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  1 / 9 MEDLINE  
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[PMID]:28039833
[Au] Autor:Venkatachalam P; Jayalakshmi N; Geetha N; Sahi SV; Sharma NC; Rene ER; Sarkar SK; Favas PJ
[Ad] Endereço:Periyar University, Department of Biotechnology, Plant Genetic Engineering and Molecular Biology Lab, Periyar Palkalai Nagar, Salem, 636 011, Tamil Nadu, India. Electronic address: pvenkat67@yahoo.com.
[Ti] Título:Accumulation efficiency, genotoxicity and antioxidant defense mechanisms in medicinal plant Acalypha indica L. under lead stress.
[So] Source:Chemosphere;171:544-553, 2017 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was designed to assess the physiological and biochemical changes in roots and shoots of the herb Acalypha indica grown under hydroponic conditions during exposure to lead (Pb) (100-500 mg L ) for 1-12 d. The accumulation of Pb by A. indica plants was found to be 121.6 and 17.5 mg g dry weight (DW) in roots and shoots, respectively, when exposed to a Pb concentration of 500 mg L . The presence of Pb ions in stem, root and leaf tissues was confirmed by scanning electron microscope (SEM) and Energy-dispersive X-ray spectroscopy (EDX) analyses. Concerning the activity of antioxidant enzymes, viz., peroxidase (POX) catalase (CAT) and ascorbate peroxidase (APX), they were induced at various regimes during 5, 8 and 12 d of Pb exposure in both the leaves and roots than untreated controls. Lead treatment increased superoxide dismutase (SOD) activity in both the leaf and root tissues over control, irrespective of the duration of exposure. Anew, it was observed that Pb treatments induced variations in the number and intensity of protein bands. Random amplified polymorphic DNA (RAPD) results show that the Pb treatment caused genotoxicity on DNA molecules as evidenced by the amplification of new bands and the absence of normal DNA amplicons in treated plants. Results confirm that A. indica is a Pb accumulator species, and the antioxidants might play a crucial role in the detoxification of Pb-induced toxic effects.
[Mh] Termos MeSH primário: Acalypha/efeitos dos fármacos
Chumbo/toxicidade
[Mh] Termos MeSH secundário: Acalypha/genética
Acalypha/metabolismo
Ascorbato Peroxidases/metabolismo
Catalase/metabolismo
DNA de Plantas/efeitos dos fármacos
Hidroponia
Peroxidação de Lipídeos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Peroxidase/metabolismo
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/metabolismo
Proteínas de Plantas/metabolismo
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/metabolismo
Brotos de Planta/efeitos dos fármacos
Brotos de Planta/metabolismo
Plantas Medicinais/efeitos dos fármacos
Plantas Medicinais/metabolismo
Técnica de Amplificação ao Acaso de DNA Polimórfico
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Plant Proteins); 2P299V784P (Lead); EC 1.11.1.11 (Ascorbate Peroxidases); EC 1.11.1.6 (Catalase); EC 1.11.1.7 (Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170101
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:25880167
[Au] Autor:Santiago C; Lim KH; Loh HS; Ting KN
[Ad] Endereço:Faculty of Science, University of Nottingham Malaysia Campus, Jalan Broga, 43500, Semenyih, Selangor, Malaysia. Carolina.Santiago@nottingham.edu.my.
[Ti] Título:Prevention of cell-surface attachment and reduction of penicillin-binding protein 2a (PBP2a) level in methicillin-resistant Staphylococcus aureus biofilms by Acalypha wilkesiana.
