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[PMID]:29241121
[Au] Autor:Udayabhanu J; Kannan V; Tiwari M; Natesan G; Giovanni B; Perumal V
[Ad] Endereço:Department of Biotechnology, Periyar University, Periyar Palkalai Nagar, Salem 636 011, Tamil Nadu, India.
[Ti] Título:Nanotitania crystals induced efficient photocatalytic color degradation, antimicrobial and larvicidal activity.
[So] Source:J Photochem Photobiol B;178:496-504, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Textile industries release tonnes of harmful toxic dyes into the environment, causing severe effects on living organisms, including humans. Mosquitoes vectors spread important diseases which cause millions of human deaths worldwide. To control mosquitoes a number of synthetic mosquitocidal agents have been employed but all these pesticides pose harmful effects to human health and non-target species and also led to resistance development in treated vectors. Microbial strains are also developing resistance to the available antibiotics, this currently represents a major public health challenge. The current study is focused on the green synthesis of titanium dioxide nanoparticles (TiO NPs) using aqueous leaf extracts of Euphorbia hirta. Results suggested an efficient remedy for the above mentioned problems using TiO NPs against the dye degradation, mosquito larvae and bacterial pathogens. The fabrication of TiO NPs was confirmed by UV-visible spectroscopy, the biomolecules involved in the synthesis process were evidenced by Fourier transform infra-red spectroscopy (FT-IR), the crystalline structure was observed by using X-ray powder diffraction (XRD) analysis. Spherical shaped TiO NPs were recorded using field emission scanning electron microscopy (FESEM). Energy dispersive X-ray spectroscopy (EDX) results showed the elemental composition of TiO NPs. Enhanced rate of photocatalytic dye degradation efficacy was recorded in in methylene blue (95.8%) followed by crystal violet (86.7%). Antibacterial activity assays indicated growth inhibition was highest in Staphylococcus epidermidis and Proteus vulgaris. The LC of TiO NPs and E. hirta extract on Aedes aegypti larvae were 13.2mg/l and 81.2mg/l, while on Culex quinquefasciatus they were 6.89mg/l and 46.1mg/l respectively. Overall, based on the results of the present study, the green engineered nanotitania could be considered as novel and promising photocatalytic, antibacterial, and mosquitocidal agent.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Corantes/química
Nanopartículas Metálicas/química
Titânio/química
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Aedes/crescimento & desenvolvimento
Animais
Anti-Infecciosos/farmacologia
Compostos Azo/química
Catálise
Escherichia coli/efeitos dos fármacos
Euphorbia/química
Euphorbia/metabolismo
Química Verde
Larva/efeitos dos fármacos
Luz
Nanopartículas Metálicas/toxicidade
Azul de Metileno/química
Fotólise/efeitos dos fármacos
Fotólise/efeitos da radiação
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Azo Compounds); 0 (Coloring Agents); 0 (Plant Extracts); 15FIX9V2JP (titanium dioxide); 6B4TC34456 (methyl orange); D1JT611TNE (Titanium); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:27775975
[Au] Autor:Huerth KA; Hawkes JE; Meyer LJ; Powell DL
[Ad] Endereço:From the *University at Buffalo School of Medicine, New York, NY; †The University of Utah Department of Dermatology, Salt Lake City; and ‡Veterans Administration Hospital, Salt Lake City, UT.
[Ti] Título:The Scourge of the Spurge Family-An Imitator of Rhus Dermatitis.
[So] Source:Dermatitis;27(6):372-381, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. We examined case reports spanning 40 years and discovered that spurge-induced ICD tends to befall children and middle-aged adults who unwittingly encounter the plant through play or horticulture, respectively. Clinical presentation is pleomorphic. Erythema, edema, burning, vesicles, and pruritus of acute onset and rapid resolution are frequently observed. We present a classic case of ICD in a 12-year-old girl after exposure to Euphorbia myrsinites and review the literature on phytodermatitis caused by members of the Euphorbiaceae family.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/diagnóstico
Dermatite por Toxicodendron/diagnóstico
Euphorbia/efeitos adversos
[Mh] Termos MeSH secundário: Criança
Dermatite Alérgica de Contato/etiologia
Diagnóstico Diferencial
Euphorbiaceae
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29253734
[Au] Autor:Wang AH; Tian XG; Cui YL; Huo XK; Zhang BJ; Deng S; Feng L; Ma XC; Jia JM; Wang C
[Ad] Endereço:School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, People's Republic of China.
