Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.341.937.324 [Categoria DeCS]
Referências encontradas : 23 [refinar]
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  1 / 23 MEDLINE  
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[PMID]:27439729
[Au] Autor:Mortazavi SMJ; Mortazavi G; Paknahad M
[Ad] Endereço:Medical Physics Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Histological and histochemical study of the protective role of rosemary extract against harmful effect of cell phone electromagnetic radiation on the parotid glands.
[So] Source:Acta Histochem;118(6):657-658, 2016 Jul.
[Is] ISSN:1618-0372
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Telefone Celular
Radiação Eletromagnética
Ledum/química
Glândula Parótida/lesões
[Mh] Termos MeSH secundário: Seres Humanos
Glândula Parótida/efeitos dos fármacos
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE


  2 / 23 MEDLINE  
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[PMID]:27393196
[Au] Autor:Metrak M; Aneta E; Wilkomirski B; Staszewski T; Suska-Malawska M
[Ad] Endereço:Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, ul. Zwirki i Wigury 101, 02-089, Warsaw, Poland.
[Ti] Título:Interspecific differences in foliar 1 PAHs load between Scots pine, birch, and wild rosemary from three polish peat bogs.
[So] Source:Environ Monit Assess;188(8):456, 2016 Aug.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pine needles are one of the most commonly used bioindicators of polycyclic aromatic hydrocarbons (PAHs) in the environment. Therefore, the main objective of the current research was the assessment of PAHs accumulation potential of Scots pine (Pinus sylvestris L.) needles in comparison to wild rosemary (Rhododendron tomentosum Harmaja) and birch (Betula spp.) leaves. Our study was carried out on three peat bogs subjected to different degree of anthropopression, which gave us also the opportunity to identify local emission sources. Pine needles had the lowest accumulation potential from all the studied species. The highest accumulation potential, and hence carcinogenic potential, was observed for wild rosemary leaves. As far as emission sources are concerned, the most pronounced influence on atmospheric PAHs loads had traditional charcoal production, resulting in great influx of heavy PAHs. Observed seasonal changes in PAHs concentrations followed the pattern of winter increase, caused mainly by heating season, and summer decrease, caused mainly by volatilization of light PAHs.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Betula
Ledum
Pinus sylvestris
Folhas de Planta/química
Hidrocarbonetos Aromáticos Policíclicos/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Polônia
Estações do Ano
Solo
Zonas Úmidas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Soil)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160710
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-016-5465-2


  3 / 23 MEDLINE  
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[PMID]:26916332
[Au] Autor:Li S; Brault A; Sanchez Villavicencio M; Haddad PS
[Ad] Endereço:a Natural Health Products and Metabolic Diseases Laboratory, CIHR Team in Aboriginal Antidiabetic Medicines, Department of Pharmacology , Université De Montréal , Montreal , Canada ;
[Ti] Título:Rhododendron groenlandicum (Labrador tea), an antidiabetic plant from the traditional pharmacopoeia of the Canadian Eastern James Bay Cree, improves renal integrity in the diet-induced obese mouse model.
[So] Source:Pharm Biol;54(10):1998-2006, 2016 Oct.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Content Our team has identified Labrador tea [Rhododendron groenlandicum L. (Ericaceae)] as a potential antidiabetic plant from the traditional pharmacopoeia of the Eastern James Bay Cree. In a previous in vivo study, the plant extract was tested in a high-fat diet (HFD)-induced obese model using C57BL/6 mice and it improved glycaemia, insulinaemia and glucose tolerance. Objective In the present study, we assessed the plant's potential renoprotective effects. Materials and methods Rhododendron groenlandicum was administered at 250 mg/kg/d to mice fed HFD for 8 weeks to induce obesity and mild diabetes. Histological (periodic acid-Schiff (PAS), Masson and Oil Red O staining), immunohistochemical (IHC) and biochemical parameters were assessed to evaluate the renoprotective potential of R. groenlandicum treatment for an additional 8 weeks. Results Microalbuminuria and renal fibrosis were developed in HFD-fed mice. Meanwhile, there was a tendency for R. groenlandicum to improve microalbuminuria, with the values of albumin-creatinine ratio (ACR) reducing from 0.69 to 0.53. Renal fibrosis value was originally 4.85 arbitrary units (AU) in HFD-fed mice, dropped to 3.27 AU after receiving R. groenlandicum treatment. Rhododendron groenlandicum reduced renal steatosis by nearly one-half, whereas the expression of Bcl-2-modifying factor (BMF) diminished from 13.96 AU to 9.43 AU. Discussion and conclusions Taken altogether, the results suggest that R. groenlandicum treatment can improve renal function impaired by HFD.
[Mh] Termos MeSH primário: Diabetes Mellitus/tratamento farmacológico
Nefropatias Diabéticas/prevenção & controle
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
Ledum
Obesidade/complicações
Extratos Vegetais/farmacologia
Agentes Urológicos/farmacologia
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Albuminúria/etiologia
Albuminúria/prevenção & controle
Animais
Citoproteção
Diabetes Mellitus/etiologia
Nefropatias Diabéticas/etiologia
Nefropatias Diabéticas/patologia
Nefropatias Diabéticas/fisiopatologia
Dieta Hiperlipídica
Modelos Animais de Doenças
Fibrose
Hipoglicemiantes/isolamento & purificação
Rim/metabolismo
Rim/patologia
Rim/fisiopatologia
Ledum/química
Camundongos Endogâmicos C57BL
Farmacopeias como Assunto
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Plantas Medicinais
Agentes Urológicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Bmf protein, mouse); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Urological Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160227
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1137953


