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Pesquisa : B01.650.940.800.575.912.250.342 [Categoria DeCS]
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[PMID]:27556451
[Au] Autor:Dos Santos Ramos MA; de Toledo LG; Calixto GM; Bonifácio BV; de Freitas Araújo MG; Dos Santos LC; de Almeida MT; Chorilli M; Bauab TM
[Ad] Endereço:Department of Biological Sciences, School of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, São Paulo 14800-903, Brazil. matheusramos_91@hotmail.com.
[Ti] Título:Syngonanthus nitens Bong. (Rhul.)-Loaded Nanostructured System for Vulvovaginal Candidiasis Treatment.
[So] Source:Int J Mol Sci;17(8), 2016 Aug 22.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Herbal-loaded drug delivery nanotechnological systems have been extensively studied recently. The antimicrobial activity of medicinal plants has shown better pharmacological action when such plants are loaded into a drug delivery system than when they are not loaded. Syngonanthus nitens Bong. (Rhul.) belongs to the Eriocaulaceae family and presents antiulcerogenic, antioxidant, antibacterial, and antifungal activity. The aim of this study was to evaluate the antifungal activity of Syngonanthus nitens (S. nitens) extract that was not loaded (E) or loaded (SE) into a liquid crystal precursor system (S) for the treatment of vulvovaginal candidiasis (VVC) with Candida albicans. The minimal inhibitory concentration (MIC) was determined by the microdilution technique. Additionally, we performed hyphae inhibition and biofilm tests. Finally, experimental candidiasis was evaluated in in vivo models with Wistar female rats. The results showed effective antifungal activity after incorporation into S for all strains tested, with MICs ranging from 31.2 to 62.5 µg/mL. Microscopic observation of SE revealed an absence of filamentous cells 24 h of exposure to a concentration of 31.2 µg/mL. E demonstrated no effective action against biofilms, though SE showed inhibition against biofilms of all strains. In the in vivo experiment, SE was effective in the treatment of infection after only two days of treatment and was more effective than E and amphotericin B. The S. nitens is active against Candida albicans (C. albicans) and the antifungal potential is being enhanced after incorporation into liquid crystal precursor systems (LCPS). These findings represent a promising application of SE in the treatment of VVC.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Candidíase Vulvovaginal/tratamento farmacológico
Eriocaulaceae/química
Nanoestruturas/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Candida albicans/efeitos dos fármacos
Candida albicans/patogenicidade
Candidíase Vulvovaginal/microbiologia
Sistemas de Liberação de Medicamentos/métodos
Feminino
Extratos Vegetais/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


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[PMID]:26912176
[Au] Autor:Fernando CD; Soysa P
[Ad] Endereço:Department of Biochemistry & Molecular Biology, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo, 08, Sri Lanka. dilankafdo86@gmail.com.
[Ti] Título:Evaluation of Hepatoprotective activity of Eriocaulon quinquangulare in vitro using porcine liver slices against ethanol induced liver toxicity and free radical scavenging capacity.
