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Pesquisa : B01.650.940.800.575.912.250.346.500 [Categoria DeCS]
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[PMID]:27004438
[Au] Autor:Rubio NC; Thurmann D; Krumbiegel F; Pragst F
[Ad] Endereço:Forensic Toxicology Laboratory, Cipolletti, Patagonia, Argentina.
[Ti] Título:Behaviour of hygrine and cuscohygrine in illicit cocaine production establishes their use as markers for chewing coca leaves in contrast with cocaine abuse.
[So] Source:Drug Test Anal;9(2):323-326, 2017 Feb.
[Is] ISSN:1942-7611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hygrine (HYG) and cuscohygrine (CUS) are natural alkaloids of coca leaves but are not found in illicit cocaine seizures. Therefore, they were proposed as markers for coca chewing in contrast to cocaine abuse in urine and hair testing. In order to examine at which step of the illegal cocaine production these compounds are lost, coca leaves were processed according to an authentic procedure by extraction with lime and kerosene, re-extraction with sulphuric acid, and precipitation of coca paste with ammonia. Non-extracted and extracted coca leaves, acidic extract and coca paste were analyzed by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for cocaine, ecgonine methyl ester (EME), cinnamoylcocaine (CIN), HYG, and CUS. It follows from the results that under these conditions, HYG and CUS are extracted only to a minor extent by kerosene and are not precipitated from the acidic re-extract in the coca paste. Due to this behaviour in illegal cocaine production, they fulfil the conditions as markers for coca chewing in an optimal way. However, for unambiguous discrimination between coca chewing and cocaine abuse in human samples, additional markers of manufactured cocaine are required. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Acetona/análogos & derivados
Coca/química
Cocaína/análise
Folhas de Planta/química
Pirrolidinas/análise
[Mh] Termos MeSH secundário: Acetona/análise
Cromatografia Líquida
Cocaína/análogos & derivados
Transtornos Relacionados ao Uso de Cocaína/diagnóstico
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Mastigação
Drogas Ilícitas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pyrrolidines); 0 (Street Drugs); 1364PS73AF (Acetone); 49H1LNM62X (hygrine); 93FJ3823VL (cuscohygrine); I5Y540LHVR (Cocaine); O3I44O988U (cinnamoylcocaine); Y35FJB3QBJ (ecgonine methyl ester)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1002/dta.1972


