Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.082 [Categoria DeCS]
Referências encontradas : 117 [refinar]
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  1 / 117 MEDLINE  
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[PMID]:28837611
[Au] Autor:Ros-Santaella JL; Pintus E
[Ad] Endereço:Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic.
[Ti] Título:Rooibos (Aspalathus linearis) extract enhances boar sperm velocity up to 96 hours of semen storage.
[So] Source:PLoS One;12(8):e0183682, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rooibos (Aspalathus linearis) is a native shrub from South African fynbos and has become very popular in the last decades for its antioxidant and medicinal attributes. Several studies have shown its beneficial properties in numerous cell lines, but to date, the in vitro effects of rooibos extract on sperm cells are still unknown. In this study, boar semen was supplemented with four concentrations both of fermented and unfermented rooibos extracts during 96 h of liquid storage at 17°C. The effects of rooibos extracts on sperm velocity, membrane integrity, and acrosomal status were evaluated at 2 h, 48 h, and 96 h of semen storage. Overall our results indicate that rooibos extract enhances sperm velocity, protects the acrosome structure, and tends to preserve the membrane integrity during semen storage. Although the unfermented rooibos showed higher total polyphenol content and total antioxidant capacity than the fermented one, the latter had better effects on sperm velocity leading to, for instance, an increase of 30% in the rectilinear velocity (VSL) at 48 h compared to the control group. Taking into account the different storage times, we established a suitable range of extracts concentrations to be used in boar semen. The rooibos extract ought to be considered as a powerful and natural source of antioxidants for the preservation of boar semen.
[Mh] Termos MeSH primário: Aspalathus/química
Extratos Vegetais/farmacologia
Motilidade Espermática/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Masculino
Preservação Biológica
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183682


  2 / 117 MEDLINE  
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[PMID]:28428087
[Au] Autor:Pereira CG; Barreira L; da Rosa Neng N; Nogueira JMF; Marques C; Santos TF; Varela J; Custódio L
[Ad] Endereço:Centre of Marine Sciences, University of Algarve, Faculty of Sciences and Technology, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal. Electronic address: cagpereira@ualg.pt.
[Ti] Título:Searching for new sources of innovative products for the food industry within halophyte aromatic plants: In vitro antioxidant activity and phenolic and mineral contents of infusions and decoctions of Crithmum maritimum L.
[So] Source:Food Chem Toxicol;107(Pt B):581-589, 2017 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linearis (Burm.f.) Dahlg. (rooibos) herbal tea was used as a reference. Sea fennel's tisanes, particularly from leaves, were rich in phenolic compounds and five of them (p-hydroxybenzoic and ferulic acids, epicatechin, pyrocatechol and 4-hydroxybenzaldehyde) were here described in C. maritimum for the first time. Chlorogenic acid was the dominant phenolic determined. Na was the most abundant mineral in all tisanes followed by Ca and Mg in leaves' tisanes and K in flowers. Sea fennel's samples had a similar antioxidant activity than those from A. linearis, and had no significant toxicity towards four different mammalian cell lines. Altogether, our results suggest that sea fennel can be a source of products and/or molecules for the food industry with antioxidant properties and minerals in the form, for example, of innovative health-promoting herbal beverages.
[Mh] Termos MeSH primário: Antioxidantes/análise
Apiaceae/química
Aspalathus/química
Minerais/análise
Pinus/química
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Bebidas/análise
Indústria Alimentícia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Minerals); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


  3 / 117 MEDLINE  
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[PMID]:28379220
[Au] Autor:Akinrinmade O; Omoruyi S; Dietrich D; Ekpo O
[Ad] Endereço:Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa.
[Ti] Título:Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats.
[So] Source:Acta Neurobiol Exp (Wars);77(1):94-105, 2017.
[Is] ISSN:1689-0035
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showed that long-term consumption of FRHT by Wistar rats signi icantly reduced brain oedema and neuronal apoptosis, but did not attenuate BBB damage following cerebral ischemia. Analysis of whole-brain homogenates showed significantly reduced lipid peroxidation levels, increased total antioxidant capacity and resulted in improved neurobehavioural outcomes in FRHT-treated rats when compared with untreated animals. Taken together, our results tend to suggest that continuous consumption of FRHT could confer some protection against ischemic brain injury (IBI) and is therefore highly recommended for patients with stroke-predisposing conditions.
[Mh] Termos MeSH primário: Aspalathus/química
Lesões Encefálicas/prevenção & controle
Fármacos Neuroprotetores/uso terapêutico
Chás de Ervas
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Barreira Hematoencefálica/efeitos dos fármacos
Barreira Hematoencefálica/fisiopatologia
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Edema Encefálico/tratamento farmacológico
Edema Encefálico/etiologia
Lesões Encefálicas/etiologia
Doenças das Artérias Carótidas/complicações
Modelos Animais de Doenças
Comportamento Exploratório/efeitos dos fármacos
Recuperação de Fluorescência Após Fotodegradação
Marcação In Situ das Extremidades Cortadas
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Capacidade de Absorbância de Radicais de Oxigênio
Extratos Vegetais
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Avemar); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Teas, Herbal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