[So] Source:BMC Complement Altern Med;15:79, 2015 Mar 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Formation of biofilm is known to enhance the virulence of methicillin-resistance Staphylococcus aureus (MRSA), which is associated with persistent infections in hospital settings. The biofilm layer essentially forms a protective barrier encapsulating the bacterial colony and thus reduces the effectiveness of chemotherapeutics. We have isolated 9EA-FC-B bioactive fraction from Acalypha wilkesiana Müll. Arg. that reverses ampicillin resistant in MRSA through inhibition of the antibiotic resistant protein, penicillin-binding protein 2a (PBP2a). In this study, we aimed to investigate the effects of 9EA-FC-B on MRSA biofilm forming capacity. METHODS: Inhibition of biofilm production and microtiter attachment assays were employed to study the anti-biofilm activity of 9EA-FC-B, while latex agglutination test was performed to investigate the effect on PBP2a in the biofilm matrix. We also attempted to characterise the chemical components of the fraction using high performance liquid chromatography (HPLC) and phytochemical analysis. RESULTS: Fraction 9EA-FC-B and ampicillin exhibited similar inhibitory effect on MRSA's biofilm production at their respective minimum inhibitory concentrations (81.56% vs 84.49%, respectively). However, the test fraction was more effective in suppressing cell surface attachment (90.85%) compared to ampicillin (37.8%). Interestingly, ampicillin enhanced the level PBP2a and in the contrary 9EA-FC-B attenuated the production of the resistant protein in the bioflim matrix. HPLC and phytochemical analysis revealed that 9EA-FC-B fraction is a complex mixture containing tannins, saponins, sterol/steroids, and glycosides. CONCLUSIONS: Bioactive fraction 9EA-FC-B inhibited the production of MRSA biofilm by preventing the initial cell-surface attachment and reducing the amount PBP2a in the matrix. PBP2a found in the biofilm matrix is believed to have a role in the development of virulence in MRSA.
[Mh] Termos MeSH primário: Acalypha/química
Antibacterianos/farmacologia
Aderência Bacteriana/efeitos dos fármacos
Proteínas de Bactérias/metabolismo
Biofilmes/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Ampicilina/farmacologia
Resistência a Medicamentos/efeitos dos fármacos
Sinergismo Farmacológico
Seres Humanos
Meticilina/farmacologia
Staphylococcus aureus Resistente à Meticilina/metabolismo
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Testes de Sensibilidade Microbiana
Proteínas de Ligação às Penicilinas/metabolismo
Extratos Vegetais/química
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Penicillin-Binding Proteins); 0 (Plant Extracts); 0 (mecA protein, Staphylococcus aureus); 7C782967RD (Ampicillin); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150417
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0615-6


  3 / 9 MEDLINE  
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[PMID]:25446604
[Au] Autor:Seebaluck R; Gurib-Fakim A; Mahomoodally F
[Ad] Endereço:Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius.
[Ti] Título:Medicinal plants from the genus Acalypha (Euphorbiaceae)--a review of their ethnopharmacology and phytochemistry.
[So] Source:J Ethnopharmacol;159:137-57, 2015 Jan 15.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Acalypha is the fourth largest genus of the Euphorbiaceae family with approximately 450-570 species. Several Acalypha species are used as medicinal plants in Africa and in the Mascarene Islands. Almost every part of the plant including the leaves, stem and roots are used as traditional remedies to treat and manage a panoply of ailments. However, there is no updated compilation of traditionally important medicinal plants from the Acalypha genus. The present review therefore, endeavors to provide for the first time an updated compilation of documented ethnopharmacological information in relation to the ethnomedicinal, ethnoveterinary, zoopharmacognosy, phytochemistry and biological activities of medicinal plants from the Acalypha genus which can subsequently open new perspectives for further pharmacological research. MATERIALS AND METHODS: A literature search was performed on Acalypha species using ethnobotanical text books and scientific databases such as Pubmed, Scopus, EBSCO, Google Scholar and other web sources such as records from PROTA, PROSEA, and Botanical Dermatology Database. The Plant List, International Plant Name index and Kew Botanical Garden Plant name databases were used to validate scientific names. RESULTS AND DISCUSSION: Plants from Acalypha genus are traditionally used in the treatment and/or management of diverse ailments such as