Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.341.984 [Categoria DeCS]
Referências encontradas : 154 [refinar]
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[PMID]:28806605
[Au] Autor:Colombo PS; Flamini G; Rodondi G; Giuliani C; Santagostini L; Fico G
[Ad] Endereço:Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy; Orto Botanico G.E. Ghirardi, Dipartimento di Scienze Farmaceutiche, Via Religione 25, 25088, Toscolano Maderno, Brescia, Italy. Electronic address: pasico19@virgilio.it.
[Ti] Título:Phytochemistry of European Primula species.
[So] Source:Phytochemistry;143:132-144, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The genus Primula is the largest among the Primulaceae and is widespread mainly in the cold and temperate regions of the Northern Hemisphere. Since the beginning of the Twentieth century, several studies on the phytochemical composition of different species of Primula have been carried out. The main constituents examined were tissue and epicuticular flavonoids and saponins, which are of therapeutic significance. Only in recent years studies of the volatiles emitted by leaves and flowers have been carried out as well, but they are restricted to a small number of species. Only a few authors have documented the morphology and function of glandular trichomes in relation to the production of flavonoids and volatile organic compounds (VOCs). The use of Primula in folk medicine is described in the literature. Investigation of the biological and pharmacological activities of Primula are reported. This study aims at providing a collection of publications on the genus Primula along with a critical revision of literature data. It focuses on the possible taxonomic significance of the secondary metabolites and on their ecological role as attractors for pollinators and deterrents against herbivores and parasites, in order to build the base for further studies.
[Mh] Termos MeSH primário: Flavonoides/isolamento & purificação
Primula/química
Primulaceae/química
[Mh] Termos MeSH secundário: Europa (Continente)
Flavonoides/química
Flores
Estrutura Molecular
Folhas de Planta/química
Saponinas/química
Saponinas/isolamento & purificação
Tricomas/metabolismo
Compostos Orgânicos Voláteis/química
Compostos Orgânicos Voláteis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Flavonoids); 0 (Saponins); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


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[PMID]:28573234
[Au] Autor:Yildirim AB; Guner B; Karakas FP; Turker AU
[Ad] Endereço:Abant Izzet Baysal University, Department of Field Crops, Faculty of Agricultural and Environmental Science, Bolu, Turkey.
[Ti] Título:EVALUATION OF ANTIBACTERIAL, ANTITUMOR, ANTIOXIDANT ACTIVITIES AND PHENOLIC CONSTITUENTS OF FIELD-GROWN AND VITRO-GROWN L.
[So] Source:Afr J Tradit Complement Altern Med;14(2):177-187, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: L. (Yellow loosestrife) is a medicinal plant in the family Myrsinaceae. It has been used in the treatment of fever, ulcer, diarrhea and wounds in folk medicine. It has also analgesic, expectorant, astringent and anti-inflammatory activities. Two different sources of the plant (field-grown and -grown) were used to evaluate the biological activities (antibacterial, antitumor and antioxidant) of plant materials were collected from plants that were previously regenerated in our laboratory. MATERIALS AND METHODS: Plant materials were extracted with water, ethanol and acetone. For antibacterial test, disc diffusion method and 10 different pathogenic bacteria were used. Antioxidant activity was indicated by using DPPH method. The total phenol amount by using Folin-Ciocaltaeu method and the total flavonoid amount by using aluminum chloride (AlCl ) colorimetric method were determined. RESULTS: Generally, yellow loosestrife extracts demonstrated antibacterial activity against Gram-positive bacteria and . Strong antitumor activity of yellow loosestrife was observed via potato disc diffusion bioassay. Nine different phenolics were also determined and compared by using High-Performance Liquid Chromatography (HPLC). CONCLUSION: Future investigations should be focused on fractionation of the extracts to identify active components for biological activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Flavonoides/farmacologia
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Primulaceae/química
[Mh] Termos MeSH secundário: Compostos de Bifenilo/metabolismo
Cromatografia Líquida de Alta Pressão
Flavonoides/análise
Fenóis/análise
Picratos/metabolismo
Extratos Vegetais/química
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/crescimento & desenvolvimento
Staphylococcus epidermidis/efeitos dos fármacos
Staphylococcus epidermidis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.19


