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[PMID]:29328637
[Au] Autor:Filipovic M; Gledovic A; Lukic M; Tasic-Kostov M; Isailovic T; Pantelic I; Vuleta G; Savic S
[Ti] Título:Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficacy on normal and sodium lauryl sulfate - irritated skin?.
[So] Source:Vojnosanit Pregl;73(11):991-1002, 2016 11.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into li-posomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams' stabilization. Methods: With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepi-dermal water loss (TEWL), erythema index (EI) and viscoelas-ticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results: After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, espe-cially for the squalene-containing cream. Conclusion: Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the in-vestigated actives incorporated into alkyl polyglucoside emulsi-fier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well. [Projekat Ministarstva nauke Republike Srbije, br. TR34031]
[Mh] Termos MeSH primário: Emulsificantes/administração & dosagem
Glucosídeos/administração & dosagem
Azeite de Oliva/química
Rhododendron/citologia
Creme para a Pele/administração & dosagem
Testes de Irritação da Pele/métodos
Pele/efeitos dos fármacos
Dodecilsulfato de Sódio/toxicidade
Esqualeno/administração & dosagem
Células-Tronco/fisiologia
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Segurança de Produtos ao Consumidor
Método Duplo-Cego
Elasticidade
Emulsificantes/efeitos adversos
Feminino
Glucosídeos/efeitos adversos
Seres Humanos
Lipossomos
Fitoterapia
Plantas Medicinais
Medição de Risco
Sérvia
Pele/metabolismo
Pele/patologia
Creme para a Pele/efeitos adversos
Esqualeno/efeitos adversos
Esqualeno/isolamento & purificação
Fatores de Tempo
Viscosidade
Perda Insensível de Água/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Emulsifying Agents); 0 (Glucosides); 0 (Liposomes); 0 (Olive Oil); 368GB5141J (Sodium Dodecyl Sulfate); 7QWM220FJH (Squalene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150116122F


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[PMID]:29059200
[Au] Autor:Fang L; Tong J; Dong Y; Xu D; Mao J; Zhou Y
[Ad] Endereço:Institute of Fruit & Forest Tree, Wuhan Academy of Agricultural Science & Technology, Wuhan, Hubei, China.
[Ti] Título:De novo RNA sequencing transcriptome of Rhododendron obtusum identified the early heat response genes involved in the transcriptional regulation of photosynthesis.
[So] Source:PLoS One;12(10):e0186376, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhododendron spp. is an important ornamental species that is widely cultivated for landscape worldwide. Heat stress is a major obstacle for its cultivation in south China. Previous studies on rhododendron principally focused on its physiological and biochemical processes, which are involved in a series of stress tolerance. However, molecular or genetic properties of rhododendron's response to heat stress are still poorly understood. The phenotype and chlorophyll fluorescence kinetics parameters of four rhododendron cultivars were compared under normal or heat stress conditions, and a cultivar with highest heat tolerance, "Yanzhimi" (R. obtusum) was selected for transcriptome sequencing. A total of 325,429,240 high quality reads were obtained and assembled into 395,561 transcripts and 92,463 unigenes. Functional annotation showed that 38,724 unigenes had sequence similarity to known genes in at least one of the proteins or nucleotide databases used in this study. These 38,724 unigenes were categorized into 51 functional groups based on Gene Ontology classification and were blasted to 24 known cluster of orthologous groups. A total of 973 identified unigenes belonged to 57 transcription factor families, including the stress-related HSF, DREB, ZNF, and NAC genes. Photosynthesis was significantly enriched in the Kyoto Encyclopedia of Genes and Genomes pathway, and the changed expression pattern was illustrated. The key pathways and signaling components that contribute to heat tolerance in rhododendron were revealed. These results provide a potentially valuable resource that can be used for heat-tolerance breeding.
