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Pesquisa : B01.650.940.800.575.912.250.341.937.267 [Categoria DeCS]
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[PMID]:28603132
[Au] Autor:Alam F; Saqib QN; Shah AJ
[Ad] Endereço:Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
[Ti] Título:Airways and vascular smooth muscles relaxant activities of Gaultheria trichophylla.
[So] Source:Pak J Pharm Sci;30(1):199-203, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The aim of this experimental work was to explore the potential pharmacological activities of Gaultheria trichophylla Royle in hyperactive respiratory and vascular conditions. Gaultheria trichophylla was extracted with solvents, phytochemical detection tests were performed, and rabbit trachea and aorta strips were used to evaluate its effects on airways and vascular smooth muscles. Qualitative phytochemical tests showed the presence of flavonoids, alkaloids, anthraquinones, saponins, terpenoids, and condensed tannins. The methanol extract caused inhibition (EC values of 3.12 mg/mL) of carbachol (1 µM) and partial relaxation of K (80 mM) caused contractions in tracheal strips. The chloroform extract was comparatively more potent against carbachol than K+ induced contraction with EC values of 0.64 and 2.26 mg/mL, respectively. However, the n-hexane extract showed more potency against K than cabachol induced contractions, as in case with verapamil, with EC values of 0.61 and 6.58 mg/mL, respectively. In isolated prepared trachea, the extracts displaced the carbachol concentration response curves and maximum response was suppressed. In rabbit aorta preparations, methanol and n-hexane extracts partially relaxed phenylephrine (1 µM) and K induced vasoconstrictions. However, the chloroform extract inhibited phenylephrine induced contractions and exhibited a vasoconstrictor effect at lower concentrations and a relaxant effect at higher concentrations against K precontractions. The data indicates that, in addition to others, the extracts of G .trichophylla possess verapamil like Ca channel blocking components which explain the possible role of this plant in respiratory and vascular conditions.
[Mh] Termos MeSH primário: Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Bloqueadores dos Canais de Cálcio/farmacologia
Gaultheria/química
Músculo Liso Vascular/efeitos dos fármacos
Extratos Vegetais/farmacologia
Traqueia/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Broncodilatadores/isolamento & purificação
Bloqueadores dos Canais de Cálcio/isolamento & purificação
Canais de Cálcio/efeitos dos fármacos
Canais de Cálcio/metabolismo
Clorofórmio/química
Relação Dose-Resposta a Droga
Feminino
Hexanos/química
Técnicas In Vitro
Masculino
Metanol/química
Músculo Liso Vascular/metabolismo
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/farmacologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Coelhos
Solventes/química
Traqueia/metabolismo
Vasodilatadores/isolamento & purificação
Verapamil/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Calcium Channel Blockers); 0 (Calcium Channels); 0 (Hexanes); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Solvents); 0 (Vasodilator Agents); 2DDG612ED8 (n-hexane); 7V31YC746X (Chloroform); CJ0O37KU29 (Verapamil); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28272321
[Au] Autor:Michel P; Owczarek A; Matczak M; Kosno M; Szymanski P; Mikiciuk-Olasik E; Kilanowicz A; Wesolowski W; Olszewska MA
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, 1 Muszynskiego, 90-151 Lodz, Poland. piotr.michel@umed.lodz.pl.
[Ti] Título:Metabolite Profiling of Eastern Teaberry (Gaultheria procumbens L.) Lipophilic Leaf Extracts with Hyaluronidase and Lipoxygenase Inhibitory Activity.
