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Pesquisa : B01.650.940.800.575.912.250.341.984.662 [Categoria DeCS]
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[PMID]:28093981
[Au] Autor:Shuveksh PS; Ahmed K; Padhye S; Schobert R; Biersack B
[Ad] Endereço:ISTRA, Abeda Inamdar Senior College, University of Pune, Pune 411001, India.
[Ti] Título:Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives.
[So] Source:Curr Med Chem;24(18):1998-2009, 2017.
[Is] ISSN:1875-533X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Like the impressive biological properties of embelin, its chemical aspects have raised the interest of scientists in the field as well. A detailed understanding of the chemistry of embelin is necessary to fully exploit it medicinally. METHODS: Search for embelin isolation and its chemical modifications was carried out using web-based literature searching tools such as Pubmed and Scifinder. Pertinent literature is covered up to 2016. Structures of bioactive embelin derivatives are provided. RESULTS: Pure embelin, obtained from Embelia ribes berries extraction or by total synthesis, was applied for a number of biological assays. Semi-synthetic and total synthetic approaches led to new high affinity embelin-derived inhibitors of crucial protein targets and to new embelin derivatives with improved pharmacological properties (e.g., with better water-solubility or as applications for drug carrier systems). CONCLUSION: This review provides a summary of the rich chemistry of embelin and the latest developments in the field of optimized (semi-)synthetic embelin derivatives including their biological activities.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Benzoquinonas/química
Benzoquinonas/farmacologia
Embelia/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/síntese química
Antioxidantes/isolamento & purificação
Benzoquinonas/síntese química
Benzoquinonas/isolamento & purificação
Técnicas de Química Sintética/métodos
Desenho de Drogas
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzoquinones); SHC6U8F5ER (embelin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.2174/0929867324666170116125731


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[PMID]:27984799
[Au] Autor:Durg S; Veerapur VP; Neelima S; Dhadde SB
[Ad] Endereço:Independent Researcher, Bengaluru 560028, Karnataka, India. Electronic address: sharanabasappadurg@yahoo.com.
[Ti] Título:Antidiabetic activity of Embelia ribes, embelin and its derivatives: A systematic review and meta-analysis.
[So] Source:Biomed Pharmacother;86:195-204, 2017 Feb.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Embelia ribes (ER) has been documented in Ayurveda for treating various diseases, including diabetes mellitus (DM). The present systematic review and meta-analysis evaluated the efficacy and safety of ER and its active bio-marker, embelin and its derivatives in the treatment of DM. Literature search was performed in PubMed/MEDLINE, EMBASE, Scopus, ScienceDirect, Scifinder, and Google Scholar. Using Review Manager, meta-analysis of ER/embelin/derivatives of embelin versus diabetic control was performed with inverse-variance model, providing mean differences (MDs) and 95% confidence intervals (CIs). Heterogeneity was determined by I statistic. A total of 13 studies were included in the systematic review and meta-analysis, and were conducted in experimental rats. ER and embelin significantly (P≤0.01) resorted blood glucose (MD, -231.30; CI, -256.79, -205.82; and MD, -154.70; CI, -168.65, -140.74) and glycosylated haemoglobin (MD, -6.36; CI, -8.33, -4.39; and MD,-4.68; CI, -7.76, -1.60), respectively. Meta-analysis findings also reported considerable restoration of insulin, lipid profile, haemodynamic parameters, serum and oxidative stress markers. The derivatives of embelin, 6-bromoembelin and vilangin, also improved diabetic condition. In addition, treatments also ameliorated body weight changes due to diabetes. The present systematic review and meta-analysis supports scientific evidence for the antidiabetic activity of ER/embelin/derivatives of embelin. However, further research is warranted in clinical trials to validate the present findings.
[Mh] Termos MeSH primário: Diabetes Mellitus/tratamento farmacológico
Embelia
Hipoglicemiantes/uso terapêutico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus/metabolismo
Seres Humanos
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27104858
[Au] Autor:Dhayalan M; Denison MI; L AJ; Krishnan K; N NG
[Ad] Endereço:a Department of Chemical Engineering , Alagappa College of Technology, Anna University , Chennai , India.
[Ti] Título:In vitro antioxidant, antimicrobial, cytotoxic potential of gold and silver nanoparticles prepared using Embelia ribes.
[So] Source:Nat Prod Res;31(4):465-468, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In recent years, the green synthesis of gold (GNPs) and silver (SNPs) nanoparticles has gained great interest among chemists and researchers. The present study reports an eco-friendly, cost-effective, rapid and easy method for the synthesis of gold and silver nanoparticles using the seed extract of Embelia ribes (SEEr) as capping and reducing agent. The synthesised GNPs and SNPs were characterised using the following techniques: UV-vis spectroscopy, DLS, HR-TEM, FT-IR and XRD. The free radical scavenging potential of GNPs and SNPs was measured by DPPH assay and Phosphomolybdenum assay. Further, the antimicrobial activity against two micro-organisms were tested using disc diffusion method and cytotoxicity of GNPs and SNPs was determined against MCF-7 cell lines at different concentrations by MTT assay. Both the GNPs and SNPs prepared from E. ribes comparatively showed promising results thereby proving their clinical importance.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antineoplásicos/farmacologia
Antioxidantes/farmacologia
Embelia/metabolismo
Nanopartículas Metálicas
[Mh] Termos MeSH secundário: Ouro/farmacologia
Seres Humanos
Células MCF-7
Extratos Vegetais/metabolismo
Sementes/metabolismo
Prata/farmacologia
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Plant Extracts); 3M4G523W1G (Silver); 7440-57-5 (Gold)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160423
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1166499


