Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.350.825 [Categoria DeCS]
Referências encontradas : 13 [refinar]
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  1 / 13 MEDLINE  
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[PMID]:28443465
[Au] Autor:Sathish Kumar P; Viswanathan MBG; Venkatesan M; Balakrishna K
[Ad] Endereço:1 Centre for Research and Development of Siddha-Ayurveda Medicines (CRDSAM), Department of Plant Science, Bharathidasan University, Tiruchirappalli, India.
[Ti] Título:Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells.
[So] Source:Tumour Biol;39(4):1010428317698387, 2017 Apr.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The triterpenoid, bauerenol, from Suregada angustifolia (Baill. ex Muell.-Arg.) Airy Shaw (Euphorbiaceae) was screened for anti-cancer property using hepatocellular carcinoma cell line, HepG2. Bauerenol exhibited growth inhibitory and apoptosis inducing potential against HepG2 cancer cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxic assay revealed that bauerenol treatment significantly reduced the growth of HepG2 cells in a time- and dose-dependent manner with 50% growth inhibitory concentration doses of 45 and 25 µg/mL at 24 and 48 h treatments, respectively. Bauerenol-induced cell death reflected apoptotic morphological features, that is, cell membrane blebbing, vacuolization, chromatin condensation, and nuclear fragmentation. In addition, bauerenol treatment diminished the mitochondrial membrane potential, by inducing the efflux of cytochrome c, downregulating the levels of anti-apoptotic Bcl-2 as well as upregulating the levels of pro-apoptotic Bax, and inducing caspase activation and poly (ADP-ribose) polymerase cleavage. Moreover, bauerenol treatment activates p38MAPK and inactivates the anti-apoptotic kinases Akt and ERK1/2 through the induction of reactive oxygen species. Furthermore, bauerenol-mediated S-phase arrest was associated with downregulation of cell cycle-rate-limiting factor (cyclin D1) and upregulation of cyclin-dependent kinase inhibitor p21 and tumor suppressor p53. Interestingly, pre-treatment of cells with reactive oxygen species inhibitor and p38 inhibitor significantly decreases bauerenol-induced cytotoxicity, Bax upregulation, and p38 activation. This study clearly states that bauerenol induces cell cycle arrest and apoptosis through the reactive oxygen species-dependent p38MAPK activation in HepG2 cancer cells.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/tratamento farmacológico
Neoplasias Hepáticas/tratamento farmacológico
Triterpenos/administração & dosagem
Proteínas Quinases p38 Ativadas por Mitógeno/biossíntese
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/genética
Carcinoma Hepatocelular/patologia
Ciclina D1/biossíntese
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Células Hep G2
Seres Humanos
Neoplasias Hepáticas/genética
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Espécies Reativas de Oxigênio/metabolismo
Suregada/química
Triterpenos/química
Proteína X Associada a bcl-2/biossíntese
Proteínas Quinases p38 Ativadas por Mitógeno/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCND1 protein, human); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Triterpenes); 0 (bcl-2-Associated X Protein); 136601-57-5 (Cyclin D1); 6466-94-0 (bauerenol); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317698387


  2 / 13 MEDLINE  
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[PMID]:24334235
[Au] Autor:Yan RY; Wang HQ; Kang J; Chen RY
[Ad] Endereço:Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
[Ti] Título:Pyrrolidine-type iminosugars from leaves of Suregada glomerulata.
[So] Source:Carbohydr Res;384:9-12, 2014 Jan 30.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the H2O extract of leaves of Suregada glomerulata led to the isolation of ten pyrrolidine-type iminosugars. The chemical structures of the six new compounds (4-6, 8-10) were elucidated as 2,5-imino-2,4,5-trideoxy-d-manno-heptitol (4-deoxy-homoDMDP) (4), 2,5-imino-2,4,5-trideoxy-d-gulo-heptitol (5), 2,5-imino-2,4,5,6-tetradeoxy-d-gulo-heptitol (6), 6-C-butyl-4-deoxy-DMDP (8), 6-C-(8-hydroxyoctyl)-DMDP (9), and 6-C-(8-hydroxyoctyl)-2,5-dideoxy-2,5-imino-d-galactitol (10), respectively, on the basis of spectroscopic data analysis (NMR and HRESIMS). Compounds 4-6 and 8 were characterized as rarely seen 4-deoxy pyrrolidine-type iminosugars. Pyrrolidine-type iminosugars with a long-side chain have been found in the restrictive plant families Moraceae, Campanulaceae, and Hyacinthaceae. The discovery of compounds 9 and 10 with a C8 side chain from S. glomerulata (Euphorbiaceae) expands the range of distribution for the iminosugars in plants. The 8-hydroxyoctyl side-chain represents a new addition for the molecular diversity of iminosugars. The compounds 1-10 were evaluated for inhibitory activity against rat intestinal α-glucosidase. However, all the test compounds showed no significant inhibitory activities to the glucosidase.
[Mh] Termos MeSH primário: Imino Açúcares/química
Imino Açúcares/isolamento & purificação
Folhas de Planta/química
Pirrolidinas/química
Suregada/química
[Mh] Termos MeSH secundário: Conformação Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Imino Sugars); 0 (Pyrrolidines); LJU5627FYV (pyrrolidine)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140113
[Lr] Data última revisão:
140113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131217
[St] Status:MEDLINE


