Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.350 [Categoria DeCS]
Referências encontradas : 967 [refinar]
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[PMID]:28587572
[Au] Autor:Maffo T; Melong R; Nganteng DND; Wafo P; Ali MS; Ngadjui BT
[Ad] Endereço:a Faculty of Science, Department of Organic Chemistry , University of Yaounde I , Yaoundé , Cameroon.
[Ti] Título:Neomacrodione: a new degraded diterpenoid from the roots of Neoboutonia macrocalyx Beng (Euphorbiaceae).
[So] Source:Nat Prod Res;32(1):85-90, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new degraded diterpenoid 3,6-dihydroxy-1,7-dimethyl-9,10-phenantroquinone (neomacrodione) (1) together seven known compounds were isolated from the roots of Neoboutonia macrocalyx (Euphorbiaceae). The structures of the compounds were established based on their NMR and mass spectrometric data in conjunction with those previously reported in the literature. Compound (1) displayed moderate antibacterial activities.
[Mh] Termos MeSH primário: Antibacterianos/química
Diterpenos/química
Euphorbiaceae/química
Fenantrenos/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Diterpenos/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Fenantrenos/farmacologia
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Diterpenes); 0 (Phenanthrenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335729


  2 / 967 MEDLINE  
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[PMID]:29315331
[Au] Autor:Invernizzi C; Nogueira E; Juri P; Santos E; Arredondo D; Branchiccela B; Mendoza Y; Antúnez K
[Ad] Endereço:Sección Etología, Instituto de Biología, Facultad de Ciencias, Montevideo, Uruguay.
[Ti] Título:Epormenis cestri secretions in Sebastiania schottiana trees cause mass death of honey bee Apis mellifera larvae in Uruguay.
[So] Source:PLoS One;13(1):e0190697, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:For more than 60 years, sporadic cases of massive summer honey bee larvae mortality in colonies located near freshwater systems with abundant riparian vegetation have been reported in Uruguay. This odd phenomenon, known as "River disease" by beekeepers, can lead to colony death by depopulation. The aim of this study was to detect the causes of larvae death. Different experiments and analyses were performed using affected apiaries located between two important water courses. 1 day old larvae were the most susceptible and substances that killed the larvae were present in the nectar but not in the pollen. A palynological analysis of nectar samples showed that bees collect this resource from commonly pollinated floral species in the country. However, abundant fungi spores and conidia were found, which indicates that the bees also collected honeydews. In the riparian vegetation, bees were observed collecting the secretions of the planthopper Epormenis cestri on Sebastiania schottiana trees. It was found that the mortality period of larvae overlaps with the presence of E. cestri. Larvae maintained in the laboratory were fed (i) nectar from healthy colonies, (ii) nectar from affected colonies, and (iii) secretions of E. cestri. The mortality of the larvae that received nectar from colonies affected with River disease and secretions of E. cestri was higher than the mortality of those receiving nectar from healthy colonies. This represents the first report of planthopper honeydew causing mass larval mortality in honey bees.
[Mh] Termos MeSH primário: Colapso da Colônia
Euphorbiaceae/química
Insetos/metabolismo
Larva
[Mh] Termos MeSH secundário: Animais
Uruguai
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190697


  3 / 967 MEDLINE  
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[PMID]:29357846
[Au] Autor:Endougou Effa AM; Gantier E; Hennebelle T; Roumy V; Rivière C; Dimo T; Kamtchouing P; Desreumaux P; Dubuquoy L
[Ad] Endereço:Université Lille Nord de France, F-59000, Lille, France. effanmary@gmail.com.
[Ti] Título:Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models.
[So] Source:BMC Complement Altern Med;18(1):24, 2018 Jan 22.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hepatitis is a liver inflammation caused by different agents and remains a public health problem worldwide. Medicinal plants are an important source of new molecules being considered for treatment of this disease. Our work aims at evaluating the hepatoprotective properties of Neoboutonia velutina, a Cameroonian medicinal plant. METHODS: The aqueous extract has been prepared using phytochemical methods. HepG2 cells were used to assess anti-inflammatory properties of the extract at different concentrations. Acute hepatitis models (Carbon tetrachloride and Concanavalin A) were performed in mice receiving or not receiving, different extract doses by gavage. Liver injury was assessed using histology, transaminases and pro-inflammatory markers. Extract antioxidant and radical scavenging capacities were evaluated. RESULTS: The extract led to a significant decrease in pro-inflammatory cytokine expression in vitro and to a remarkable protection of mice from carbon tetrachloride-induced liver injury, as shown by a significant decrease in dose-dependent transaminases level. Upon extract treatment, inflammatory markers were significantly decreased and liver injuries were limited as well. In the Concanavalin A model, the extract displayed weak effects. CONCLUSIONS: Taking into account underlying mechanisms in both hepatitis models, we demonstrate the extract's radical scavenging capacity. Neoboutonia velutina displays a potent hepatoprotective effect mediated through radical scavenging properties.
[Mh] Termos MeSH primário: Euphorbiaceae/química
Fígado/efeitos dos fármacos
Casca de Planta/química
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Tetracloreto de Carbono/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Citocinas/análise
Citocinas/metabolismo
Células Hep G2
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Extratos Vegetais/química
Substâncias Protetoras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Plant Extracts); 0 (Protective Agents); CL2T97X0V0 (Carbon Tetrachloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2091-2