[Ti] Título:Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2.
[So] Source:Phytochemistry;146:82-90, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A chemical investigation of the roots of Euphorbia ebracteolata identified eighteen diterpenoids and glycosides. On the basis of spectroscopic data, they were determined to be ent-kauranes, ent-atisanes, tigliane derivatives, ingenane, and ent-abietanes, among which were eleven previously undescribed diterpenoids. The inhibitory effects of the isolated compounds against human carboxylesterase 2 (hCE-2) were evaluated in vitro, which revealed moderate inhibitory effects with IC values < 50 µM. Next, the inhibitory kinetics were evaluated for the putative hCE-2 inhibitor 4ß,9α,16,20-tetrahydroxy-14(13 → 12)-abeo-12αH-1,6-tigliadiene-3,13-dione (IC 3.88 µM), and results indicated competitive inhibition with K 4.94 µM. Additionally, none of the diterpenoids showed cytotoxic effects against five human tumor cell lines as determined by MTT assays.
[Mh] Termos MeSH primário: Carboxilesterase/antagonistas & inibidores
Diterpenos/farmacologia
Inibidores Enzimáticos/farmacologia
Euphorbia/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Carboxilesterase/metabolismo
Diterpenos/química
Diterpenos/isolamento & purificação
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Seres Humanos
Conformação Molecular
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Enzyme Inhibitors); EC 3.1.1.1 (CES2 protein, human); EC 3.1.1.1 (Carboxylesterase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:28973486
[Au] Autor:Krauter PC; Heinz KM; Arthurs S
[Ad] Endereço:Department of Entomology, Texas A&M University, 370 Olsen Blvd., College Station, TX 77843-2475.
[Ti] Título:Protecting Unrooted Cuttings From Bemisia tabaci (Hemiptera Aleyrodidae) During Propagation.
[So] Source:J Insect Sci;17(4), 2017 Jul 01.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In North America, the sweetpotato whitefly, Bemisia tabaci Genn., is an important pest of greenhouse poinsettia. Growers have limited options to control this pest during propagation of cuttings, which are rooted under mist for several weeks. Early establishment of this pest increases the difficulty of managing the whitefly and retaining high aesthetic standard during the remaining crop production phase. We evaluated two neonicotinoids with translaminar activity, thiamethoxam (Flagship 25WG), and acetamiprid (TriStar 70 WSP), for control of B. tabaci pre-infested on unrooted cuttings propagated under mist. In an experimental greenhouse, both materials significantly reduced whitefly populations, providing an average reduction of 87.8% and 61.5% total recovered whitefly stages respectively, compared with controls. In another test, dipping cuttings in thiamethoxam (immersion treatment) did not improve control significantly, when compared with foliar sprays applied at label rate. In a commercial greenhouse operation, immersion treatments of thiamethoxam on pre-infested poinsettia cuttings maintained whiteflies at ≤ 0.02/plant, compared with up to 0.33/plant in untreated cuttings. Our data suggest that treating unrooted cuttings before or at the start of propagation can be part of an overall strategy for growers to manage whiteflies in poinsettia production.
[Mh] Termos MeSH primário: Hemípteros
Controle de Insetos/métodos
Inseticidas/administração & dosagem
Nitrocompostos/administração & dosagem
Oxazinas/administração & dosagem
Piridinas/administração & dosagem
Tiazóis/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Euphorbia
Feminino
Masculino
Neonicotinoides
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Oxazines); 0 (Pyridines); 0 (Thiazoles); 5HL5N372P0 (acetamiprid); 747IC8B487 (thiamethoxam)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1093/jisesa/iex056


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[PMID]:28836990
[Au] Autor:Tuhin RH; Begum MM; Rahman MS; Karim R; Begum T; Ahmed SU; Mostofa R; Hossain A; Abdel-Daim M; Begum R
[Ad] Endereço:Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
[Ti] Título:Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats.