[Mh] Termos MeSH primário: Genes de Plantas
Fotossíntese/genética
Rhododendron/genética
Transcrição Genética/fisiologia
Transcriptoma
[Mh] Termos MeSH secundário: Regulação da Expressão Gênica de Plantas
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186376


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[PMID]:28626039
[Au] Autor:Tulyananda T; Nilsen ET
[Ad] Endereço:Department of Biological Sciences, 2119 Derring Hall, 1405 Perry Street, Virginia Tech, Blacksburg, Virginia 24061 USA enilsen@vt.edu.
[Ti] Título:The role of idioblasts in leaf water relations of tropical .
[So] Source:Am J Bot;104(6):828-839, 2017 Jun.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Although much is known about the anatomy of idioblasts, the relationship of leaf idioblasts to leaf physiology is poorly known. Our goal was to understand the relationship between idioblast abundance and leaf water relations. Tropical epiphytic and shrub species were the model system. METHODS: Leaf succulence and idioblast metrics of 61 plants representing 17 species were compared with stomatal and water relation metrics. Correlation, ANOVA, and regression were used to understand which water relation traits were best aligned with the proportion of the leaf occupied by idioblasts for epiphytic and shrub species. KEY RESULTS: Idioblast volume per leaf area varied from 1.4-9.5 mm ·cm among accessions, and an index of stomatal area per leaf area varied from 0.08-3.3. Succulence, stomatal, and water relation metrics varied significantly among species. Total idioblast volume was negatively correlated with leaf succulence metrics, and positively correlated with relative water content at the turgor loss point. Idioblasts were better related to capacitance in thin leaves. All idioblast metrics were significantly greater in epiphytic species. CONCLUSIONS: Leaf idioblasts can have a significant effect on leaf-lamina water relations. Idioblasts likely function as a water buffering system for thin leaves in tropical species. The association of idioblast prominence with leaf water buffering is greatest for epiphytic species with thin leaves. Thus, the proliferation of leaf idioblasts may have been an important innovation for species diversification into tropical epiphytic habitats.
[Mh] Termos MeSH primário: Folhas de Planta/fisiologia
Rhododendron/fisiologia
Água/fisiologia
[Mh] Termos MeSH secundário: Ecossistema
Clima Tropical
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1600425


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[PMID]:28611072
[Au] Autor:Medeiros JS; Burns JH; Nicholson J; Rogers L; Valverde-Barrantes O
[Ad] Endereço:The Holden Arboretum, 9500 Sperry Road, Kirtland, Ohio 44094 USA jmedeiros@holdenarb.org.
[Ti] Título:Decoupled leaf and root carbon economics is a key component in the ecological diversity and evolutionary divergence of deciduous and evergreen lineages of genus .
[So] Source:Am J Bot;104(6):803-816, 2017 Jun.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE: We explored trait-trait and trait-climate relationships for 27 species while accounting for phylogenetic relationships and within-species variation to investigate whether leaf and root traits are coordinated across environments and over evolutionary time, as part of a whole-plant economics spectrum. METHODS: We examined specific leaf area (SLA) and four root traits: specific root length (SRL), specific root tip abundance (SRTA), first order diameter, and link average length, for plants growing in a cold, seasonal climate (Kirtland, Ohio) and a warmer, less seasonal climate (Federal Way, Washington) in the United States. We estimated a phylogeny and species' climate of origin, determined phylogenetic signal on mean traits and within-species variation, and used phylogenetically informed analysis to compare trait-trait and trait-climate relationships for deciduous and evergreen lineages. RESULTS: Mean SLA and within-species variation in SRL were more similar between close relatives than expected by chance. SLA and root traits differed according to climate of origin and across growth environments, though SLA differed within- and among-species less than roots. A negative SRL-SRTA correlation indicates investment in foraging scale vs. precision as a fundamental trade-off defining the root economic spectrum. Also, the deciduous clade exhibited a strong negative relationship between SLA and SRL, while evergreen clades showed a weaker positive or no relationship. CONCLUSIONS: Our work suggests that natural selection has shaped relationships between above- and belowground traits in genus and that leaf and root traits may evolve independently. Morphological decoupling may help explain habitat diversity among species, as well as the changes accompanying the divergence of deciduous and evergreen lineages.