  4 / 117 MEDLINE  
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[PMID]:28358310
[Au] Autor:Bowles S; Joubert E; de Beer D; Louw J; Brunschwig C; Njoroge M; Lawrence N; Wiesner L; Chibale K; Muller C
[Ad] Endereço:Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7130, South Africa. sandra.bowles@mrc.ac.za.
[Ti] Título:Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.
[So] Source:Molecules;22(4), 2017 Mar 30.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Insight into the mechanisms of intestinal transport and metabolism of aspalathin will provide important information for dose optimisation, in particular for studies using mouse models. Aspalathin transportation across the intestinal barrier (Caco-2 monolayer) tested at 1-150 µM had an apparent rate of permeability (P ) typical of poorly absorbed compounds (1.73 × 10 cm/s). Major glucose transporters, sodium glucose linked transporter 1 (SGLT1) and glucose transporter 2 (GLUT2), and efflux protein (P-glycoprotein, PgP) (1.84 × 10 cm/s; efflux ratio: 1.1) were excluded as primary transporters, since the P of aspalathin was not affected by the presence of specific inhibitors. The P of aspalathin was also not affected by constituents of aspalathin-enriched rooibos extracts, but was affected by high glucose concentration (20.5 mM), which decreased the P value to 2.9 × 10 cm/s. Aspalathin metabolites (sulphated, glucuronidated and methylated) were found in mouse urine, but not in blood, following an oral dose of 50 mg/kg body weight of the pure compound. Sulphates were the predominant metabolites. These findings suggest that aspalathin is absorbed and metabolised in mice to mostly sulphate conjugates detected in urine. Mechanistically, we showed that aspalathin is not actively transported by the glucose transporters, but presumably passes the monolayer paracellularly.
[Mh] Termos MeSH primário: Aspalathus/química
Chalconas/farmacocinética
Absorção Intestinal
Intestinos/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Transporte Biológico
Células CACO-2
Chalconas/administração & dosagem
Seres Humanos
Camundongos
Permeabilidade
Extratos Vegetais/química
Urina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chalcones); 0 (Plant Extracts); 0 (aspalathin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


  5 / 117 MEDLINE  
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[PMID]:28236460
[Au] Autor:Walters NA; de Villiers A; Joubert E; de Beer D
[Ad] Endereço:Department of Food Science, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa; Plant Bioactives Group, Post-Harvest and Wine Technology Division, Agricultural Research Council (ARC), Infruitec-Nietvoorbij, Private Bag X5026, Stellenbosch, 7599, South Africa.
[Ti] Título:Phenolic profiling of rooibos using off-line comprehensive normal phase countercurrent chromatography×reversed phase liquid chromatography.
[So] Source:J Chromatogr A;1490:102-114, 2017 Mar 24.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Limited performance of one dimensional chromatographic methods provides the incentive for the development of multidimensional chromatographic techniques for the analysis of complex mixtures. Rooibos (Aspalathus linearis) represents such a complex sample, containing a range of phenolic compounds that cannot be separated and identified using a single chromatographic technique within a reasonable run time. By implementing NP high performance countercurrent chromatography (NP-HPCCC) in the first dimension ( D) and RP ultra-high pressure LC (RP-UHPLC) in the second dimension ( D), a highly orthogonal (∼80%) off-line comprehensive two-dimensional separation of rooibos phenolic compounds was achieved in a total analysis time of 17h. The use of a gradient for the D HPCCC separation ensured a good spread of relatively polar flavonoid di-C-glycosides and less polar mono- and di-O-glycosides, while the highly efficient UHPLC method was able to separate compounds eluting in the same D fraction. Analysis of green ("unfermented") and traditional "fermented" rooibos samples enabled tentative identification of 39 phenolic compounds based on UV-vis and MS characteristics, of which 18 have not previously been reported in rooibos. Scolymoside (a flavone), hesperidin (a flavanone) and phloretin-3',5'-di-C-ß-d-glucopyranoside (a dihydrochalcone) were identified for the first time in rooibos by comparison with authentic reference standards.
[Mh] Termos MeSH primário: Aspalathus/química
Cromatografia de Fase Reversa/métodos
Distribuição Contracorrente/métodos
Flavonoides/análise
Glicosídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Glycosides)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