  3 / 13 MEDLINE  
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[PMID]:23993676
[Au] Autor:Yan RY; Wang HQ; Liu C; Kang J; Chen RY
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, PR China.
[Ti] Título:α-Glucosidase-inhibitory iminosugars from the leaves of Suregada glomerulata.
[So] Source:Bioorg Med Chem;21(21):6796-803, 2013 Nov 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A water extract of the leaves of Suregada glomerulata (Euphorbiaceae) was found to inhibit rat small intestinal α-glucosidase. An examination of the extract afforded 20 iminosugars including one pyrrolidine and 19 piperidines. The structures of the 10 new compounds (11-20) were determined by NMR, and MS spectroscopic data analyses, and chemical correlations. The novelty of the identified compounds mainly stems from the loss of a hydroxy at C-4 and the presence of an 8-hydroxyoctyl side chain. Nine N-alkyl derivatives including N-methyl (1a, 8a, and 13a), N-butyl (1b, 2b, and 9b) and N,N-dimethyl (1c, 2c, and 9c) were synthesized. The compounds were tested for rat small intestinal α-glucosidase inhibitory activity. In total, 15 compounds, including compounds 11, 12, 15, and 19 and the three derivatives 8a, 9b, and 13a, showed inhibitory activity with IC50 values less than 40µM. In vivo results showed that total alkaloids of S. glomerulata (10mg/kg) and four major iminosugars 1, 2, 3, and 9 (10mg/kg) can lower the postprandial blood glucose level after sucrose and starch load in healthy male ICR mice.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/química
Inibidores de Glicosídeo Hidrolases
Hipoglicemiantes/química
Imino Açúcares/química
Suregada/química
[Mh] Termos MeSH secundário: Animais
Glicemia/análise
Inibidores Enzimáticos/metabolismo
Inibidores Enzimáticos/uso terapêutico
Hiperglicemia/tratamento farmacológico
Hipoglicemiantes/metabolismo
Hipoglicemiantes/uso terapêutico
Imino Açúcares/isolamento & purificação
Imino Açúcares/metabolismo
Intestino Delgado/enzimologia
Espectroscopia de Ressonância Magnética
Masculino
Camundongos
Camundongos Endogâmicos ICR
Conformação Molecular
Folhas de Planta/química
Folhas de Planta/metabolismo
Ligação Proteica
Ratos
Suregada/metabolismo
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Enzyme Inhibitors); 0 (Glycoside Hydrolase Inhibitors); 0 (Hypoglycemic Agents); 0 (Imino Sugars); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130903
[St] Status:MEDLINE