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[PMID]:27716065
[Au] Autor:Luck K; Jirschitzka J; Irmisch S; Huber M; Gershenzon J; Köllner TG
[Ad] Endereço:Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, D-07745, Jena, Germany.
[Ti] Título:CYP79D enzymes contribute to jasmonic acid-induced formation of aldoximes and other nitrogenous volatiles in two Erythroxylum species.
[So] Source:BMC Plant Biol;16(1):215, 2016 Oct 04.
[Is] ISSN:1471-2229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Amino acid-derived aldoximes and nitriles play important roles in plant defence. They are well-known as precursors for constitutive defence compounds such as cyanogenic glucosides and glucosinolates, but are also released as volatiles after insect feeding. Cytochrome P450 monooxygenases (CYP) of the CYP79 family catalyze the formation of aldoximes from the corresponding amino acids. However, the majority of CYP79s characterized so far are involved in cyanogenic glucoside or glucosinolate biosynthesis and only a few have been reported to be responsible for nitrogenous volatile production. RESULTS: In this study we analysed and compared the jasmonic acid-induced volatile blends of two Erythroxylum species, the cultivated South American crop species E. coca and the African wild species E. fischeri. Both species produced different nitrogenous compounds including aliphatic aldoximes and an aromatic nitrile. Four isolated CYP79 genes (two from each species) were heterologously expressed in yeast and biochemically characterized. CYP79D62 from E. coca and CYP79D61 and CYP79D60 from E. fischeri showed broad substrate specificity in vitro and converted L-phenylalanine, L-isoleucine, L-leucine, L-tryptophan, and L-tyrosine into the respective aldoximes. In contrast, recombinant CYP79D63 from E. coca exclusively accepted L-tryptophan as substrate. Quantitative real-time PCR revealed that CYP79D60, CYP79D61, and CYP79D62 were significantly upregulated in jasmonic acid-treated Erythroxylum leaves. CONCLUSIONS: The kinetic parameters of the enzymes expressed in vitro coupled with the expression patterns of the corresponding genes and the accumulation and emission of (E/Z)-phenylacetaldoxime, (E/Z)-indole-3-acetaldoxime, (E/Z)-3-methylbutyraldoxime, and (E/Z)-2-methylbutyraldoxime in jasmonic acid-treated leaves suggest that CYP79D60, CYP79D61, and CYP79D62 accept L-phenylalanine, L-leucine, L-isoleucine, and L-tryptophan as substrates in vivo and contribute to the production of volatile and semi-volatile nitrogenous defence compounds in E. coca and E. fischeri.
[Mh] Termos MeSH primário: Coca/enzimologia
Coca/genética
Ciclopentanos/metabolismo
Sistema Enzimático do Citocromo P-450/genética
Compostos de Nitrogênio/metabolismo
Oximas/metabolismo
Oxilipinas/metabolismo
Proteínas de Plantas/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Coca/metabolismo
Sistema Enzimático do Citocromo P-450/química
Sistema Enzimático do Citocromo P-450/metabolismo
Filogenia
Proteínas de Plantas/química
Proteínas de Plantas/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Alinhamento de Sequência
Especificidade da Espécie
Compostos Orgânicos Voláteis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopentanes); 0 (Nitrogen Compounds); 0 (Oximes); 0 (Oxylipins); 0 (Plant Proteins); 0 (Volatile Organic Compounds); 6RI5N05OWW (jasmonic acid); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27281548
[Au] Autor:González Arbeláez LF; Ciocci Pardo A; Fantinelli JC; Caldiz C; Ríos JL; Schinella GR; Mosca SM
[Ad] Endereço:Centro de Investigaciones Cardiovasculares CCT-CONICET, Universidad Nacional de La Plata , 60 y 120, 1900 La Plata, Argentina.
[Ti] Título:Ex Vivo Treatment with a Polyphenol-Enriched Cocoa Extract Ameliorates Myocardial Infarct and Postischemic Mitochondrial Injury in Normotensive and Hypertensive Rats.
[So] Source:J Agric Food Chem;64(25):5180-7, 2016 Jun 29.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our objective was to determine the effects of a polyphenol-enriched cocoa extract (PCE) on myocardial postischemic alterations in normotensive (Wistar rats, W) and spontaneously hypertensive rats (SHR). Isolated hearts were submitted to 110 min of perfusion or 20 min stabilization, 30 min global ischemia, and 60 min reperfusion (R). Other hearts were treated with PCE at the onset of R. Infarct size, the reduced glutathione (GSH), and the expression of phospho-Akt, P-GSK-3ß, and P-eNOS were assessed. In isolated mitochondria, the Ca(2+)-mediated response of mitochondrial permeability transition pore (mPTP), membrane potential (Δψm), and superoxide production were determined. PCE decreased infarct size, partly preserved GSH, increased the P-Akt, P-GSK-3ß, and P-eNOS contents, improved mPTP response to Ca(2+), decreased the superoxide production, and restored Δψm. These data show that PCE decreases the cardiac postischemic damage in W rats and SHR and suggest that Akt/GSK-3ß/eNOS dependent pathways are involved.
[Mh] Termos MeSH primário: Cardiotônicos/administração & dosagem
Coca/química
Hipertensão/tratamento farmacológico
Isquemia/complicações
Infarto do Miocárdio/complicações
Extratos Vegetais/administração & dosagem
Polifenóis/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/efeitos dos fármacos
Glutationa/metabolismo
Quinase 3 da Glicogênio Sintase/metabolismo
Coração/efeitos dos fármacos
Coração/fisiopatologia
Seres Humanos
Hipertensão/etiologia
Hipertensão/fisiopatologia
Técnicas In Vitro
Masculino
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Proteínas de Transporte da Membrana Mitocondrial/efeitos dos fármacos
Proteínas de Transporte da Membrana Mitocondrial/metabolismo
Miocárdio/metabolismo
Ratos
Ratos Endogâmicos SHR
Ratos Wistar
Superóxidos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 0 (Mitochondrial Membrane Transport Proteins); 0 (Plant Extracts); 0 (Polyphenols); 0 (mitochondrial permeability transition pore); 11062-77-4 (Superoxides); EC 2.7.11.26 (Glycogen Synthase Kinase 3); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b01669