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[PMID]:26084371
[Au] Autor:Debebe Y; Tefera M; Mekonnen W; Abebe D; Woldekidan S; Abebe A; Belete Y; Menberu T; Belayneh B; Tesfaye B; Nasir I; Yirsaw K; Basha H; Dawit A; Debella A
[Ad] Endereço:Ethiopian Public Health Institute, Biomedical and Clinical Research Team, Traditional and Modern Medicine Research Directorate, P.O.Box 1242, Addis Ababa, Ethiopia. papioan@gmail.com.
[Ti] Título:Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites.
[So] Source:BMC Complement Altern Med;15:187, 2015 Jun 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Embelia schimperi has been used for the treatment of intestinal parasites especially tapeworm infestations for centuries in Ethiopia. However, there is lack of scientific based evidences regarding the efficacy, safety and phytochemical analysis of this plant despite its frequent use as an anthelmintic. This study has therefore evaluated the efficacy and acute toxicity of E. schimperi thereby generating relevant preclinical information. METHODS: The anthelmintic activities of the crude hydroalcoholic extract of E. schimperi and the isolated compound, embelin, were conducted using in vivo and in vitro models against the dwarf tapeworm, Hymenolepis nana, and the hookworm, Necator americanus, respectively. LD50 of the crude hydroalcoholic extract was determined using Swiss albino mice following the OECD guidelines. Chemical characterization of the isolated embelin was conducted using UV-spectroscopy, HPLC and NMR. RESULTS: In the acute toxicity study no prominent signs of toxicity and mortality were recorded among the experimental animals at the highest administered dose. Hence the LD50 of the plant was found to be higher than 5000 mg/kg. In vivo cestocidal activity of the crude hydroalcoholic extract of E. schimperi showed 100% parasite clearance at 1000 mg/kg, while the diammonium salt of embelin showed 85.3% parasite clearance at 750 mg/kg. The in vitro anthelminthic activity study revealed that the LC50 value of the crude extract and albendazole were 228.7 and 51.33 µg/mL, respectively. CONCLUSION: The results clearly indicated that the hydroalcoholic extract of E. schimperi and the diammonium salt of the isolated compound embelin had anthelmintic activity against hookworm larva in vitro and H. nana in vivo. Hence the findings of this study showed Embelia schimperi appears to possess some anthelmintic activity that may support the usage of these plants by local traditional healers to treat helminthic infestations.
[Mh] Termos MeSH primário: Anti-Helmínticos
Embelia/química
Extratos Vegetais
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/química
Anti-Helmínticos/farmacologia
Etiópia
Himenolepíase/parasitologia
Hymenolepis nana/efeitos dos fármacos
Camundongos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Plant Extracts)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150620
[Lr] Data última revisão:
150620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150619
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0711-7