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[PMID]:27775975
[Au] Autor:Huerth KA; Hawkes JE; Meyer LJ; Powell DL
[Ad] Endereço:From the *University at Buffalo School of Medicine, New York, NY; †The University of Utah Department of Dermatology, Salt Lake City; and ‡Veterans Administration Hospital, Salt Lake City, UT.
[Ti] Título:The Scourge of the Spurge Family-An Imitator of Rhus Dermatitis.
[So] Source:Dermatitis;27(6):372-381, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. We examined case reports spanning 40 years and discovered that spurge-induced ICD tends to befall children and middle-aged adults who unwittingly encounter the plant through play or horticulture, respectively. Clinical presentation is pleomorphic. Erythema, edema, burning, vesicles, and pruritus of acute onset and rapid resolution are frequently observed. We present a classic case of ICD in a 12-year-old girl after exposure to Euphorbia myrsinites and review the literature on phytodermatitis caused by members of the Euphorbiaceae family.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/diagnóstico
Dermatite por Toxicodendron/diagnóstico
Euphorbia/efeitos adversos
[Mh] Termos MeSH secundário: Criança
Dermatite Alérgica de Contato/etiologia
Diagnóstico Diferencial
Euphorbiaceae
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 967 MEDLINE  
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[PMID]:28910307
[Au] Autor:Vasek J; Hlásná Cepková P; Viehmannová I; Ocelák M; Cachique Huansi D; Vejl P
[Ad] Endereço:Department of Genetics and Breeding, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká, Prague, Czech Republic.
[Ti] Título:Dealing with AFLP genotyping errors to reveal genetic structure in Plukenetia volubilis (Euphorbiaceae) in the Peruvian Amazon.
[So] Source:PLoS One;12(9):e0184259, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An analysis of the population structure and genetic diversity for any organism often depends on one or more molecular marker techniques. Nonetheless, these techniques are not absolutely reliable because of various sources of errors arising during the genotyping process. Thus, a complex analysis of genotyping error was carried out with the AFLP method in 169 samples of the oil seed plant Plukenetia volubilis L. from small isolated subpopulations in the Peruvian Amazon. Samples were collected in nine localities from the region of San Martin. Analysis was done in eight datasets with a genotyping error from 0 to 5%. Using eleven primer combinations, 102 to 275 markers were obtained according to the dataset. It was found that it is only possible to obtain the most reliable and robust results through a multiple-level filtering process. Genotyping error and software set up influence both the estimation of population structure and genetic diversity, where in our case population number (K) varied between 2-9 depending on the dataset and statistical method used. Surprisingly, discrepancies in K number were caused more by statistical approaches than by genotyping errors themselves. However, for estimation of genetic diversity, the degree of genotyping error was critical because descriptive parameters (He, FST, PLP 5%) varied substantially (by at least 25%). Due to low gene flow, P. volubilis mostly consists of small isolated subpopulations (ΦPT = 0.252-0.323) with some degree of admixture given by socio-economic connectivity among the sites; a direct link between the genetic and geographic distances was not confirmed. The study illustrates the successful application of AFLP to infer genetic structure in non-model plants.
[Mh] Termos MeSH primário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Euphorbiaceae/genética
Técnicas de Genotipagem
[Mh] Termos MeSH secundário: Peru
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184259