diabetes, jaundice, hypertension, fever, liver inflammation, schistosomiasis, dysentery, respiratory problems including bronchitis, asthma and pheumonia as well as skin conditions such as scabies, eczema and mycoses. Approximately 124 species were listed in ethnobotanical studies with some botanical description and others mentioned from different web sources. However, only 40 species have been included in the present review due to the unavailability of ethnopharmacological data on the remaining species. Among the 40 cited species, 30 were traditionally used for the treatment and/or management of approximately 70 human diseases or health conditions. Two species, Acalypha alnifolia and Acalypha fruticosa are used as insecticides and sand fly repellent respectively. Only 2 species (Acalypha fruticosa and Acalypha indica) are used in ethnoveterinary practice and have similar human and veterinary applications. In zoopharmacognosy, only Acalypha ornata has been mentioned. Natives from Africa, Central America, North America, Southern China, India, Bangladesh, Papua New Guinea and Mascarenes islands utilize Acalypha species as ethnomedicine. Traditionally used Acalypha species have been reported to possess at least one of the following biological activities: antimicrobial, anti-diabetic, antioxidant, anti-inflammatory, larvidal, pupicidal, hepatoprotective, anticancer, leishmanicidal, antihyperglycemic, antihypertensive, anti-venom, analgesic, anthelmintic, antiemetic, laxative, expectorant, diuretic, post-coital antifertility effects and wound healing. A total of 167 compounds have been identified from 19 species, with 16 from eight species were reported to be bioactive. CONCLUSION: The present review represents 32.3% of species from the Acalypha genus and can be considered as the first compilation of ethnopharmacologically useful plants from this genus. There is a great potential to discover new biologically active phytochemicals from the Acalypha genus because only few species have been studied comprehensively. Therefore, the clinical evaluation of species from this genus is warranted in future studies to confirm the ethnomedicinal claims and for the safety approval of therapeutic applications.
[Mh] Termos MeSH primário: Acalypha
Plantas Medicinais
[Mh] Termos MeSH secundário: Acalypha/química
Etnofarmacologia
Seres Humanos
Compostos Fitoquímicos/análise
Fitoterapia
Preparações de Plantas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Preparations)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:141222
[Lr] Data última revisão:
141222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  4 / 9 MEDLINE  
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[PMID]:25426700
[Au] Autor:Anokwuru CP; Sinisi A; Samie A; Taglialatela-Scafati O
[Ad] Endereço:a Department of Basic Science , School of Science and Technology, Babcock University , Ilisan Remo , Nigeria.
[Ti] Título:Antibacterial and antioxidant constituents of Acalypha wilkesiana.
[So] Source:Nat Prod Res;29(12):1180-3, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of Acalypha wilkesiana. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, geraniin, corilagin, quadrangularic acid M and shikimic acid were purified and isolated. Shikimic acid, reported for the first time from this plant, proved to be the major metabolite of the extract. All the four isolated compounds showed bactericidal activity against extended spectrum beta-lactamase-producing Klebsiella pneumoniae (700603), while corilagin was the single compound to exhibit antioxidant activity (IC50 53 µg/mL).
[Mh] Termos MeSH primário: Acalypha/química
Antibacterianos/farmacologia
Depuradores de Radicais Livres/farmacologia
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Glucosídeos/química
Glucosídeos/isolamento & purificação
Taninos Hidrolisáveis/química
Taninos Hidrolisáveis/isolamento & purificação
Klebsiella pneumoniae/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Fitosteróis/química
Fitosteróis/isolamento & purificação
Folhas de Planta/química
Ácido Chiquímico/química
Ácido Chiquímico/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Free Radical Scavengers); 0 (Glucosides); 0 (Hydrolyzable Tannins); 0 (Phytosterols); 0 (Plant Extracts); 0 (quadrangularic acid M); 29MS2WI2NU (Shikimic Acid); 60976-49-0 (Geraniin); 62LOS9TW6D (corilagin)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141127
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.983105


  5 / 9 MEDLINE  
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[PMID]:25390027
[Au] Autor:Olukunle JO; Jacobs EB; Ajayi OL; Biobaku KT; Abatan MO
[Ti] Título:Toxicological evaluation of the aqueous extract of Acalypha wilkesiana in Wistar albino rats.