[So] Source:BMC Complement Altern Med;17(1):423, 2017 Aug 24.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal population. It is a common practice to use the whole to heal wounds. Several pharmacological properties including antiseptic, anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant. The aim of present work was to evaluate the wound healing property in diabetic animals by oral and topical administration of ethanolic extract of E. hirta whole plant. METHODS: The ethanolic extract of E. hirta was subjected to determine the total phenolic content and total flavonoid content using galic acid and quercetin, respectively as standard. A single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared in normal saline was administered to produce diabetes in rats, after overnight fasting. For analyzing the rate of contraction of wound, excision wounds sized 4.90cm and of 2 mm depth were used. Oral (100, 200 and 400 mg/kg/day; p.o.) and topical treatment with the extract (5% and 10% ointment 50 mg/kg/day) and standard (5% povidone iodine ointment 50 mg/kg/day) was started on the day of induction of wound and continued up to 16 days. The means of wound area measurement between groups at different time intervals were compared using ANOVA and Dunnet's test. The diabetic wound healing mechanism was studied by measuring the plasma level of glucose, malondialdehyde (MDA) and nitric oxide (NO) in both control and treated groups. For the confirmation of activity, histopathology of the wounds tissues from excision wound model was performed. RESULTS: Phytochemical investigations showed the presence of various phytoconstituents (carbohydrates, saponins, alkaloids, glycosides, steroids, flavonoids, tannins). In the ethanolic extract of E. hirta the total phenol content was 285 ± 3.22 mg/g whereas the total flavonoid content was 118.46 ± 1.85 mg/g. In the present study, E. hirta caused significant wound closer both orally (35.92%, 44.69% and 61.42% at the doses of 100, 200 and 400, respectively) and topically (32.86% and 36.32% at the doses of 5% and 10%) treated groups as compared to diabetic control. However, the orally treated groups showed more significant effect than the topically treated groups. Moreover, oral administration of E. hirta ethanolic extract significantly reduced the blood glucose levels in diabetic wound rats (p < 0.01) on day 8 and day 16 as compared to the diabetic wound control (p < 0.01). On the other hand, topical application of E. hirta did not influence the blood glucose levels in diabetic rats (p > 0.05). It also demonstrated a significant decrease in the plasma levels of lipid malondialdehyde and nitric oxide. The results of biochemical parameters were further supported by the histopathological changes of different organs (liver, pancrease, kidney, heart and skin from wound area) which were evidenced through a decrease in inflammatory cell infiltration. CONCLUSION: The present study demonstrates that E. hirta whole plant extract promotes healing of wounds more significantly as compared to diabetic control rats, where healing is otherwise delayed.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/metabolismo
Euphorbia/química
Extratos Vegetais/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aloxano
Animais
Glicemia/efeitos dos fármacos
Feminino
Flavonoides
Extratos Vegetais/uso terapêutico
Polifenóis
Ratos
Pele/efeitos dos fármacos
Úlcera Cutânea/tratamento farmacológico
Úlcera Cutânea/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 6SW5YHA5NG (Alloxan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1930-x


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[PMID]:28760607
[Au] Autor:Wang AH; Huo XK; Feng L; Sun CP; Deng S; Zhang HL; Zhang BJ; Ma XC; Jia JM; Wang C
[Ad] Endereço:School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, People's Republic of China.
[Ti] Título:Phenolic glycosides and monoterpenoids from the roots of Euphorbia ebracteolata and their bioactivities.
[So] Source:Fitoterapia;121:175-182, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The bioactive substance investigation of Euphorbia ebracteolata obtained 17 compounds by various chromatographic techniques. Their structures were elucidated using widely spectroscopic data, including ESI-MS, HRESI-MS, CD, 1D- and 2D-NMR, which gave 5 new phenolic glucosides and 4 new monoterpenoids. The phenolic glucosides and monoterpenoids showed the inhibitory effect against the human carboxylesterase-2 (hCE-2) using a fluorescence bioassay in vitro, with the strongest inhibitor compound 4 (IC 7.17µM). The antioxidant effects of these isolated compounds were evaluated using a DPPH scavenging assay. All of the phenolic acids displayed the DPPH scavenging effect, especially that eight compounds have better effect than vitamin C, with the IC values ranging from 4.52 to 7.52µM. Additionally, compounds 1-17 showed no cytotoxic effect against five human cancer cell lines by MTT assay.
