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Pesquisa : B01.650.940.800.575.912.250.350.505 [Categoria DeCS]
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[PMID]:27941980
[Au] Autor:Rizvi W; Fayazuddin M; Singh O; Naeem SS; Moin S; Akhtar K; Kumar A
[Ad] Endereço:Department of Pharmacology, Jawaharlal NehruMedical College, Aligarh Muslim University, Aligarh, India.
[Ti] Título:Cytokine Attenuation and Free Radical Scavenging Activity of a New Flavanone7,4'-Dihydroxy-3″,3″-Dimethyl -(5,6-Pyrano-2″-One)- 8- (3‴,3‴-Dimethyl Allyl)- Isolated from Mallotus philippensis: Possible Mechanism for Its Anti-Inflammatory Activity.
[So] Source:PLoS One;11(12):e0167294, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mallotus philippensis L.(MP) commonly known as Kamala tree in Hindi,is a small to medium-sized monoecious tree.The objective of the study was to evaluate the anti-inflammatory activity of MPand a new flavanoneisolated from it by using in vivo models of inflammation.Albino wistar rats of either sex weighing 150-200g were used. Seven groups were made (n = 6), namely normal control group (normal saline, 1 ml/kg), standard control group (acetylsalicylic acid, 100 mg/kg), methanol crude extract (300 and 500 mg/kg), ethylacetate fraction (300 and 500 mg/kg) and active compound 4 (new flavanone, 50 mg/kg). The anti-inflammatory activity was studied using carrageenan induced paw edema method and cotton pellet granuloma method. Levels of cytokines (TNF-α, IL-1and IL-6) and activity of antioxidant enzymeslike catalase and glutathione peroxidase were estimated. It was found that the methanol extract, ethylacetate fraction and Flavanonedemonstrated significant reduction in paw edema in carrageenan induced paw edema method as compared to control. They also diminished the serum TNF-α, IL-6 and IL-1 levels. Significantly attenuated the malondialdehyde levels and increased the activities of catalase and glutathione peroxidase in paw tissue. Similarly there was asignificant decrease in granuloma formation in cotton pellet induced granuloma method. In conclusion, MP extracts and the newflavanonepossess anti-inflammatory activity and this might be due to the inhibition of various cytokines and increased free radical scavenging activity.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Flavanonas/farmacologia
Depuradores de Radicais Livres/farmacologia
Mallotus (Planta)/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Carragenina/efeitos adversos
Catalase/antagonistas & inibidores
Catalase/metabolismo
Citocinas/sangue
Edema/tratamento farmacológico
Edema/etiologia
Edema/patologia
Flavanonas/química
Depuradores de Radicais Livres/química
Glutationa Peroxidase/antagonistas & inibidores
Glutationa Peroxidase/metabolismo
Granuloma/tratamento farmacológico
Granuloma/etiologia
Granuloma/patologia
Inflamação/tratamento farmacológico
Inflamação/etiologia
Inflamação/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Flavanones); 0 (Free Radical Scavengers); 0 (Plant Extracts); 9000-07-1 (Carrageenan); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167294


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[PMID]:27444343
[Au] Autor:Chhiber N; Kaur T; Singla S
[Ad] Endereço:Department of Biochemistry, Panjab University, Chandigarh-160015, India.
[Ti] Título:Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats.
[So] Source:Phytomedicine;23(10):989-97, 2016 Sep 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oxalate and/or calcium oxalate, is known to induce free radical production, subsequently leading to renal epithelial injury. Oxidative stress and mitochondrial dysfunction have emerged as new targets for managing oxalate induced renal injury. HYPOTHESIS: Plant products and antioxidants have gained tremendous attention in the prevention of lithiatic disease. Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., has shown free radical scavenging, antioxidant activity and has been reported to interfere in signaling pathways leading to inflammation and apoptosis. In this study, the potential role of rottlerin, in rats exposed to hyperoxaluric environment was explored. METHODS: Hyperoxaluria was induced by administering 0.4% ethylene glycol and 1% ammonium chloride in drinking water to male wistar rats for 9 days. Rottlerin was administered intraperitoneally at 1mg/kg/day along with the hyperoxaluric agent. Prophylactic efficacy of rottlerin to diminish hyperoxaluria induced renal dysfunctionality and crystal load was examined along with its effect on free radicals generating pathways in hyperoxaluric rats. RESULTS: 0.4% ethylene glycol and 1% ammonium chloride led to induction of hyperoxaluria, oxiadtive stress and mitochondrial damage in rats. Rottlerin treatment reduced NADPH oxidase activity, prevented mitochondrial dysfunction and maintained antioxidant environment. It also refurbished renal functioning, tissue integrity and diminished urinary crystal load in hyperoxaluric rats treated with rottlerin. CONCLUSIONS: Thus, the present investigation suggests that rottlerin evidently reduced hyperoxaluric consequences and the probable mechanism of action of this drug could be attributed to its ability to quench free radicals by itself and interrupting signaling pathways involved in pathogenesis of stone formation.
[Mh] Termos MeSH primário: Acetofenonas/farmacologia
Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/tratamento farmacológico
Antioxidantes/farmacologia
Oxalato de Cálcio/metabolismo
Radicais Livres/metabolismo
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetofenonas/uso terapêutico
Animais
Antioxidantes/uso terapêutico
Oxalato de Cálcio/uso terapêutico
Radicais Livres/uso terapêutico
Frutas/química
Índia
Masculino
Mallotus (Planta)/química
Oxirredução
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetophenones); 0 (Antioxidants); 0 (Free Radicals); 0 (Plant Extracts); 2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE


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[PMID]:27228055
[Au] Autor:Eaton AL; Dalal S; Cassera MB; Zhao S; Kingston DG
[Ad] Endereço:Department of Chemistry and the Virginia Tech Center for Drug Discovery and ‡Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
[Ti] Título:Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds.
[So] Source:J Nat Prod;79(6):1679-83, 2016 Jun 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The phloroglucinol mallotojaponin C (1) from Mallotus oppositifolius, which was previously shown by us to have both antiplasmodial and cytocidal activities against the malaria parasite Plasmodium falciparum, was synthesized in three steps from 2',4',6'-trihydroxyacetophenone, and various derivatives were synthesized in an attempt to improve the bioactivity of this class of compounds. Two derivatives, the simple prenylated phloroglucinols 12 and 13, were found to have comparable antiplasmodial activities to that of mallotojaponin C.
[Mh] Termos MeSH primário: Antimaláricos/síntese química
Antimaláricos/farmacologia
Mallotus (Planta)/química
Floroglucinol/análogos & derivados
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimaláricos/química
Estrutura Molecular
Floroglucinol/síntese química
Floroglucinol/química
Floroglucinol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (mallotojaponin C); DHD7FFG6YS (Phloroglucinol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160527
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00347


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[PMID]:27089412
[Au] Autor:Kukuia KK; Ameyaw EO; Woode E; Mante PK; Adongo DW
[Ti] Título:Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius.
[So] Source:J Basic Clin Physiol Pharmacol;27(5):523-32, 2016 Sep 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: One of the major drawbacks of current depression pharmacotherapy is the delay in symptom improvement, aside from the untoward side effects and lack of efficacy against refractory depression. This work therefore investigated a possible rapid-onset and sustained antidepressant effect of Mallotus oppositifolius. METHODS: Onset of the antidepressant effect of hydroalcoholic extract from the leaves of M. oppositifolius was investigated using the open space swim test, a chronic depression model. The possible effects of the extract on cognitive dysfunction measured in the Morris water maze and weight gain were also investigated. RESULTS: M. oppositifolius extract, after the first day of treatment, reversed the state of immobility in mice. This effect was sustained even after drug treatment was halted and the antidepressant effect verified in the tail suspension test. The extract also increased the total distance travelled by the mice and reversed the cognitive impairment induced by the depressed state but had no effect on weight variation. CONCLUSIONS: M. oppositifolius exhibits a rapid-onset and sustained antidepressant effect in mice.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Depressão/tratamento farmacológico
Mallotus (Planta)/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Elevação dos Membros Posteriores/métodos
Masculino
Camundongos
Atividade Motora/efeitos dos fármacos
Fitoterapia/métodos
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE


