Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.341.875.500 [Categoria DeCS] Referências encontradas : 385 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28873598 [Au] Autor: Santos ADDC; Fonseca FA; Dutra LM; Santos MFC; Menezes LRA; Campos FR; Nagata N; Ayub R; Barison A [Ad] Endereço: NMR Center, Departamento de Química, Universidade Federal do Paraná, 81530-900 Curitiba, PR, Brazil. Electronic address: alandiegormn@gmail.com. [Ti] Título: H HR-MAS NMR-based metabolomics study of different persimmon cultivars (Diospyros kaki) during fruit development. [So] Source: Food Chem;239:511-519, 2018 Jan 15. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: H HR-MAS NMR spectroscopy was used to track the metabolic changes throughout the whole development of astringent ('Giombo') and non-astringent ('Fuyu') cultivars of persimmon (Diospyros kaki). The NMR data revealed the low concentration of amino acids (threonine, alanine, citrulline and GABA) and organic acids (malic acid). In addition, the signals of carbohydrates (sucrose, glucose and fructose) seemed to play the most important role in the fruit development. In both cultivars, the growth was characterized by fluctuating sucrose concentration along with a constant increase in both glucose and fructose. In the initial growth stage, the polyphenol composition was quite different between the cultivars. Gallic acid was detected throughout the growth of 'Giombo', while for 'Fuyu', signals of polyphenols disappeared over time. Additional multivariate analysis suggested that these cultivars share many metabolic similarities during development. These findings might help the comprehension of fruit development, which in turn, impacts the quality of the fruits. [Mh] Termos MeSH primário: Diospyros [Mh] Termos MeSH secundário: Frutas Imagem por Ressonância Magnética Metabolômica Polifenóis [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Polyphenols) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171128 [Lr] Data última revisão: 171128 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170907 [St] Status: MEDLINE

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[PMID]: 28870200 [Au] Autor: Park SB; Park GH; Song HM; Son HJ; Um Y; Kim HS; Jeong JB [Ad] Endereço: Department of Medicinal Plant Resources, Andong National University, Andong, 36729, Republic of Korea. [Ti] Título: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. [So] Source: BMC Complement Altern Med;17(1):445, 2017 Sep 05. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail. In this study, we elucidated anti-cancer activity and potential molecular mechanism of DKC against human colorectal cancer cells. METHODS: Anti-cell proliferative effect of 70% ethanol extracts from the calyx of Diospyros kaki (DKC-E70) was evaluated by MTT assay. The effect of DKC-E70 on the expression of cyclin D1 in the protein and mRNA level was evaluated by Western blot and RT-PCR, respectively. RESULTS: DKC-E70 suppressed the proliferation of human colorectal cancer cell lines such as HCT116, SW480, LoVo and HT-29. Although DKC-E70 decreased cyclin D1 expression in protein and mRNA level, decreased level of cyclin D1 protein by DKC-E70 occurred at the earlier time than that of cyclin D1 mRNA, which indicates that DKC-E70-mediated downregulation of cyclin D1 protein may be a consequence of the induction of degradation and transcriptional inhibition of cyclin D1. In cyclin D1 degradation, we found that cyclin D1 downregulation by DKC-E70 was attenuated in presence of MG132. In addition, DKC-E70 phosphorylated threonine-286 (T286) of cyclin D1 and T286A abolished cyclin D1 downregulation by DKC-E70. We also observed that DKC-E70-mediated T286 phosphorylation and subsequent cyclin D1 degradation was blocked in presence of the inhibitors of ERK1/2, p38 or GSK3ß. In cyclin D1 transcriptional inhibition, DKC-E70 inhibited the expression of ß-catenin and TCF4, and ß-catenin/TCF-dependent luciferase activity. CONCLUSIONS: Our results suggest that DKC-E70 may downregulate cyclin D1 as one of the potential anti-cancer targets through cyclin D1 degradation by T286 phosphorylation dependent on ERK1/2, p38 or GSK3ß, and cyclin D1 transcriptional inhibition through Wnt signaling. From these findings, DKC-E70 has potential to be a candidate for the development of chemoprevention or therapeutic agents for human colorectal cancer. [Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem Neoplasias Colorretais/genética Ciclina D1/genética Ciclina D1/metabolismo Diospyros/química Extratos Vegetais/administração & dosagem Complexo de Endopeptidases do Proteassoma/metabolismo [Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos Neoplasias Colorretais/tratamento farmacológico Neoplasias Colorretais/metabolismo Neoplasias Colorretais/fisiopatologia Células HCT116 Células HT29 Seres Humanos Fosforilação Complexo de Endopeptidases do Proteassoma/genética Proteólise beta Catenina/genética beta Catenina/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Plant Extracts); 0 (beta Catenin); 136601-57-5 (Cyclin D1); EC 3.4.25.1 (Proteasome Endopeptidase Complex) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170908 [Lr] Data última revisão: 170908 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170906 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-1954-2

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[PMID]: 28827842 [Au] Autor: Matsumura Y; Kitabatake M; Ouji-Sageshima N; Yasui S; Mochida N; Nakano R; Kasahara K; Tomoda K; Yano H; Kayano SI; Ito T [Ad] Endereço: Department of Immunology, Nara Medical University, Kashihara, Nara, Japan. [Ti] Título: Persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of Mycobacterium avium complex (MAC) disease. [So] Source: PLoS One;12(8):e0183489, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions. In this study, we evaluated the effects of soluble persimmon-derived tannins on opportunistic MAC disease. Soluble tannins were hydrolyzed and evaluated by the oxygen radical absorbance capacity (ORAC) method. The ORAC value of soluble tannin hydrolysate was approximately five times greater than that of soluble tannin powder. In addition, soluble tannin hydrolysate exhibited high bacteriostatic activity against MAC in vitro. Furthermore, in an in vivo study, MAC infected mice fed a soluble tannin-containing diet showed significantly higher anti-bacterial activity against MAC and less pulmonary granuloma formation compared with those fed a control diet. Tumor necrosis factor α and inducible nitric oxide synthase levels were significantly lower in lungs of the soluble tannin diet group compared with the control diet group. Moreover, proinflammatory cytokines induced by MAC stimulation of bone marrow-derived macrophages were significantly decreased by addition of soluble tannin hydrolysate. These data suggest that soluble tannin from persimmons might attenuate the pathogenesis of pulmonary NTM infection. [Mh] Termos MeSH primário: Antibacterianos/uso terapêutico Diospyros/química Modelos Animais de Doenças Inflamação/tratamento farmacológico Infecção por Mycobacterium avium-intracellulare/tratamento farmacológico Taninos/uso terapêutico [Mh] Termos MeSH secundário: Animais Feminino Camundongos Camundongos Endogâmicos BALB C [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Tannins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171013 [Lr] Data última revisão: 171013 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170823 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0183489

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[PMID]: 28811126 [Au] Autor: Ding Y; Ren K; Dong H; Song F; Chen J; Guo Y; Liu Y; Tao W; Zhang Y [Ad] Endereço: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China. [Ti] Título: Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis. [So] Source: Chem Biol Interact;275:210-217, 2017 Sep 25. [Is] ISSN: 1872-7786 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: Persimmon (Diospyros kaki L.) leaves are extensively used in Chinese medicine and are also excellent source of dietary polyphenols. Here we investigated the antiproliferative and pro-apoptotic activity of the total flavonoids extracted from persimmon leaves (FPL) in PC-3 cells. After treating cells with different concentration of FPL, Quercetin or Rutin for 24 h, MTT and flow cytometry were used to measure the cytotoxicity, apoptotic rate and cell cycle arrest. Compared with Quercetin and Rutin, FPL showed higher cytotoxicity at 12.5 and 25 µg/ml concentrations and also presented lower IC in PC-3 cells. In addition, FPL induced PC-3 cells apoptosis by activation of oxidative stress, as detected by ROS, MDA, nitrite and iNOS activity, and increased mitochondrial membrane permeability. Morphological changes, inactivation of Bcl-2, upregulation of BAX, release of cytochrome c and activation of downstream apoptotic signaling in FPL-treated PC-3 cells also suggested apoptotic death. Meanwhile, FPL significantly inhibited migration of PC-3 cells. Therefore, FPL inhibited proliferation, migration and induced apoptosis of PC-3 cells by