  4 / 23 MEDLINE  
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[PMID]:26707751
[Au] Autor:Eid HM; Ouchfoun M; Saleem A; Guerrero-Analco JA; Walshe-Roussel B; Musallam L; Rapinski M; Cuerrier A; Martineau LC; Arnason JT; Haddad PS
[Ad] Endereço:Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada; Canadian Institutes of Health Research Team in Aboriginal Antidiabetic Medicines and Montreal Diabetes Research Center, Montreal, Canada; Department of Pharmacogno
[Ti] Título:A combination of (+)-catechin and (-)-epicatechin underlies the in vitro adipogenic action of Labrador tea (Rhododendron groenlandicum), an antidiabetic medicinal plant of the Eastern James Bay Cree pharmacopeia.
[So] Source:J Ethnopharmacol;178:251-7, 2016 Feb 03.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Rhododendron groenlandicum (Oeder) Kron & Judd (Labrador tea) was identified as an antidiabetic plant through an ethnobotanical study carried out with the close collaboration of Cree nations of northern Quebec in Canada. OBJECTIVES: In a previous study the plant showed glitazone-like activity in a 3T3-L1 adipogenesis bioassay. The current study sought to identify the active compounds responsible for this potential antidiabetic activity using bioassay guided fractionation based upon an in vitro assay that measures the increase of triglycerides content in 3T3-L1 adipocyte. MATERIALS AND METHODS: Isolation and identification of the crude extract's active constituents was carried out. The 80% ethanol extract was fractionated using silica gel column chromatography. Preparative HPLC was then used to isolate the constituents. The identity of the isolated compounds was confirmed by UV and mass spectrometry. RESULTS: Nine chemically distinct fractions were obtained and the adipogenic activity was found in fraction 5 (RGE-5). Quercetins, (+)-catechin and (-)-epicatechin were detected and isolated from this fraction. While (+)-catechin and (-)-epicatechin stimulated adipogenesis (238±26% and 187±21% relative to vehicle control respectively) at concentrations equivalent to their concentrations in the active fraction RGE-5, none afforded biological activity similar to RGE-5 or the plant's crude extract when used alone. When cells were incubated with a mixture of the two compounds, the adipogenic activity was close to that of the crude extract (280.7±27.8 vs 311± 30%). CONCLUSION: Results demonstrate that the mixture of (+)-catechin and (-)-epicatechin is responsible for the adipogenic activity of Labrador tea. This brings further evidence for the antidiabetic potential of R. groenlandicum and provides new opportunities to profile active principles in biological fluids or in traditional preparations.
[Mh] Termos MeSH primário: Adipogenia/efeitos dos fármacos
Catequina/farmacologia
Hipoglicemiantes/farmacologia
Ledum/química
Extratos Vegetais/farmacologia
Rhododendron/química
[Mh] Termos MeSH secundário: Células 3T3
Animais
Baías
Linhagem Celular
Medicina Tradicional/métodos
Camundongos
Plantas Medicinais/química
Quebeque
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151229
[St] Status:MEDLINE