[Mh] Termos MeSH primário: Carbono/metabolismo
Filogenia
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Rhododendron/classificação
[Mh] Termos MeSH secundário: Evolução Biológica
Clima
Ecossistema
Ohio
Rhododendron/metabolismo
Washington
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7440-44-0 (Carbon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1700051


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[PMID]:28594250
[Au] Autor:Choi HL; Park KH; Park JS; Choi HY; Kim H; Kim SM
[Ad] Endereço:a Department of Emergency Medicine , Chungbuk National University Hospital , Cheongju , Republic of Korea.
[Ti] Título:Relationship between blood toxin level and clinical features in patients with grayanotoxin poisoning - six clinical cases.
[So] Source:Clin Toxicol (Phila);55(9):991-995, 2017 Nov.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study was to investigate grayanotoxin (GTX) levels in the blood of patients with GTX intoxication and in the consumed Rhododendron liqueur, and to determine whether there was an association between blood GTX level and the patient's clinical status. METHODS: In September 2015, six patients were concurrently presented to the emergency department with various toxicity symptoms, which occurred after the consumption of Rhododendron liqueur at the same toxin concentration. Liquid chromatography-tandem mass spectrometry analysis was conducted on blood samples obtained from six cases of GTX intoxication treated in our emergency department. RESULTS: At the initial evaluation in the emergency department, the mean arterial pressure of the patients ranged from 36.7 to 76.7 mm Hg. The concentrations of GTX-I and GTX-III in Rhododendron liqueur were 1.436 and 16.907 ng/mL, respectively. The initial blood GTX-III and GTX-I levels ranged from 2.9 to 58.0 ng/mL and the lower limit of quantification (LLOQ) to 8.33 ng/mL, respectively. After 20 h, the mean arterial pressure ranged from 76.7 to 93.3 mm Hg, while the blood GTX-III and GTX-I levels ranged from the LLOQ to 17.8 and 2.52 ng/mL, respectively. DISCUSSION: We estimated that the minimum blood GTX-III and GTX-I levels that caused hypotension were between 17.83 and 27.3 ng/mL, and 2.52 and 4.55 ng/mL, respectively.
[Mh] Termos MeSH primário: Diterpenos/sangue
Diterpenos/envenenamento
Hipotensão/sangue
Hipotensão/induzido quimicamente
Extratos Vegetais/envenenamento
Rhododendron/envenenamento
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Pressão Sanguínea/efeitos dos fármacos
Cromatografia Líquida
Diterpenos/isolamento & purificação
Feminino
Seres Humanos
Hipotensão/diagnóstico
Hipotensão/fisiopatologia
Masculino
Meia-Idade
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Envenenamento/sangue
Envenenamento/diagnóstico
Envenenamento/fisiopatologia
Estudos Retrospectivos
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Diterpenes); 0 (Plant Extracts); W4E6HC3T2B (grayanotoxin I); ZKR09NT58C (grayanotoxin III)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1331448


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[PMID]:28542212
[Au] Autor:Die JV; Arora R; Rowland LJ
[Ad] Endereço:Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland, United States of America.
[Ti] Título:Proteome dynamics of cold-acclimating Rhododendron species contrasting in their freezing tolerance and thermonasty behavior.