[Mh] Termos MeSH primário: Euphorbia/química
Glicosídeos/química
Monoterpenos/química
Fenóis/química
[Mh] Termos MeSH secundário: Carboxilesterase/antagonistas & inibidores
Linhagem Celular Tumoral
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Glicosídeos/isolamento & purificação
Seres Humanos
Estrutura Molecular
Monoterpenos/isolamento & purificação
Fenóis/isolamento & purificação
Extratos Vegetais/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Free Radical Scavengers); 0 (Glycosides); 0 (Monoterpenes); 0 (Phenols); 0 (Plant Extracts); EC 3.1.1.1 (CES2 protein, human); EC 3.1.1.1 (Carboxylesterase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


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[PMID]:28678491
[Au] Autor:Flores-Giubi ME; Durán-Peña MJ; Botubol-Ares JM; Escobar-Montaño F; Zorrilla D; Macías-Sánchez AJ; Hernández-Galán R
[Ad] Endereço:Departamento de Química Orgánica, Instituto de Biomoléculas, and ‡Departamento de Química Física, Facultad de Ciencias, Universidad de Cádiz , Campus Universitario Puerto Real s/n, 11510, Puerto Real, Cádiz, Spain.
[Ti] Título:Gaditanone, a Diterpenoid Based on an Unprecedented Carbon Skeleton Isolated from Euphorbia gaditana.
[So] Source:J Nat Prod;80(7):2161-2165, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel diterpenoid, gaditanone (2), which possesses an unprecedented 5/6/4/6-fused gaditanane tetracyclic ring skeleton, and a new jatrophane (1) were isolated from the aerial parts of Euphorbia gaditana. The chemical structures and absolute configurations were determined by extensive spectroscopic NMR studies and ECD data analysis. A proposed biosynthetic pathway is presented for compound 2.
[Mh] Termos MeSH primário: Diterpenos/isolamento & purificação
Euphorbia/química
[Mh] Termos MeSH secundário: Vias Biossintéticas
Diterpenos/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (gaditanone); 0 (jatrophane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00332


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[PMID]:28671832
[Au] Autor:Esposito M; Nothias LF; Retailleau P; Costa J; Roussi F; Neyts J; Leyssen P; Touboul D; Litaudon M; Paolini J
[Ad] Endereço:Laboratory of Natural Products Chemistry, UMR CNRS SPE 6134, University of Corsica , 20250, Corte, France.
[Ti] Título:Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking.
[So] Source:J Nat Prod;80(7):2051-2059, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six new premyrsinol esters (1-6) and one new myrsinol ester (8) were isolated from an aerial parts extract of Euphorbia pithyusa, together with a known premyrsinol (7) and two known dideoxyphorbol esters (9 and 10), following a bioactivity-guided purification procedure using a chikungunya virus (CHIKV) cell-based assay. The structures of the new diterpene esters (1-6 and 8) were elucidated by MS and NMR spectroscopic data interpretation. Compounds 1-10 were evaluated against CHIKV replication, and results showed that the 4ß-dideoxyphorbol ester 10 was the most active compound, with an EC value of 4.0 ± 0.3 µM and a selectivity index of 10.6. To gain more insight into the structural diversity of diterpenoids produced by E. pithyusa, the initial extract and chromatographic fractions were analyzed by LC-MS/MS. The generated data were annotated using a molecular networking procedure and revealed that dozens of unknown premyrsinane, myrsinane, and tigliane analogues were present.