  5 / 23 MEDLINE  
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[PMID]:25916863
[Au] Autor:Ouchfoun M; Eid HM; Musallam L; Brault A; Li S; Vallerand D; Arnason JT; Haddad PS
[Ad] Endereço:Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, P.O. Box 6128, Station Centre-Ville, Montréal, QC, H3C 3J7, Canada.
[Ti] Título:Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model.
[So] Source:Eur J Nutr;55(3):941-54, 2016 Apr.
[Is] ISSN:1436-6215
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Using a diet-induced obesity (DIO) mouse model, we investigated the antidiabetic effect of Labrador tea [Rhododendron groenlandicum (Oeder) Kron and Judd], a beverage and medicinal tea used by the Cree Nations of northern Quebec. METHODS: C57BL6 mice were divided into five groups and given standard chow (~4 % of lipids) or high-fat diet (~35 % of lipids) for 8 weeks until they became obese and insulin resistant. Treatment began by adding the plant extract at three doses (125, 250 and 500 mg/kg) to the high-fat diet for another 8 weeks. At the end of the study, insulin-sensitive tissues (liver, skeletal muscle, adipose tissue) were collected to investigate the plant's molecular mechanisms. RESULTS: Labrador tea significantly reduced blood glucose (13 %), the response to an oral glucose tolerance test (18.2 %) and plasma insulin (65 %) while preventing hepatic steatosis (42 % reduction in hepatic triglyceride levels) in DIO mice. It stimulated insulin-dependent Akt pathway (55 %) and increased the expression of GLUT4 (53 %) in skeletal muscle. In the liver, Labrador tea stimulated the insulin-dependent Akt and the insulin-independent AMP-activated protein kinase pathways. The improvement in hepatic steatosis observed in DIO-treated mice was associated with a reduction in inflammation (through the IKK α/ß) and a decrease in the hepatic content of SREBP-1 (39 %). CONCLUSIONS: Labrador tea exerts potential antidiabetic action by improving insulin sensitivity and mitigating high-fat diet-induced obesity and hyperglycemia. They validate the safety and efficacy of this plant, a promising candidate for culturally relevant complementary treatment in Cree diabetics.
[Mh] Termos MeSH primário: Hipoglicemiantes/farmacologia
Resistência à Insulina
Ledum/química
Obesidade/sangue
Extratos Vegetais/farmacologia
Rhododendron/química
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Alanina Transaminase/sangue
Fosfatase Alcalina/sangue
Animais
Aspartato Aminotransferases/sangue
Glicemia/metabolismo
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Creatinina/sangue
Dieta Hiperlipídica/efeitos adversos
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Fígado Gorduroso/prevenção & controle
Teste de Tolerância a Glucose
Transportador de Glucose Tipo 4/genética
Transportador de Glucose Tipo 4/metabolismo
Insulina/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/metabolismo
Obesidade/tratamento farmacológico
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Glucose Transporter Type 4); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 0 (Slc2a4 protein, mouse); 0 (Triglycerides); AYI8EX34EU (Creatinine); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE
[do] DOI:10.1007/s00394-015-0908-z


  6 / 23 MEDLINE  
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[PMID]:26172328
[Au] Autor:Napoli EM; Siracusa L; Saija A; Speciale A; Trombetta D; Tuttolomondo T; La Bella S; Licata M; Virga G; Leone R; Leto C; Rubino L; Ruberto G
[Ad] Endereço:Istituto del C.N.R. di Chimica Biomolecolare, Via Paolo Gaifami 18, IT-95126 Catania, (phone: +39-0957338347; fax: +39-0957338310).
[Ti] Título:Wild Sicilian rosemary: phytochemical and morphological screening and antioxidant activity evaluation of extracts and essential oils.
[So] Source:Chem Biodivers;12(7):1075-94, 2015 Jul.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:To identify the best biotypes, an extensive survey of Sicilian wild rosemary was carried out by collecting 57 samples from various sites, followed by taxonomic characterization from an agronomic perspective. All the biotypes collected were classified as Rosmarinus officinalis L. A cluster analysis based on the morphological characteristics of the plants allowed the division of the biotypes into seven main groups, although the characteristics examined were found to be highly similar and not area-dependent. Moreover, all samples were analyzed for their phytochemical content, applying an extraction protocol to obtain the nonvolatile components and hydrodistillation to collect the essential oils for the volatile components. The extracts were characterized by LC-UV-DAD/ESI-MS, and the essential oils by GC-FID and GC/MS analyses. In the nonvolatile fractions, 18 components were identified, namely, 13 flavones, two organic acids, and three diterpenes. In the volatile fractions, a total of 82 components were found, with as predominant components α-pinene and camphene among the monoterpene hydrocarbons and 1,8-cineole, camphor, borneol, and verbenone among the oxygenated monoterpenes. Cluster analyses were carried out on both phytochemical profiles, allowing the separation of the rosemary samples into different chemical groups. Finally, the total phenol content and the antioxidant activity of the essential oils and extracts were determined with the Folin-Ciocalteu (FC) colorimetric assay, the UV radiation-induced peroxidation in liposomal membranes (UV-IP test), and the scavenging activity of the superoxide radical (O$\rm{{_{2}^{{^\cdot} -}}}$). The present study confirmed that the essential oils and organic extracts of the Sicilian rosemary samples analyzed showed a considerable antioxidant/free radical-scavenging activity.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Ledum/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Compostos Fitoquímicos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Estrutura Molecular
Óleos Voláteis/isolamento & purificação
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oils, Volatile); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150716
[Lr] Data última revisão:
150716
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150715
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201400274


