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Pesquisa : B01.650.940.800.575.912.250.401.025 [Categoria DeCS]
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[PMID]:29394892
[Au] Autor:Afsar T; Razak S; Almajwal A; Khan MR
[Ad] Endereço:Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
[Ti] Título:Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue.
[So] Source:BMC Complement Altern Med;18(1):49, 2018 Feb 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmacological properties. The current investigation aimed to assess the protective potential of A. hydaspica polyphenol rich ethyl acetate extract (AHE) against cisplatin (CP) induced pulmonary toxicity. METHODS: Rats were divided into six groups. Group 1 served as control (saline); Group 2 (drug control) recieved single dose of CP (7.5 mg/kg i.p.) on 1st day; Group 3 (extract control) (400 mg/kg bw, p.o.) received AHE for one week; Group 4 (Post-treated) and Group 5 (pretreated) received AHE (400 mg/kg bw/day, p.o) for 7 days after and before CP (7.5 mg/kg b.w., i.p.) respectively; Group 6 (Standard control) received silymarin (100 mg/kg b.w/7 days) before CP. At the end of dosing rats were sacrificed and pulmonary tissue samples were processed for the evaluation of antioxidant enzymes, oxidative stress markers, genotoxicity and histopathological alterations. RESULTS: CP caused body weights loss and increase pulmonary tissue weight. The CP significantly increases oxidative stress markers and decreases tissue antioxidant enzyme levels. Furthermore, CP induced deleterious changes in the microanatomy of pulmonary tissue by rupturing the alveolar septa, thickening of alveolar walls, and injuring the cells with subsequent collapse of blood vessels. AHE pretreatment returned MDA, NO, H O production and improved tissue antioxidant enzyme levels to near normalcy. The histological observations evidenced that AHE effectively rescues the lungs from CP-mediated oxidative damage. CP induction in rats also caused DNA fragmentation which was restored by AHE treatment. Our results suggest that pretreatment more significantly improve CP induced deleterious effects compared with post treatment indicating protective effect. Potency of AHE pretreatment is similar to silymarin. CONCLUSION: These findings demonstrated that A. hydaspica AHE extract might serve as potential adjuvant that prevents CP persuaded pulmonary toxicity due to its intrinsic antioxidant potential and polyphenolic constituents.
[Mh] Termos MeSH primário: Acacia/química
Antioxidantes/farmacologia
Cisplatino/efeitos adversos
Dano ao DNA/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Peso Corporal/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Tamanho do Órgão/efeitos dos fármacos
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2113-0


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[PMID]:29284479
[Au] Autor:Afsar T; Razak S; Batoo KM; Khan MR
[Ad] Endereço:Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. tayyaba_sona@yahoo.com.
[Ti] Título:Acacia hydaspica R. Parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural Cardiomyocyte alterations in rats.
[So] Source:BMC Complement Altern Med;17(1):554, 2017 Dec 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of doxorubicin (DOX) an anthracycline antineoplastic agent is withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the primary cause of DOX induced cardiotoxicity. We have investigated whether polyphenol rich ethyl acetate extract of Acacia hydaspica (AHE) can attenuate doxorubicin-induced cardiotoxicity via inhibition of oxidative stress. METHODS: AHE was administered orally to rats once daily for 6 weeks at doses of 200 and 400 mg/kg b.w. DOX (3 mg/kg b.w. i.p., single dose/week) was administered for 6 weeks (chronic model). The parameters studied to evaluate cardioprotective potential were the serum cardiac function biomarkers (CK, CKMB, AST and LDH), hematological parameters, cardiac tissue antioxidant enzymatic status and oxidative stress markers, and histopathological analysis to validate biochemical findings. RESULTS: Chronic 6 week treatment of DOX significantly deteriorated cardiac function biomarkers and decreased the activities of antioxidant enzymes, whereas significant increase in oxidative stress biomarkers was noticed in comparison to control group. AHE dose dependently protected DOX-induced leakage of cardiac enzymes in serum and ameliorated DOX-induced oxidative stress; as evidenced by decreasing lipid peroxidation, H O and NO content with increase in phase I and phase II antioxidant enzymes. Doxorubicin treatment produced severe morphological lesions, leucopenia, decrease in red blood cell counts and hemoglobin concentrations. AHE co-treatment protected the heart and blood elements from the toxic effects of doxorubicin as indicated by the recovery of hematological parameters to normal values and prevention of myocardial injuries in a dose dependent way. The protective potency of AHE (400 mg/kg b.w) was equivalent to silymarin. CONCLUSION: Results revealed that AHE showed protective effects against DOX induce cardiotoxicity. The protective effect might attribute to its polyphenolic constituents and antioxidant properties. AHE might be helpful in combination therapies as safer and efficient.
