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Pesquisa : B01.650.940.800.575.912.250.341.937.774.750 [Categoria DeCS]
Referências encontradas : 669 [refinar]
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[PMID]:28778552
[Au] Autor:Nowacka M; Fijalkowska A; Wiktor A; Dadan M; Tylewicz U; Dalla Rosa M; Witrowa-Rajchert D
[Ad] Endereço:Department of Food Engineering and Process Management, Faculty of Food Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland. Electronic address: malgorzata_nowacka@sggw.pl.
[Ti] Título:Influence of power ultrasound on the main quality properties and cell viability of osmotic dehydrated cranberries.
[So] Source:Ultrasonics;83:33-41, 2018 Feb.
[Is] ISSN:1874-9968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to investigate the effect of ultrasound treatment in two osmotic solutions, carried out at different time, on some physical properties, antioxidant activity and cell survival of cranberries. Ultrasound treatment was conducted at 21kHz for 30 and 60min in liquid medium: 61.5% sucrose solution and 30% sucrose solution with 0.1% steviol glycosides addition. Some samples before the ultrasound treatment were subjected to cutting or blanching. The results showed that dry matter content and concentration of the dissolved substances increased during ultrasound treatment in osmotic solution, however higher value was observed for treatment in 61.5% sucrose solution and for longer time. Water activity and volume of cranberries did not change after the ultrasonic treatment. Combined treatment led to colour and antioxidant activity alterations as well. A cell viability of whole and cut samples decreased after 60min of osmotic treatment and completely lost in the blanched samples.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos da radiação
Dessecação/métodos
Conservação de Alimentos/métodos
Qualidade dos Alimentos
Ondas de Choque de Alta Energia
Osmose/efeitos da radiação
Vaccinium macrocarpon/efeitos da radiação
[Mh] Termos MeSH secundário: Sobrevivência Celular/fisiologia
Diterpenos Caurânicos/química
Relação Dose-Resposta à Radiação
Análise de Alimentos
Glucosídeos/química
Dose de Radiação
Sacarose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Kaurane); 0 (Glucosides); 0YON5MXJ9P (stevioside); 57-50-1 (Sucrose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


  2 / 669 MEDLINE  
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[PMID]:28693863
[Au] Autor:Nowacka M; Fijalkowska A; Dadan M; Rybak K; Wiktor A; Witrowa-Rajchert D
[Ad] Endereço:Department of Food Engineering and Process Management, Faculty of Food Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland. Electronic address: malgorzata_nowacka@sggw.pl.
[Ti] Título:Effect of ultrasound treatment during osmotic dehydration on bioactive compounds of cranberries.
[So] Source:Ultrasonics;83:18-25, 2018 Feb.
[Is] ISSN:1874-9968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to investigate the influence of ultrasound treatment applied in osmotic solution on bioactive compounds, such as vitamin C, polyphenols, anthocyanins and flavonoids content as well as antioxidant activity in cranberries (Vaccinium oxycoccus). Ultrasound treatment was performed at the frequency of 21kHz for 30 and 60min in two osmotic solutions - 61.5% sucrose and 30% sucrose with an addition of 0.1% of steviol glycosides. Before the ultrasound treatment the material was subjected to cutting or blanching. The obtained results indicated that the influence of ultrasound waves on cranberries depends on a type of bioactive component. The ultrasound treated cranberries as well as the ones subjected to cutting or blanching enhanced by ultrasound were characterized mainly by a lower content of bioactive compounds.
[Mh] Termos MeSH primário: Biopolímeros/química
Biopolímeros/efeitos da radiação
Dessecação/métodos
Osmose/efeitos da radiação
Ondas Ultrassônicas
Vaccinium macrocarpon/química
Vaccinium macrocarpon/efeitos da radiação
[Mh] Termos MeSH secundário: Relação Dose-Resposta à Radiação
Conservação de Alimentos/métodos
Dose de Radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biopolymers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE


  3 / 669 MEDLINE  
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[PMID]:28854658
[Au] Autor:Gervais A; Fournier V; Sheffield CS; Chagnon M
[Ad] Endereço:Centre de recherche en innovation sur les végétaux (CRIV), Université Laval, 2480, boulevard Hochelaga, Québec, QC, G1V 0A6.
[Ti] Título:Assessing Wild Bee Biodiversity in Cranberry Agroenvironments: Influence of Natural Habitats.