activation of oxidative stress and mitochondrial-related apoptosis. [Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos Proliferação Celular/efeitos dos fármacos Diospyros/química Flavonoides/farmacologia Mitocôndrias/efeitos dos fármacos Estresse Oxidativo/efeitos dos fármacos Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Pontos de Checagem do Ciclo Celular/efeitos dos fármacos Linhagem Celular Tumoral Movimento Celular/efeitos dos fármacos Citocromos c/metabolismo Diospyros/metabolismo Flavonoides/química Flavonoides/isolamento & purificação Seres Humanos Potencial da Membrana Mitocondrial/efeitos dos fármacos Mitocôndrias/metabolismo Óxido Nítrico/metabolismo Óxido Nítrico Sintase Tipo II/metabolismo Extratos Vegetais/química Folhas de Planta/química Folhas de Planta/metabolismo Proteínas Proto-Oncogênicas c-bcl-2/metabolismo Espécies Reativas de Oxigênio/metabolismo Regulação para Cima/efeitos dos fármacos Proteína X Associada a bcl-2/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flavonoids); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Reactive Oxygen Species); 0 (bcl-2-Associated X Protein); 31C4KY9ESH (Nitric Oxide); 9007-43-6 (Cytochromes c); EC 1.14.13.39 (Nitric Oxide Synthase Type II) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170817 [St] Status: MEDLINE

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[PMID]: 28779899 [Au] Autor: Sak B; Jandová A; Dolezal K; Kvác M; Kvetonová D; Hlásková L; Rost M; Olsanský M; Nurcahyo W; Foitová I [Ad] Endereço: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic. Electronic address: casio@paru.cas.cz. [Ti] Título: Effects of selected Indonesian plant extracts on E. cuniculi infection in vivo. [So] Source: Exp Parasitol;181:94-101, 2017 Oct. [Is] ISSN: 1090-2449 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The present study was conducted to evaluate the methanolic extracts from several plant leaves widely used in traditional medicine to cure digestive tract disorders and in the self-medication of wild animals such as non-human primates, namely Archidendron fagifolium, Diospyros sumatrana, Shorea sumatrana, and Piper betle leaves, with regard to their antimicrosporidial activity against Encephalitozoon cuniculi in immunocompetent BALB/c mice determined using molecular detection of microsporidial DNA (qPCR) in various tissues and body fluids of infected, treated mice. Of the plant extracts tested, Diospyros sumatrana provided the most promising results, reducing spore shedding by 88% compared to untreated controls. Moreover, total burden per 1 g of tissue in the D. sumatrana extract-treated group reached 87% reduction compared to untreated controls, which was comparable to the effect of the standard drug, Albendazole. This data represents the baseline necessary for further research focused on determining the structure, activity and modes of action of the active compounds, mainly of D. sumatrana, enabling subsequent development of antimicrosporidial remedies. [Mh] Termos MeSH primário: Antifúngicos/uso terapêutico Diospyros/química Encephalitozoon cuniculi/efeitos dos fármacos Encefalitozoonose/tratamento farmacológico Extratos Vegetais/uso terapêutico [Mh] Termos MeSH secundário: Albendazol/farmacologia Albendazol/uso terapêutico Animais Antifúngicos/farmacologia Cercopithecus aethiops DNA Fúngico/isolamento & purificação Dimetil Sulfóxido/farmacologia Dimetil Sulfóxido/uso terapêutico Dipterocarpaceae/química Fabaceae/química Fezes/parasitologia Trato Gastrointestinal/microbiologia Imunocompetência Indonésia Camundongos Camundongos Endogâmicos BALB C Piper betle/química Extratos Vegetais/farmacologia Folhas de Planta/química Esporos Fúngicos/efeitos dos fármacos Células Vero [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antifungal Agents); 0 (DNA, Fungal); 0 (Plant Extracts); F4216019LN (Albendazole); YOW8V9698H (Dimethyl Sulfoxide) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170920 [Lr] Data última revisão: 170920 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170807 [St] Status: MEDLINE