  4 / 227 MEDLINE  
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[PMID]:27006288
[Au] Autor:Mallette JR; Casale JF; Jordan J; Morello DR; Beyer PM
[Ad] Endereço:U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, Dulles, VA 20166 USA.
[Ti] Título:Geographically Sourcing Cocaine's Origin - Delineation of the Nineteen Major Coca Growing Regions in South America.
[So] Source:Sci Rep;6:23520, 2016 Mar 23.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previously, geo-sourcing to five major coca growing regions within South America was accomplished. However, the expansion of coca cultivation throughout South America made sub-regional origin determinations increasingly difficult. The former methodology was recently enhanced with additional stable isotope analyses ((2)H and (18)O) to fully characterize cocaine due to the varying environmental conditions in which the coca was grown. An improved data analysis method was implemented with the combination of machine learning and multivariate statistical analysis methods to provide further partitioning between growing regions. Here, we show how the combination of trace cocaine alkaloids, stable isotopes, and multivariate statistical analyses can be used to classify illicit cocaine as originating from one of 19 growing regions within South America. The data obtained through this approach can be used to describe current coca cultivation and production trends, highlight trafficking routes, as well as identify new coca growing regions.
[Mh] Termos MeSH primário: Alcaloides/química
Coca/classificação
Deutério/análise
Isótopos de Oxigênio/análise
[Mh] Termos MeSH secundário: Coca/química
Coca/crescimento & desenvolvimento
Aprendizado de Máquina
Espectrometria de Massas
Filogeografia
América do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Oxygen Isotopes); AR09D82C7G (Deuterium)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1038/srep23520


  5 / 227 MEDLINE  
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[PMID]:26669733
[Au] Autor:Ferreira F
[Ad] Endereço:a Independent Researcher , Vigo , Spain.
[Ti] Título:De-demonizing the VRAEM: A Peruvian-Cocalero Area.
[So] Source:Subst Use Misuse;51(1):41-53, 2016 Jan 02.
[Is] ISSN:1532-2491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The valley of the rivers Apurímac, Ene, and Mantaro (VRAEM) is the main center of coca production in Peru. This is a jungle area located between southern highland regions, and is notorious for the presence of drug-trafficking and the last remnants of Shining Path guerrillas. As a result, it occupies a central place in security policies in Peru, and has been "demonized" in the national imaginary. OBJECTIVE: This article explores the current situation, recent history, and most important collectives of the VRAEM, challenging stereotypes about it. METHODS: The article is based on short-term fieldwork undertaken in the VRAEM in March 2008, and long-term research conducted in Ayacucho in 2008-2009; and it is contextualized in relation to the literature on coca producing areas and drug policies. RESULTS: The negative image of the VRAEM started in the context of the 1980s-1990s coca boom and Peruvian armed conflict. State policies in the area since then have been mainly based on militarization and repression, contributing to maintain that negative image, which differs of a complex and nuanced local reality. A coca eradication campaign started in 2014, bringing major changes. CONCLUSIONS: The negative image of the VRAEM is largely unfair, and has been mainly based on stereotypes and prejudices. This negative stereotyping contributes to justify and maintain inefficient and pernicious state policies in the area, and to criminalize local people. There is an urgent need for fieldwork-based studies in the area to counteract those negative stereotypes and monitor current events.
[Mh] Termos MeSH primário: Controle de Medicamentos e Entorpecentes
Formulação de Políticas
Estereotipagem
[Mh] Termos MeSH secundário: Coca
Seres Humanos
Peru
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151217
[St] Status:MEDLINE
[do] DOI:10.3109/10826084.2015.1074693


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[PMID]:26507611
[Au] Autor:Biondich AS; Joslin JD
[Ad] Endereço:Department of Emergency Medicine, SUNY Upstate Medical University, Syracuse, NY. Electronic address: amybee@me.com.
[Ti] Título:Coca: High Altitude Remedy of the Ancient Incas.
[So] Source:Wilderness Environ Med;26(4):567-71, 2015 Dec.
[Is] ISSN:1545-1534
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of coca leaf for medicinal purposes is a centuries-old tradition of the native peoples of South America. Coca products are thought by many laypersons to provide risk-free benefits to users participating in strenuous activities at high altitude. Physiologic studies of coca have increased understanding of its possible mechanism of action as well as its potential impact on high altitude activities. This present work explores the role of coca throughout the history of the Andean peoples and explores whether this ancient remedy has a place in modern medicine. A focused summary of research articles with particular relevance to the field of wilderness medicine is also included to better provide the reader with lessons not only from history but also from another culture.
[Mh] Termos MeSH primário: Doença da Altitude/terapia
Coca
Medicina Tradicional/métodos
Plantas Medicinais
[Mh] Termos MeSH secundário: Altitude
Doença da Altitude/prevenção & controle
Coca/química
Cocaína/análise
Cocaína/farmacologia
História do Século XVI
História Antiga
Seres Humanos
Medicina Tradicional/história
Folhas de Planta
Guias de Prática Clínica como Assunto
América do Sul
Medicina Selvagem/métodos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE


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[PMID]:26085110
[Au] Autor:Jang YJ; Koo HJ; Sohn EH; Kang SC; Rhee DK; Pyo S
[Ad] Endereço:School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 440-746, Republic of Korea. snpyo@skku.edu.
[Ti] Título:Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways.
[So] Source:Food Funct;6(7):2365-74, 2015 Jul.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Obesity is characterized by hypertrophy and/or by the differentiation or adipogenesis of pre-existing adipocytes. In this study, we investigated the inhibitory effects of theobromine, a type of alkaloid in cocoa, on adipocyte differentiation of 3T3-L1 preadipocytes and its mechanisms of action. Theobromine inhibited the accumulation of lipid droplets, the expression of PPARγ and C/EBPα, and the mRNA expression of aP2 and leptin. The inhibition of adipogenic differentiation by theobromine occurred primarily in the early stages of differentiation. In addition, theobromine arrested the cell cycle at the G0/G1 phase and regulated the expressions of CDK2, p27, and p21. Theobromine treatment increased AMPK phosphorylation and knockdown of AMPKα1/α2 prevented the ability of theobromine to inhibit PPARγ expression in the differentiating 3T3-L1 cells. Theobromine reduced the phosphorylation of ERK and JNK. Moreover, the secretion and the mRNA level of TNF-α and IL-6 were inhibited by theobromine treatment. These data suggest that theobromine inhibits adipocyte differentiation during the early stages of adipogenesis by regulating the expression of PPARγ and C/EBPα through the AMPK and ERK/JNK signaling pathways in 3T3-L1 preadipocytes.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Adipogenia/efeitos dos fármacos
Coca/química
Extratos Vegetais/farmacologia
Teobromina/farmacologia
[Mh] Termos MeSH secundário: Células 3T3-L1
Proteínas Quinases Ativadas por AMP/genética
Adipócitos/efeitos dos fármacos
Adipócitos/metabolismo
Animais
Proteína alfa Estimuladora de Ligação a CCAAT/genética
Proteína alfa Estimuladora de Ligação a CCAAT/metabolismo
Regulação para Baixo
Interleucina-6/genética
Interleucina-6/metabolismo
MAP Quinase Quinase 4/genética
MAP Quinase Quinase 4/metabolismo
Camundongos
Quinases de Proteína Quinase Ativadas por Mitógeno/genética
Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo
PPAR gama/genética
PPAR gama/metabolismo
Fosforilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCAAT-Enhancer-Binding Protein-alpha); 0 (Interleukin-6); 0 (PPAR gamma); 0 (Plant Extracts); EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 2.7.12.2 (MAP Kinase Kinase 4); EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases); OBD445WZ5P (Theobromine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150619
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo00397k


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[PMID]:26070752
[Au] Autor:Jay M
[Ad] Endereço:Independent Scholar. Electronic address: info@mikejay.net.
[Ti] Título:Miracle or Menace?: The Arrival of Cocaine 1860-1900.
[So] Source:Int Rev Neurobiol;120:27-39, 2015.
[Is] ISSN:2162-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The arrival of cocaine was the formative episode in the modern understanding of the benefits and dangers of neurostimulants. European culture and medicine had historically been poor in stimulant plants and drugs. When coca and cocaine appeared in nineteenth-century Europe, doctors, pharmacists, and the public struggled to understand their benefits and risks, and to formulate a distinction between use and abuse.
[Mh] Termos MeSH primário: Coca/efeitos adversos
Cocaína/história
[Mh] Termos MeSH secundário: História do Século XIX
História do Século XX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150613
[Lr] Data última revisão:
150613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150614
[St] Status:MEDLINE