[So] Source:J Complement Integr Med;12(1):53-6, 2015 Mar.
[Is] ISSN:1553-3840
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acalypha wilkesiana (Euphorbiaceae) is highly accepted for traditional treatment of human plasmodiasis in Africa. METHODS: The toxicological effects of the aqueous leaf extract of A. wilkesiana were studied in 45 male and female Wistar albino rats. An acute toxicity testing was done using 21 rats divided into seven groups and LD50 determined. In the sub-chronic toxicity study, the extract was administered orally over a period of 28 days to rats in three groups with doses of 400 mg kg-1, 800 mg kg-1 and 1,600 mg kg-1, respectively, and the fourth group administered with water served as control. Blood samples were collected for hematological and serum biochemical analysis; organs of the animals were harvested for histopathological examination. RESULTS: The acute toxicity testing showed that the extract was non-toxic at doses up to 3,000 mg kg-1 and the LD50 was calculated to be 2,828.34 mg kg-1. The study showed that at 1,600 mg kg-1 dose, the extract caused a decrease in the level of neutrophils (NEUT) while lymphocytes (LYMP) were statistically significantly increased. The administration of the extract also resulted in varying significant dose dependent increase in the levels of aspartate amino transferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). There were also significant increases in the level of total protein (TP), urea (URN) and albumin (GLB) especially at 1,600 mg kg-1 dosage. Histopathology showed that the extract caused mild to severe significant lesions that are dose dependent in the liver and kidney when compared with the control group. CONCLUSIONS: Prolonged administration of high dose of A. wilkesiana extract has tendency to cause organ toxicity.
[Mh] Termos MeSH primário: Acalypha/efeitos adversos
Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
Extratos Vegetais/efeitos adversos
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Fosfatase Alcalina/sangue
Animais
Aspartato Aminotransferases/sangue
Feminino
Rim/metabolismo
Fígado/enzimologia
Masculino
Ratos Wistar
Testes de Toxicidade Aguda
Ureia/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 8W8T17847W (Urea); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141113
[St] Status:MEDLINE


  6 / 9 MEDLINE  
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[PMID]:24285125
[Au] Autor:Olukunle JO; Adenubi OT; Biobaku KT; Sogebi EA
[Ti] Título:Anti-inflammatory and analgesic effects of methanol extract and fractions of Acalypha wilkesiana leaves.
[So] Source:J Basic Clin Physiol Pharmacol;26(2):181-4, 2015 Mar.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study was carried out to evaluate the anti-inflammatory and the analgesic potentials of Acalypha wilkesiana leaf extract in experimental animals. METHODS: The anti-inflammatory potential was investigated using an acute rat model. Aspirin at 150 mg/kg, indomethacin at 10 mg/kg as positive control, and methanolic extracts and solvent fractions of A. wilkesiana at doses of 400 and 200 mg/kg, respectively, were administered orally to rats and compared with a negative control group given 10 mL/kg Tween 80. At an A. wilkesiana dose of 400 mg/kg body weight, the analgesic effect was also studied using the hot plate method and the acetic acid-induced writhing model in mice. RESULTS: Percentage inhibition of the paw volume was highest in rats administered indomethacin (85.7%) followed by the group administered methanolic extract of A. wilkesiana (74.1%), whereas the group given aspirin had 65.5% inhibition of edema and the group given a 200 mg/kg dose of chloroform fraction of A. wilkesiana had 93% inhibition of increase in paw volume, a value higher than the performance of the standard drugs indomethacin (85%) and aspirin (68%). Also, the extract caused an increase in the reaction time in the hot plate test and in the acetic acid test. The mean number of writhings was significantly reduced in the group of mice administered 400 mg/kg extract of A. wilkesiana leaves (25.8±1.3) when compared with the control (46.7±1.4) but higher than the group of mice administered the standard analgesic agent paracetamol (23.5±1.3). CONCLUSIONS: This study suggested that A. wilkesiana leaves have anti-inflammatory and analgesic potential comparable with those of standard drugs.