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[PMID]: 28768928 [Au] Autor: Higa M; Takashima Y; Yokaryo H; Harie Y; Suzuka T; Ogihara K [Ad] Endereço: Department of Chemistry, Biology, and Marine Science, Faculty of Science, University of the Ryukyus. [Ti] Título: Naphthoquinone Derivatives from Diospyros maritima. [So] Source: Chem Pharm Bull (Tokyo);65(8):739-745, 2017. [Is] ISSN: 1347-5223 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: From the chloroform extract of the fresh fruits of Diospyros maritima BLUME (Ebenaceae), five new naphthoquinone derivatives, 2,7'-dimethyl-2',3-bijuglone (27), 2,7'-dimethyl-3,3'-bijuglone (28), 2,7'-dimethyl-6,8'-bijuglone (29), 7,7'-dimethyl-3,3'-ethylidenebijuglone (30), and 2',7-dimethyl-3,6'-ethylidenebijuglone (31), were isolated, in addition to twenty-one known naphthoquinone derivatives: plumbagin (4), droserone (5), 2,3-epoxyplumbagin (8), 3,3'-biplumbagin (9), chitranone (10), 3,8'-biplumbagin (11), elliptinone (12), maritinone (13), isozeylanone (14), methylene-3,3'-biplumbagin (15), ethylidene-3,3'-biplumbagin (16), ethylidene-3,6'-biplumbagin (17), ethylidene-6,6'-biplumbagin (18), 7-methyl-ß-dihydrojuglone (19), 7-methyljuglone (20), 2,3-epoxy-7-methyljuglone (21), neodiospyrin (22), mamegakinone (23), ehretione (24), isoxylospyrin (25) and ß-dihydroplumbagin (26). The structures of the new compounds were established by spectral analysis. The quinones obtained from the chloroform extract of the fruits were compared with previously reported quinones obtained from ethanol extracts. The quinones in the fruits were categorized in three groups: quinones from ethanol extract only, quinones from chloroform extract only, and quinones from both extracts. The six naphthoquinones, 19-21, 25, 26, and 29, were examined for their ichthyotoxic activity and germination inhibitory activity. Quinones 19-21, 26, and 29 showed ichthyotoxic activity against Japanese killifish (Oryzias latipes var.) at 10 ppm; quinones 19 to 21 and 26 showed germination inhibitory activity toward lettuce seeds (Lactuca sativa L. var. Great Lakes) at 100 ppm. [Mh] Termos MeSH primário: Diospyros/química Naftoquinonas/isolamento & purificação Naftoquinonas/farmacologia [Mh] Termos MeSH secundário: Animais Fundulidae Estrutura Molecular Naftoquinonas/química Oryzias [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Naphthoquinones) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170829 [Lr] Data última revisão: 170829 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170804 [St] Status: MEDLINE [do] DOI: 10.1248/cpb.c17-00178

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[PMID]: 28754574 [Au] Autor: Sato M; Takase T; Yamaguchi K [Ad] Endereço: Fukushima University, Faculty of Symbolic System Science, 1 Kanayagawa, Fukushima, 960-1248, Japan; Fruit Tree Research Center, Fukushima Agricultural Technology Center, 1 Dannohigashi, Hirano, Iizaka-cho, Fukushima, 960-0231, Japan. Electronic address: satou_mamoru_01@pref.fukushima.lg.jp. [Ti] Título: Effects of bark washing and epiphytic moss on Cs activity concentration in bark and stemflow in Japanese persimmon (Diospyros kaki Thunb.). [So] Source: J Environ Radioact;178-179:360-366, 2017 Nov. [Is] ISSN: 1879-1700 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The effects of bark washing, and of epiphytic moss growing on the bark surfaces, on the Cs activity concentrations in bark and stemflow samples were evaluated at two Japanese persimmon orchards located in Fukushima City and Date City, both approximately 60-65 km northwest of the Fukushima Dai-ichi nuclear power plant. The means of Cs in stemflow captured by 1 g of sphagnum placed on the main trunks of washed and unwashed trees, and on sites with moss and with no moss growing on bark of the non-washed trees in Date City, were 0.37 Bq, 1.08Bq, 0.77 Bq and 0.52 Bq respectively. The Cs was significantly lower in the washed bark and in the absence of moss at p = 0.00031 and p = 0.0443 by t-test respectively. The Cs in directly-collected stemflow on the main trunks was significantly higher for the unwashed tree at 6.0 Bq L compared with the washed tree at 1.1 Bq L (p = 0.017 by Tukey's test). The extraction rate of dissolved Cs with deionized water was 7.3% even after stirring for 40 h. These results indicate that the moss acts as reservoir of Cs, and that bark-washing decontamination can reduce the additional Cs supply from moss in subsequent years following the radioactive fallout. [Mh] Termos MeSH primário: Briófitas/química Radioisótopos de Césio/análise Acidente Nuclear de Fukushima Monitoramento de Radiação/métodos Cinza Radioativa/análise [Mh] Termos MeSH secundário: Diospyros/química Japão Centrais Nucleares Casca de Planta/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cesium Radioisotopes); 0 (Radioactive Fallout) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171110 [Lr] Data última revisão: 171110 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170730 [St] Status: MEDLINE