  6 / 117 MEDLINE  
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[PMID]:28192609
[Au] Autor:Grant J; Ryland D; Isaak CK; Prashar S; Siow YL; Taylor CG; Aliani M
[Ad] Endereço:Dept. of Human Nutritional Sciences, Univ. of Manitoba, Winnipeg, MB, Canada.
[Ti] Título:Effect of Vitamin D Fortification and Saskatoon Berry Syrup Addition on the Flavor Profile, Acceptability, and Antioxidant Properties of Rooibos Tea (Aspalathus linearis).
[So] Source:J Food Sci;82(3):807-817, 2017 Mar.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The unique characteristics and healthful reputation of caffeine-free rooibos tea (RT) make it an ideal carrier for vitamin D supplementation, and a potential base for the addition of Saskatoon berry syrup (SBS), a natural flavor additive. The objective of this study was to determine the effect of vitamin D fortification and SBS addition on the flavor profile, consumer acceptability, and antioxidant properties of RT. Six formulations (RT, RT with SBS, RT with SBS and vitamin D , RT with vitamin D , green tea [GT], and GT with SBS) were evaluated by 12 trained panelists and 114 consumers. The formulations were also assessed for antioxidant capacity, physical characteristics, and untargeted phytochemical content. Sensory results revealed that the mean intensity values for berry and sweet attributes were significantly higher (P < 0.05) while bitter and astringent attributes were significantly lower when SBS was added to RT samples compared to those without syrup. Acceptability of flavor, aftertaste, and overall acceptability were also significantly higher for the RT with SBS. The addition of SBS to RT significantly increased the antioxidant capacities which may increase the related health benefits of RT. SBS contributed several polyphenols, particularly flavonoids, to the tea. Vitamin D added to RT formulations did not significantly affect the sensory attributes, acceptability, or antioxidant content. For the development of a functional vitamin D fortified iced-tea beverage that can be consumed as part of the daily diet, SBS could be a favorable flavoring additive that may provide additional health benefits.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Aspalathus
Colecalciferol/administração & dosagem
Comportamento do Consumidor
Rosaceae/química
Paladar
Chás de Ervas/análise
[Mh] Termos MeSH secundário: Antioxidantes/análise
Flavonoides/análise
Flavonoides/farmacologia
Aromatizantes
Manipulação de Alimentos/métodos
Alimentos Fortificados
Frutas/química
Seres Humanos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Flavoring Agents); 0 (Plant Extracts); 0 (Teas, Herbal); 1C6V77QF41 (Cholecalciferol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13646


  7 / 117 MEDLINE  
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[PMID]:28189260
[Au] Autor:Marini F; de Beer D; Walters NA; de Villiers A; Joubert E; Walczak B
[Ad] Endereço:Department of Chemistry, University of Rome "La Sapienza", P.le Aldo Moro 5, I-00185 Rome, Italy.
[Ti] Título:Multivariate analysis of variance of designed chromatographic data. A case study involving fermentation of rooibos tea.
[So] Source:J Chromatogr A;1489:115-125, 2017 Mar 17.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An ultimate goal of investigations of rooibos plant material subjected to different stages of fermentation is to identify the chemical changes taking place in the phenolic composition, using an untargeted approach and chromatographic fingerprints. Realization of this goal requires, among others, identification of the main components of the plant material involved in chemical reactions during the fermentation process. Quantitative chromatographic data for the compounds for extracts of green, semi-fermented and fermented rooibos form the basis of preliminary study following a targeted approach. The aim is to estimate whether treatment has a significant effect based on all quantified compounds and to identify the compounds, which contribute significantly to it. Analysis of variance is performed using modern multivariate methods such as ANOVA-Simultaneous Component Analysis, ANOVA - Target Projection and regularized MANOVA. This study is the first one in which all three approaches are compared and evaluated. For the data studied, all tree methods reveal the same significance of the fermentation effect on the extract compositions, but they lead to its different interpretation.
[Mh] Termos MeSH primário: Aspalathus/química
Cromatografia/métodos
Fermentação
Chá/química
[Mh] Termos MeSH secundário: Análise Multivariada
Fenóis/química
Extratos Vegetais/química
Extratos Vegetais/metabolismo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts); 0 (Tea)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


