIALS AND METHOD: Rats of either sex were divided into seven experimental groups, each comprising six animals. Group I served as control and given vehicle (Tween 80, 2%, v/v in water) and Group II were treated with gentamicin intraperitoneally (100mg/kg/day) for eight days. Group III-V received crude extract at three different doses 100mg/kg, 150mg/kg and 200mg/kg, respectively. Group VI received 100mg/kg of the methanolic fraction and Group VII 100mg/kg of the aqueous fraction. The extract was administered orally two days before and eight days concomitantly with gentamicin. Following treatment, blood and renal tissue were used to assess creatinine, blood urea nitrogen (BUN), malondialdehyde (MDA), antioxidant enzymes and tubular necrosis using recommended procedures. In addition, free radical scavenging activity was determined using in vitro methods. RESULTS: Gentamicin significantly increased serum creatinine and BUN, MDA and tubular necrosis in rats. It also decreased activity of catalase and superoxide dismutase as well as levels of gluthatione. Pre- and co-treatment with the crude extract and solvent fractions of Euclea divinorum leaves reversed gentamicin-induced alterations as evidenced by a decrease in tubular necrosis, serum and oxidant markers as well as by an increase in antioxidant molecules. Effect was found to decrease with dose when the crude extract was used and maximum protection was conferred by 100mg/kg of the methanolic fraction in both in vivo and in vitro studies. CONCLUSIONS: Euclea divinorum reversed gentamicin-induced nephrotoxicity, probably via its antioxidant activity. The fact that the methanol fraction conferred maximum protection suggests that semi-polar antioxidant principles might be responsible for the observed effect.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Ebenaceae
Nefropatias/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Catalase/metabolismo
Feminino
Gentamicinas
Glutationa/metabolismo
Nefropatias/induzido quimicamente
Nefropatias/metabolismo
Nefropatias/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Extratos Vegetais/farmacologia
Folhas de Planta
Ratos
Ratos Sprague-Dawley
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Gentamicins); 0 (Plant Extracts); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121212
[St] Status:MEDLINE


  8 / 21 MEDLINE  
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[PMID]:22652367
[Au] Autor:Kaluwa Kaingu C; Oduma JA; Kanui T
[Ad] Endereço:Nairobi University, P.O. Box 30197, 00100 Nairobi, Kenya. catekaluwa@yahoo.co.uk
[Ti] Título:Preliminary investigation of contractile activity of Ricinus communis and Euclea divinorum extracts on isolated rabbit uterine strips.
[So] Source:J Ethnopharmacol;142(2):496-502, 2012 Jul 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Ricinus communis and Euclea divinorum of the family Euphorbiaceae and Ebenaceae, respectively, are traditionally used by Traditional Birth Attendants (TBAs) in Machakos district of Kenya to induce or augment labor, manage protracted labor, post-partum hemorrhage and retained after birth. Ethno-pharmacological relevance of the study will be the provision of scientific evidence and justification for the ethnic use of both plants as oxytocic agents in the initiation of labor, treatment of prolonged labor, post-partum hemorrhage and retained placenta. MATERIALS AND METHODS: The plants were harvested in the wild, identified and voucher specimens preserved. The root bark was processed to powder form, from which aqueous and ethanol extracts were obtained. Each of the extracts was separately tested on isolated uterine muscle tissue from non-pregnant and pregnant rabbits. The effect on contraction frequency (number of contractions per second) in the absence or presence of oxytocin was evaluated statistically using ANOVA. P values <0.05 were considered significant. RESULTS AND CONCLUSIONS: All uteri exhibited a strong initial contraction following exposure to the aqueous and ethanol root bark extracts of both plants. After recovery, the resumed contraction frequencies varied with the plant extract and exogenous hormone. The results show that the extracts of both plants were able to stimulate uterine tissue contractility directly and to augment the tissue's response to oxytocin. The increase in uterine contractions as a percentage relative to negative controls was particularly significant in pregnant rabbit tissues in the presence of oxytocin, where increments of up to 245% were observed. Further pharmacological studies are however required to determine the active principles, possible mechanisms of action, efficacy and safety margins of the plant extracts.
[Mh] Termos MeSH primário: Ebenaceae
Fitoterapia
Preparações de Plantas/farmacologia
Complicações na Gravidez
Ricinus
Contração Uterina/efeitos dos fármacos
Útero/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Quênia
Ocitócicos/farmacologia
Ocitocina/farmacologia
Casca de Planta
Preparações de Plantas/uso terapêutico
Raízes de Plantas
Gravidez
Complicações na Gravidez/tratamento farmacológico
Coelhos
Útero/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxytocics); 0 (Plant Preparations); 50-56-6 (Oxytocin)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:130520
[Lr] Data última revisão:
130520
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120602
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2012.05.026