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[PMID]:26998192
[Au] Autor:Khan H; Amin H; Ullah A; Saba S; Rafique J; Khan K; Ahmad N; Badshah SL
[Ad] Endereço:Department of Chemistry, Islamia College University, Peshawar 25120, Pakistan.
[Ti] Título:Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis.
[So] Source:Oxid Med Cell Longev;2016:1051925, 2016.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two important biologically active compounds were isolated from Mallotus philippensis. The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin (1) and 11-O-galloylbergenin (2). The in vitro antioxidant and antiplasmodial activities of the isolated compounds were determined. For the antioxidant potential, three standard analytical protocols, namely, DPPH radical scavenging activity (RSA), reducing power assay (RPA), and total antioxidant capacity (TAC) assay, were adopted. The results showed that compound 2 was found to be more potent antioxidant as compared to 1. Fascinatingly, compound 2 displayed better EC50 results as compared to α-tocopherol while being comparable with ascorbic acid. The antiplasmodial assay data showed that both the compound exhibited good activity against chloroquine sensitive strain of Plasmodium falciparum (D10) and IC50 values were found to be less than 8 µM. The in silico molecular docking analyses were also performed for the determination of binding affinity of the isolated compounds using P. falciparum proteins PfLDH and Pfg27. The results showed that compound 2 has high docking score and binding affinity to both protein receptors as compared to compound 1. The demonstrated biological potentials declared that compound 2 could be the better natural antioxidant and antiplasmodial candidate.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Antioxidantes/farmacologia
Benzopiranos/farmacologia
Ácido Gálico/análogos & derivados
Mallotus (Planta)/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antimaláricos/química
Antimaláricos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Benzopiranos/química
Benzopiranos/isolamento & purificação
Ácido Gálico/química
Ácido Gálico/isolamento & purificação
Ácido Gálico/farmacologia
Espectroscopia de Ressonância Magnética
Simulação de Acoplamento Molecular
Testes de Sensibilidade Parasitária
Extratos Vegetais/isolamento & purificação
Plasmodium falciparum/efeitos dos fármacos
Plasmodium falciparum/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (11-O-galloylbergenin); 0 (Antimalarials); 0 (Antioxidants); 0 (Benzopyrans); 0 (Plant Extracts); 632XD903SP (Gallic Acid); L84RBE4IDC (bergenin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE
[do] DOI:10.1155/2016/1051925


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[PMID]:26764087
[Au] Autor:Roy VK; Chenkual L; Gurusubramanian G
[Ad] Endereço:Department of Zoology, Mizoram Central University, Aizawl, 796004 Mizoram, India.
[Ti] Título:Mallotus roxburghianus modulates antioxidant responses in pancreas of diabetic rats.
[So] Source:Acta Histochem;118(2):152-63, 2016 Mar.
[Is] ISSN:1618-0372
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Mallotus roxburghianus has long been used by Mizo tribal people for the treatment of diabetes. Scientific validation at known doses may provide information about its safety and efficacy. Methanolic leaf extract of M. roxburghianus (MRME 100 and 400mg/kg) was tested in comparison with normal and alloxan diabetic rats for 28 days p.o. in terms of body and pancreatic weight, blood glucose level, antioxidant enzymes, expression of visfatin and PCNA, histopathology and histomorphometric measurements of pancreas. The results were evaluated statistically using ANOVA, correlation and regression and Principal component analysis (PCO). MRME (100 and 400mg/kg) treatment significantly (p<0.0001) decreased the body weight, blood glucose level, improved the mass and size of pancreas, elevated the levels of antioxidant enzymes and up regulate the expression of visfatin and PCNA. PCO analysis was good to fitness and prediction distinguishes the therapeutic effects of M. roxburghianus from the alloxan induced diabetic rats. MRME has significant role in protecting animals from alloxan-induced diabetic oxidative stress in pancreas and exhibited promising antihyperglycaemic and antioxidant activities along with significant reversal of disturbed antioxidant status and lipid peroxidative damage. Pancreatic architecture and physiology under diabetic oxidative stress have been significantly modulated by MRME and validated as a drug candidate for antidiabetic treatment. M. roxburghianus treatment restores the antioxidant enzyme system and rejuvenates the islets mass in alloxanized rat by accelerating visfatin and PCNA expression in pancreatic tissue.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Glicemia
Citocinas/metabolismo
Diabetes Mellitus Experimental/sangue
Avaliação Pré-Clínica de Medicamentos
Hipoglicemiantes/uso terapêutico
Peroxidação de Lipídeos
Mallotus (Planta)/química
Malondialdeído/metabolismo
Nicotinamida Fosforribosiltransferase/metabolismo
Tamanho do Órgão
Estresse Oxidativo
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
Extratos Vegetais/uso terapêutico
Antígeno Nuclear de Célula em Proliferação/metabolismo
Ratos Wistar
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Cytokines); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Proliferating Cell Nuclear Antigen); 4Y8F71G49Q (Malondialdehyde); EC 1.15.1.1 (Superoxide Dismutase); EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase); EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, rat)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE


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[PMID]:26459670
[Au] Autor:Kumar Roy V; Marak TR; Gurusubramanian G
[Ad] Endereço:a Department of Zoology , Mizoram University , Aizawl , Mizoram , India.
[Ti] Título:Alleviating effect of Mallotus roxburghianus in heat-induced testicular dysfunction in Wistar rats.
[So] Source:Pharm Biol;54(5):905-18, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Hyperthermia causes detrimental effects on the testes leading to fertility problems. Mallotus roxbhurghianus Muell. Arg. (Euphorbiaceae) is used in traditional medicine and possesses antioxidant property. However, the mechanisms remain unknown in the context of alleviative action of M. roxburghianus against heat stress. OBJECTIVE: The objective of this study was to demonstrate the alleviating activity of M. roxburghianus and its mechanism in scrotal hyperthermia. MATERIALS AND METHODS: Scrotal hyperthermia experiments were performed in three groups (n = 7 per group) consisting of (i) the control group (C) maintained at 22 °C for 30 min, (ii) the heat stress-induced group (HS), and (iii) the heat stress-induced M. roxburghianus-treated group (HSM - 400 mg/kg each) in a thermostatically controlled water bath at 43 °C for 30 min. Subsequent to the heat treatment HS group, rats were treated with saline p.o and methanol extract of M. roxburghianus was administered to the rats of HSM group along with their standard food for 14 d. Scrotal hyperthermic effects were evaluated. RESULTS: Scrotal hyperthermia significantly (p < 0.0001) elevated malondialdehyde levels while decreasing the body and testes weights, serum testosterone, and antioxidant enzyme levels due to oxidative stress. Disorganisation of seminiferous tubules and arrest of spermatogenesis were observed in the HS group. The administration of methanol extract of M. roxburghianus (400 mg/kg) for 14 d after heat treatment significantly suppressed the lipid peroxidation, restored the antioxidant enzyme and testosterone levels, revived the spermatogenesis, and increased the cell proliferation activity in the HSM group. DISCUSSION AND CONCLUSION: The methanol extract of M. roxburghianus accelerates testicular recovery from the damaging influence of hyperthermia.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Temperatura Alta/efeitos adversos
Mallotus (Planta)
Extratos Vegetais/farmacologia
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Masculino
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
Escroto/efeitos dos fármacos
Escroto/metabolismo
Escroto/patologia
Testículo/metabolismo
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151014
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1091480


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[PMID]:26672344
[Au] Autor:Zhu CL
[Ti] Título:[Chemical Constituents from Mallotus paniculatus (II)].
[So] Source:Zhong Yao Cai;38(4):764-5, 2015 Apr.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the chemical constituents of Mallotus paniculaus radix. METHODS: The compounds were isolated with column chromatography. The chemical structures were identified by spectral and spectroscopic technology. RESULTS: Seven compounds were isolated from the n-BuOH extract and identified as scopoletin(1), isoscopletin(2), erythordiol(3), apigenin(4), 4-methoxybenzoic acid(5), acetylaleuritolic acid(6) and ß-daucosterol (7). CONCLUSION: compounds 2 - 6 are isolated from this plant for the first time.
[Mh] Termos MeSH primário: Mallotus (Planta)/química
Compostos Fitoquímicos/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Apigenina
Compostos Fitoquímicos/isolamento & purificação
Escopoletina
Sitosteroides
Triterpenos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Sitosterols); 0 (Triterpenes); 28937-85-1 (acetylaleuritolic acid); 7V515PI7F6 (Apigenin); KLF1HS0SXJ (Scopoletin); U45VN859W3 (lyoniside)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151217
[Lr] Data última revisão:
151217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE


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[PMID]:26549273
[Au] Autor:Roy VK; Chenkual L; Gurusubramanian G
[Ad] Endereço:Department of Zoology, Mizoram Central University, Aizawl 796004, Mizoram, India. Electronic address: vikas4araria@gmail.com.
[Ti] Título:Protection of testis through antioxidant action of Mallotus roxburghianus in alloxan-induced diabetic rat model.
[So] Source:J Ethnopharmacol;176:268-80, 2015 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Mallotus roxburghianus is used for its antihyperglycaemic properties in Southeast Asia especially in Northeast India (Mizoram) and is also recognized in traditional medicine. About 90% of diabetic patients have been associated with reproductive impairments. The primary aim of this investigation is to examine the effects of diabetes on oxidative stress, steroidogenesis, histopathology, proliferation of germ cells with proliferative cell nuclear antigen (PCNA) and antioxidant status, and alleviative effect of M. roxburghianus on the testis dysfunction. MATERIALS AND METHODS: Methanolic leaf extract of M. roxburghianus was given to male albino Wistar rats by oral gavage to study the acute toxicity. Phyto-chemical composition of the methanol extract of M. roxburghianus was analyzed by GC-MS. Male Wistar rats were divided into six groups with seven animals in each group: untreated control; M. roxburghianus methanolic extract control (MRME, 400mg/kg); Alloxan diabetic control group (150 mg/kg); diabetic with 100mg/kg MRME treatment; diabetic with 400mg/kg MRME treatment; and diabetic with glibenclamide (0.1mg/kg) treatment. Diabetes was induced by a single intraperitoneal injection of 150 mg/kg alloxan and was confirmed by testing fasting plasma blood glucose levels 5 days after injection. MRME was administered orally for 28 days. Body and testis weights, serum testosterone, testis malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione S transferase (GST) and protein levels were measured, and testis tissue was examined histopathologically and immunohistochemically (PCNA). RESULTS: No sign of mortality and organ toxicity was observed up to 3000 mg/kg in acute toxicity assay of MRME and inferred to be non-toxic and safe. Bergenin and betulinic acid are the major components of MRME with many biological activities. MRME treatment rendered significant increases in body weight, testis weight, testes-body weight ratio, down regulated the MDA levels, reduced the degeneration and disruption of seminiferous tubule structure, restored the antioxidant enzymes and serum testosterone levels, increased the PCNA activities and attenuated the testes injury. CONCLUSION: MRME treatment to diabetic rats improves diabetes induced oxidative damage in testis as well as provides protection to testis. Phenols (Bergenin) and terpenes (Betulinic acid) were the main compounds of MRME that show antioxidant and antidiabetic activities and indeed validated its traditional use in the management of diabetes related testicular impairment.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Mallotus (Planta)
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Antioxidantes/toxicidade
Catalase/metabolismo
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/patologia
Glutationa/metabolismo
Glutationa Transferase/metabolismo
Hipoglicemiantes/farmacologia
Hipoglicemiantes/toxicidade
Rim/efeitos dos fármacos
Rim/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Tamanho do Órgão/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/toxicidade
Folhas de Planta
Antígeno Nuclear de Célula em Proliferação/metabolismo
Ratos Wistar
Superóxido Dismutase/metabolismo
Testículo/efeitos dos fármacos
Testículo/patologia
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Proliferating Cell Nuclear Antigen); 3XMK78S47O (Testosterone); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151110
[St] Status:MEDLINE


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[PMID]:26463755
[Au] Autor:Kabran FA; Okpekon TA; Roblot F; Séon-Méniel B; Leblanc K; Bories C; Champy P; Yolou SF; Loiseau PM; Djakouré LA; Figadère B; Maciuk A
[Ad] Endereço:Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Côte d'Ivoire; Laboratoire de Pharmacognosie, UMR BioCIS, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 92296 Châtenay-Malabry, France. Ele
[Ti] Título:Bioactive phloroglucinols from Mallotus oppositifolius.
[So] Source:Fitoterapia;107:100-104, 2015 Dec.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The two new acylphloroglucinol derivatives, methylene-bis-aspidinol AB (1) and mallopposinol (2), together with the nine known compounds, aspidinol B (3), methylene-bis-aspidinol (4), (+)-α-tocopherol (5), lupeol (6), stigmasterol (7), phytol (8), bergenin (9), squalene (11) and methyl gallate (10) were isolated from the leaves of Mallotus oppositifolius. Their structures were elucidated by spectral analysis including MS, 1D and 2D-NMR spectroscopy. In vitro trypanocidal and antileishmanial activities of compounds 1-9 were evaluated. Mallopposinol (2) and aspidinol B (3) displayed weak antileishmanial activities against Leishmania donovani promastigotes, with EC50 values of 21.3 and 38.8µM, respectively. Only the methylene-bis-aspidinol (4) exhibited trypanocidal activity against Trypanosoma brucei brucei trypomastigotes (LC100=0.8µM) similar to the reference drug pentamidine (LC100=0.4µM).
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Leishmania donovani/efeitos dos fármacos
Mallotus (Planta)/química
Floroglucinol/farmacologia
Trypanosoma brucei brucei/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antiprotozoários/isolamento & purificação
Concentração Inibidora 50
Estrutura Molecular
Floroglucinol/isolamento & purificação
Extratos Vegetais/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Plant Extracts); DHD7FFG6YS (Phloroglucinol)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151015
[St] Status:MEDLINE



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