  7 / 23 MEDLINE  
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[PMID]:25427723
[Au] Autor:Baananou S; Bagdonaite E; Marongiu B; Piras A; Porcedda S; Falconieri D; Boughattas NA
[Ad] Endereço:a Laboratory of Pharmacology , Faculty of Medicine, University of Monastir , 5019 Monastir , Tunisia.
[Ti] Título:Supercritical CO2 extract and essential oil of aerial part of Ledum palustre L.--Chemical composition and anti-inflammatory activity.
[So] Source:Nat Prod Res;29(11):999-1005, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The anti-inflammatory activity of two extracts from the aerial parts of Ledum palustre has been reported. The volatile oil was obtained by supercritical fluid extraction (SFE) and the essential oil by hydrodistillation (HD). The oils were analysed by gas chromatography-mass spectrometry to monitor their composition. Both extracts shared as main compound (41.0-43.4%) ledol (23.3-26.7%) and ascaridole (15.1-4.5%). The anti-inflammatory activity was evaluated by the subcutaneous carrageenan injection-induced hind paw oedema. The treated animals received essential oil (SFE and HD), the reference group received ketoprofen or piroxicam and the control group received NaCl 0.9%. A statistical analysis was performed by the Student t-test. The results show that L. palustre essential oil enhanced a significant inhibition of oedema (50-73%) for HD oil and (52-80%) for SFE oil. These results were similar to those obtained with piroxicam (70%) and ketoprofen (55%).
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Ledum/química
Óleos Voláteis/química
Componentes Aéreos da Planta/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Animais
Cromatografia com Fluido Supercrítico
Edema/tratamento farmacológico
Cromatografia Gasosa-Espectrometria de Massas
Lituânia
Monoterpenos/química
Monoterpenos/isolamento & purificação
Peróxidos/química
Peróxidos/isolamento & purificação
Ratos Wistar
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Peroxides); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (ledol); 1718D0GEVJ (ascaridole)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:150428
[Lr] Data última revisão:
150428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141128
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.965167


  8 / 23 MEDLINE  
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[PMID]:25156477
[Au] Autor:Dampc A; Luczkiewicz M
[Ad] Endereço:Department of Pharmacognosy, Medical University of Gdansk, 80-416, Gdansk, Poland.
[Ti] Título:Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety.
[So] Source:J Sci Food Agric;95(8):1577-83, 2015 Jun.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Labrador tea is a name for the dried leaves of Rhododendron groenlandicum, R. tomentosum or R. neoglandulosum (family Ericaceae, previously genus Ledum) as well as for the beverage native to North America, which is made from them. The above species are rich in the essential oil, which gives a conifer aroma to the tisane. Labrador tea is a valuable source of ascorbic acid, with tonic, improving digestion and relaxing activity. However, this beverage should not be drunk more than once daily because of the ledol and grayanotoxin toxicity. The common recipe for making Labrador tea is to add one teaspoonful of dried leaves to one cup of boiling water and to brew for 5 min. It is often sweetened or enriched with other flavors. Additionally, Labrador tea dried leaves are used to spice meat, soups, sauces, salads, beer, cakes and other dishes. In agriculture, its insecticidal properties can be useful for controlling pests.
[Mh] Termos MeSH primário: Bebidas
Manipulação de Alimentos
Inocuidade dos Alimentos
Ledum
[Mh] Termos MeSH secundário: Diterpenos/análise
Diterpenos/toxicidade
Flavonoides/análise
Manipulação de Alimentos/métodos
Seres Humanos
Inseticidas
Ledum/química
Ledum/toxicidade
América do Norte
Óleos Voláteis/análise
Fitoterapia
Extratos Vegetais/efeitos adversos
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Folhas de Planta/química
Sesquiterpenos/análise
Sesquiterpenos/toxicidade
Especiarias
Toxinas Biológicas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Diterpenes); 0 (Flavonoids); 0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Toxins, Biological); 0 (ledol); W4E6HC3T2B (grayanotoxin I)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140827
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.6889