  4 / 13 MEDLINE  
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[PMID]:23973813
[Au] Autor:Shin MC; Zhang J; David AE; Trommer WE; Kwon YM; Min KA; Kim JH; Yang VC
[Ad] Endereço:Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, 48109, USA.
[Ti] Título:Chemically and biologically synthesized CPP-modified gelonin for enhanced anti-tumor activity.
[So] Source:J Control Release;172(1):169-78, 2013 Nov 28.
[Is] ISSN:1873-4995
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The ineffectiveness of small molecule drugs against cancer has generated significant interest in more potent macromolecular agents. Gelonin, a plant-derived toxin that inhibits protein translation, has attracted much attention in this regard. Due to its inability to internalize into cells, however, gelonin exerts only limited tumoricidal effect. To overcome this cell membrane barrier, we modified gelonin, via both chemical conjugation and genetic recombination methods, with low molecular weight protamine (LMWP), a cell-penetrating peptide (CPP) which was shown to efficiently ferry various cargoes into cells. Results confirmed that gelonin-LMWP chemical conjugate (cG-L) and recombinant gelonin-LMWP chimera (rG-L) possessed N-glycosidase activity equivalent to that of unmodified recombinant gelonin (rGel); however, unlike rGel, both gelonin-LMWPs were able to internalize into cells. Cytotoxicity studies further demonstrated that cG-L and rG-L exhibited significantly improved tumoricidal effects, with IC50 values being 120-fold lower than that of rGel. Moreover, when tested against a CT26 s.c. xenograft tumor mouse model, significant inhibition of tumor growth was observed with rG-L doses as low as 2 µg/tumor, while no detectable therapeutic effects were seen with rGel at 10-fold higher doses. Overall, this study demonstrated the potential of utilizing CPP-modified gelonin as a highly potent anticancer drug to overcome limitations of current chemotherapeutic agents.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/uso terapêutico
Neoplasias/tratamento farmacológico
Proteínas Inativadoras de Ribossomos Tipo 1/química
Proteínas Inativadoras de Ribossomos Tipo 1/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/metabolismo
Linhagem Celular Tumoral
Peptídeos Penetradores de Células/química
Peptídeos Penetradores de Células/genética
Peptídeos Penetradores de Células/uso terapêutico
Seres Humanos
Masculino
Camundongos
Camundongos Nus
Neoplasias/patologia
Ratos
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/genética
Proteínas Recombinantes de Fusão/uso terapêutico
Proteínas Inativadoras de Ribossomos Tipo 1/genética
Suregada/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cell-Penetrating Peptides); 0 (Recombinant Fusion Proteins); 0 (Ribosome Inactivating Proteins, Type 1); 75037-46-6 (GEL protein, Gelonium multiflorum)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130827
[St] Status:MEDLINE


  5 / 13 MEDLINE  
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[PMID]:20940031
[Au] Autor:Yan RY; Wang HQ; Liu C; Chen RY; Yu DQ
[Ad] Endereço:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xiannongtan Street, Beijing, 100050, People's Republic of China.
[Ti] Título:Three new water-soluble alkaloids from the leaves of Suregada glomerulata (Blume) Baill.
[So] Source:Fitoterapia;82(2):247-50, 2011 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Three new water-soluble alkaloids (1-3) together with twelve known compounds (4-15) have been isolated from the water extract of leaves of Suregada glomerulata. Their structures were determined by spectroscopic analysis and chemical method. Compounds 1-3 were evaluated for their in vitro inhibitory activity against α-glucosidase and HIV-1 replication. However, no significant activities were found.
[Mh] Termos MeSH primário: Extratos Vegetais/química
Piranos/isolamento & purificação
Pirrolidinas/isolamento & purificação
Suregada/química
[Mh] Termos MeSH secundário: HIV-1
Estrutura Molecular
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Piranos/química
Pirrolidinas/química
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2alpha-carboxymethyl-5alpha-dimethylamino-4alpha-hydroxytetrahydropyran); 0 (5beta-carboxymethyl-3alpha-hydroxy-2beta-hydroxymethyl-1,1-dimethylpyrrolidine); 0 (5beta-carboxymethyl-3alpha-hydroxy-2beta-hydroxymethyl-1-methylpyrrolidine); 0 (Plant Extracts); 0 (Pyrans); 0 (Pyrrolidines); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:110125
[Lr] Data última revisão:
110125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101014
[St] Status:MEDLINE
[do] DOI:10.1016/j.fitote.2010.10.004