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[PMID]:25818695
[Au] Autor:Shirole RL; Shirole NL; Saraf MN
[Ad] Endereço:Department of Pharmacology, A. R. A. College of Pharmacy, Dhule, Maharashtra, India. Electronic address: rahulshirole@rediffmail.com.
[Ti] Título:Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome.
[So] Source:J Ethnopharmacol;168:356-63, 2015 Jun 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Embelia ribes Burm. f. (Fam. Myrsinaceae) locally known as Vidanga have been used for treating tumors, ascites, bronchitis, jaundice, diseases of the heart and brain in traditional Indian medicine. However, no scientific studies providing new insights in its pharmacological properties with respect to acute respiratory distress syndrome have been investigated. AIM: The present investigation aimed to elucidate the effectiveness of Embelin isolated from Embelia ribes seeds on attenuation of LPS-induced acute respiratory distress syndrome in murine models. METHODS: Embelin (5, 10 and 20 mg/kg/day, i.p.) and Roflumilast (1 mg/kg/day, p.o.) were administered for four days and prior to LPS in rats (i.t.). Four hour after LPS challenge animals were anesthesized and bronchoalveolar lavage was done with ice-cold phosphate buffer. Assessment of BAL fluid was done for albumin, total protein, total cell and neutrophil count, TNF-α levels, nitrosoative stress. Superior lobe of right lung was used for histopathologic evaluation. Inferior lobe of right lung was used to obtain lung edema. Left lung was used for myeloperoxidase estimation. Arterial blood was collected immediately and analyzed for pH, pO2 and pCO2 were estimated. RESULTS: Pretreatment with embelin (5, 10 and 20 mg/kg, i.p.) decreased lung edema, mononucleated cellular infiltration, nitrate/nitrite, total protein, albumin concentrations, TNF-α in the bronchoalveolar lavage fluid and myeloperoxidase activity in lung homogenate. Embelin markedly prevented pO2 down-regulation and pCO2 augmentation. Additionally, it attenuated lung histopathological changes in acute respiratory distress syndrome model. CONCLUSION: The study demonstrates the effectiveness of Embelia ribes Burm. f. (Fam. Myrsinaceae) seeds in acute respiratory distress syndrome possibly related to its anti-inflammatory and protective effect against LPS induced airway inflammation by reducing nitrosative stress, reducing physiological parameters of blood gas change, TNF-α and mononucleated cellular infiltration indicating it as a potential therapeutic agent for acute respiratory distress syndrome.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Benzoquinonas/uso terapêutico
Embelia
Síndrome do Desconforto Respiratório do Adulto/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Benzoquinonas/isolamento & purificação
Benzoquinonas/farmacologia
Líquido da Lavagem Broncoalveolar/química
Líquido da Lavagem Broncoalveolar/citologia
Contagem de Células
Edema/tratamento farmacológico
Edema/metabolismo
Edema/patologia
Feminino
Lipopolissacarídeos
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Pulmão/patologia
Nitratos/metabolismo
Nitritos/metabolismo
Peroxidase/metabolismo
Fitoterapia
Ratos
Ratos Sprague-Dawley
Síndrome do Desconforto Respiratório do Adulto/metabolismo
Síndrome do Desconforto Respiratório do Adulto/patologia
Sementes
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzoquinones); 0 (Lipopolysaccharides); 0 (Nitrates); 0 (Nitrites); 0 (Tumor Necrosis Factor-alpha); EC 1.11.1.7 (Peroxidase); SHC6U8F5ER (embelin)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150524
[Lr] Data última revisão:
150524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150331
[St] Status:MEDLINE


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[PMID]:25527005
[Au] Autor:Dang PH; Nguyen NT; Nguyen HX; Nguyen LB; Le TH; Do TN; Can MV; Nguyen MT
[Ad] Endereço:Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
[Ti] Título:α-Glucosidase inhibitors from the leaves of Embelia ribes.
[So] Source:Fitoterapia;100:201-7, 2015 Jan.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel and rare 1,4-dehydrated ceramide, embelamide (1), and a new C-glycoalkaloid which is based on a ß-carboline ring system, 1-(2'-deoxy-α-d-ribopyranosyl)-ß-carboline (4), were isolated from the CHCl3 soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds (2-3, 5-15). Their structures were elucidated on the basis of spectroscopic data. Compounds 1, and 5-12 possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 1.3 to 155.0 µM, than that of a positive control acarbose (IC50, 214.5 µM).
[Mh] Termos MeSH primário: Ceramidas/química
Embelia/química
Inibidores de Glicosídeo Hidrolases/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Ceramidas/isolamento & purificação
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ceramides); 0 (Glycoside Hydrolase Inhibitors); 0 (embelamide)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:150127
[Lr] Data última revisão:
150127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141221
[St] Status:MEDLINE


