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[PMID]: | 27984799 |
[Au] Autor: | Durg S; Veerapur VP; Neelima S; Dhadde SB |
[Ad] Endereço: | Independent Researcher, Bengaluru 560028, Karnataka, India. Electronic address: sharanabasappadurg@yahoo.com. |
[Ti] Título: | Antidiabetic activity of Embelia ribes, embelin and its derivatives: A systematic review and meta-analysis. |
[So] Source: | Biomed Pharmacother;86:195-204, 2017 Feb. | [Is] ISSN: | 1950-6007 |
[Cp] País de publicação: | France |
[La] Idioma: | eng |
[Ab] Resumo: | Embelia ribes (ER) has been documented in Ayurveda for treating various diseases, including diabetes mellitus (DM). The present systematic review and meta-analysis evaluated the efficacy and safety of ER and its active bio-marker, embelin and its derivatives in the treatment of DM. Literature search was performed in PubMed/MEDLINE, EMBASE, Scopus, ScienceDirect, Scifinder, and Google Scholar. Using Review Manager, meta-analysis of ER/embelin/derivatives of embelin versus diabetic control was performed with inverse-variance model, providing mean differences (MDs) and 95% confidence intervals (CIs). Heterogeneity was determined by I statistic. A total of 13 studies were included in the systematic review and meta-analysis, and were conducted in experimental rats. ER and embelin significantly (P≤0.01) resorted blood glucose (MD, -231.30; CI, -256.79, -205.82; and MD, -154.70; CI, -168.65, -140.74) and glycosylated haemoglobin (MD, -6.36; CI, -8.33, -4.39; and MD,-4.68; CI, -7.76, -1.60), respectively. Meta-analysis findings also reported considerable restoration of insulin, lipid profile, haemodynamic parameters, serum and oxidative stress markers. The derivatives of embelin, 6-bromoembelin and vilangin, also improved diabetic condition. In addition, treatments also ameliorated body weight changes due to diabetes. The present systematic review and meta-analysis supports scientific evidence for the antidiabetic activity of ER/embelin/derivatives of embelin. However, further research is warranted in clinical trials to validate the present findings. |
[Mh] Termos MeSH primário: |
Diabetes Mellitus/tratamento farmacológico Embelia Hipoglicemiantes/uso terapêutico Extratos Vegetais/uso terapêutico
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[Mh] Termos MeSH secundário: |
Animais Diabetes Mellitus/metabolismo Seres Humanos Hipoglicemiantes/isolamento & purificação Hipoglicemiantes/farmacologia Estresse Oxidativo/efeitos dos fármacos Estresse Oxidativo/fisiologia Extratos Vegetais/isolamento & purificação Extratos Vegetais/farmacologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; META-ANALYSIS; REVIEW |
[Nm] Nome de substância:
| 0 (Hypoglycemic Agents); 0 (Plant Extracts) |
[Em] Mês de entrada: | 1702 |
[Cu] Atualização por classe: | 170209 |
[Lr] Data última revisão:
| 170209 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161217 |
[St] Status: | MEDLINE |
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