  6 / 13 MEDLINE  
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[PMID]:20849942
[Au] Autor:Tewtrakul S; Subhadhirasakul S; Cheenpracha S; Yodsaoue O; Ponglimanont C; Karalai C
[Ad] Endereço:Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand. supinyat@yahoo.com
[Ti] Título:Anti-inflammatory principles of Suregada multiflora against nitric oxide and prostaglandin E2 releases.
[So] Source:J Ethnopharmacol;133(1):63-6, 2011 Jan 07.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:AIM OF THE STUDY: The stem bark of Suregada multiflora and the isolated compounds were carried out to investigate for anti-inflammatory activity. MATERIALS AND METHODS: The stem bark of Suregada multiflora and its isolated compounds were tested for their anti-inflammatory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostraglandin E(2) (PGE(2)) releases in RAW264.7 cells as well as the anti-inflammatory mechanism on mRNA expression of the active compound (5, helioscopinolide A). RESULTS: The extract of Suregada multiflora possessed potent NO inhibitory effect with an IC(50) value of 8.6 µg/ml. Among the isolated compounds, helioscopinolide A (5) exhibited the highest activity against NO release with an IC(50) value of 9.1 µM, followed by helioscopinolide C (6) and suremulol D (2) with IC(50) values of 24.5 and 29.3 µM, respectively. The IC(50) value of 5 against PGE(2) production was found to be 46.3 µM. The mechanism in transcriptional level of compound 5 was found to inhibit iNOS and COX-2 mRNA expressions in dose-dependent manners. CONCLUSIONS: The present study may support the traditional use of Suregada multiflora stem bark for treatment of inflammatory-related diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Dinoprostona/metabolismo
Diterpenos Abietanos/farmacologia
Macrófagos/efeitos dos fármacos
Óxido Nítrico/metabolismo
Extratos Vegetais/farmacologia
Suregada
[Mh] Termos MeSH secundário: Animais
Ciclo-Oxigenase 2/metabolismo
Diterpenos Abietanos/isolamento & purificação
Inflamação/tratamento farmacológico
Lipopolissacarídeos/imunologia
Macrófagos/imunologia
Macrófagos/metabolismo
Camundongos
Óxido Nítrico Sintase Tipo II/metabolismo
Fitoterapia
Casca de Planta
Extratos Vegetais/isolamento & purificação
RNA Mensageiro/análise
RNA Mensageiro/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Diterpenes, Abietane); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (helioscopinolide A); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100921
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2010.09.003


  7 / 13 MEDLINE  
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[PMID]:20569134
[Au] Autor:Innocent E; Joseph CC; Gikonyo NK; Nkunya MH; Hassanali A
[Ad] Endereço:Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania. einnocent@muhas.ac.tz
[Ti] Título:Constituents of the essential oil of Suregada zanzibariensis leaves are repellent to the mosquito, Anopheles gambiae s.s.
[So] Source:J Insect Sci;10:57, 2010.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In traditional African communities, repellent volatiles from certain plants generated by direct burning or by thermal expulsion have played an important role in protecting households against vectors of malaria and other diseases. Previous research on volatile constituents of plants has shown that some are good sources of potent mosquito repellents. In this bioprospecting initiative, the essential oil of leaves of the tree, Suregada zanzibariensis Verdc. (Angiospermae: Euphobiaceae) was tested against the mosquito, Anopheles gambiae s.s. Giles (Diptera: Culicidae) and found to be repellent. Gas chromatography (GC), GC-linked mass spectrometry (GC-MS) and, where possible, GC-co-injections with authentic compounds, led to the identification of about 34 compounds in the essential oil. About 56% of the constituents were terpenoid ketones, mostly methyl ketones. Phenylacetaldehyde (14.4%), artemisia ketone (10.1%), (1S)-(-)-verbenone (12.1%) and geranyl acetone (9.4%) were the main constituents. Apart from phenylacetaldehyde, repellent activities of the other main constituents were higher than that of the essential oil. The blends of the main constituents in proportions found in the essential oil were more repellent to An. gambiae s.s. than was the parent oil (p < 0.05), and the presence of artemisia ketone in the blend caused a significant increase in the repellency of the resulting blend. These results suggested that blends of some terpenoid ketones can serve as effective An. gambiae s.s. mosquito repellents.
[Mh] Termos MeSH primário: Anopheles/efeitos dos fármacos
Controle de Mosquitos/métodos
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/toxicidade
Folhas de Planta/química
Suregada/química
[Mh] Termos MeSH secundário: Acetaldeído/análogos & derivados
Acetaldeído/isolamento & purificação
Acetaldeído/toxicidade
Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oils, Volatile); GO1N1ZPR3B (Acetaldehyde); U8J5PLW9MR (phenylacetaldehyde)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100624
[St] Status:MEDLINE
[do] DOI:10.1673/031.010.5701