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[PMID]:28173950
[Au] Autor:Dai LM; Huang RZ; Zhang B; Hua J; Wang HS; Liang D
[Ad] Endereço:State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
[Ti] Título:Cytotoxic triterpenoid saponins from Lysimachia foenum-graecum.
[So] Source:Phytochemistry;136:165-174, 2017 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eleven oleanane-type triterpenoid saponins, foegraecumosides A-K, and eight known ones, were isolated from the aerial parts of Lysimachia foenum-graecum. Their structures were elucidated by spectroscopic data analyses and chemical methods. All isolated saponins were evaluated for their cytotoxicity against four human cancer cell lines (NCI-H460, MGC-803, HepG2, and T24). Seven saponins containing the aglycone cyclamiretin A exhibited moderate cytotoxicity against all tested human cancer cell lines, with IC values of 9.3-24.5 µM. Simultaneously, the cytotoxic activities of foegraecumosides A and B, lysichriside A, ardisiacrispins A and B, cyclaminorin, and 3-O-α-L-rhamnopyranosyl-(1 â†’ 2)-ß-d-glucopyranosyl-(1 â†’ 4)-α-l-arabinopyranosyl-cyclamiretin A were tested on drug-resistant lung cancer cell lines (A549 and A549/CDDP, respectively). Ardisiacrispin B displayed moderate cytotoxicity against A549/CDDP, with an IC value of 8.7 µM and a resistant factor (RF) of 0.9.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Componentes Aéreos da Planta/química
Primulaceae/química
Saponinas/isolamento & purificação
Saponinas/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/química
Ácido Oleanólico/isolamento & purificação
Ácido Oleanólico/farmacologia
Saponinas/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (Saponins); 0 (Triterpenes); 0 (foegraecumoside A); 112766-96-8 (ardisiacrispin B); 5172-34-9 (cyclamiretin A); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE


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[PMID]:27840409
[Au] Autor:Zhang SR; Xu YS; Jin E; Zhu LC; Xia B; Chen XF; Li FZ; Ma SL
[Ad] Endereço:College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
[Ti] Título:Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance.
[So] Source:Acta Pharmacol Sin;38(1):100-109, 2017 Jan.
[Is] ISSN:1745-7254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most gefitinib-treated patients with non-small cell lung cancer (NSCLC) would eventually develop resistance. Lysimachia capillipes (LC) capilliposide extracts from LC Hemsl. show both in vitro and in vivo anti-cancer effects. In this study we investigated whether LC capilliposide in combination with gefitinib could overcome the resistance of NSCLC cells to gefitinib and identified the signaling pathways involved. Treatment with LC capilliposide alone inhibited the growth of a panel of NSCLC cell lines (PC-9, H460, H1975, H1299 and PC-9-GR) sensitive or resistant to gefitinib with IC values in the range of µg/mL. In the gefitinib-resistant PC-9-GR cells (which have a T790M EGFR mutation), LC capilliposide (at the IC30, i.e.1.2 µg/mL) markedly enhanced the inhibitory effects of gefitinib with its IC50 value being decreased from 6.80±1.00 to 0.77±0.12 µmol/L. By using the median effect analysis we showed that combination treatment of LC capilliposide and gefitinib could restore gefitinib sensitivity in PC-9-GR cells. Furthermore, LC capilliposide (1.2 µg/mL) significantly increased the apoptotic responses to gefitinib (0.77 µmol/L) in PC-9-GR cells, but did not affect gefitinib-induced G /G arrest. Moreover, LC capilliposide (1.2 µg/mL) in combination with gefitinib (0.77, 1.0 µmol/L) markedly decreased the phosphorylation of the EGFR downstream signaling molecule AKT, which neither LC capilliposide nor gefitinib alone affected. In PC-9-GR cells with siRNA knockdown of AKT, addition of LC capilliposide was unable to increase gefitinib sensitivity. In a PC-9-GR xenograft mouse model, combination treatment with LC capilliposide (15 mg·kg ·d , ip) and gefitinib (50 mg·kg ·d , ip) dramatically enhanced tumor growth suppression (with a TGI of 109.3%), compared with TGIs of 22.6% and 56.6%, respectively, in mice were treated with LC capilliposide or gefitinib alone. LC capilliposide can restore the cells' sensitivity to gefitinib through modulation of pAKT levels, suggesting that a combination of LC capilliposide and gefitinib may be a promising therapeutic strategy to overcome gefitinib resistance in NSCLCs with a T790M mutation.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/enzimologia
Neoplasias Pulmonares/enzimologia
Primulaceae/química
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Quinazolinas/uso terapêutico
Saponinas/uso terapêutico
Triterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Apoptose/efeitos dos fármacos
Carcinoma Pulmonar de Células não Pequenas/patologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Feminino
Seres Humanos
Neoplasias Pulmonares/patologia
Camundongos
Fosforilação/efeitos dos fármacos
Inibidores de Proteínas Quinases/farmacologia
Inibidores de Proteínas Quinases/uso terapêutico
Proteínas Proto-Oncogênicas c-akt/metabolismo
Quinazolinas/farmacologia
RNA Interferente Pequeno/farmacologia
Saponinas/farmacologia
Triterpenos/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (LC capilliposide); 0 (Protein Kinase Inhibitors); 0 (Quinazolines); 0 (RNA, Small Interfering); 0 (Saponins); 0 (Triterpenes); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); S65743JHBS (gefitinib)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE
[do] DOI:10.1038/aps.2016.116