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[PMID]: 28638861 [Au] Autor: Dushimemaria F; Preez CID; Mumbengegwi DR [Ad] Endereço: Science, Technology & Innovation Division, Multidisciplinary Research Centre, University of Namibia, Private Bag 13301, 340 Mandume Ndemufayo Avenue, Pionierspark. Windhoek, Namibia. [Ti] Título: RANDOMIZED ANTICANCER AND CYTOTOXICITY ACTIVITIES OF AND . [So] Source: Afr J Tradit Complement Altern Med;14(4):1-7, 2017. [Is] ISSN: 2505-0044 [Cp] País de publicação: Nigeria [La] Idioma: eng [Ab] Resumo: BACKGROUND: Plants have consistently proven to be a reliable and yet not fully explored source of medicines. In light of this, there is a constant demand for new treatment regimens for cancer. Namibia has a rich diversity of plant species of over 4300 with 17 % of them being endemic to Namibia. Plants growing in Namibia's diverse climatic zones produce many secondary metabolites as part of adaptation to their environment. This article focused on the screening of such phytochemicals and their cytotoxic and anticancer properties . Two Namibian plants and were randomly selected for this purpose. MATERIALS AND METHODS: The plants were screened for the presence of coumarins, alkaloids, flavonoids, anthraquinones, steroids and terpenoids using thin layer chromatography. Anticancer screening was performed on a panel of three cancer cell lines, while cytotoxicity was determined using a human fibroblast cell line, both using the SRB method. RESULTS: Alkaloids, anthraquinones, flavonoids and steroids were detected in both organic and aqueous extracts of the two plants. The organic plant extracts had a greater anti-proliferative effect on the cancer cell lines than the aqueous extracts; the organic root extract was the most potent with an IC of 16.08, 29.12 and 24.67 µg/mL against TK10, UACC62 and MCF7 cells, respectively. Furthermore, cytotoxicity analysis revealed the non-toxic nature of the extracts, except for the organic root extract of that showed significant cytotoxicity (IC 13.03 µg/mL). CONCLUSION: is a potential candidate for the development of a plant based cancer treatment. The study showed the value of random screening in drug discovery from plants for pharmacological activity that is unrelated to their ethnomedicinal uses. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia Diospyros/química Fabaceae/química Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química Antineoplásicos Fitogênicos/isolamento & purificação Antineoplásicos Fitogênicos/toxicidade Linhagem Celular Tumoral Proliferação Celular/efeitos dos fármacos Seres Humanos Neoplasias/tratamento farmacológico Neoplasias/fisiopatologia Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Extratos Vegetais/toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170623 [St] Status: MEDLINE [do] DOI: 10.21010/ajtcam.v14i4.1

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[PMID]: 28617146 [Au] Autor: Othong R; Trakulsrichai S; Wananukul W [Ad] Endereço: a Department of Emergency Medicine, Faculty of Medicine Vajira Hospital , Navamindradhiraj University , Bangkok , Thailand. [Ti] Título: Diospyros rhodocalyx (Tako-Na), a Thai folk medicine, associated with hypokalemia and generalized muscle weakness: a case series. [So] Source: Clin Toxicol (Phila);55(9):986-990, 2017 Nov. [Is] ISSN: 1556-9519 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Diospyros rhodocalyx (Tako-Na) is a Thai folk medicine purported to promote longevity, treat impotence, etc. We present patients with hypokalemia, weakness and hypertension after consuming Tako-Na tea. CASE SERIES: Case 1: A 61-year-old man was brought in nine hours after drinking 400-500 mL of Tako-Na tea. One handful of Tako-Na bark was boiled in water to make tea. He had vomiting and watery diarrhea six hours after drinking it. He took no medications and had no history of hypertension. The only remarkable vital sign was BP 167/90 mmHg. Physical examination revealed generalized muscle weakness. Laboratory findings were potassium 2.7 mmol/L, bicarbonate 24 mmol/L, and transtubular potassium gradient (TTKG) 5.6. He was discharged the next day with a BP 140/90 mmHg and potassium 4.2 mmol/L. Case 2: A 78-year-old man, a friend of case 1, also drank Tako-Na tea from the same pot at the same time as case 1. He also had vomiting and diarrhea six hours later. He took no medications despite past history of hypertension (baseline SBP 140-160). Initial BP was 230/70 mmHg. He also had muscle weakness. Laboratory findings were potassium 3.3 mmol/L, bicarbonate 24 mmol/L, TTKG 7.37 and normal thyroid function. He was also