[So] Source:BMC Complement Altern Med;16:74, 2016 Feb 24.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Production of reactive oxygen species is a common cause in alcohol induced liver diseases. Decoction prepared from the whole plant of Eriocaulon quinquingulare is prescribed to treat liver disorders. The aim of this study was to investigate the hepatoprotective activity and antioxidant capacity of the water extract of E. quinquangulare in vitro. METHOD: The aqueous extract of the whole plant of E. quinquangulare (AEQ) was investigated for its phytochemical constituents, antioxidant and membrane stabilization properties in-vitro. The antioxidant activities of AEQ were investigated using 1,1-Diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical, nitric oxide scavenging and ferric reducing antioxidant power (FRAP) assays. Membrane stabilizing effect of the extract was determined by hypotonic solution induced human erythrocyte hemolytic assay (HEHA). Further, hepatoprotective activity against ethanol induced hepatotoxicity was carried out using porcine liver slices. RESULTS: The total phenolics and flavonoids were 10.3 ± 1.6 w/w % gallic acid equivalents and 45.6 ± 3.8 w/w % (-)-epigallocatechin gallate equivalents respectively. The values of EC50 for DPPH, hydroxyl radical and nitric oxide scavenging assays were 37.2 ± 1.7 µg/ml, 170.5 ± 6.6 µg/ml and 31.8 ± 2.2 µg/ml respectively. The reducing capability of AEQ was 6.9 ± 0.2 w/w % L-ascorbic acid equivalents in the FRAP assay. For hypotonic solution induced HEHA, the IC50 was 1.79 ± 0.04 mg/ml. A significant decrease (p < 0.05) was observed in ALT, AST and LDH release from the liver slices treated with AEQ compared to the ethanol treated liver slices. A significant reduction in lipid peroxidation (p < 0.05) was also observed in liver slices treated with the plant extract compared to that of the ethanol treated liver slices. CONCLUSIONS: The results suggest AEQ possess hepatoprotective activity against ethanol induced liver toxicity of porcine liver slices which can be attributed to antioxidant properties and membrane stabilizing effects caused by the plant material.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Doença Hepática Induzida por Substâncias e Drogas
Eriocaulaceae/química
Flavonoides/farmacologia
Fígado/efeitos dos fármacos
Fenóis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/uso terapêutico
Compostos de Bifenilo/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Membrana Eritrocítica/efeitos dos fármacos
Etanol/efeitos adversos
Flavonoides/análise
Flavonoides/uso terapêutico
Radicais Livres/metabolismo
Seres Humanos
Técnicas In Vitro
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/metabolismo
Óxido Nítrico/metabolismo
Estresse Oxidativo
Fenóis/análise
Fenóis/uso terapêutico
Fitoterapia
Picratos/metabolismo
Extratos Vegetais/uso terapêutico
Suínos
Transaminases/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Free Radicals); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); 3K9958V90M (Ethanol); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 2.6.1.- (Transaminases)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1044-x


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[PMID]:26719688
[Au] Autor:dos Santos Ramos MA; Calixto G; de Toledo LG; Bonifácio BV; dos Santos LC; de Almeida MT; Chorilli M; Bauab TM
[Ad] Endereço:Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil.
[Ti] Título:Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Ruhland against infection by Candida krusei.
[So] Source:Int J Nanomedicine;10:7455-66, 2015.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Vaginal infections caused by Candida krusei are a problem of extreme complexity due to the intrinsic resistance to azole drugs. The species Syngonanthus nitens (Bong.) Ruhland is a plant of the Eriocaulaceae family that has demonstrated promising antifungal activity. In phyto-formulation research, liquid crystal precursor mucoadhesive systems (LCPM) stand out as drug delivery systems for vaginal administration because they increase the activity and overcome the problems associated with plant-based medicines. Therefore, the objective of this study was to evaluate the potential of the methanolic extract of scapes of S. nitens (S. nitens extract [SNE]) and an SNE-loaded LCPM against C. krusei as prophylaxis for vulvovaginal candidiasis. LCPM formulation developed consisted of oleic acid as the oil phase (50% w/w), polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol (40% w/w) as the surfactant and a polymeric dispersion containing 2.5% Carbopol(®) 974P and 2.5% polycarbophil (10% w/w) as the aqueous phase. LCPM formulation developed was characterized using polarized light microscopy, rheological analysis, and in vitro mucoadhesive studies. Different strains of C. krusei, including one standard strain (American Type Culture Collection 6258) and three clinically isolated strains from the vaginal region (CKV1, 2, and 3), were used to determine the minimum inhibitory concentration, inhibition of biofilms, and time kill. The in vivo prophylaxis assay was performed using the standard strain (American Type Culture Collection 6258). The analyses of F by polarized light microscopy and rheology showed isotropy; however, the addition of 100% artificial vaginal mucus (F100) made it more viscous and anisotropic. Moreover, the mucoadhesive strength was modified, which makes F an excellent formulation for vaginal applications. SNE was active against all strains studied, with minimum inhibitory concentration values ranging from 125 to 62.5 µg/mL; after incorporating SNE into F (FE), these values decreased to 62.5 to 31.2 µg/mL, demonstrating that incorporation into the formulation potentiated the action of SNE. Additionally, the time kill assays showed that both forms of SNE were capable of controlling growth, thereby suggesting a possible fungistatic mechanism. Unloaded SNE was not active against C. krusei biofilms, but FE was active against a clinical strain (CKV2). In vivo analysis showed that FE was able to prevent the development of infection following 10 days of administration. We concluded that the formulation developed in this study was an important vehicle for the delivery of SNE based on the improved antifungal activity in all in vitro and in vivo analyses. Furthermore, the extract incorporated into the system may serve as an important prophylactic agent against vaginal infections caused by C. krusei.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida/efeitos dos fármacos