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[PMID]:25240254
[Au] Autor:Singh B; Guru SK; Sharma R; Bharate SS; Khan IA; Bhushan S; Bharate SB; Vishwakarma RA
[Ad] Endereço:Natural Products Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180001, India.
[Ti] Título:Synthesis and anti-proliferative activities of new derivatives of embelin.
[So] Source:Bioorg Med Chem Lett;24(20):4865-70, 2014 Oct 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Embelin (1), a benzoquinone isolated from Embelia ribes is known to possess variety of biological activities. Despite of several promising biological activities, preclinical efforts on embelin were hampered because of its poor aqueous solubility. In order to address the solubility issue, herein, we have synthesized a series of Mannich products of embelin by treating it with various secondary amines. The synthesized compounds were screened for antiproliferative and antimicrobial activities. In cytotoxicity screening, the benzyl-piperidine linked derivative 8m was found to possess better antiproliferative activity compared to parent natural product embelin against a panel of cell lines including HCT-116, MCF-7, MIAPaCa-2 and PC-3 with IC50 values of 30, 41, 34 and 36 µM, respectively. The mechanistic study of compound 8m revealed that it exhibits cytotoxicity via induction of apoptosis and mitochondrial membrane potential loss. Further, the compounds were tested for antimicrobial activity where dimethylamino- 8a and piperidine linked derivative 8b displayed antibacterial activity against Staphylococcus aureus with MIC values of 8 and 16 µg/mL, respectively. Mannich derivatives did now show improved aqueous solubility, however their hydrochloride salts 8a·HCl, 8b·HCl and 8m·HCl showed significantly improved aqueous solubility without affecting biological activities of parent Mannich derivatives.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Benzoquinonas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Antineoplásicos Fitogênicos/síntese química
Antineoplásicos Fitogênicos/química
Benzoquinonas/síntese química
Benzoquinonas/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Embelia/química
Células HCT116
Seres Humanos
Células MCF-7
Testes de Sensibilidade Microbiana
Estrutura Molecular
Staphylococcus aureus/efeitos dos fármacos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Benzoquinones); SHC6U8F5ER (embelin)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140922
[St] Status:MEDLINE


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[PMID]:25172792
[Au] Autor:Joy B; Nishanth Kumar S; Soumya MS; Radhika AR; Vibin M; Abraham A
[Ad] Endereço:Agroprocessing and Natural Product Division, National Institute for Interdisciplinary Sciences and Technology (CSIR), Thiruvananthapuram 695 019, Kerala, India. Electronic address: bjoy1571@gmail.com.
[Ti] Título:Embelin (2,5-dihydroxy-3-undecyl-p-benzoquinone): a bioactive molecule isolated from Embelia ribes as an effective photodynamic therapeutic candidate against tumor in vivo.
[So] Source:Phytomedicine;21(11):1292-7, 2014 Sep 25.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present study was carried out to assess the photosensitizing potential of embelin, the biologically active natural product isolated from Embelia ribes in photodynamic therapy (PDT) experiments in vivo. In vitro PDT clearly indicated that embelin recorded significant cytotoxicity in Ehrlich's Ascites Carcinoma (EAC) cells, which is superior to 5-aminolevulinic acid, a known photodynamic compound. For in vivo experiments solid tumor was induced using EAC cells in the male Swiss albino mice of groups I, II, III and IV. Group I served as the control (without solid tumor), group II served as tumor bearing mice without treatment and groups III and IV served as treatments. At the completion of 4 weeks of induction, the tumor bearing mice from group III and IV were given an intraperitoneal injection with embelin (12.5mg/kg body weight). After 24h, tumor area in the Group III and IV animals was exposed to visible light from a 1,000 W halogen lamp. The mice from groups I to III were sacrificed 2 weeks after the PDT treatment and the marker enzymes (myeloperoxidase [MPO], ß-d-glucuronidase, and rhodanese) were assayed and expression of Bcl-2 and Bax were analyzed in normal and tumor tissues. Animals from group IV were sacrificed after 90 days of PDT treatment and the above mentioned parameters were recorded. Reduction in tumor volume and reversal of biochemical markers to near normal levels were observed in the treated groups. This is the first report on PDT using a natural compound for solid tumor control in vivo. The uniqueness of the mode of treatment lies in the selective uptake of the nontoxic natural compound, embelin from the medicinal plant E. ribes used in Indian system of medicine, by the solid tumor cells and their selective destruction using PDT without affecting the neighboring normal cells, which is much advantageous over radiation therapy now frequently used.
[Mh] Termos MeSH primário: Benzoquinonas/farmacologia
Carcinoma de Ehrlich/tratamento farmacológico
Embelia/química
Fotoquimioterapia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzoquinones); SHC6U8F5ER (embelin)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140831
[St] Status:MEDLINE