[Mh] Termos MeSH primário: Acalypha/química
Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/administração & dosagem
Analgésicos/isolamento & purificação
Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Feminino
Inflamação/tratamento farmacológico
Inflamação/patologia
Masculino
Metanol/química
Camundongos
Dor/tratamento farmacológico
Dor/patologia
Extratos Vegetais/administração & dosagem
Folhas de Planta
Ratos
Ratos Wistar
Solventes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Solvents); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150306
[Lr] Data última revisão:
150306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131129
[St] Status:MEDLINE


  7 / 9 MEDLINE  
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[PMID]:25101303
[Au] Autor:Santiago C; Pang EL; Lim KH; Loh HS; Ting KN
[Ad] Endereço:Faculty of Science, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
[Ti] Título:Reversal of ampicillin resistance in MRSA via inhibition of penicillin-binding protein 2a by Acalypha wilkesiana.
[So] Source:Biomed Res Int;2014:965348, 2014.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The inhibitory activity of a semipure fraction from the plant, Acalypha wilkesiana assigned as 9EA-FC-B, alone and in combination with ampicillin, was studied against methicillin-resistant Staphylococcus aureus (MRSA). In addition, effects of the combination treatment on PBP2a expression were investigated. Microdilution assay was used to determine the minimal inhibitory concentrations (MIC). Synergistic effects of 9EA-FC-B with ampicillin were determined using the fractional inhibitory concentration (FIC) index and kinetic growth curve assay. Western blot experiments were carried out to study the PBP2a expression in treated MRSA cultures. The results showed a synergistic effect between ampicillin and 9EA-FC-B treatment with the lowest FIC index of 0.19 (synergism ≤ 0.5). The presence of 9EA-FC-B reduced the MIC of ampicillin from 50 to 1.56 µg mL(-1). When ampicillin and 9EA-FC-B were combined at subinhibitory level, the kinetic growth curves were suppressed. The antibacterial effect of 9EA-FC-B and ampicillin was shown to be synergistic. The synergism is due the ability of 9EA-FC-B to suppress the activity of PBP2a, thus restoring the susceptibility of MRSA to ampicillin. Corilagin was postulated to be the constituent responsible for the synergistic activity showed by 9EA-FC-B.
[Mh] Termos MeSH primário: Ampicilina/administração & dosagem
Sinergismo Farmacológico
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Acalypha/química
Resistência a Ampicilina/efeitos dos fármacos
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/genética
Proteínas de Ligação às Penicilinas/biossíntese
Peptídeo Sintases/biossíntese
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Penicillin-Binding Proteins); 0 (Plant Extracts); 0 (penicillin-binding protein 2a, Streptococcus); 7C782967RD (Ampicillin); EC 6.3.2.- (Peptide Synthases)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150805
[Lr] Data última revisão:
150805
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140808
[St] Status:MEDLINE
[do] DOI:10.1155/2014/965348


  8 / 9 MEDLINE  
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[PMID]:24747845
[Au] Autor:Sivaraj R; Rahman PK; Rajiv P; Narendhran S; Venckatesh R
[Ad] Endereço:School of Science and Engineering, Teesside University, Middlesbrough - TS1 3BA, Tees Valley, UK; Department of Biotechnology, School of Life Sciences, Karpagam University, Eachanari Post, Coimbatore 641 021, Tamil Nadu, India. Electronic address: rajeshwarishivaraj@gmail.com.