discharged the next day with a BP 148/70 mmHg and potassium 4.2 mmol/L. Case 3-7: These were patients reported to a poison center and their potassium concentrations were 1.4, 1.4, 3.3, 1.3 and 1.2 mmol/L, respectively. Three of them were intubated and case 3 died. CONCLUSIONS: Tako-Na contains betulin, betulinic acid, taraxerone, lupeol, and lupenone. Their structures are similar to glycyrrhetic acid, the active metabolite of glycyrrhizic acid found in licorice which is well known to cause pseudoaldosteronism. Glycyrrhetic acid is potent in inhibiting 11-beta-hydroxysteroid dehydrogenase, and causes pseudoaldosteronism. We hypothesize that the compounds in Tako-Na act in the same way as glycyrrhetic acid in producing pseudoaldosteronism. [Mh] Termos MeSH primário: Diospyros/efeitos adversos Hipopotassemia/induzido quimicamente Medicina Tradicional/efeitos adversos Força Muscular/efeitos dos fármacos Debilidade Muscular/induzido quimicamente Músculo Esquelético/efeitos dos fármacos Preparações de Plantas/efeitos adversos Potássio/sangue [Mh] Termos MeSH secundário: Idoso Biomarcadores/sangue Pressão Sanguínea/efeitos dos fármacos Eletrocardiografia Feminino Frequência Cardíaca/efeitos dos fármacos Seres Humanos Hipertensão/induzido quimicamente Hipertensão/fisiopatologia Hipopotassemia/sangue Hipopotassemia/diagnóstico Hipopotassemia/terapia Síndrome de Liddle/induzido quimicamente Masculino Meia-Idade Debilidade Muscular/diagnóstico Debilidade Muscular/fisiopatologia Debilidade Muscular/terapia Músculo Esquelético/fisiopatologia Fitoterapia/efeitos adversos Plantas Medicinais/efeitos adversos Estudos Retrospectivos Tailândia Complexos Ventriculares Prematuros/induzido quimicamente Complexos Ventriculares Prematuros/fisiopatologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Plant Preparations); RWP5GA015D (Potassium) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170911 [Lr] Data última revisão: 170911 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170616 [St] Status: MEDLINE [do] DOI: 10.1080/15563650.2017.1330957

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[PMID]: 28603127 [Au] Autor: Tahir L; Aslam A; Ahmed S [Ad] Endereço: ACRC, PCSIR Labs. Complex, Ferouzpur Road, Lahore, Pakistan / Department of Microbiology, Qauid-i-Azam University, Islamabad, Pakistan. [Ti] Título: Antibacterial activities of Diospyros blancoi, Phoenix dactylifera and Morus nigra against dental caries causing pathogens: An in vitro study. [So] Source: Pak J Pharm Sci;30(1):163-169, 2017 Jan. [Is] ISSN: 1011-601X [Cp] País de publicação: Pakistan [La] Idioma: eng [Ab] Resumo: The study was undertaken to determine the in-vitro antibacterial potential of Diospyrosblancoi, Phoenix dactylifera and Morusnigra leaf extracts in hexane, chloroform, methanol, ethyl-acetate and aqueous extracts against dental caries causing bacteria. Disc diffusion assay was used to determine the antibacterial efficacy; the extracts were further separated using Thin Layer Chromatography and the anti-biofilm activity of the extracts was also determined. The preliminary phytochemical screening of the extracts revealed the presences of flavonoids, saponins, alkaloids and tannins because of which the extracts showed strong antibacterial activity against the selected pathogens. The ethyl-acetate extracts showed maximum inhibitory effect on biofilm formation by S. mutans.96% inhibition was observed in methanol extract of Diospyrosblancoi, and 95% in ethyl acetate extract. The results evidenced that the plants inhibit the growth of oral bacteria responsible for dental caries with their abundance source of secondary metabolites and can be used as an alternative treatment for caries, thus minimizing the antibiotics used to treat the disease in local medicine. [Mh] Termos MeSH primário: Antibacterianos/farmacologia Arecaceae/química Bactérias/efeitos dos fármacos Cárie Dentária/prevenção & controle Diospyros/química Morus/química Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação Bactérias/crescimento & desenvolvimento Bactérias/patogenicidade Cárie Dentária/microbiologia Testes de Sensibilidade a Antimicrobianos por Disco-Difusão Fitoterapia Extratos Vegetais/isolamento & purificação Folhas de Planta/química Plantas Medicinais Solventes/química [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Solvents) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171103 [Lr] Data última revisão: 171103 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170613 [St] Status: MEDLINE

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