  8 / 13 MEDLINE  
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[PMID]:19235682
[Au] Autor:He SL; Yan RY; Zuo L; Chen RY
[Ad] Endereço:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
[Ti] Título:ent-Abietane and ent-kaurane diterpenoids from the roots of Suregada glomerulata.
[So] Source:Planta Med;75(6):641-6, 2009 May.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Twelve ENT-abietane and ENT-kaurane type diterpenoids, 1- 12, including five new compounds 1- 5, were isolated from the roots of Suregada glomerulata. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and other spectroscopic studies, and the structures of 1 and 2 were confirmed by X-ray crystallography. Cytotoxic activities against five human tumor cell lines were evaluated.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Diterpenos Abietanos/isolamento & purificação
Diterpenos Caurânicos/isolamento & purificação
Extratos Vegetais/química
Suregada/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Diterpenos Abietanos/química
Diterpenos Abietanos/farmacologia
Diterpenos Caurânicos/química
Diterpenos Caurânicos/farmacologia
Seres Humanos
Estrutura Molecular
Extratos Vegetais/farmacologia
Raízes de Plantas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Abietane); 0 (Diterpenes, Kaurane); 0 (Plant Extracts)
[Em] Mês de entrada:0911
[Cu] Atualização por classe:090811
[Lr] Data última revisão:
090811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090225
[St] Status:MEDLINE
[do] DOI:10.1055/s-0029-1185378


  9 / 13 MEDLINE  
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[PMID]:18205316
[Au] Autor:Yan RY; Tan YX; Cui XQ; Chen RY; Yu DQ
[Ad] Endereço:Key Laboratory of Bio Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
[Ti] Título:Diterpenoids from the roots of Suregada glomerulata.
[So] Source:J Nat Prod;71(2):195-8, 2008 Feb.
[Is] ISSN:0163-3864
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six new diterpenoids, 7beta,8alpha-dihydroxy-12-oxo- ent-abietan-16,14-olide ( 1), 3,4,18beta-cyclopropa-7beta,17-dihydroxy- ent-abieta-8(14),13(15)-dien-16,12-olide ( 2), 3alpha,7beta-dihydroxy- ent-abieta-8(14),13(15)-dien-16,12-olide ( 3), 3-oxo-8beta,14beta-epoxy- ent-abieta-11,13(15)-dien-16,12-olide ( 4), 17-hydroxy- ent-pimara-8(14),15-dien-3-one ( 5), and 3alpha,6beta-dihydroxy- ent-kaur-16-ene ( 6), and two known compounds, 7beta-hydroxy- ent-abieta-8(14),13(15)-dien-16,12-olide ( 7) and jolkinolide B, were isolated from roots of Suregada glomerulata. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and other spectroscopic studies. The structure of compound 1 was confirmed by X-ray crystallography. Cytotoxic activities were evaluated against five human tumor cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Diterpenos/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Plantas Medicinais/química
Suregada/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Cristalografia por Raios X
Diterpenos/química
Diterpenos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Seres Humanos
Conformação Molecular
Estrutura Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes); 0 (Drugs, Chinese Herbal); 37905-08-1 (jolkinolide B)
[Em] Mês de entrada:0804
[Cu] Atualização por classe:080225
[Lr] Data última revisão:
080225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080122
[St] Status:MEDLINE
[do] DOI:10.1021/np0705211


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[PMID]:18027660
[Au] Autor:Yan RY; Chen RY
[Ad] Endereço:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
[Ti] Título:[Studies on chemical constituents of Suregada glomerulata II].
[So] Source:Zhongguo Zhong Yao Za Zhi;32(16):1653-5, 2007 Aug.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the chemical constituents of Suregada glomeruldata. METHOD: Isolation and purification were carried out on silica gel, sephardex LH -20, ODS column chromatography etc. Constituents were identified by physicochemical properties and spectral analysis. RESULT: Nine compounds, Jolkinolide B (1), 8alpha, 14-dihydro-7-oxo-jolkinolide E (2), helioscopinolide B (3), ent-kauran-16beta, 17-diol (4), 7-oxo-beta-sitosterol (5), scopoletin (6), adenosine (7), 1'-sinapoylglucose (8), sucrose (9), were obtained and identified. CONCLUSION: Compounds 2-9 were isolated from S. glomerulata for the first time.
[Mh] Termos MeSH primário: Diterpenos Abietanos/isolamento & purificação
Plantas Medicinais/química
Escopoletina/isolamento & purificação
Sacarose/isolamento & purificação
Suregada/química
[Mh] Termos MeSH secundário: Cromatografia em Gel
Diterpenos Abietanos/química
Escopoletina/química
Sacarose/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Diterpenes, Abietane); 0 (helioscopinolide B); 57-50-1 (Sucrose); KLF1HS0SXJ (Scopoletin)
[Em] Mês de entrada:0810
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071122
[St] Status:MEDLINE



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