[Ti] Título:Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;129:255-8, 2014 Aug 14.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Copper oxide nanoparticles were synthesized by biological method using aqueous extract of Acalypha indica leaf and characterized by UV-visible spectroscopy, XRD, FT-IR, SEM TEM and EDX analysis. The synthesised particles were highly stable, spherical and particle size was in the range of 26-30 nm. The antimicrobial activity of A.indica mediated copper oxide nanoparticles was tested against selected pathogens. Copper oxide nanoparticles showed efficient antibacterial and antifungal effect against Escherichia coli, Pseudomonas fluorescens and Candida albicans. The cytotoxicity activity of A.indica mediated copper nanoparticles was evaluated by MTT assay against MCF-7 breast cancer cell lines and confirmed that copper oxide nanoparticles have cytotoxicity activity.
[Mh] Termos MeSH primário: Acalypha/química
Anti-Infecciosos/química
Antineoplásicos/química
Cobre/química
Nanopartículas/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/síntese química
Anti-Infecciosos/farmacologia
Antineoplásicos/síntese química
Antineoplásicos/farmacologia
Bactérias/efeitos dos fármacos
Infecções Bacterianas/tratamento farmacológico
Neoplasias da Mama/tratamento farmacológico
Candida albicans/efeitos dos fármacos
Candidíase/tratamento farmacológico
Linhagem Celular Tumoral
Cobre/farmacologia
Feminino
Química Verde/métodos
Seres Humanos
Nanopartículas/ultraestrutura
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Plant Extracts); 789U1901C5 (Copper); T8BEA5064F (cuprous oxide)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140527
[Lr] Data última revisão:
140527
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140422
[St] Status:MEDLINE


  9 / 9 MEDLINE  
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[PMID]:22805085
[Au] Autor:Mouli KC; Vijaya T; Dattatreya Rao S
[Ad] Endereço:Department of Biotechnology, Sri Venkateswara University, Andhra Pradesh, India.
[Ti] Título:Effectiveness of flavonoid-rich leaf extract of Acalypha indica in reversing experimental myocardial ischemia: biochemical and histopathological evidence.
[So] Source:Zhong Xi Yi Jie He Xue Bao;10(7):784-92, 2012 Jul.
[Is] ISSN:1672-1977
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In this study, we investigated the antimyocardial ischemic effects of flavonoid-rich methanolic leaf extract of Acalypha indica (AIE). METHODS: An animal model of myocardial ischemic injury was induced by isoproterenol (ISO) in adult rats. Albino Wistar rats were pretreated with the AIE (100 and 200 mg/kg body weight orally) for 30 d followed by ISO (85 mg/kg subcutaneously) at an interval of 24 h for 2 d. At the end of the experimental period (12 h after the second dose of ISO injection), rats were sacrificed by anaesthetization with an intramuscular injection of ketamine hydrochloride (24 mg/kg). To ensure anti-ischemic potential of AIE, the plasma lipids such as total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), free fatty acids (FFA), phospholipids (PL), myocardial lipids and hepatic lipids (TC, TG, FFA and PL) were estimated. Histopathology of heart tissue was also examined. RESULTS: Administration of AIE maintained the levels of plasma lipids in all the treatment groups (100 and 200 mg/kg) when compared with the ISO-injected model rats. Histopathological examination of heart tissue of ISO-administered model rat showed myofiber loss, extensive subendocardial necrosis, infiltration of inflammatory cells, marked myocellular edema and vacuolar degeneration. However, pretreatment with AIE at 200 mg/kg showed predominantly normal myocardium structure with myofibers appeared and no inflammatory cell infiltration, edema and necrosis. CONCLUSION: The biochemical and histological evidence from this study shows that AIE is protective against ISO-induced myocardial ischemia.
[Mh] Termos MeSH primário: Acalypha
Flavonoides/farmacologia
Isquemia Miocárdica/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Colesterol
Lipoproteínas HDL
Lipoproteínas LDL
Fosfolipídeos
Folhas de Planta
Ratos
Ratos Wistar
Triglicerídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL); 0 (Phospholipids); 0 (Plant Extracts); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:120718
[Lr] Data última revisão:
120718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120719
[St] Status:MEDLINE



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