[Mh] Termos MeSH primário: Acacia/química
Antioxidantes/farmacologia
Cardiotoxinas/toxicidade
Doxorrubicina/toxicidade
Miócitos Cardíacos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Biomarcadores/sangue
Coração/efeitos dos fármacos
Masculino
Extratos Vegetais/química
Polifenóis/química
Polifenóis/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Cardiotoxins); 0 (Plant Extracts); 0 (Polyphenols); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2061-0


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[PMID]:29058615
[Au] Autor:Njanje I; Bagla VP; Beseni BK; Mbazima V; Lebogo KW; Mampuru L; Mokgotho MP
[Ad] Endereço:Department of Biochemistry, Microbiology and Biotechnology, Faculty of Science and Agriculture, University of Limpopo, Turfloop Campus, Private Bag X1106, Sovenga, Limpopo, 0727, South Africa. injanje@gmail.com.
[Ti] Título:Defatting of acetone leaf extract of Acacia karroo (Hayne) enhances its hypoglycaemic potential.
[So] Source:BMC Complement Altern Med;17(1):482, 2017 Oct 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Conventional drugs used to treat diabetes are too expensive, toxic and rarely available to rural communities. This study was aimed at investigating the phytochemical differences and hypoglycaemic effects (α-amylase enzyme inhibition, glucose uptake, GLUT4 translocation and phosphorylation of MAPKs) of non-defatted and defatted acetone leaf extract of Acacia karroo. METHODS: Qualitative phytochemical analyses of extracts were determined using standard chemical tests and total phenolic contents using the Folin-Ciocalteu reagent method. Presence of antioxidant constituents was determined using DPPH scavenging and ferric reducing power assays. Alpha amylase enzyme inhibitory potential was determined chromogenically and cytotoxicity of the extracts on C2C12 muscle and 3T3-L1 cells using the MTT assay. Glucose uptake by the cells was determined colorimetrically and the most active extract was evaluated for its ability to translocate GLUT4 and MAPKs phosphorylation potential using immunofluorescence microscopy and dot blot analysis, respectively. RESULTS: Phenols, flavonoids, tannins, saponins and cardiac glycosides were detected in both extracts. Defatting of the plant material resulted in low amounts of phenols (0.432 ± 0.014 TAE/mg), DPPH scavenging activity (EC 0.40 ± 0.012 mg/ml), low toxicity and high ferric reducing power (EC 1.13 ± 0.017 mg/ml), α-amylase enzyme inhibition (IC 30.2 ± 3.037 µg/ml) and glucose uptake by both cells. The defatted extract showed an increase in GLUT4 translocation (at 25 µg/ml) with decrease in Akt expression while in combination with insulin showed a decrease in GLUT4 translocation. A finding, that is implicative that the effect of the extract on GLUT4 translocation in C2C12 cells was not Akt dependent. The defatted extract in the absence and presence of insulin show varying phosphorylation levels of CREB, p38, GSK-3 and ERK2 which are important in cell survival and metabolism. CONCLUSION: This study represents the first report on the hypoglycemic potential of A. karroo and presence of compounds that can be exploited in the search for therapeutics with antidiabetic effect.