[So] Source:J Econ Entomol;110(4):1424-1432, 2017 Aug 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The conservation of bee populations for pollination in agricultural landscapes has attracted a lot of recent research interest, especially for crop industries undergoing expansion to meet increased production demands. In Canada, much growth has been occurring with commercial cranberry production, a field crop which is largely dependent on bee pollination. Wild bee pollinators could be negatively impacted by losses of natural habitat surrounding cranberry fields to accommodate increased production, but growers have little insight on how to manage their lands to maximize the presence of wild bees. Here, we described a 2-yr study where bee diversity and species composition were investigated to better understand the dynamic between natural habitat and cranberry fields. Bees were sampled using pan-traps and hand netting both within cranberry fields and in one of the three adjacent natural habitat types once a week during the crop flowering period. We found that bee community composition among cranberry fields did not differ based on the respective adjacent habitat type, but fields bordered by meadows were marginally less diverse than fields bordered by forest. As one would expect, field and natural habitat communities differed in terms of species composition and species richness. There was no evidence that one type of natural habitat was more favorable for the bees than another. Future agrobiodiversity studies should simultaneously examine bee diversity comprised in both crop fields and adjacent natural environments to better understand the species dynamics essential to the preservation of pollination services.
[Mh] Termos MeSH primário: Distribuição Animal
Abelhas/fisiologia
Biodiversidade
Produtos Agrícolas
Ecossistema
Vaccinium macrocarpon
[Mh] Termos MeSH secundário: Animais
Produtos Agrícolas/crescimento & desenvolvimento
Quebeque
Vaccinium macrocarpon/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox173


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[PMID]:28844930
[Au] Autor:Peron G; Sut S; Pellizzaro A; Brun P; Voinovich D; Castagliuolo I; Dall'Acqua S
[Ad] Endereço:Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
[Ti] Título:The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli.
[So] Source:Fitoterapia;122:67-75, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cranberry procyanidins and quercetin derivatives are considered possible active compounds against urinary tract infections (UTIs). In this paper a small group (n=6) of healthy subjects consumed a product containing 360mg of cranberry extract (42.6% w/w of PAC-A and 14.6% w/w of PAC-B) and 200mg of quercetin. Urine samples were collected after 2,4,6,8, and 24h. The changes in antiadhesive properties against urophatogenic E. coli of the urinary output were determined in vitro and modification to urinary metabolome were studied by LC-MS. Significant antiadhesive properties of urine samples were observed, with the greatest effect 6-8h after oral administration, confirming the possible usefulness of cranberry containing products in urinary tract infections (UTI). Metabolomic analysis revealed that valeric acid and valerolactone derivatives that were detected in 6 and 8h sample, while 4-hydroxy-5-(phenyl)-valeric acid-O-glucuronide and 5-(3',4'-dihydroxyphenyl)-γ-valerolactone at 6h and 4-hydroxy-5-(phenyl)-valeric acid-O-sulphate, 3-hydroxyphenyl-valeric acid, 5-(4'-hydroxyphenyl)-gamma-valerolactone-4'-O-glucuronide and 4-hydroxy-5-(3'-hydroxyphenyl)-valeric acid-3'-O-sulphate were the most abundant at 8h. The present study shows that the antiadhesive properties of urine sample after cranberry consumption are not ascribable to the direct effect of PAC-A, because their levels in urinary output are in the range of ng/mL. On the other hand, significant metabolites that were detected are mainly metabolites of intestinal action on polyphenols and PACs, as well as glucuronidated and sulphated quercetin, suggesting an important role of intestinal modification of phytoconstituents in the cranberry extract mechanism of action.
[Mh] Termos MeSH primário: Aderência Bacteriana/efeitos dos fármacos
Metaboloma
Extratos Vegetais/farmacologia
Escherichia coli Uropatogênica/efeitos dos fármacos
Vaccinium macrocarpon/química
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Intestinos/metabolismo
Lactonas/farmacologia
Masculino
Metabolômica
Ácidos Pentanoicos/farmacologia
Polifenóis/farmacologia
Proantocianidinas/farmacologia
Quercetina/farmacologia
Infecções Urinárias/tratamento farmacológico
Urina/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lactones); 0 (Pentanoic Acids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Proanthocyanidins); 9IKM0I5T1E (Quercetin); GZK92PJM7B (n-pentanoic acid); O7056XK37X (gamma-valerolactone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28635280
[Au] Autor:Peron G; Pellizzaro A; Brun P; Schievano E; Mammi S; Sut S; Castagliuolo I; Dall'Acqua S
[Ad] Endereço:Department of Pharmaceutical and Pharmacological Sciences, University of Padova , Via Marzolo 5, 35131 Padova, Italy.