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[PMID]:27487244
[Au] Autor:Etti CJ; Yusof YA; Chin NL; Mohd Tahir S
[Ad] Endereço:a Department of Process and Food Engineering, Faculty of Engineering , Universiti Putra Malaysia , Serdang , Selangor , Malaysia.
[Ti] Título:Tableting Properties and Compression Models of Labisia pumila Tablets.
[So] Source:J Diet Suppl;14(2):132-145, 2017 Mar 04.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The tableting properties of Labisia pumila herbal powder, which is well known for its therapeutic benefits was investigated. The herbal powder was compressed into tablets using a stainless steel cylindrical uniaxial die of 13-mm- diameter with compaction pressures ranging from 7 to 25 MPa. Two feed weights, 0.5 and 1.0 g were used to form tablets. Some empirical models were used to describe the compressibility behavior of Labisia pumila tablets. The strength and density of tablets increased with increase in compaction pressure and resulted in reduction in porosity of the tablets. Smaller feeds, higher forces and increase in compaction pressure, contributed to more coherent tablets. These findings can be used to enhance the approach and understanding of tableting properties of Labisia pumila herbal powder tablets.
[Mh] Termos MeSH primário: Composição de Medicamentos/métodos
Pós/química
Primulaceae/química
Comprimidos/química
[Mh] Termos MeSH secundário: Força Compressiva
Porosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Powders); 0 (Tablets)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


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[PMID]:27308956
[Au] Autor:Gao YY; Zeng P; Jia CL; Zhang Y; Zhang T; Jia Q; Li YM
[Ad] Endereço:a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
[Ti] Título:Two new phenols from Lysimachia patungensis.
[So] Source:J Asian Nat Prod Res;19(1):28-34, 2017 Jan.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new phenols, methyl 3-(2-O-ß-d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate (1) and myricetin-3,3',5'-tri-O-α-l-rhamnopyranoside (2), together with six known phenols compounds (3-8), were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz. Their structures were elucidated on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, UV, IR, and NMR. All the known phenols were isolated from the genus Lysimachia for the first time. A preliminary bioassay revealed that compounds 3 and 7 exhibited significant protective effects against hydrogen peroxide-induced damage in human retinal endothelial cells (HRECs) with the concentration of 10 µM, respectively. Compound 1 showed moderate activity against the HRECs damage at 100 µM.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Flavonoides/isolamento & purificação
Glucosídeos/isolamento & purificação
Glicosídeos/isolamento & purificação
Fenóis/isolamento & purificação
Primulaceae/química
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Medicamentos de Ervas Chinesas/química
Células Endoteliais/efeitos dos fármacos
Flavonoides/química
Glucosídeos/química
Glicosídeos/química
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fenóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Glucosides); 0 (Glycosides); 0 (Phenols); 0 (methyl 3-(2-O-beta-D-glucopyranosyl-3-hydroxy-5-methoxyphenyl)propionate); 0 (myricetin-3,3',5'-tri-O-alpha-L-rhamnopyranoside); 76XC01FTOJ (myricetin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1183652