[Mh] Termos MeSH primário: Acacia/química
Antioxidantes/farmacologia
Glucose/metabolismo
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/farmacocinética
Antioxidantes/toxicidade
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Glucose/análise
Transportador de Glucose Tipo 4/metabolismo
Hipoglicemiantes/química
Hipoglicemiantes/farmacocinética
Hipoglicemiantes/toxicidade
Camundongos
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Fenóis/química
Fenóis/farmacocinética
Fenóis/farmacologia
Fenóis/toxicidade
Fosforilação/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/farmacocinética
Extratos Vegetais/toxicidade
alfa-Amilases/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glucose Transporter Type 4); 0 (Hypoglycemic Agents); 0 (Phenols); 0 (Plant Extracts); EC 2.7.11.24 (Mitogen-Activated Protein Kinases); EC 3.2.1.1 (alpha-Amylases); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1987-6


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[PMID]:28880962
[Au] Autor:Gaisberger H; Kindt R; Loo J; Schmidt M; Bognounou F; Da SS; Diallo OB; Ganaba S; Gnoumou A; Lompo D; Lykke AM; Mbayngone E; Nacoulma BMI; Ouedraogo M; Ouédraogo O; Parkouda C; Porembski S; Savadogo P; Thiombiano A; Zerbo G; Vinceti B
[Ad] Endereço:Bioversity International, Via dei Tre Denari 472/a, Maccarese (Rome), Italy.
[Ti] Título:Spatially explicit multi-threat assessment of food tree species in Burkina Faso: A fine-scale approach.
[So] Source:PLoS One;12(9):e0184457, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Over the last decades agroforestry parklands in Burkina Faso have come under increasing demographic as well as climatic pressures, which are threatening indigenous tree species that contribute substantially to income generation and nutrition in rural households. Analyzing the threats as well as the species vulnerability to them is fundamental for priority setting in conservation planning. Guided by literature and local experts we selected 16 important food tree species (Acacia macrostachya, Acacia senegal, Adansonia digitata, Annona senegalensis, Balanites aegyptiaca, Bombax costatum, Boscia senegalensis, Detarium microcarpum, Lannea microcarpa, Parkia biglobosa, Sclerocarya birrea, Strychnos spinosa, Tamarindus indica, Vitellaria paradoxa, Ximenia americana, Ziziphus mauritiana) and six key threats to them (overexploitation, overgrazing, fire, cotton production, mining and climate change). We developed a species-specific and spatially explicit approach combining freely accessible datasets, species distribution models (SDMs), climate models and expert survey results to predict, at fine scale, where these threats are likely to have the greatest impact. We find that all species face serious threats throughout much of their distribution in Burkina Faso and that climate change is predicted to be the most prevalent threat in the long term, whereas overexploitation and cotton production are the most important short-term threats. Tree populations growing in areas designated as 'highly threatened' due to climate change should be used as seed sources for ex situ conservation and planting in areas where future climate is predicting suitable habitats. Assisted regeneration is suggested for populations in areas where suitable habitat under future climate conditions coincides with high threat levels due to short-term threats. In the case of Vitellaria paradoxa, we suggest collecting seed along the northern margins of its distribution and considering assisted regeneration in the central part where the current threat level is high due to overexploitation. In the same way, population-specific recommendations can be derived from the individual and combined threat maps of the other 15 food tree species. The approach can be easily transferred to other countries and can be used to analyze general and species specific threats at finer and more local as well as at broader (continental) scales in order to plan more selective and efficient conservation actions in time. The concept can be applied anywhere as long as appropriate spatial data are available as well as knowledgeable experts.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/métodos
Alimentos
[Mh] Termos MeSH secundário: Acacia
Adansonia
Anacardiaceae
Annona
Balanites
Bombax
Burkina Faso
Mudança Climática
Ecossistema
Olacaceae
Tamarindus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184457


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[PMID]:28813440
[Au] Autor:Strydom M; Veldtman R; Ngwenya MZ; Esler KJ
[Ad] Endereço:Department of Conservation Ecology and Entomology, Stellenbosch University, Matieland, South Africa.
[Ti] Título:Invasive Australian Acacia seed banks: Size and relationship with stem diameter in the presence of gall-forming biological control agents.
[So] Source:PLoS One;12(8):e0181763, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Australian Acacia are invasive in many parts of the world. Despite significant mechanical and biological efforts to control their invasion and spread, soil-stored seed banks prevent their effective and sustained removal. In response South Africa has had a strong focus on employing seed reducing biological control agents to deal with Australian Acacia invasion, a programme that is considered as being successful. To provide a predictive understanding for their management, seed banks of four invasive Australian acacia species (Acacia longifolia, A. mearnsii, A. pycnantha and A. saligna) were studied in the Western Cape of South Africa. Across six to seven sites for each species, seed bank sizes were estimated from dense, monospecific stands by collecting 30 litter and soil samples. Average estimated seed bank size was large (1017 to 17261 seed m-2) as was annual input into the seed bank, suggesting that these seed banks are not residual but are replenished in size annually. A clear relationship between seed bank size and stem diameter was established indicating that mechanical clearing should be conducted shortly after fire-stimulated recruitment events or within old populations when seed banks are small. In dense, monospecific stands seed-feeding biological control agents are not effective in reducing seed bank size.