[Ti] Título:Antiadhesive Activity and Metabolomics Analysis of Rat Urine after Cranberry (Vaccinium macrocarpon Aiton) Administration.
[So] Source:J Agric Food Chem;65(28):5657-5667, 2017 Jul 19.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cranberry (Vaccinium macrocarpon Aiton) is used to treat noncomplicated urinary tract infections (UTIs). A-type procyanidins (PAC-A) are considered the active constituents able to inhibit bacterial adhesion to the urinary epithelium. However, the role of PAC-A in UTIs is debated, because of their poor bioavailability, extensive metabolism, limited knowledge about urinary excretion, and contradictory clinical trials. The effects of 35-day cranberry supplementation (11 mg/kg PAC-A, 4 mg/kg PAC-B) were studied in healthy rats using a ultra performance liquid chromatography-mass spectrometry (UPLC-MS)-based metabolomics approach. Microbial PAC metabolites, such as valeric acid and valerolactone derivatives, were related to cranberry consumption. An increased urinary excretion of glucuronidated metabolites was also observed. In a further experiment, urine samples were collected at 2, 4, 8, and 24 h after cranberry intake and their antiadhesive properties were tested against uropathogenic Escherichia coli. The 8 h samples showed the highest activity. Changes in urinary composition were studied by ultra performance liquid chromatography-time-of-flight (UPLC-QTOF), observing the presence of PAC metabolites. The PAC-A2 levels were measured in all collected samples, and the highest amounts, on the order of ng/mL, were found in the samples collected after 4 h. Results indicate that the antiadhesive activity against uropathogenic bacteria observed after cranberry consumption is ascribable to PAC-A metabolites rather than to a direct PAC-A effect, as the measured PAC-A levels in urine was lower than those reported as active in the literature.
[Mh] Termos MeSH primário: Aderência Bacteriana/efeitos dos fármacos
Infecções por Escherichia coli/tratamento farmacológico
Extratos Vegetais/administração & dosagem
Infecções Urinárias/tratamento farmacológico
Urina/microbiologia
Escherichia coli Uropatogênica/fisiologia
Vaccinium macrocarpon/química
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais/análise
Infecções por Escherichia coli/metabolismo
Infecções por Escherichia coli/microbiologia
Infecções por Escherichia coli/urina
Feminino
Seres Humanos
Masculino
Metabolômica
Ratos
Ratos Sprague-Dawley
Infecções Urinárias/metabolismo
Infecções Urinárias/microbiologia
Infecções Urinárias/urina
Escherichia coli Uropatogênica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01856


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[PMID]:28525344
[Au] Autor:Balan BJ; Lewicki S; Siwicki AK; Stelmasiak M; Skopinski P; Skopinska-Rózewska E; Wasiutynski A; Zdanowski R
[Ad] Endereço:.
[Ti] Título:Morphometric abnormalities in spleen and kidney of the progeny of mice fed American cranberry extract (Vaccinium macrocarpon) during pregnancy and lactation.
[So] Source:Pol J Vet Sci;20(1):57-65, 2017 Mar 28.
[Is] ISSN:1505-1773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cranberries and cranberry-derived diet supplements are often recommended for the treatment of urinary tract infections, also during pregnancy. These products contain strongly anti-angiogenic chemical compounds which could not be indifferent to the developing fetus. In the present work we evaluated the effect of feeding pregnant and lactating mice American cranberry extract (daily dose 0.88 mg) on the morphology and some parameters of spleen and kidney function of their adult progeny. Six weeks after delivery the morphometry of spleen and kidney, cytometric analysis of spleen lymphocytes, evaluation of humoral response to SRBC (Sheep Red Blood Cells), and examination of serum creatinine/urea concentration, were performed in the offspring. Spleens of progeny from experimental (E) group differed from the spleens of progeny of control mice in the lower number of lymphatic nodules and their larger diameter. Cytometry of spleen cells from progeny of E mothers revealed more CD19+ and CD8+ lymphocytes than in the control group. No difference was seen in the response to immunization by red blood cells of sheep (SRBC) between control and E offspring. An increase in the diameter of glomeruli was observed in the kidneys of the experimental group in comparison with the control group. No abnormalities in creatinine and urea serum level were observed. A higher concentration of VEGF and bFGF in E offspring sera in comparison to the controls was seen. CONCLUSION: Although the observed differences between the control and experimental group were not large, caution is recommended in using cranberries and their extracts during pregnancy until more research will be done on this topic.
[Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos
Rim/anormalidades
Lactação/fisiologia
Extratos Vegetais/toxicidade
Baço/anormalidades
Vaccinium macrocarpon/química
[Mh] Termos MeSH secundário: Animais
Anticorpos
Eritrócitos/imunologia
Feminino
Rim/citologia
Rim/efeitos dos fármacos
Fígado/anormalidades
Fígado/efeitos dos fármacos
Camundongos
Extratos Vegetais/química
Gravidez
Ovinos/sangue
Baço/citologia
Baço/efeitos dos fármacos
Timo/anormalidades
Timo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


  7 / 669 MEDLINE  
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[PMID]:28423417
[Au] Autor:Steffan SA; Chasen EM; Deutsch AE; Mafra-Neto A
[Ad] Endereço:USDA-ARS Vegetable Crops Research Unit, 1630 Linden Drive, Madison, WI 53706 ( shawn.steffan@ars.usda.gov ; elissa.chasen@ars.usda.gov ).
[Ti] Título:Multi-Species Mating Disruption in Cranberries (Ericales: Ericaceae): Early Evidence Using a Flowable Emulsion.
[So] Source:J Insect Sci;17(2), 2017 Jan 01.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pheromone-based mating disruption has proven to be a powerful pest management tactic in many cropping systems. However, in the cranberry system, a viable mating disruption program does not yet exist. There are commercially available pheromones for several of the major pests of cranberries, including the cranberry fruitworm, Acrobasis vaccinii Riley (Lepidoptera: Pyralidae) and blackheaded fireworm, Rhopobota naevana (Hübner) (Lepidoptera: Tortricidae). Previous studies have shown that mating disruption represents a promising approach for R. naevana management although carrier and delivery technologies have remained unresolved. The present study examined the suitability of Specialized Pheromone & Lure Application Technology (SPLAT; ISCA Technologies, Inc., Riverside, CA), a proprietary wax and oil blend, to serve as a pheromone carrier in the cranberry system. In 2013 and 2014, we tested a blend of pheromones targeting A. vaccinii and R. naevana in field-scale, replicated trials. Pheromones were loaded into SPLAT and the resulting "SPLAT BFW CFW" formulation was deployed in commercial cranberry marshes. We compared moth trap-catch counts within SPLAT-treated blocks to those of conventionally managed blocks. In 2013, applications of SPLAT BFW CFW resulted in highly successful disruption of R. naevana and promising, though inconsistent, disruption of A. vaccinii. To improve disruption of A. vaccinii, the pheromone load was increased in 2014, providing 92% and 74% reductions in trap-catch for R. naevana and A. vaccinii, respectively. Importantly, larval infestation rates in SPLAT-treated blocks were lower than those of conventionally managed blocks. These results suggest that a multispecies mating disruption system (SPLAT BFW CFW) may represent an effective pesticide-alternative for serious pests of cranberries.
[Mh] Termos MeSH primário: Mariposas/fisiologia
Controle Biológico de Vetores/métodos
Feromônios/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
Vaccinium macrocarpon
[Mh] Termos MeSH secundário: Animais
Especificidade da Espécie
Vaccinium macrocarpon/crescimento & desenvolvimento
Wisconsin
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pheromones); 0 (insect attractants)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1093/jisesa/iex025


  8 / 669 MEDLINE  
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[PMID]:28415444
[Au] Autor:H R R; Dhamecha D; Jagwani S; Patil D; Hegde S; Potdar R; Metgud R; Jalalpure S; Roy S; Jadhav K; Tiwari NK; Koduru S; Hugar S; Dodamani S
[Ad] Endereço:Department of Periodontics, KLE VK Institute of Dental Sciences, KLE University, Nehru Nagar, Belgaum 590010, Karnataka, India. Electronic address: dr.rashree@gmail.com.