[So] Source:Molecules;22(3), 2017 Mar 06.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The phytochemical profile and anti-inflammatory activity of Gaultheria procumbens dry lipophilic leaf extracts were evaluated. Forty compounds were identified by GC-MS, representing 86.36% and 81.97% of the petroleum ether (PE) and chloroform (CHE) extracts, respectively, with ursolic acid (28.82%), oleanolic acid (10.11%), methyl benzoate (10.03%), and methyl salicylate (6.88%) dominating in CHE, and methyl benzoate (21.59%), docosane (18.86%), and octacosane (11.72%) prevailing in PE. Three components of CHE were fully identified after flash chromatography isolation and spectroscopic studies as (6S,9R)-vomifoliol (4.35%), 8-demethyl-latifolin (1.13%), and 8-demethylsideroxylin (2.25%). Hyaluronidase and lipoxygenase inhibitory activity was tested for CHE (IC50 = 282.15 ± 10.38 µg/mL and 899.97 ± 31.17 µg/mL, respectively), PE (IC50 = 401.82 ± 16.12 µg/mL and 738.49 ± 15.92 µg/mL), and nine of the main constituents versus heparin (IC50 = 366.24 ± 14.72 µg/mL) and indomethacin (IC50 = 92.60 ± 3.71 µg/mL) as positive controls. With the best activity/concentration relationships, ursolic and oleanolic acids were recommended as analytical markers for the extracts and plant material. Seasonal variation of both markers following foliar development was investigated by UHPLC-PDA. The highest levels of ursolic (5.36-5.87 mg/g DW of the leaves) and oleanolic (1.14-1.26 mg/g DW) acids were observed between August and October, indicating the optimal season for harvesting.
[Mh] Termos MeSH primário: Gaultheria/química
Hialuronoglucosaminidase/antagonistas & inibidores
Inibidores de Lipoxigenase/química
Inibidores de Lipoxigenase/farmacologia
Compostos Fitoquímicos/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Cromatografia Gasosa-Espectrometria de Massas
Espectroscopia de Ressonância Magnética
Metabolômica/métodos
Estrutura Molecular
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipoxygenase Inhibitors); 0 (Phytochemicals); 0 (Plant Extracts); EC 3.2.1.35 (Hyaluronoglucosaminidase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:28215572
[Au] Autor:Zhang MY; Fritsch PW; Ma PF; Wang H; Lu L; Li DZ
[Ad] Endereço:Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China; Plant Germplasm and Genomics Center, Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 65
[Ti] Título:Plastid phylogenomics and adaptive evolution of Gaultheria series Trichophyllae (Ericaceae), a clade from sky islands of the Himalaya-Hengduan Mountains.
[So] Source:Mol Phylogenet Evol;110:7-18, 2017 May.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gaultheria series Trichophyllae Airy Shaw is an angiosperm clade of high-alpine shrublets endemic to the Himalaya-Hengduan Mountains and characterized by recent species divergence and convergent character evolution that has until recently caused much confusion in species circumscription. Although multiple DNA sequence regions have been employed previously, phylogenetic relationships among species in the group have remained largely unresolved. Here we examined the effectiveness of the plastid genome for improving phylogenetic resolution within the G. series Trichophyllae clade. Plastid genomes of 31 samples representing all 19 recognized species of the series and three outgroup species were sequenced with Illumina Sequencing technology. Maximum likelihood (ML), maximum parsimony (MP) and Bayesian inference (BI) phylogenetic analyses were performed with various datasets, i.e., that from the whole plastid genome, coding regions, noncoding regions, large single-copy region (LSC) and inverted-repeat region a (IRa). The partitioned whole plastid genome with inverted-repeat region b (IRb) excluded was also analyzed with ML and BI. Tree topologies based on the whole plastid genome, noncoding regions, and LSC region datasets across all analyses, and that based on the partitioned dataset with ML and BI analyses, are identical and generally strongly supported. Gaultheria series Trichophyllae form a clade with three species and one variety that is sister to a clade of the remaining 16 species; the latter comprises seven main subclades. Interspecific relationships within the series are strongly supported except for those based on the coding-region and IRa-region datasets. Eight divergence hotspot regions, each possessing >5% percent variable sites, were screened across the whole plastid genome of the 28 individuals sampled in the series. Results of morphological character evolution reconstruction diagnose several clades, and a hypothesis of adaptive evolution for plant habit is postulated.