[So] Source:PLoS One;12(5):e0177389, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To gain a better understanding of cold acclimation in rhododendron and in woody perennials in general, we used the 2D-DIGE technique to analyze the rhododendron proteome during the seasonal development of freezing tolerance. We selected two species varying in their cold acclimation ability as well as their thermonasty response (folding of leaves in response to low temperature). Proteins were extracted from leaves of non-acclimated (NA) and cold acclimated (CA) plants of the hardier thermonastic species, R. catawbiense (Cata.), and from leaves of cold acclimated plants of the less hardy, non-thermonastic R. ponticum (Pont.). All three protein samples (Cata.NA, Cata.CA, and Pont.CA) were labeled with different CyDyes and separated together on a single gel. Triplicate gels were run and protein profiles were compared resulting in the identification of 72 protein spots that consistently had different abundances in at least one pair-wise comparison. From the 72 differential spots, we chose 56 spots to excise and characterize further by mass spectrometry (MS). Changes in the proteome associated with the seasonal development of cold acclimation were identified from the Cata.CA-Cata.NA comparisons. Differentially abundant proteins associated with the acquisition of superior freezing tolerance and with the thermonastic response were identified from the Cata.CA-Pont.CA comparisons. Our results indicate that cold acclimation in rhododendron involves increases in abundance of several proteins related to stress (freezing/desiccation tolerance), energy and carbohydrate metabolism, regulation/signaling, secondary metabolism (possibly involving cell wall remodeling), and permeability of the cell membrane. Cold acclimation also involves decreases in abundance of several proteins involved in photosynthesis. Differences in freezing tolerance between genotypes can probably be attributed to observed differences in levels of proteins involved in these functions. Also differences in freezing tolerance may be attributed to higher levels of some constitutive protective proteins in Cata. than in Pont. that may be required to overcome freeze damage, such as glutathione peroxidase, glutamine synthetase, and a plastid-lipid-associated protein.
[Mh] Termos MeSH primário: Aclimatação/fisiologia
Congelamento
Proteoma
Rhododendron/fisiologia
[Mh] Termos MeSH secundário: Regulação da Expressão Gênica de Plantas
Folhas de Planta/metabolismo
Especificidade da Espécie
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Eletroforese em Gel Diferencial Bidimensional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteome)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177389


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[PMID]:28288764
[Au] Autor:Guo X; Shang X; Li B; Zhou XZ; Wen H; Zhang J
[Ad] Endereço:Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, PR China.
[Ti] Título:Acaricidal activities of the essential oil from Rhododendron nivale Hook. f. and its main compund, δ-cadinene against Psoroptes cuniculi.
[So] Source:Vet Parasitol;236:51-54, 2017 Mar 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper, the acaricidal activities of Rhododendron nivale Hook. f. and its main compound, δ-cadinene were investigated, and the chemical composition of the essential oil was analyzed. The results showed that among aqueous, 70% ethanols, acetic ether, chloroform, petroleum ether and essential oil extracts from the shoots and leaves, the essential oil showed the best in vitro acaricidal activity against adult P. cuniculi, which occurred in a concentration- and time-dependent manner. The median lethal time (LT ) values of four concentrations (33.33-4.17mg/ml) of the essential oil ranged from 1.476 to 25.900h, respectively. After the treatment of P. cuniculi with the essential oil and ivermectin, infected rabbits were free of scabs or secretions in the ear canal by day 20. Then, the percent yield of essential oil from the leaves and shoots was 2.45% (w/w), which includes 50 compounds. The primary component identified was terpenes, and among of compounds identified from the essential oil of R. nivale the highest relative content was δ-cadinene, which also presented the marked acaricidal activity against Psoroptes cuniculi in vitro. These findings provide evidence for the use of acaricides as a traditional medicine and indicate that the essential oil and δ-cadinene could be used to control mites in livestock.
[Mh] Termos MeSH primário: Acaricidas
Infestações por Ácaros/veterinária
Óleos Voláteis
Psoroptidae
Coelhos
Rhododendron/química
Sesquiterpenos
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa-Espectrometria de Massas
Infestações por Ácaros/parasitologia
Infestações por Ácaros/prevenção & controle
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (delta-cadinene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


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[PMID]:28107754
[Au] Autor:Ye P; Yang XL; Chen X; Shi C
[Ad] Endereço:Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: yp800111@163.com.