Candidíase Vulvovaginal/tratamento farmacológico
Sistemas de Liberação de Medicamentos
Eriocaulaceae/química
Cristais Líquidos
Muco/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibioticoprofilaxia
Antifúngicos/química
Candidíase Vulvovaginal/microbiologia
Portadores de Fármacos
Feminino
Testes de Sensibilidade Microbiana
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Drug Carriers); 0 (Plant Extracts)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160101
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S92638


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[PMID]:26559183
[Au] Autor:Watanabe MT; Hensold N; Sano PT
[Ad] Endereço:Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
[Ti] Título:Syngonanthus androgynus, a Striking New Species from South America, its Phylogenetic Placement and Implications for Evolution of Bisexuality in Eriocaulaceae.
[So] Source:PLoS One;10(11):e0141187, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present study, we describe and illustrate a remarkable new species of Syngonanthus from South America (Bolivia, Brazil and Peru). This new species is quickly distinguished from all species in the genus by trimerous and bisexual flowers, a unique set of characteristics in Syngonanthus. Complementary to this study, sequences of 33 species were downloaded from GenBank and four species had sequences newly generated for this study. Molecular phylogenetic analyses based on nuclear ribosomal ITS and the plastid regions psbA-trnH and trnL-F were performed to determine its systematic position. The results have shown S. androgynus closely related to a well-supported clade that has been treated as Syngonanthus sect. Carphocephalus. Floral traits associated with this new plant also were surveyed. Character reconstruction suggests that the bisexual flowers originated independently more than once in the genus. However, trimerous flowers appear to be an ancestral condition of the whole genus.
[Mh] Termos MeSH primário: Evolução Biológica
Eriocaulaceae/fisiologia
Filogenia
[Mh] Termos MeSH secundário: Eriocaulaceae/classificação
Flores/fisiologia
Meristema/fisiologia
Dados de Sequência Molecular
América do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0141187


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Vilegas, Wagner
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[PMID]:26511617
[Au] Autor:Batista LM; Lima GR; De Almeida AB; Magri Lde P; Calvo TR; Ferreira AL; Pellizzon CH; Hiruma-Lima CA; Vilegas W; Sano PT; Brito AR
[Ad] Endereço:Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Laboratório de Farmacologia do Trato Gastrintestinal, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil. leoniab@uol.com.br.
[Ti] Título:Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus.
[So] Source:BMC Complement Altern Med;15:391, 2015 Oct 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Syngonanthus arthrotrichus and Syngonanthus bisulcatus, currently known for Comanthera aciphylla (Bong.) L.R.Parra & Giul. and Comanthera bisulcata (Koern.) L.R. Parra & Giul, popularly known in Brazil as "sempre-vivas," are plants from the family Eriocaulaceae. They are found in the states of Minas Gerais and Bahia. The species are known to be rich in flavonoids to which their gastroprotective activity has been attributed. In this research, experimental protocols were performed to elucidate the associated mechanisms of action. METHODS: The activity was evaluated using induced gastric ulcer models (acetic acid and ethanol-induced gastric lesions in NEM or L-NAME pre-treated mice, and by ischemia/reperfusion). Antioxidant enzymes, serum somatostatin, and gastrin were also evaluated. RESULTS: In chronic gastric ulcers, a single daily oral dose of Sa-FRF or Sb-FRF (100 mg/kg body wt.) for 14 consecutive days accelerated ulcer healing to an extent similar to that seen with an equal dose of cimetidine. The pre-treatment of mice with NEM (N-ethylmaleimide) or L-NAME (N-nitro-L-arginine) abolished the protective activity of Sa-FRF, Sa-FDF, Sb-FDF and Sb-FRF or Sa-FRF and Sb-FRF, respectively, which indicates that antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective. Sa-FRF and Sb-FRF (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by ischemia/reperfusion (72 and 76 %, respectively). It also decreased lipid peroxidation and restored total thiols in the gastric wall of mice that had been treated with ethanol. When administered to rats submitted to ethanol-induced gastric lesions, Sa-FRF and Sb-FRF (100 mg/kg, p.o.) increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. CONCLUSIONS: The results indicate significant healing effects and gastroprotective activity for the Sa-FRF and Sb-FRF, which probably involves the participation of SH groups, nitric oxide (NO), the antioxidant system, somatostatin, and gastrin. All are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.