[Mh] Termos MeSH primário: Ecossistema
Evolução Molecular
Gaultheria/genética
Genomas de Plastídeos
Ilhas
Filogenia
Plastídeos/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Teorema de Bayes
Flores/anatomia & histologia
Frutas/anatomia & histologia
Gaultheria/anatomia & histologia
Funções Verossimilhança
Folhas de Planta/anatomia & histologia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28049535
[Au] Autor:Alam F; Saqib QN; Ashraf M
[Ad] Endereço:Department of Pharmacy, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan. alamfiaz@ciit.net.pk.
[Ti] Título:Gaultheria trichophylla (Royle): a source of minerals and biologically active molecules, its antioxidant and anti-lipoxygenase activities.
[So] Source:BMC Complement Altern Med;17(1):3, 2017 Jan 03.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gaultheria trichophylla (Royle) is used as food and for treating many ailments in folk medicine especially against inflammation. The purpose of this in vitro study was to evaluate the ability of extracts of G. trichophylla as anti-oxidant and anti-inflammatory agent and for its mineral contents. METHODS: Powdered plant material (100 g) was extracted with 100 ml each of methanol, chloroform, and n-hexane using soxhlet extractor. Antioxidant activity of methanol extract was assessed by DPPH radical scavenging and FRAP assays. Determination of enzyme inhibition activity was determined using 5-LOX inhibitory activity. Total phenolic and flavonoids contents were measured by Folin-Chicalteu and colorimeteric methods respectively. Minerals and heavy metals contents were determined using Atomic absorption spectrophotometer. Qualitative HPLC analysis were performed using some standard phenolic compounds. RESULTS: The highest phenolic (17.5 ± 2.5 mg GA equivalent/g) and flavonoids (41.3 ± 0.1 mg QE equivalent/g) concentrations were found in methanol extract, which also showed more scavenging activity of 1, 1-diphenyl-2-picrylhydrazyl and ferrous reducing power with IC = 81.2 ± 0.2 and IC = 11.2 ± 0.1 µg/ml, respectively. The methanol and chloroform extracts showed best inhibition of 5-lipoxygenase enzyme with 90.5 ± 0.7% and 66.9 ± 0.1% at 0.5 mg/ml, respectively. G. trichophylla extract was also evaluated for mineral contents (K, Na, Ca, Mg, Fe, and Cu), and for chemical profiling of heavy metals (Cr, Pb, Cd, Co, Zn, Ni and Hg). CONCLUSION: Our current findings suggest that this plant is good source of minerals and concentration of all heavy metals were within permissible limits. The results revealed that this ignored plant has great pharmaceutical and nutraceutical potential.
[Mh] Termos MeSH primário: Antioxidantes/análise
Gaultheria/química
Inibidores de Lipoxigenase/análise
Minerais/análise
[Mh] Termos MeSH secundário: Flavonoides/análise
Lipoxigenases/análise
Metais Pesados/análise
Oxirredução
Fenóis/análise
Proteínas de Plantas/análise
Feijão de Soja/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Lipoxygenase Inhibitors); 0 (Metals, Heavy); 0 (Minerals); 0 (Phenols); 0 (Plant Proteins); EC 1.13.11.- (Lipoxygenases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1511-4


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[PMID]:28071039
[Au] Autor:Pliszka B; Huszcza-Ciolkowska G; Wierzbicka E
[Ad] Endereço:Chair of Chemistry, University of Warmia and Mazury in Olsztyn, Poland.
[Ti] Título:Effects of solvents and extraction methods on the content and antiradical activity of polyphenols from fruits Actinidia arguta, Crataegus monogyna, Gaultheria procumbens and Schisandra chinensis.
[So] Source:Acta Sci Pol Technol Aliment;15(1):57-63, 2016 Jan-Mar.