[Ti] Título:Hyperoside attenuates OVA-induced allergic airway inflammation by activating Nrf2.
[So] Source:Int Immunopharmacol;44:168-173, 2017 Mar.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Allergic airways disease (AAD) is one of the most common medical illnesses that is associated with an increased allergic airway inflammation. Hyperoside, an active compound isolated from Rhododendron brachycarpum G. Don, has been reported to have anti-inflammatory effect. The aim of this study was to analyze the protective effect of hyperoside on OVA-induced allergic airway inflammation in mice. In the present study, the mouse asthma model was induced by given OVA and hyperoside was administrated 1h before OVA challenge. The levels of IL-4, IL-5, IL-13, and IgE were detected by ELISA. H&E staining was used to assess lung histopathological changes. The expression of NF-κB p65, IκB, HO-1, and Nf-E2 related factor 2 (Nrf2) were measured by western blot analysis. The results showed that hyperoside significantly reduced the inflammatory cells infiltration and the levels of IL-4, IL-5, IL-13, and IgE. Hyperoside significantly inhibited OVA-induced oxidative stress as demonstrated by decreased MDA, and increased GSH and SOD levels. Treatment of hyperoside also inhibited OVA-induced airway hyperresponsiveness (AHR). Furthermore, the results showed that treatment of hyperoside significantly inhibited LPS-induced NF-κB activation. In addition, hyperoside was found to activate Nrf2/HO-1 signaling pathway. In conclusion, these results suggest that hyperoside ameliorates OVA-induced allergic airway inflammation by activating Nrf2 signaling pathway.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Pulmão/efeitos dos fármacos
Fator 2 Relacionado a NF-E2/metabolismo
Pneumonia/tratamento farmacológico
Quercetina/análogos & derivados
Rhododendron/imunologia
[Mh] Termos MeSH secundário: Animais
Asma/induzido quimicamente
Células Cultivadas
Citocinas/sangue
Seres Humanos
Imunoglobulina E/sangue
Pulmão/patologia
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/metabolismo
Ovalbumina/imunologia
Estresse Oxidativo/efeitos dos fármacos
Quercetina/uso terapêutico
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Cytokines); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, mouse); 37341-29-0 (Immunoglobulin E); 8O1CR18L82 (hyperoside); 9006-59-1 (Ovalbumin); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:27816176
[Au] Autor:Tuan NQ; Oh J; Park HB; Ferreira D; Choe S; Lee J; Na M
[Ad] Endereço:College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea; Phutho College of Pharmacy, Viettri City, Phutho Province, Viet Nam.
[Ti] Título:A grayanotox-9(11)-ene derivative from Rhododendron brachycarpum and its structural assignment via a protocol combining NMR and DP4 plus application.
[So] Source:Phytochemistry;133:45-50, 2017 Jan.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A growing body of evidence points to the useful roles of computational approaches in the structural characterization of natural products. Rhododendron brachycarpum has been traditionally used for the control of diabetes, hepatitis, hypertension, and rheumatoid arthritis and classified as an endangered species in Korea. A grayanotox-9(11)-ene derivative along with five known diterpenoids, were isolated from the MeOH extract of R. brachycarpum. Extensive 1D and 2D NMR experiments were conducted to establish the 2D structure and relative configuration of the grayanotox-9(11)-ene derivative. Comparison of simulated and experimental ECD spectra resulted in an inconclusive outcome to assign its absolute configuration. Alternatively, gauge-including atomic orbitals (GIAO) NMR chemical shift calculations, with support by the advanced statistical method DP4 plus, and acid hydrolysis were employed to establish its absolute configuration. This work exemplifies how NMR analysis, combined with quantum mechanics calculations, is a viable approach to accomplish structural assignment of minor abundance molecules in lieu of X-ray crystallography or chiroptical approaches.