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[PMID]:27737477
[Au] Autor:Koczurkiewicz P; Kowolik E; Podolak I; Wnuk D; Piska K; Labedz-Maslowska A; Wójcik-Pszczola K; Pekala E; Czyz J; Michalik M
[Ad] Endereço:Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
[Ti] Título:Synergistic Cytotoxic and Anti-invasive Effects of Mitoxantrone and Triterpene Saponins from Lysimachia ciliata on Human Prostate Cancer Cells.
[So] Source:Planta Med;82(18):1546-1552, 2016 Dec.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Triterpene saponins are secondary metabolites typical for higher plants. They possess a wide range of pharmaceutical and biological activities. These include anti-inflammatory, vasoprotective, expectorant, and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs has opened new perspectives for their application in combined cancer chemotherapy. In this study, the biological activity of the saponin fraction isolated from (denoted as CIL-1/2) was evaluated to assess its chemosensitizing activity in prostate cancer cell lines (DU-145, PC-3). No cytotoxic or cytostatic effect of the CIL-1/2 fraction administered at the concentration of 0.5 µg/mL was observed. In contrast, cocktails of CIL-1/2 and mitoxantrone (a drug commonly used in prostate cancer therapy) exerted synergistic cytostatic and proapoptotic effects. Furthermore, the synergy of proapoptotic activities of the analyzed cocktails is accompanied by their synergistic effects on prostate cancer cell movement and invasiveness. The significantly weaker impact of this cocktail on normal prostate cells additionally adds to the significance of our data and confirms that the CIL-1/2 fraction might be considered a potent adjuvant for prostate cancer chemotherapy.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Mitoxantrona/farmacologia
Primulaceae/química
Neoplasias da Próstata/patologia
Saponinas/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Saponins); 0 (Triterpenes); BZ114NVM5P (Mitoxantrone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27604279
[Au] Autor:Copeland SM; Harrison SP
[Ad] Endereço:Environmental Science and Policy, University of California, Davis, CA, USA scopeland@ucdavis.edu.
[Ti] Título:Shading and litter mediate the effects of soil fertility on the performance of an understorey herb.
[So] Source:Ann Bot;118(6):1187-1198, 2016 Nov.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Soil fertility and topographic microclimate are common determinants of plant species distributions. However, biotic conditions also vary along these abiotic gradients, and may mediate their effects on plants. In this study, we investigated whether soils and topographic microclimate acted directly on the performance of a focal understorey plant, or indirectly via changing biotic conditions. METHODS: We examined direct and indirect relationships between abiotic variables (soil fertility and topographic microclimate) and biotic factors (overstorey and understorey cover, litter depth and mycorrhizal colonization) and the occurrence, density and flowering of a common understorey herb, Trientalis latifolia, in the Klamath-Siskiyou Mountains, Oregon, USA. RESULTS: We found that the positive effects of soil fertility on Trientalis occurrence were mediated by greater overstorey shading and deeper litter. However, we did not find any effects of topographic microclimate on Trientalis distribution that were mediated by the biotic variables we measured. The predictive success of Trientalis species distribution models with soils and topographic microclimate increased by 12 % with the addition of the biotic variables. CONCLUSIONS: Our results reinforce the idea that species distributions are the outcome of interrelated abiotic gradients and biotic interactions, and suggest that biotic conditions, such as overstorey density, should be included in species distribution models if data are available.
[Mh] Termos MeSH primário: Primulaceae/fisiologia
[Mh] Termos MeSH secundário: Ecologia
Micorrizas/metabolismo
Primulaceae/crescimento & desenvolvimento
Reprodução/fisiologia
Solo
Microbiologia do Solo
Luz Solar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE


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[PMID]:27596932
[Au] Autor:Huu CN; Kappel C; Keller B; Sicard A; Takebayashi Y; Breuninger H; Nowak MD; Bäurle I; Himmelbach A; Burkart M; Ebbing-Lohaus T; Sakakibara H; Altschmied L; Conti E; Lenhard M
[Ad] Endereço:Institute for Biochemistry and Biology, University of Potsdam, Potsdam-Golm, Germany.
[Ti] Título:Presence versus absence of CYP734A50 underlies the style-length dimorphism in primroses.
[So] Source:Elife;5, 2016 Sep 06.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Heterostyly is a wide-spread floral adaptation to promote outbreeding, yet its genetic basis and evolutionary origin remain poorly understood. In Primula (primroses), heterostyly is controlled by the S-locus supergene that determines the reciprocal arrangement of reproductive organs and incompatibility between the two morphs. However, the identities of the component genes remain unknown. Here, we identify the Primula CYP734A50 gene, encoding a putative brassinosteroid-degrading enzyme, as the G locus that determines the style-length dimorphism. CYP734A50 is only present on the short-styled S-morph haplotype, it is specifically expressed in S-morph styles, and its loss or inactivation leads to long styles. The gene arose by a duplication specific to the Primulaceae lineage and shows an accelerated rate of molecular evolution. Thus, our results provide a mechanistic explanation for the Primula style-length dimorphism and begin to shed light on the evolution of the S-locus as a prime model for a complex plant supergene.
[Mh] Termos MeSH primário: Sistema Enzimático do Citocromo P-450/metabolismo
Flores/anatomia & histologia
Proteínas de Plantas/metabolismo
Primula/anatomia & histologia
Primula/enzimologia
[Mh] Termos MeSH secundário: Sistema Enzimático do Citocromo P-450/genética
Evolução Molecular
Duplicação Gênica
Perfilação da Expressão Gênica
Inativação Gênica
Primula/genética
Primulaceae
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


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[PMID]:27382921
[Au] Autor:Medina-López CF; Plascencia-Jatomea M; Cinco-Moroyoqui FJ; Yépiz-Gómez MS; Cortez-Rocha MO; Rosas-Burgos EC
[Ad] Endereço:a Department of Food Science Research and Graduate Studies , University of Sonora , Hermosillo , Sonora , Mexico.
[Ti] Título:Potentiation of antifungal effect of a mixture of two antifungal fractions obtained from Baccharis glutinosa and Jacquinia macrocarpa plants.
[So] Source:J Environ Sci Health B;51(11):760-8, 2016 Nov.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present work was to evaluate the effect of mixtures of antifungal fractions extracted from Baccharis glutinosa and Jacquinia macrocarpa plants on the development of the filamentous fungi Aspergillus flavus and Fusarium verticillioides. The minimal inhibitory concentration that inhibited 50% of growth (MIC50) of each plant antifungal fraction was determined from the percentage radial growth inhibition of both fungi. Binomial mixtures made with both plant fractions were used at their MIC50 to determine the Fractional Inhibitory Concentration index (FIC index) for each fungus in order to evaluate their synergistic effect. Each synergistic mixture was analyzed in their effect on spore germination, spore size, spore viability, mitotic divisions, hyphal diameter and length, and number of septa per hypha. Some antifungal mixtures, even at low concentrations, showed higher antifungal effect than those of the individual antifungal fraction. The FIC indices of mixtures that showed the highest antifungal activity against A. flavus and F. verticillioides were 0.5272 and 0.4577, respectively, indicating a synergistic effect against both fungi. Only 12% and 8% of the spores of A. flavus and F. verticillioides, respectively, treated with the synergistic mixtures, were able to germinate, although their viability was not affected. An increase in the number of septa per hypha of both fungi was observed. The results indicated that the synergistic mixtures strongly affected the fungal growth even at lower concentrations than those of the individual plant fractions.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus flavus/efeitos dos fármacos
Baccharis/química
Fusarium/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Primulaceae/química
[Mh] Termos MeSH secundário: México
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2016.1198641



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