  9 / 23 MEDLINE  
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Registro de Ensaios Clínicos
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[PMID]:25365012
[Au] Autor:Bermejo LM; López-Plaza B; Weber TK; Palma-Milla S; Iglesias C; Reglero G; Gómez-Candela C
[Ad] Endereço:Nutrition Department, Hospital La Paz Health Research Institute (IdiPAZ), La Paz University Hospital (Spain).. laura.bermejol@salud.madrid.org.
[Ti] Título:Impact of cooked functional meat enriched with omega-3 fatty acids and rosemary extract on inflammatory and oxidative status; a randomised, double-blind, crossover study.
[So] Source:Nutr Hosp;30(5):1084-91, 2014 11 01.
[Is] ISSN:1699-5198
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIM: n-3 fatty acid intake has been associated with inflammatory benefits in cardiovascular disease (CVD). Functionalising meat may be of great interest. The aim of the present study was to assess the effect of functional meat containing n-3 and rosemary extract on inflammatory and oxidative status markers in subjects with risk for CVD. METHODS AND RESULTS: A randomised, double-blind, cross-over study was undertaken to compare the effects on the above markers of consuming functional or control meat products. 43 volunteers with at least two lipid profile variables showing risk for CVD were randomly assigned to receive functional meat (FM) or control meat (CM) over 12-weeks with a 4-week wash-out interval before crossover. Functional effects were assessed by examining lipid profile, CRP, PAI-1, TNF-alpha, IL-6, fibrinogen (inflammatory markers), and TBARS, FRAP and 8-iso-PGF2 (oxidative status markers). 33 subjects (24 women) aged 50.7±8.8 years completed the study. In FM treatment, PAI-1, fibrinogen and 8-iso-PGF2 decreased significantly after 12 weeks, while FRAP significantly increased. In contrast, in CM treatment, a significant increase was seen in PAI-1, while FRAP significantly declined. Significant differences were also seen between the FM and CM treatments after 12 weeks in terms of the change observed in PAI-1, FRAP and 8-iso-PGF2 values. No significant differences were seen in anthropometric variables nor were adverse effects reported. CONCLUSION: The consumption of FM containing n-3 and rosemary extract improved oxidative and inflammatory status of people with at least two lipid profile variables showing risk for CVD. The inclusion of such functional meat in a balanced diet might be a healthy lifestyle option.
[Mh] Termos MeSH primário: Ácidos Graxos Ômega-6/uso terapêutico
Alimento Funcional
Ledum/química
Carne
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Culinária
Estudos Cross-Over
Dieta
Método Duplo-Cego
Ácidos Graxos Ômega-6/administração & dosagem
Feminino
Seres Humanos
Lipídeos/sangue
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Fatty Acids, Omega-6); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141104
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.3305/nh.2014.30.5.8048


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[PMID]:25345143
[Au] Autor:Lv M
[Ti] Título:[Preparation and quality evaluation of microcapsules of volatile oil from Ledum palustre].
[So] Source:Zhong Yao Cai;37(4):675-8, 2014 Apr.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the preparation of microcapsules of volatile oil from Ledum palustre and its quality evaluation. METHODS: The microcapsules were prepared by complex coacervation with encapsulation efficiency as evaluation index, and the preparation was optimized by orthogonal experimental design. RESULTS: The optimum condition of microcapsules prepared was that 5% gelatin and gum arabic was material, with core material ratio of 1: 2; pH 4.0 and glutaraldehyde in an amount of 1.0 mL. The average encapsulation efficiency of microcapsules of volatile oil from Ledum palustre was 79.62%. Microcapsules was distributed evenly without adhesion through microscopic observation and more than 73% of the microcapsule size distribution between 10 - 14 microm. Microcapsules was spherical and the surface folded by using electron microscope scanning. The test solution and reference solution appeared same spot in the same location compared with the negative control solution. CONCLUSION: The preparation process is simple, stable and feasible.
[Mh] Termos MeSH primário: Composição de Medicamentos/métodos
Gelatina/química
Goma Arábica/química
Ledum/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Cápsulas
Preparações de Ação Retardada
Portadores de Fármacos/química
Estabilidade de Medicamentos
Gelatina/administração & dosagem
Glutaral/administração & dosagem
Glutaral/química
Goma Arábica/administração & dosagem
Concentração de Íons de Hidrogênio
Microscopia Eletrônica de Varredura
Óleos Voláteis/administração & dosagem
Tamanho da Partícula
Óleos Vegetais/administração & dosagem
Óleos Vegetais/química
Propriedades de Superfície
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsules); 0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Oils, Volatile); 0 (Plant Oils); 9000-01-5 (Gum Arabic); 9000-70-8 (Gelatin); T3C89M417N (Glutaral)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:141027
[Lr] Data última revisão:
141027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141028
[St] Status:MEDLINE



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