[Mh] Termos MeSH primário: Antiulcerosos/administração & dosagem
Eriocaulaceae/química
Extratos Vegetais/administração & dosagem
Substâncias Protetoras/administração & dosagem
Úlcera Gástrica/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/metabolismo
Seres Humanos
Masculino
Camundongos
Óxido Nítrico/metabolismo
Ratos
Ratos Wistar
Úlcera Gástrica/metabolismo
Úlcera Gástrica/fisiopatologia
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Plant Extracts); 0 (Protective Agents); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0923-x


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[PMID]:26369427
[Au] Autor:Fan Y; Lu H; Ma H; Feng F; Hu X; Zhang Q; Wang J; Xu Y; Zhao Q
[Ad] Endereço:School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. zhaoqingchun1967@163.com ynxu@syphu.edu.cn and Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China. zhaoqingchun1967@163.com.
[Ti] Título:Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition.
[So] Source:Food Funct;6(12):3746-59, 2015 Dec.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eriocaulon sieboldianum (Sieb. & Zucc. ex Steud.) is an edible and medicinal plant used in traditional Chinese medicine. Often in combination with other herbs, it is processed into healthcare beverages for expelling wind-heat, protecting eyes, and reducing blood lipids. Besides, its water decoction together with other herbs has been utilized to treat cancer in China. However, the active ingredients and the precise cellular mechanisms of E. sieboldianum remain to be elucidated. The Aurora kinase family plays critical roles in the regulation of cell division and has attracted great attention to the identification of small-molecule Aurora kinase inhibitors for potential treatment of cancer. A molecular docking study was employed for docking of the most bioactive compounds. Hispidulin (HPDL) and quercetin-3-O-(6''-O-galloyl)-ß-D-galactopyranoside (QGGP) were singled out as potent inhibitors of Aurora kinase. Their inhibitory activity towards Aurora kinase was further confirmed by the obvious decrease in autophosphorylation of Aurora-A (Thr288) and Aurora-B (Thr232). Moreover, the induction of cell cycle arrest in HepG2 cells and the suppressed phosphorylation of histone H3 were also consistent with the inhibition of Aurora kinase. The data indicate that the E. sieboldianum extract and its two active compounds, HPDL and QGGP, could effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways. These findings could improve the understanding and enhance the development of drugs based on E. sieboldianum and raise its application value in anticancer therapy or prevention. In addition, our results indicated that Aurora kinase might be a novel target of HPDL and QGGP.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Eriocaulaceae/química
Extratos Vegetais/farmacologia
Inibidores de Proteínas Quinases/farmacologia
[Mh] Termos MeSH secundário: Aurora Quinase A/antagonistas & inibidores
Aurora Quinase A/metabolismo
Aurora Quinase B/antagonistas & inibidores
Aurora Quinase B/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
China
Flavonas/farmacologia
Galactosídeos/farmacologia
Ácido Gálico/análogos & derivados
Ácido Gálico/farmacologia
Células Hep G2
Seres Humanos
Fosforilação
Extratos Vegetais/química
Quercetina/análogos & derivados
Quercetina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavones); 0 (Galactosides); 0 (Plant Extracts); 0 (Protein Kinase Inhibitors); 0 (quercetin-3-O-(6''-galloyl) beta-D-galactopyranoside); 632XD903SP (Gallic Acid); 9IKM0I5T1E (Quercetin); EC 2.7.11.1 (Aurora Kinase A); EC 2.7.11.1 (Aurora Kinase B); N7F61604C2 (hispidulin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150916
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo00371g


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[PMID]:25298094
[Au] Autor:Jung Y; Shin SY; Yong Y; Jung H; Ahn S; Lee YH; Lim Y
[Ad] Endereço:Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul, 143-701, Korea.