[Ti] Título:Formulation of thermoreversible gel of cranberry juice concentrate: Evaluation, biocompatibility studies and its antimicrobial activity against periodontal pathogens.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:1506-1514, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present work aims to investigate the efficacy of thermoreversible gel of cranberry juice concentrate (CJC) as local drug delivery for the treatment of periodontitis. CJC was initially tested for its antimicrobial activities like MIC, MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms (S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis (PG), T. forsythia (TF)) responsible for periapical and periodontal infections. Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%). CJC was evaluated for its biocompatibility using periodontal fibroblasts by cell based MTT assay and found to be nontoxic. Influence of CJC on periodontopathogen PG derived virulence factors (fimA and kgp) was studied using real time polymerase chain reaction (RT-PCR) technique wherein down regulation of selected genes demonstrated inhibitory effect against PG virulence factors. Thermoreversible gel of CJC was formulated by cold method using poloxamer 407 as thermosensitive polymer and carbopol 934 as mucoadhesive polymer and evaluated for its gelation temperature, viscosity, gel strength and mucoadhesive strength. Comparison of optimized thermoreversible gel of CJC (500mg/ml) with commercially available chlorhexidine gluconate gel (0.2%) using agar well diffusion demonstrated equal zone of inhibition against SM, EF, AA, PG & TF. Hence the formulated thermoreversible gel of CJC could serve as a novel herbal alternative to currently available periodontal treatment modalities.
[Mh] Termos MeSH primário: Antibacterianos
Bactérias/crescimento & desenvolvimento
Fibroblastos/metabolismo
Sucos de Frutas e Vegetais
Teste de Materiais
Periodonto/microbiologia
Vaccinium macrocarpon/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Células Cultivadas
Avaliação Pré-Clínica de Medicamentos
Fibroblastos/citologia
Géis
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gels)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  9 / 669 MEDLINE  
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[PMID]:28364867
[Au] Autor:Caretto M; Giannini A; Russo E; Simoncini T
[Ad] Endereço:University of Pisa, Italy.
[Ti] Título:Preventing urinary tract infections after menopause without antibiotics.
[So] Source:Maturitas;99:43-46, 2017 May.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Urinary tract infections (UTIs) are the most common bacterial infections in women, and increase in incidence after the menopause. It is important to uncover underlying abnormalities or modifiable risk factors. Several risk factors for recurrent UTIs have been identified, including the frequency of sexual intercourse, spermicide use and abnormal pelvic anatomy. In postmenopausal women UTIs often accompany the symptoms and signs of the genitourinary syndrome of menopause (GSM). Antimicrobial prophylaxis has been demonstrated to be effective in reducing the risk of recurrent UTIs in women, but this may lead to drug resistance of both the causative microorganisms and the indigenous flora. The increasing prevalence of Escherichia coli (the most prevalent uropathogen) that is resistant to antimicrobial agents has stimulated interest in novel non-antibiotic methods for the prevention of UTIs. Evidence shows that topical estrogens normalize vaginal flora and greatly reduce the risk of UTIs. The use of intravaginal estrogens may be reasonable in postmenopausal women not taking oral estrogens. A number of other strategies have been used to prevent recurrent UTIs: probiotics, cranberry juice and d-mannose have been studied. Oral immunostimulants, vaginal vaccines and bladder instillations with hyaluronic acid and chondroitin sulfate are newer strategies proposed to improve urinary symptoms and quality of life. This review provides an overview of UTIs' prophylaxis without antibiotics, focusing on a practical clinical approach to women with UTIs.
[Mh] Termos MeSH primário: Estrogênios/uso terapêutico
Manose/uso terapêutico
Menopausa
Extratos Vegetais/uso terapêutico
Probióticos/uso terapêutico
Infecções Urinárias/prevenção & controle
Vaccinium macrocarpon
[Mh] Termos MeSH secundário: Administração Intravaginal
Coito
Feminino
Seres Humanos
Incidência
Microbiota
Qualidade de Vida
Recidiva
Fatores de Risco
Vagina/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Estrogens); 0 (Plant Extracts); PHA4727WTP (Mannose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


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[PMID]:28291888
[Au] Autor:Juthani-Mehta M; Van Ness PH; Peduzzi P
[Ad] Endereço:Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut.
[Ti] Título:Cranberry Capsules for bacteriuria Plus Pyuria in Nursing Home Residents-Reply.
[So] Source:JAMA;317(10):1078-1079, 2017 03 14.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bacteriúria
Piúria
[Mh] Termos MeSH secundário: Cápsulas
Seres Humanos
Casas de Saúde
Infecções Urinárias
Vaccinium macrocarpon
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Capsules)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170422
[Lr] Data última revisão:
170422
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.0092



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