  6 / 967 MEDLINE  
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[PMID]:28846740
[Au] Autor:Ribeiro PPC; Silva DMLE; Assis CF; Correia RTP; Damasceno KSFDSC
[Ad] Endereço:Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brasil.
[Ti] Título:Bioactive properties of faveleira (Cnidoscolus quercifolius) seeds, oil and press cake obtained during oilseed processing.
[So] Source:PLoS One;12(8):e0183935, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To the best of our knowledge, this is the first report in the literature concerning the bioactive properties of faveleira products. This work focuses on the physicochemical evaluation of faveleira oil, as well as it investigates the bioactive properties of faveleira seeds, faveleira oil and the press cake obtained during the oilseed processing. The seeds were cold pressed and the following tests were performed: physicochemical characteristics (acidity, peroxide values, moisture and volatile matter, density and viscosity) and fatty acid profile of faveleira oil; total phenolic and flavonoid content of faveleira seed and press cake; antibacterial activity of seed, oil and press cake; and antioxidant activity (DPPH radical scavenging activity, reducing power assay, total antioxidant capacity, superoxide radical scavenging assay and oxygen radical absorbance capacity) of seed, oil and press cake. Our work demonstrated that the faveleira seed oil has low acidity (0.78 ± 0.03% oleic acid) and peroxide value (1.13 ± 0.12 mEq/1000g), associated with the relevant concentration of linoleic acid (53.56%). It was observed that important phenolics (398.89 ± 6.34 mg EAG/100 g), especially flavonoids (29.81 ± 0.71 mg RE/g) remain in the press cake, which indicates that the by-product of the faveleira oilseed production constitutes a rich residual source of bioactive compounds. No bacterial growth inhibition was detected, but all samples including faveleira seeds, press cake, oil and its fractions have potent antioxidant activities, mainly the press cake, with oxygen radical absorbance capacity of 28.39 ± 4.36 µM TE/g. Our results also show that faveleira oil has potential to be used as edible oil and the press cake should be used to contain the most antioxidants from seed.
[Mh] Termos MeSH primário: Euphorbiaceae/metabolismo
Óleos Vegetais/metabolismo
Sementes/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Euphorbiaceae/embriologia
Ácidos Graxos/metabolismo
Flavonoides/metabolismo
Fenóis/metabolismo
Extratos Vegetais/metabolismo
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Fatty Acids); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183935


  7 / 967 MEDLINE  
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[PMID]:28803995
[Au] Autor:Saetang P; Rukachaisirikul V; Phongpaichit S; Preedanon S; Sakayaroj J; Borwornpinyo S; Seemakhan S; Muanprasat C
[Ad] Endereço:Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
[Ti] Título:Depsidones and an α-pyrone derivative from Simpilcillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf.
[So] Source:Phytochemistry;143:115-123, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 µg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 µg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Depsídeos/isolamento & purificação
Euphorbiaceae/química
Hevea/química
Lactonas/isolamento & purificação
Pironas/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antifúngicos/química
Antifúngicos/farmacologia
Cercopithecus aethiops
Cryptococcus neoformans/efeitos dos fármacos
Depsídeos/química
Depsídeos/farmacologia
Lactonas/química
Lactonas/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Folhas de Planta/química
Pironas/química
Pironas/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Depsides); 0 (Lactones); 0 (Pyrones); 3580-77-6 (depsidone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


  8 / 967 MEDLINE  
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[PMID]:28791544
[Au] Autor:Kyallo M; Ateka EM; Sseruwagi P; Ascencio-Ibáñez JT; Ssemakula MO; Skilton R; Ndunguru J
[Ad] Endereço:Biosciences eastern and central Africa-International Livestock Research Institute (BecA-ILRI) Hub, P.O. Box 30709-00100, Nairobi, Kenya. m.kyalo@cgiar.org.
[Ti] Título:Infectivity of Deinbollia mosaic virus, a novel weed-infecting begomovirus in East Africa.
[So] Source:Arch Virol;162(11):3439-3445, 2017 Nov.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Weed-infecting begomoviruses play an important role in the epidemiology of crop diseases because they can potentially infect crops and contribute to the genetic diversity of crop-infecting begomoviruses. Despite the important epidemiological role that weed-infecting begomoviruses play, they remain insufficiently studied in Africa. Recently, we identified Deinbollia mosaic virus (DMV), a distinct begomovirus found naturally infecting the weed host Deinbollia borbonica (Sapindaceae) in Kenya and Tanzania. In this study, we investigated the capacity of DMV to infect a restricted host range of Solanaceae and Euphorbiaceae species. Biolistic inoculation of Nicotiana benthamiana with concatemeric DNAs resulted in systemic infection associated with yellow mosaic symptoms, while DNA partial dimers caused asymptomatic systemic infection. DMV was not infectious to cassava (Manihot esculenta Crantz), suggesting host resistance to the virus. Here, we demonstrate the first experimental infectivity analysis of DMV in N. benthamiana and cassava.
[Mh] Termos MeSH primário: Begomovirus/fisiologia
Euphorbiaceae/virologia
Doenças das Plantas/virologia
Plantas Daninhas/virologia
Solanaceae/virologia
[Mh] Termos MeSH secundário: África Oriental
Folhas de Planta/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3495-x