[Ti] Título:Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships.
[So] Source:Chem Biol Drug Des;85(5):574-85, 2015 May.
[Is] ISSN:1747-0285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although several plant-derived flavones inhibit aurora B kinase (aurB), quantitative relationships between the structural properties of plant-derived flavones and their inhibitory effects on aurB remain unclear. In this report, these quantitative structure-activity relationships were obtained. For quercetagetin, found in the Eriocaulon species, showing the best IC50 value among the flavone derivatives tested in this report, further biological tests were performed using cell-based assays, including Western blot analysis, flow cytometry, and immunofluorescence microscopy. In vitro cellular experiments demonstrated that quercetagetin inhibits aurB. The molecular-binding mode between quercetagetin and aurB was elucidated using in silico docking. Quercetagetin binds to aurB, aurA, and aurC and prevents the active phosphorylation of all three aurora kinases. In addition, quercetagetin triggers mitotic arrest and caspase-mediated apoptosis. These observations suggest that quercetagetin is an aurora kinase inhibitor. Induction of mitosis-associated tumor cell death by quercetagetin is a promising strategy for developing novel chemotherapeutic anticancer agents.
[Mh] Termos MeSH primário: Aurora Quinase B/antagonistas & inibidores
Flavonas/química
Inibidores de Proteínas Quinases/química
Relação Quantitativa Estrutura-Atividade
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Aurora Quinase A/antagonistas & inibidores
Aurora Quinase A/metabolismo
Aurora Quinase B/metabolismo
Aurora Quinase C/antagonistas & inibidores
Aurora Quinase C/metabolismo
Sítios de Ligação
Cromonas/química
Cromonas/isolamento & purificação
Cromonas/toxicidade
Eriocaulaceae/química
Eriocaulaceae/metabolismo
Flavonas/isolamento & purificação
Flavonas/toxicidade
Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos
Células HCT116
Seres Humanos
Pontos de Checagem da Fase M do Ciclo Celular/efeitos dos fármacos
Microscopia de Fluorescência
Simulação de Acoplamento Molecular
Fosforilação/efeitos dos fármacos
Inibidores de Proteínas Quinases/isolamento & purificação
Inibidores de Proteínas Quinases/toxicidade
Estrutura Terciária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chromones); 0 (Flavones); 0 (Protein Kinase Inhibitors); EC 2.7.11.1 (Aurora Kinase A); EC 2.7.11.1 (Aurora Kinase B); EC 2.7.11.1 (Aurora Kinase C); S2V45N7G3B (flavone); SV68G507VO (quercetagetin)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141010
[St] Status:MEDLINE
[do] DOI:10.1111/cbdd.12445


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Texto completo SciELO Brasil
[PMID]:25627592
[Au] Autor:Coelho FF; Martins RP; Figueira JE; Demetrio GR
[Ad] Endereço:Departamento de Biologia, Setor de Botânica, Universidade Federal de Lavras - UFLA, Campus Universitário, Lavras, MG, Brazil.
[Ti] Título:Soil factors effects on life history attributes of Leiothrix spiralis and Leiothrix vivipara (Eriocaulaceae) on rupestrian grasslands in Southeastern Brazil.
[So] Source:Braz J Biol;74(4):828-36, 2014 Nov.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:In this study, we hypothesized that the life history traits of Leiothrix spiralis and L. vivipara would be linked to soil factors of the rupestrian grasslands and that rosette size would be influenced by soil moisture. Soil analyses were performed from five populations of L. spiralis and four populations of L. vivipara. In each area, three replicates were employed in 19 areas of occurrence of Leiothrix species, and we quantified the life history attributes. The microhabitats of these species show low favorability regarding to soil factors. During the dry season, their rosettes decreased in diameter due the loss of its most outlying leaves. The absence of seedlings indicated the low fecundity of both species. However, both species showed rapid population growth by pseudovivipary. Both L. spiralis and L. vivipara exhibit a kind of parental care that was quantified by the presence of connections between parental-rosettes and ramets. The findings of the present study show that the life history traits are linked to soil factors.