[Mh] Termos MeSH primário: Acacia
Espécies Introduzidas
Banco de Sementes
Sementes
[Mh] Termos MeSH secundário: Agentes de Controle Biológico
Ecossistema
Caules de Planta
Densidade Demográfica
Solo
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Control Agents); 0 (Soil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181763


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[PMID]:28720134
[Au] Autor:Sadiq MB; Tharaphan P; Chotivanich K; Tarning J; Anal AK
[Ad] Endereço:Food Engineering and Bioprocess Technology, Asian Institute of Technology, Klongluang, PO Box 4, Bangkok, Pathumthani, 12120, Thailand.
[Ti] Título:In vitro antioxidant and antimalarial activities of leaves, pods and bark extracts of Acacia nilotica (L.) Del.
[So] Source:BMC Complement Altern Med;17(1):372, 2017 Jul 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The emergence of drug resistant malaria is threatening our ability to treat and control malaria in the Southeast Asian region. There is an urgent need to develop novel and chemically diverse antimalarial drugs. This study aimed at evaluating the antimalarial and antioxidant potentials of Acacia nilotica plant extracts. METHODS: The antioxidant activities of leaves, pods and bark extracts were determined by standard antioxidant assays; reducing power capacity, % lipid peroxidation inhibition and ferric reducing antioxidant power assay. The antimalarial activities of plant extracts against Plasmodium falciparum parasites were determined by the 48 h schizont maturation inhibition assay. Further confirmation of schizonticide activity of extracts was made by extending the incubation period up to 96 h after removing the plant extract residues from parasites culture. Inhibition assays were analyzed by dose-response modelling. RESULTS: In all antioxidant assays, leaves of A. nilotica showed higher antioxidant activity than pods and bark. Antimalarial IC values of leaves, pods and bark extracts were 1.29, 4.16 and 4.28 µg/ml respectively, in the 48 h maturation assay. The IC values determined for leaves, pods and bark extracts were 3.72, 5.41 and 5.32 µg/ml respectively, after 96 h of incubation. All extracts inhibited the development of mature schizont, indicating schizonticide activity against P. falciparum. CONCLUSION: A. nilotica extracts showed promising antimalarial and antioxidant effects. However, further investigation is needed to isolate and identify the active components responsible for the antimalarial and antioxidant effects.
[Mh] Termos MeSH primário: Acacia
Antimaláricos/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Resistência a Medicamentos
Frutas
Concentração Inibidora 50
Malária/tratamento farmacológico
Fitoterapia
Casca de Planta
Folhas de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1878-x


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[PMID]:28686690
[Au] Autor:Pereira APA; Andrade PAM; Bini D; Durrer A; Robin A; Bouillet JP; Andreote FD; Cardoso EJBN
[Ad] Endereço:Departament of Soil Science, "Luiz de Queiroz" College of Agriculture, ESALQ/USP, University of São Paulo, Piracicaba, São Paulo, Brazil.
[Ti] Título:Shifts in the bacterial community composition along deep soil profiles in monospecific and mixed stands of Eucalyptus grandis and Acacia mangium.
[So] Source:PLoS One;12(7):e0180371, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our knowledge of the rhizosphere bacterial communities in deep soils and the role of Eucalyptus and Acacia on the structure of these communities remains very limited. In this study, we targeted the bacterial community along a depth profile (0 to 800 cm) and compared community structure in monospecific or mixed plantations of Acacia mangium and Eucalyptus grandis. We applied quantitative PCR (qPCR) and sequence the V6 region of the 16S rRNA gene to characterize composition of bacterial communities. We identified a decrease in bacterial abundance with soil depth, and differences in community patterns between monospecific and mixed cultivations. Sequence analysis indicated a prevalent effect of soil depth on bacterial communities in the mixed plant cultivation system, and a remarkable differentiation of bacterial communities in areas solely cultivated with Eucalyptus. The groups most influenced by soil depth were Proteobacteria and Acidobacteria (more frequent in samples between 0 and 300 cm). The predominant bacterial groups differentially displayed in the monospecific stands of Eucalyptus were Firmicutes and Proteobacteria. Our results suggest that the addition of an N2-fixing tree in a monospecific cultivation system modulates bacterial community composition even at a great depth. We conclude that co-cultivation systems may represent a key strategy to improve soil resources and to establish more sustainable cultivation of Eucalyptus in Brazil.