[Mh] Termos MeSH primário: Antivirais/isolamento & purificação
Antivirais/farmacologia
Vírus Chikungunya/efeitos dos fármacos
Diterpenos/isolamento & purificação
Diterpenos/farmacologia
Euphorbia/química
[Mh] Termos MeSH secundário: Animais
Antivirais/química
Cercopithecus aethiops
Diterpenos/química
França
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Componentes Aéreos da Planta/química
Células Vero
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Diterpenes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00233


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[PMID]:28612702
[Au] Autor:Mar TB; Xavier CAD; Lima ATM; Nogueira AM; Silva JCF; Ramos-Sobrinho R; Lau D; Zerbini FM
[Ad] Endereço:1​Dep de Fitopatologia/BIOAGRO, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil 2​National Research Institute for Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil.
[Ti] Título:Genetic variability and population structure of the New World begomovirus Euphorbia yellow mosaic virus.
[So] Source:J Gen Virol;98(6):1537-1551, 2017 Jun.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The emergence of begomoviruses (whitefly-transmitted viruses classified in the genus Begomovirus, family Geminiviridae) in Brazil probably occurred by horizontal transfer from non-cultivated plants after the introduction of Bemisia tabaci MEAM1. The centre of diversity of Euphorbia heterophylla (Euphorbiaceae) is located in Brazil and Paraguay, where it is an invasive species in soybean and other crops. Reports of possible begomovirus infection of E. heterophylla in Brazil date back to the 1950s. In 2011, Euphorbia yellow mosaic virus (EuYMV) was described in symptomatic plants collected in the Brazilian state of Goiás. Here we assess the genetic variability and population structure of begomoviruses infecting E. heterophylla in samples collected throughout nine Brazilian states from 2009 to 2014. A total of 158 and 57 haplotypes were compared in DNA-A and DNA-B datasets, respectively. Analysis comparing population structure in a large sampled area enabled us to differentiate two subpopulations. Further, the application of discriminant analysis of principal components allowed the differentiation of six subpopulations according to sampling locations and in agreement with phylogenetic analysis. In general, negative selection was predominant in all six subpopulations. Interestingly, we were able to reconstruct the phylogeny based on the information from the 23 sites that contributed most to the geographical structure proposed, demonstrating that these polymorphisms hold supporting information to discriminate between subpopulations. These sites were mapped in the genome and compared at the level of amino acid changes, providing insights into how genetic drift and selection contribute to maintain the patterns of begomovirus population variability from a geographical structuring point of view.
[Mh] Termos MeSH primário: Begomovirus/classificação
Begomovirus/genética
Euphorbia/virologia
Variação Genética
Filogeografia
Doenças das Plantas/virologia
[Mh] Termos MeSH secundário: Begomovirus/isolamento & purificação
Brasil
Evolução Molecular
Haplótipos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000784


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[PMID]:28590124
[Au] Autor:Gao J; Aisa HA
[Ad] Endereço:Key Laboratory of Chemistry of Plant Resources in Arid Regions and ‡State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011, People's Republic of China.
[Ti] Título:Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.
[So] Source:J Nat Prod;80(6):1767-1775, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten new terpenoids, including five diterpenoids (1-5), three nortriterpenoids (6-8), and two triterpenoids (9, 10), and 15 known terpenoids (11-25) were isolated from an acetone extract of Euphorbia soongarica. Sooneuphoramine (1) is the first example of a euphoractine B-type diterpenoid alkaloid, while sooneuphanones A-C (6-8) are rare nortriterpenoids from the Euphorbia genus. The isolated terpenoids were tested for their cytotoxicity and multidrug resistance (MDR) reversal activity, 10 of which showed moderate cytotoxicity against the KB and KBv200 cell lines, while 11 compounds exhibited P-gp modulating potential. The triterpenoid sooneuphanone D (9) possessed a remarkable MDR reversal activity much higher than the positive control, verapamil.
[Mh] Termos MeSH primário: Resistência a Múltiplos Medicamentos/efeitos dos fármacos
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Euphorbia/química
Terpenos/isolamento & purificação
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/farmacologia
Algoritmos
Diterpenos
Doxorrubicina
Resistência a Medicamentos Antineoplásicos
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Seres Humanos
Células KB
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Terpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Diterpenes); 0 (Drugs, Chinese Herbal); 0 (Terpenes); 0 (ent-7beta,14-dihydroxy-11alpha-methoxy-18-aldehyde-11beta-20-epoxy-kaur-16-en-15-one); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b01099



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