[Is] ISSN:1898-9594
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In line with the current tendency towards the production of the so-called safe foods, the use of environmentally-friendly methods for the extraction of polyphenols from fruits has been sought. Citric acid is a good solvent in the preparation of phenolic compounds for the food and pharmaceutical industries because it is a natural antioxidant and is non-toxic for the environment. Furthermore, new sources of polyphenols from fruit of orchard plants that are less known in Poland have been looked for. The aim of this study was  to assess the content and antiradical activity of polyphenolic compounds in fruit extracts, depending on the extraction method employed. In addition, the yield of extraction processes was assessed. METHODS: The experimental materials were fruits of the following plants: Actinidia arguta, Crataegus monogyna, Gaultheria procumbens, Schisandra chinensis. For the extraction, aqueous solutions of citric acid (CAE) and methanol (ME) were used. The following were determined in fruit extracts: the content of total phenols (TP) and anthocyanins (A), and antiradical activity (DPPH and ABTS). RESULTS: In general, the C. monogyna fruit extracts were distinguished by the highest TP and A content. The TP and A content was significantly higher in fruit extracts obtained with the CAE method than in the ones produced with the ME method. The highest mean A/TP ratio was determined for S. chinensis fruit extracts. The antiradical activity (DPPH and ABTS) in fruit extracts did not depend on an extraction method, but on fruit species. Overall, a higher yield of extraction processes was achieved for the CAE method than for the ME method. CONCLUSIONS: The present study indicates that the selected extraction methods are able to obtain polyphenolic extracts from fruits with a high antiradical activity and high yield. The use of citric acid in order to extract polyphenols from fruits may be an alternative to the conventional extraction method, while being eco-friendly and more effective than the latter.
[Mh] Termos MeSH primário: Actinidia/química
Crataegus/química
Depuradores de Radicais Livres/isolamento & purificação
Frutas/química
Gaultheria/química
Polifenóis/isolamento & purificação
Schisandra/química
[Mh] Termos MeSH secundário: Antocianinas/análise
Antocianinas/química
Antocianinas/isolamento & purificação
Ácido Cítrico/química
Suplementos Nutricionais
Aditivos Alimentares/análise
Aditivos Alimentares/química
Aditivos Alimentares/isolamento & purificação
Depuradores de Radicais Livres/análise
Depuradores de Radicais Livres/química
Química Verde
Metanol
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Polônia
Polifenóis/análise
Polifenóis/química
Solventes/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Food Additives); 0 (Free Radical Scavengers); 0 (Plant Extracts); 0 (Polyphenols); 0 (Solvents); 2968PHW8QP (Citric Acid); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.17306/J.AFS.2016.1.6


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[PMID]:27006236
[Au] Autor:McDougall GJ; Austin C; Van Schayk E; Martin P
[Ad] Endereço:Environmental and Biochemical Sciences Group, Enhancing Crop Productivity and Utilisation Theme, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK. Electronic address: Gordon.mcdougall@hutton.ac.uk.
[Ti] Título:Salal (Gaultheria shallon) and aronia (Aronia melanocarpa) fruits from Orkney: Phenolic content, composition and effect of wine-making.
[So] Source:Food Chem;205:239-47, 2016 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The polyphenol content and composition of salal and aronia fruits from plants established in Orkney was examined. The composition of the salal fruits has not previously been recorded, and they contained anthocyanins, flavonols, hydroxycinnamates and proanthocyanins. The aronia fruits contained anthocyanins, hydroxycinnamates and flavonols as previously described. Although salal fruits had half the anthocyanin content of aronia fruits, salal wine had higher anthocyanin content, probably due to the relative stability of diglycoside pentose anthocyanins. The wines contained components suggestive of anthocyanin and flavonol degradation, but there was no consistent pattern to stability within phenolic sub-classes. Indeed, the wine made from equal amounts of salal and aronia fruits had patterns of recovery of individual phenolic components which could not be predicted from recoveries in wines from single fruits. This strongly suggests that stability of individual phenolic constituents during wine-making is influenced by the presence and relative stability of other components.
[Mh] Termos MeSH primário: Antocianinas/análise
Frutas/química
Gaultheria/química
Fenóis/análise
Photinia/química
Vinho/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Phenols)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE


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[PMID]:26978121
[Au] Autor:Cai YH; Guo Y; Li Z; Wu D; Li X; Zhang H; Yang J; Lu H; Sun Z; Luo HB; Yin S; Wu Y
[Ad] Endereço:School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
[Ti] Título:Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4.