[Mh] Termos MeSH primário: Acacia/fisiologia
Acidobacteria/isolamento & purificação
Eucalyptus/fisiologia
Firmicutes/isolamento & purificação
Consórcios Microbianos/fisiologia
Proteobactérias/isolamento & purificação
Microbiologia do Solo
[Mh] Termos MeSH secundário: Acidobacteria/classificação
Acidobacteria/genética
Brasil
Conservação dos Recursos Naturais
DNA Bacteriano/genética
Firmicutes/classificação
Firmicutes/genética
Proteobactérias/classificação
Proteobactérias/genética
RNA Ribossômico 16S/genética
Rizosfera
Solo/química
Árvores/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S); 0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180371


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[PMID]:28683382
[Au] Autor:Wilk M; Magdziarz A; Gajek M; Zajemska M; Jayaraman K; Gokalp I
[Ad] Endereço:AGH University of Science and Technology, Mickiewicza 30 Av., 30-056 Krakow, Poland. Electronic address: mwilk@agh.edu.pl.
[Ti] Título:Combustion and kinetic parameters estimation of torrefied pine, acacia and Miscanthus giganteus using experimental and modelling techniques.
[So] Source:Bioresour Technol;243:304-314, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel approach, linking both experiments and modelling, was applied to obtain a better understanding of combustion characteristics of torrefied biomass. Therefore, Pine, Acacia and Miscanthus giganteus have been investigated under 260°C, 1h residence time and argon atmosphere. A higher heating value and carbon content corresponding to a higher fixed carbon, lower volatile matter, moisture content, and ratio O/C were obtained for all torrefied biomass. TGA analysis was used in order to proceed with the kinetics study and Chemkin calculations. The kinetics analysis demonstrated that the torrefaction process led to a decrease in Ea compared to raw biomass. The average Ea of pine using the KAS method changed from 169.42 to 122.88kJ/mol. The changes in gaseous products of combustion were calculated by Chemkin, which corresponded with the TGA results. The general conclusion based on these investigations is that torrefaction improves the physical and chemical properties of biomass.
[Mh] Termos MeSH primário: Acacia
Biomassa
Pinus
[Mh] Termos MeSH secundário: Cinética
Poaceae
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28679629
[Au] Autor:Mohan S; Thiagarajan K; Chandrasekaran R
[Ad] Endereço:School of Bio Sciences and Technology, VIT University, Vellore, TN 632014, India.
[Ti] Título:Evaluation of ethyl gallate for its antioxidant and anticancer properties against chemical-induced tongue carcinogenesis in mice.
[So] Source:Biochem J;474(17):3011-3025, 2017 Aug 22.