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[PMID]:25974755
[Au] Autor:Prieto JP; Galvalisi M; López-Hill X; Meikle MN; Abin-Carriquiry JA; Scorza C
[Ad] Endereço:Departamento de Neurofarmacología Experimental, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
[Ti] Título:Caffeine enhances and accelerates the expression of sensitization induced by coca paste indicating its relevance as a main adulterant.
[So] Source:Am J Addict;24(5):475-81, 2015 Aug.
[Is] ISSN:1521-0391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Caffeine is an active adulterant found in several drugs of abuse including coca paste (CP). We had previously demonstrated that caffeine potentiated the acute stimulant effect induced by CP seized samples. The role of caffeine in the expression of sensitization elicited by a CP seized sample (CP1) was here evaluated. METHODS: CP1 (equivalent dose of 10 mg/kg of cocaine), cocaine (pure, 10 mg/kg), a combination of cocaine 10 mg/kg plus caffeine 2.5 mg/kg (CP1-surrogate) and saline (control) were intraperitoneally injected in male rats under two different sensitization schedules. Ambulatory locomotion was recorded in 58 animals. RESULTS: After five daily CP1 injections and 5 days of withdrawal, CP1-challenged animals displayed a more robust sensitization than cocaine-treated animals. When a 3 injections-regime of CP1-surrogate or cocaine was assayed, only CP1-surrogate was able to elicit sensitization. DISCUSSION AND CONCLUSIONS: Caffeine enhances and accelerates the CP1-induced sensitization. SCIENTIFIC SIGNIFICANCE: Results may shed light on the fast and high dependence observed in CP users.
[Mh] Termos MeSH primário: Cafeína/farmacologia
Sensibilização do Sistema Nervoso Central/efeitos dos fármacos
Coca
Transtornos Relacionados ao Uso de Cocaína/psicologia
Contaminação de Medicamentos
[Mh] Termos MeSH secundário: Animais
Nível de Alerta/efeitos dos fármacos
Relação Dose-Resposta a Droga
Seres Humanos
Injeções Intraperitoneais
Masculino
Atividade Motora/efeitos dos fármacos
Pomadas
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ointments); 3G6A5W338E (Caffeine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150515
[St] Status:MEDLINE
[do] DOI:10.1111/ajad.12245


  10 / 227 MEDLINE  
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[PMID]:25875517
[Au] Autor:Saravia Burgos J; Acosta Canedo A
[Ad] Endereço:Departamento de Medicina, Instituto de Gastroenterología Boliviano-Japonés. Cochabamba, Bolivia.
[Ti] Título:[Megacolon and sigmoid volvulus: incidence and physiopathology].
[Ti] Título:Megacolon y vólvulo de sigmoides: incidencia y fisiopatología..
[So] Source:Rev Gastroenterol Peru;35(1):38-44, 2015 Jan.
[Is] ISSN:1609-722X
[Cp] País de publicação:Peru
[La] Idioma:spa
[Ab] Resumo:The etiology of Megacolon is multiple. One of these causes and the most frequent is Chagas disease. Its complication: sigmoid volvulus was de main diagnosis in the admitted patients at the Bolivian and Japanese Gastroenterological Institute of Cochabamba Bolivia. It usually affects people of a low economic income. In this Gastroenterological Hospital a transversal and prospective study has been done, in order to know the real incidence and the physiopathology of this disease. In a six year period, from 2000 to 2006, 8.954 patients were admitted to the Hospital: of these, 814 (9.09%), where diagnosticated as lower intestinal obstruction. In 608 (74.7%) the final diagnosis was sigmoid torsion. Radiological diagnosis was made in 84% of the patients and endoscopic decompression was successful in 88.7%. As reported in the medical literature, the main cause of megacolon in this part of the world is Chagas disease. In our investigation 22% (98 patients), were serology positive to Chagas disease, and another 21.44% (95 patients) were serology negative. They were coca leaf chewers. One of coca leaf compounds is cocaine which blocks the adrenaline and noradrenaline degradation by mean of monoamine oxidase inactivation. These two hormones stay a long term of time in the target organ: the large bowel. By this mean chronic and persistent vessel constriction develops intestinal wall atrophy and lower resistance to the intraintestinal pressure.
[Mh] Termos MeSH primário: Doença de Chagas/complicações
Volvo Intestinal/etiologia
Megacolo/etiologia
Doenças do Colo Sigmoide/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Bolívia/epidemiologia
Estimulantes do Sistema Nervoso Central/toxicidade
Doença de Chagas/diagnóstico
Doença de Chagas/epidemiologia
Doença de Chagas/fisiopatologia
Coca/toxicidade
Estudos Transversais
Feminino
Seres Humanos
Incidência
Volvo Intestinal/diagnóstico
Volvo Intestinal/epidemiologia
Volvo Intestinal/fisiopatologia
Masculino
Megacolo/diagnóstico
Megacolo/epidemiologia
Meia-Idade
Prevalência
Estudos Prospectivos
Fatores de Risco
Doenças do Colo Sigmoide/diagnóstico
Doenças do Colo Sigmoide/epidemiologia
Doenças do Colo Sigmoide/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Stimulants)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150416
[St] Status:MEDLINE



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