[So] Source:Eur J Med Chem;114:134-40, 2016 May 23.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Phosphodiesterase-4 (PDE4) is an anti-inflammatory target for treatment of asthma and chronic obstructive pulmonary disease (COPD). Here, we report the isolation and characterization of 13 compounds (G1-G13) by bioassay-guided fractionation of the ethyl acetate extraction of Gaultheria yunnanensis (FRANCH.), one of which pentacyclic triterpene (G1) has never been reported. Four of them (G1, G2, G4, and G5) inhibit PDE4 with the IC50 values < 20 µM and G1 is the most potent ingredient with an IC50 of 245 nM and moderate selectivity over other PDE families. Molecular dynamics simulations suggest that G1 forms a hydrogen bond with Asn362, in addition to the hydrogen bond with Gln369 and π-π interactions with Phe372, which are commonly observed in the binding of most PDE4 inhibitors. The calculated binding free energies for the interactions of PDE4-G1 and PDE4-G2 are -19.4 and -18.8 kcal/mol, in consistence with the bioassay that G1 and G2 have IC50 of 245 nM and 542 nM, respectively. The modelling results of these active compounds may aid the rational design of novel PDE4 inhibitors as anti-inflammatory agents.
[Mh] Termos MeSH primário: Produtos Biológicos/farmacologia
Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo
Descoberta de Drogas
Gaultheria/química
Inibidores da Fosfodiesterase 4/farmacologia
[Mh] Termos MeSH secundário: Produtos Biológicos/química
Produtos Biológicos/isolamento & purificação
Relação Dose-Resposta a Droga
Ligações de Hidrogênio
Modelos Moleculares
Estrutura Molecular
Inibidores da Fosfodiesterase 4/química
Inibidores da Fosfodiesterase 4/isolamento & purificação
Plasmídeos
Proteínas Recombinantes/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biological Products); 0 (Phosphodiesterase 4 Inhibitors); 0 (Recombinant Proteins); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE


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[PMID]:26558484
[Au] Autor:Kiran S; Prakash B
[Ad] Endereço:Department of Food Protectants and Infestation Control, CSIR-Central Food Technological Research Institute , Mysore 570020, India.
[Ti] Título:Assessment of Toxicity, Antifeedant Activity, and Biochemical Responses in Stored-Grain Insects Exposed to Lethal and Sublethal Doses of Gaultheria procumbens L. Essential Oil.
[So] Source:J Agric Food Chem;63(48):10518-24, 2015 Dec 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was undertaken to investigate the insecticidal activity of chemically characterized Gaultheria procumbens essential oil (EO) and its mode of action against the Coleopteran insects Sitophilus oryzae and Rhyzopertha dominica. Gas chromatography-mass spectrometry results depicted methyl salicylate (MS) as the major compound (96.61%) of EO. EO and its major compound methyl salicylate (MS) showed 100% mortality at 150 and 5.0 µL/L air against S. oryzae and R. dominica, respectively, on 24 h of exposure. The in vivo percent inhibition of AChE activity ranged between 6.12 and 27.50%. In addition, changes in the antioxidative defense system, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and oxidized glutathione (GSSG), in test insects were estimated. A significant dose-dependent response in all test parameters was observed. The results demonstrated that G. procumbens EO could play a significant role in the formulation of EO-based insecticides for the management of stored-grain insects.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Comportamento Alimentar/efeitos dos fármacos
Gaultheria/química
Inseticidas/toxicidade
Óleos Voláteis/toxicidade
Óleos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Coleópteros/fisiologia
Gaultheria/toxicidade
Inseticidas/análise
Óleos Voláteis/análise
Óleos Vegetais/análise
Gorgulhos/efeitos dos fármacos
Gorgulhos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b03797


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[PMID]:26227503
[Au] Autor:Homa M; Fekete IP; Böszörményi A; Singh YR; Selvam KP; Shobana CS; Manikandan P; Kredics L; Vágvölgyi C; Galgóczy L
[Ad] Endereço:University of Szeged, Faculty of Science and Informatics, Department of Microbiology, Szeged, Hungary.
[Ti] Título:Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates.