[Is] ISSN:1470-8728
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cancer arising in the oral cavity is one of the major causes of mortality worldwide and demands immediate attention. Regardless of the use of advanced treatment for oral cancer, successful treatment resulting in cancer survival is low. Currently available drugs are ineffective and are toxic. Therefore, successful treatment without toxic effects remains essential. This is quite challenging, leading to the identification of natural bioactive compounds for oral cancer treatment. Thus, a plant extract rich in phenolics is preferred for studying the cellular, biochemical and molecular changes associated with oral carcinogenesis.The present study aims to deal with the above need using (L.) leaf extract (AN) and ethyl gallate (EG), a phenolic compound present in AN against oral carcinogenesis. Extension of a tumor cell line to a mouse model was investigated with 4-nitroquinoline 1-oxide (4-NQO) as carcinogen, a surrogate for tobacco. The progression of squamous cell carcinoma (SCC) was achieved through hyperplasia and dysplasia after 4-NQO induction in Swiss albino mice. Administration of AN and EG to animals undergoing dysplasia led to the inhibition of SCC, thereby reducing the tumor burden. The antioxidant capacity of AN and EG was also brought out via biochemical analysis. Further investigation of biomarkers in tongue tissues revealed the involvement of apoptosis Moreover, no adverse or toxic effect was observed earlier in rats upon oral administration of AN and EG. Thus, AN and EG shows strong hope as drugs against oral cancer progression.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Carcinoma de Células Escamosas/tratamento farmacológico
Ácido Gálico/análogos & derivados
Neoplasias Experimentais/tratamento farmacológico
Neoplasias da Língua/tratamento farmacológico
[Mh] Termos MeSH secundário: 4-Nitroquinolina-1-Óxido/toxicidade
Acacia/química
Animais
Antineoplásicos Fitogênicos/química
Antioxidantes/química
Carcinoma de Células Escamosas/induzido quimicamente
Carcinoma de Células Escamosas/metabolismo
Carcinoma de Células Escamosas/patologia
Ensaios de Seleção de Medicamentos Antitumorais
Ácido Gálico/química
Ácido Gálico/farmacologia
Masculino
Camundongos
Neoplasias Experimentais/induzido quimicamente
Neoplasias Experimentais/metabolismo
Neoplasias Experimentais/patologia
Neoplasias da Língua/induzido quimicamente
Neoplasias da Língua/metabolismo
Neoplasias da Língua/patologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 235I6UDD3L (ethyl gallate); 56-57-5 (4-Nitroquinoline-1-oxide); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1042/BCJ20170316


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[PMID]:28606074
[Au] Autor:Afsar T; Razak S; Almajwal A; Rashid Khan M
[Ad] Endereço:Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
[Ti] Título:Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats.
[So] Source:BMC Complement Altern Med;17(1):307, 2017 Jun 12.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses various phytochemicals and pharmacological activities. The current study aimed to investigate the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP induced aberrations in lipid profile and hepatotoxicity. METHODS: Rats were randomly separated into six groups (n = 6). Group 1 (control) received distilled water orally for 21 days. Groups 2 (CP control) received a single dose of CP (7.5 mg/kg bw, i.p) on day 16, group 3 (Plant control) received AHE (400 mg/kg b.w, oral) for 21 days, group 4 (post treated group); CP received on day 16 and AHE (400 mg/kg b.w/day, p.o.) was administered after CP till day 21, Group 5 (pretreated group) received AHE (400 mg/kg b.w/day, p.o.) for 21 days and CP (7.5 mg/kg b.w., i.p.) on day 16, group 6 (Silymarin + CP) received 100 mg/kg b.w., p.o. (11 doses/21 days) and CP (7.5 mg/kg b.w., i.p.) on day 16. Lipid profile, liver functional tests, oxidative stress markers, antioxidant enzymes status and histopathological changes were examined. RESULTS: The present study revealed that CP caused body weights loss and increase liver index. CP significantly increased serum total lipid, triglycerides and LDL-cholesterol levels. Conversely, it significantly decreased serum HDL-cholesterol level. CP induced marked deteriorations in serum liver function biomarkers, reduced antioxidant enzymes in tissue, while elevated tissue oxidative stress markers along with morphological injuries compared to control rats. Treatment with AHE ameliorated CP induced alterations in lipid profile, serum ALT, AST, ALP and total bilirubin levels and liver weight. Furthermore AHE treatment improved the total protein and antioxidant enzymes levels while decreased the level of MDA, H O , and NO. The altered parameters were returned to the control level with AHE pretreatment. Histopathological analysis also supported the biochemical findings. Pretreatment seems to be more effective compared to post treatment indicating protective effect. CONCLUSION: These results reveal that treatment of AHE may be useful in the prevention of CP induced hepatotoxicity due to its antioxidant potential and polyphenolic constituents.
[Mh] Termos MeSH primário: Acacia/química
Antineoplásicos/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Cisplatino/efeitos adversos
Dislipidemias/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Dislipidemias/metabolismo
Seres Humanos
Peróxido de Hidrogênio/metabolismo
Fígado/efeitos dos fármacos
Fígado/lesões
Masculino
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); BBX060AN9V (Hydrogen Peroxide); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1824-y



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