[Mh] Termos MeSH primário: Diterpenos/isolamento & purificação
Plantas Medicinais/química
Rhododendron/química
[Mh] Termos MeSH secundário: Bacillus subtilis/efeitos dos fármacos
Cristalografia por Raios X
Diterpenos/química
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Conformação Molecular
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
República da Coreia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:26863038
[Au] Autor:Kang JY; Tran KD; Seiff SR; Mack WP; Lee WW
[Ad] Endereço:*University of Miami Miller School of Medicine, Miami, Florida; †Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida; ‡Department of Ophthalmology, California Pacific Medical Center, San Francisco, California; and §Department of Ophthalmology, University of South Florida, Florida, U.S.A.
[Ti] Título:Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results.
[So] Source:Ophthal Plast Reconstr Surg;33(1):47-52, 2017 Jan/Feb.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to provide preliminary data on the potential effectiveness of the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) in reducing postoperative ecchymosis and edema in a select population of healthy volunteers after oculofacial surgery. METHODS: This retrospective review examined the postoperative course of healthy volunteers using topical Arnica and Ledum after undergoing common oculofacial procedures, including blepharoplasty, browpexy, and rhinoplasty, in the hands of 4 surgeons at tertiary referral centers from July 1, 2012 to December 31, 2012 using medical records review. Each patient included had used topical hydrogel pads (OcuMend, Cearna Inc., Chicago, IL) containing Arnica 50 M (10) 50% and Ledum 50 M (10). The pads were applied bilaterally after surgery through postoperative day 6. At each postoperative visit, the patients were evaluated by their respective surgeons and assigned a subjective physician-patient rating score comparing each patient's observed healing compared with expected healing if not using Arnica/Ledum. Photographs of patients undergoing equivalent procedures, but not using Arnica/Ledum were used as controls for comparison. Physician-patient rating scores were categorical: markedly accelerated healing defined as approximately 7 days ahead of expected, accelerated healing, defined as <7 days ahead of expected, and no appreciable difference from expected. The proportion of patients with each physician-patient rating score was calculated for postoperative days 1 to 2, 3 to 5, 6 to 8, and overall. Difference of proportions was calculated with 95% confidence intervals using Newcombe unpaired difference comparison of proportions. Photographs documenting the clinical progression of selected patients are provided. RESULTS: A total of 27 patients (16 females, 11 males) were included in the study. Age range was 18 to 70 years. The majority of patients were white (52.9%), and underwent blepharoplasty (78.9%). The median duration of follow-up was 7 days, range 1 to 14 days. The proportions of patients with markedly accelerated healing were 38.5% (5 of 13), 85.7% (6 of 7), 60.0% (12 of 20), and 51.9% (14 of 27) at POD 1 to 2, 3 to 5, 6 to 8, and overall, respectively. The proportions of patients with accelerated healing at the same time points were 15.4% (2 of 13), 14.3% (1 of 7), 30.0% (6 of 20), and 37.0% (10 of 27), respectively. The proportions of patients with no appreciable difference at the same time points were 46.2% (6 of 13), 0% (0 of 7), 10.0% (2 of 20), and 11.1% (3 of 27) of patients, respectively. The proportion of patients using Arnica/Ledum with markedly accelerated healing was significantly more than the proportion of those demonstrating no appreciable difference from expected at POD 3 to 5 (85.7% vs. 0%, p = 0.05), POD 6 to 8 (60.0% vs. 10.0%), and overall (51.9% vs. 11.1%, p = 0.05). No adverse effects were reported. CONCLUSIONS: The preliminary results from this study demonstrate that the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) may be effective in reducing postoperative ecchymosis and edema after oculofacial surgery.
[Mh] Termos MeSH primário: Arnica
Equimose/tratamento farmacológico
Edema/tratamento farmacológico
Face/cirurgia
Extratos Vegetais/uso terapêutico
Complicações Pós-Operatórias/tratamento farmacológico
Rhododendron
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Blefaroplastia/efeitos adversos
Feminino
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160211
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000000645



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