[So] Source:Planta Med;81(14):1277-84, 2015 Sep.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present study was carried out to investigate the antifungal effects of Cinnamomum zeylanicum, Citrus limon, Juniperus communis, Eucalyptus citriodora, Gaultheria procumbens, Melaleuca alternifolia, Origanum majorana, Salvia sclarea, and Thymus vulgaris essential oils against Fusarium species, the most common etiologic agents of filamentous fungal keratitis in South India. C. zeylanicum essential oil showed strong anti-Fusarium activity, whereas all the other tested essential oils proved to be less effective. The main component of C. zeylanicum essential oil, trans-cinnamaldehyde, was also tested and showed a similar effect as the oil. The in vitro interaction between trans-cinnamaldehyde and natamycin, the first-line therapeutic agent of Fusarium keratitis, was also investigated; an enhanced fungal growth inhibition was observed when these agents were applied in combination. Light and fluorescent microscopic observations revealed that C. zeylanicum essential oil/trans-cinnamaldehyde reduces the cellular metabolism and inhibits the conidia germination. Furthermore, necrotic events were significantly more frequent in the presence of these two compounds. According to our results, C. zeylanicum essential oil/trans-cinnamaldehyde provides a promising basis to develop a novel strategy for the treatment of Fusarium keratitis.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Fusarium/efeitos dos fármacos
Ceratite/microbiologia
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Cinnamomum zeylanicum/química
Citrus/química
Interações Medicamentosas
Eucalyptus/química
Fusarium/patogenicidade
Gaultheria
Seres Humanos
Índia
Juniperus/química
Testes de Sensibilidade Microbiana
Natamicina/farmacologia
Óleos Voláteis/química
Origanum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Oils, Volatile); 7864XYD3JJ (Acrolein); 8O0C852CPO (Natamycin); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150919
[Lr] Data última revisão:
150919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150801
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1546272


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[PMID]:25865038
[Au] Autor:Alam F; Najum us Saqib Q
[Ad] Endereço:Department of Pharmacy, Comsats Institute of Information Technology , Abbottabad , Pakistan.
[Ti] Título:Pharmacognostic standardization and preliminary phytochemical studies of Gaultheria trichophylla.
[So] Source:Pharm Biol;53(12):1711-8, 2015.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Gaultheria trichophylla Royle (Ericaceae) has long been used for various ailments in traditional systems of medicines; most importantly it is used against pain and inflammation. AIMS: This study determines various pharmacognostic and phytochemical standards helpful to ensure the purity, safety, and efficacy of medicinal plant G. trichophylla. MATERIAL AND METHODS: Intact aerial parts, powdered materials, and extracts were examined macro- and microscopically and pharmacognostic standardization parameters were determined in accordance with the guidelines given by the World Health Organization (WHO). Parameters including extractive values, ash values, and loss on drying were determined. Preliminary phytochemical tests, fluorescence analysis, and chromatographic profiling were performed for the identification and standardization of G. trichophylla. RESULTS: The shape, size, color, odor, and surface characteristics were noted for intact drug and powdered drug material of G. trichophylla. Light and scanning electron microscope images of cross section of leaf and powdered microscopy revealed useful diagnostic features. Histochemical, phytochemical, physicochemical, and fluorescence analysis proved useful tools to differentiate the powdered drug material. High-performance liquid chromatography (HPLC) analysis showed the presence of important phytoconstituents such as gallic acid, rutin, and quercetin. DISCUSSION AND CONCLUSIONS: The data generated from the present study help to authenticate the medicinally important plant G. trichophylla. Qualitative and quantitative microscopic features may be helpful for establishing the pharmacopeia standards. Morphology as well as various pharmacognostic aspects of different parts of the plant were studied and described along with phytochemical and physicochemical parameters, which could be helpful in further isolation and purification of medicinally important compounds.
[Mh] Termos MeSH primário: Gaultheria
Farmacognosia/métodos
Compostos Fitoquímicos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Gaultheria/citologia
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/normas
Componentes Aéreos da Planta/citologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/normas
Folhas de Planta/citologia
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150730
[Lr] Data última revisão:
150730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150414
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2014.1003355



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