  9 / 21 MEDLINE  
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Fotocópia
[PMID]:22474953
[Au] Autor:Ng'ang'a MM; Hussain H; Chhabra S; Langat-Thoruwa C; Krohn K; Hussain J; Al-Harrasi A; Green IR
[Ad] Endereço:Department of Chemistry, Kenyatta University, P.O. Box 43844-00100 Nairobi, Kenya.
[Ti] Título:Eucleanal: a new napthalene derivative from Euclea divinorum.
[So] Source:Nat Prod Commun;7(2):193-4, 2012 Feb.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new naphthalene derivative, named eucleanal (1), was isolated from Euclea divinorum Hiern., and its structure elucidated by detailed spectroscopic (1H, 13C NMR, COSY, HMQC, HMBC) and HREIMS analysis.
[Mh] Termos MeSH primário: Ebenaceae/química
Naftalenos/química
[Mh] Termos MeSH secundário: Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Naphthalenes); 0 (eucleanal)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:120405
[Lr] Data última revisão:
120405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120406
[St] Status:MEDLINE


  10 / 21 MEDLINE  
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[PMID]:21710456
[Au] Autor:Guo DL; Luo ZR
[Ad] Endereço:College of Forestry, Henan University of Science and Technology, Luoyang, China.
[Ti] Título:Genetic relationships of the Japanese persimmon Diospyros kaki (Ebenaceae) and related species revealed by SSR analysis.
[So] Source:Genet Mol Res;10(2):1060-8, 2011 Jun 07.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Simple sequence repeat (SSR) molecular markers based on 18 primers were employed to study the genetic relationship of Japanese persimmon (Diospyros kaki) specimens. Two hundred and sixty-two bands were detected in 30 Japanese persimmon samples, including 14 Japanese and 10 Chinese genotypes of Japanese persimmon (Diospyros kaki) and six related species, D. lotus, D. glaucifolia, D. oleifera, D. rhombifolia, D. virginiana, and Jinzaoshi (unclassified - previously indicated to be D. kaki). All SSR primers developed from D. kaki were successfully employed to reveal the polymorphism in other species of Diospyros. Most of the primers were highly polymorphic, with a degree of polymorphism equal to or higher than 0.66. The results from the neighbor-joining dendrogram and the principal coordinate analysis diagram were the same; i.e., the Chinese and Japanese genotypes and related species were separated and the relationships revealed were consistent with the known pedigrees. We also concluded that 'Xiangxitianshi' from Xiangxi municipality, Hunan Province, China, is actually a sport or somaclonal variant of 'Maekawa-Jirou', and that 'Jinzaoshi' should be classified as a distinct species of Diospyros. We found that SSR markers are a valuable tool for the estimation of genetic diversity and divergence in Diospyros.
[Mh] Termos MeSH primário: Ebenaceae/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Primers do DNA
Polimorfismo Genético
Antígeno Nuclear de Célula em Proliferação/genética
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Primers); 0 (Proliferating Cell Nuclear Antigen)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:110628
[Lr] Data última revisão:
110628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110629
[St] Status:MEDLINE
[do] DOI:10.4238/vol10-2gmr1100



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