[Mh] Termos MeSH primário: Eriocaulaceae/crescimento & desenvolvimento
Solo
[Mh] Termos MeSH secundário: Brasil
Eriocaulaceae/classificação
Umidade
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150129
[St] Status:MEDLINE


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[PMID]:25296228
[Au] Autor:Demetrio GR; Coelho FF; Barbosa ME
[Ad] Endereço:Departamento de Biologia, Setor de Ecologia, Universidade Federal de Lavras - UFLA, Campus Universitário, Lavras, MG, Brazil.
[Ti] Título:Body size and clonality consequences for sexual reproduction in a perennial herb of Brazilian rupestrian grasslands.
[So] Source:Braz J Biol;74(3):744-9, 2014 Aug.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Body size is one of the most important factors regarding herbaceous perennial plants life-histories, and several fitness components of these organisms are related to size. Clonal plants show distinct kinds of reproduction and can develop offspring by sexual or asexual ways. We aimed to understand how body size affects Comanthera nivea (Eriocaulaceae) sexual reproduction and to verify how clonal growth is related to flower head production in this species. We sampled 600 rosettes in rupestrian grasslands and performed linear regression analysis between body size and number of produced flower heads. We also compared the flower head production between isolated rosettes and rosettes within clones. Our results showed that body size was significantly related, but explained only a small part of flower head production. The flower head production was higher in rosettes within clones than in isolated ones. The clones presented a rosette or a small group of rosettes that concentrated the sexual reproduction. Clonality was positively associated with sexual reproduction. Clonality can represent an important way of allowing the persistence of plants by sexual reproduction in markedly seasonal stressful environments. The cases of clonality enhancing the sexual reproduction must be considered and put in focus on reproductive biology research.
[Mh] Termos MeSH primário: Eriocaulaceae/anatomia & histologia
Eriocaulaceae/fisiologia
[Mh] Termos MeSH secundário: Brasil
Eriocaulaceae/classificação
Flores/crescimento & desenvolvimento
Reprodução/fisiologia
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1503
[Cu] Atualização por classe:141009
[Lr] Data última revisão:
141009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141009
[St] Status:MEDLINE


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[PMID]:24237033
[Au] Autor:Batista LM; de Almeida AB; Lima GR; Falcão Hde S; Magri Lde P; Luiz-Ferreira A; dos Santos LC; Hiruma-Lima CA; Vilegas W; Brito AR
[Ad] Endereço:Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Laboratório de Farmacologia do Trato Gastrintestinal, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil; Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
[Ti] Título:Gastroprotective effects (in rodents) of a flavonoid rich fraction obtained from Syngonanthus macrolepsis.
[So] Source:J Pharm Pharmacol;66(3):445-52, 2014 Mar.
[Is] ISSN:2042-7158
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Syngonanthus macrolepis, popularly known in Brazil as 'sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S. macrolepis was investigated for preventing gastric ulceration in mice and rats. METHODS: The activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated. KEY FINDINGS: The Sm-FRF (100 mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation. CONCLUSIONS: The results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.
[Mh] Termos MeSH primário: Antiulcerosos/uso terapêutico
Antioxidantes/uso terapêutico
Eriocaulaceae/química
Flavonoides/uso terapêutico
Fitoterapia
Extratos Vegetais/uso terapêutico
Úlcera Gástrica/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Antiulcerosos/farmacologia
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Modelos Animais de Doenças
Flavonoides/farmacologia
Suco Gástrico
Mucosa Gástrica/efeitos dos fármacos
Ligadura
Camundongos
Camundongos Endogâmicos
Óxido Nítrico/metabolismo
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
Úlcera Gástrica/etiologia
Úlcera Gástrica/metabolismo
Compostos de Sulfidrila/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Sulfhydryl Compounds); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140218
[Lr] Data última revisão:
140218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131119
[St] Status:MEDLINE
[do] DOI:10.1111/jphp.12175



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