  9 / 967 MEDLINE  
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[PMID]:28764039
[Au] Autor:Gutiérrez LF; Quiñones-Segura Y; Sanchez-Reinoso Z; Díaz DL; Abril JI
[Ad] Endereço:Instituto de Ciencia y Tecnología de Alimentos (ICTA), Universidad Nacional de Colombia Sede Bogotá, Carrera 30 No. 45-03, Edificio 500A, Bogotá, DC 111321, Colombia. Electronic address: lfgutierreza@unal.edu.co.
[Ti] Título:Physicochemical properties of oils extracted from γ-irradiated Sacha Inchi (Plukenetia volubilis L.) seeds.
[So] Source:Food Chem;237:581-587, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study evaluated the physicochemical properties of oils extracted from γ-irradiated Sacha Inchi (Plukenetia volubilis L.) seeds (SIS) at four different doses (0, 1, 5 and 8kGy). Fatty acid composition, tocopherol content, FTIR spectra, density, refractive index, acidity, peroxide value (PV), p-anisidine index (p-An), oxidation induction period (IP), and color were chosen as test parameters. Overall, the irradiation treatment did not significantly affect the physicochemical properties of the Sacha Inchi oils, although slight increases were found in the PV and p-An, as the irradiation dose increased. γ-Irradiation led to a decrease in the concentration of γ- and δ-tocopherol, as well as in the IP. However, according to the FTIR analyses, the functional groups of the oils were not significantly affected by the γ-irradiation. These results suggest that γ-irradiation at 1-5kGy, might be recommended as a suitable eco-friendly technology for the preservation of SIS used for oil production.
[Mh] Termos MeSH primário: Euphorbiaceae
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Fenômenos Químicos
Ácidos Graxos
Sementes
Tocoferóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Plant Oils); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  10 / 967 MEDLINE  
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[PMID]:28676114
[Au] Autor:Djimeli MN; Fodouop SPC; Njateng GSS; Fokunang C; Tala DS; Kengni F; Gatsing D
[Ad] Endereço:Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
[Ti] Título:Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae).
[So] Source:BMC Complement Altern Med;17(1):349, 2017 Jul 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A. cordifolia is a plant widely used in Africa to solve many health problems. In Cameroon, it is used in the treatment of urogenital infections. As a continuation of our search for pharmacologically active agents from natural sources, the antimicrobial activity of A. cordifolia leaf extracts against E. coli and the toxicity of this extract were investigated. METHODS: The antibacterial activity of the aqueous extract from leaves of Alchornea cordifolia was carried out in vitro on Escherichia coli, as well as in vivo on E. coli-infected rat model. Phytochemical screening was performed using standard methods. The acute toxicity was investigated in mice, while at the end of treatment of infected rats, some biochemical, hematological and histological markers of toxicity were evaluated. RESULTS: The extract exhibited a bacteriostatic activity with MIC value of 1500 µg/ml. Phytochemical screening revealed the presence of phenols, tannins, triterpens, flavonoids, alkaloids, anthraquinones, anthocyanins, saponins and coumarins in the extract. The acute toxicity study showed LD values of 8.6 g/kg and 3.8 g/kg in male and female mice respectively. In vivo, the oral administration of the extract showed a dose-dependent decrease of the bacterial load as the extract at 232, 112 and 58 g/kg were able to eradicate the infection after 9, 11 and 13 days of treatment. The infected rats showed a significant (p < 0.05) increase in the level of serum creatinine, ALAT, white blood cells, and a significant (p < 0.05) decrease in the level of food and water intake, the relative weight of lungs, heart and spleen. In the treated rats, a significant (p < 0.05) increase in food and water intake and ALAT was observed at the doses of 116 and 232 mg/kg. A decrease in the red blood cells count and serum protein levels was also observed. These observations corroborate liver damages as revealed by the histopathological examination of the cross sections of this organ. CONCLUSION: The results of this assay thus showed that the extract of A. cordifolia is bacteriostatic, therapeutic at 58 g/kg bw and may be considered as slightly and almost non-toxic on females and males mice respectively.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Euphorbiaceae/química
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/isolamento & purificação
Antibacterianos/toxicidade
Escherichia coli/efeitos dos fármacos
Escherichia coli/crescimento & desenvolvimento
Infecções por Escherichia coli/tratamento farmacológico
Infecções por Escherichia coli/microbiologia
Feminino
Seres Humanos
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Folhas de Planta/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1854-5



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