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[PMID]:24849650
[Au] Autor:Dang PH; Nguyen HX; Nguyen NT; Le HN; Nguyen MT
[Ad] Endereço:Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Vietnam.
[Ti] Título:α-Glucosidase inhibitors from the stems of Embelia ribes.
[So] Source:Phytother Res;28(11):1632-6, 2014 Nov.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the ethyl acetate extract of the stems of Embelia ribes (Myrsinaceae), a new alkenylresorcinol, embeliphenol A (1), together with 11 known compounds have been isolated. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, except for 2 and 9. Compounds 1, 3-6, 8, and 12 showed more potent inhibitory activity, with IC50 values ranging from 10.4 to 116.7 µM, than that of a positive control acarbose (IC50 , 214.5 µM).
[Mh] Termos MeSH primário: Embelia/química
Inibidores de Glicosídeo Hidrolases/química
Extratos Vegetais/química
Caules de Planta/química
Resorcinóis/química
[Mh] Termos MeSH secundário: Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Estrutura Molecular
Resorcinóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycoside Hydrolase Inhibitors); 0 (Plant Extracts); 0 (Resorcinols); 0 (embeliphenol A)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:141027
[Lr] Data última revisão:
141027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140523
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5175


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[PMID]:24392738
[Au] Autor:Lulekal E; Rondevaldova J; Bernaskova E; Cepkova J; Asfaw Z; Kelbessa E; Kokoska L; Van Damme P
[Ad] Endereço:Laboratory for Tropical and Subtropical Agriculture and Ethnobotany, Department of Plant Production, Faculty of Bio-Science Engineering, Ghent University , Gent , Belgium .
[Ti] Título:Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia.
[So] Source:Pharm Biol;52(5):614-20, 2014 May.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Traditional medicinal plants have long been used in Ethiopia to treat human and livestock ailments. Despite a well-documented rich tradition of medicinal plant use in the country, their direct antimicrobial effects are still poorly known. OBJECTIVE: To investigate the antimicrobial activity of 19 medicinal plant species that were selected based on the ethnobotanical information on their traditional use to treat infectious diseases in Ankober District. METHODS: About 23 different ethanol extracts of plants obtained by maceration of various parts of 19 medicinal plant species were studied for potential antimicrobial activity using a broth microdilution method against Bacillus cereus, Bacteroides fragilis, Candida albicans, Clostridium perfringens, Enterococcus faecalis, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, Salmonella enteritidis, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes. RESULTS: Plant extracts from Embelia schimperi Vatke (Myrsinaceae) showed the strongest antibacterial activity with a minimum inhibitory concentration (MIC) value of 64 µg/ml against B. cereus, L. monocytogenes, and S. pyogenes. Growth inhibitory activities were also observed for extracts of Ocimum lamiifolium Hochst. (Lamiaceae) against S. pyogenes, and those of Rubus steudneri Schweinf. (Rosaceae) against S. epidermidis at an MIC value of 128 µg/ml. Generally, 74% of ethanol extracts (17 extracts) showed antimicrobial activity against one or more of the microbial strains tested at an MIC value of 512 µg/ml or below. DISCUSSION AND CONCLUSIONS: Results confirm the antimicrobial role of traditional medicinal plants of Ankober and warrant further investigations on promising medicinal plant species so as to isolate and characterise chemicals responsible for the observed strong antimicrobial activities.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Embelia/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Embelia/crescimento & desenvolvimento
Etiópia
Testes de Sensibilidade Microbiana
Extratos Vegetais/isolamento & purificação
Plantas Medicinais/crescimento & desenvolvimento
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140408
[Lr] Data última revisão:
140408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140108
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.858362



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