  8 / 117 MEDLINE  
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[PMID]:27590052
[Au] Autor:Diricks M; Gutmann A; Debacker S; Dewitte G; Nidetzky B; Desmet T
[Ad] Endereço:Department of Biochemical and Microbial Technology, Centre for Industrial Biotechnology and Biocatalysis, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
[Ti] Título:Sequence determinants of nucleotide binding in Sucrose Synthase: improving the affinity of a bacterial Sucrose Synthase for UDP by introducing plant residues.
[So] Source:Protein Eng Des Sel;30(3):141-148, 2017 Mar 01.
[Is] ISSN:1741-0134
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sucrose Synthase (SuSy) catalyzes the reversible conversion of sucrose and a nucleoside diphosphate (NDP) into NDP-glucose and fructose. Biochemical characterization of several plant and bacterial SuSys has revealed that the eukaryotic enzymes preferentially use UDP whereas prokaryotic SuSys prefer ADP as acceptor. In this study, SuSy from the bacterium Acidithiobacillus caldus, which has a higher affinity for ADP as reflected by the 25-fold lower Km value compared to UDP, was used as a test case to scrutinize the effect of introducing plant residues at positions in a putative nucleotide binding motif surrounding the nucleobase ring of NDP. All eight single to sextuple mutants had similar activities as the wild-type enzyme but significantly reduced Km values for UDP (up to 60 times). In addition, we recognized that substrate inhibition by UDP is introduced by a methionine at position 637. The affinity for ADP also increased for all but one variant, although the improvement was much smaller compared to UDP. Further characterization of a double mutant also revealed more than 2-fold reduction in Km values for CDP and GDP. This demonstrates the general impact of the motif on nucleotide binding. Furthermore, this research also led to the establishment of a bacterial SuSy variant that is suitable for the recycling of UDP during glycosylation reactions. The latter was successfully demonstrated by combining this variant with a glycosyltransferase in a one-pot reaction for the production of the C-glucoside nothofagin, a health-promoting flavonoid naturally found in rooibos (tea).
[Mh] Termos MeSH primário: Acidithiobacillus
Aspalathus
Glucosiltransferases
Difosfato de Uridina/química
[Mh] Termos MeSH secundário: Acidithiobacillus/enzimologia
Acidithiobacillus/genética
Difosfato de Adenosina/química
Aspalathus/enzimologia
Aspalathus/genética
Sítios de Ligação
Glucosiltransferases/química
Glucosiltransferases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
58-98-0 (Uridine Diphosphate); 61D2G4IYVH (Adenosine Diphosphate); EC 2.4.1.- (Glucosyltransferases); EC 2.4.1.13 (sucrose synthase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE
[do] DOI:10.1093/protein/gzw048


  9 / 117 MEDLINE  
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[PMID]:27897996
[Au] Autor:Magcwebeba TU; Swart P; Swanevelder S; Joubert E; Gelderblom WC
[Ad] Endereço:Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland (Stellenbosch) 7602, South Africa. tmagcwebeba@sun.ac.za.
[Ti] Título:In Vitro Chemopreventive Properties of Green Tea, Rooibos and Honeybush Extracts in Skin Cells.
[So] Source:Molecules;21(12), 2016 Nov 25.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The chemopreventive properties of the herbal teas rooibos ( ) and honeybush ( spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current study was to determine the anti-proliferative and pro-apoptotic activity of methanol and aqueous extracts of rooibos and two species in different skin cells, using green tea ( ) as a benchmark. Extracts were also characterised for their major individual polyphenols by high performance liquid chromatography and spectroscopically for the total polyphenol (TP) groups. The methanol extract of rooibos, containing higher levels of polyphenols than its aqueous extract, displayed similar activity to green tea as it selectively targeted premalignant cells by inhibiting cell proliferation at lower concentrations whilst inducing apoptosis via membrane depolarisation at higher concentrations. Specific roles of the major rooibos dihydrochalcones and flavanol/proanthocyanidin-type (FLAVA) compounds are likely to be involved. The aqueous extracts of the species were more active against cell proliferation and at inducing apoptosis which was associated with a higher FLAVA content and a reduced TP/FLAVA ratio. In contrast, their methanol extracts exhibited a cytoprotective effect against apoptosis which was related to their monomeric xanthone and flavanone content. The underlying chemopreventive properties of green tea and the herbal teas appear to be associated with diverse and complex monomeric/polymeric polyphenolic cell interactions.
[Mh] Termos MeSH primário: Aspalathus/química
Quimioprevenção
Fabaceae/química
Extratos Vegetais/farmacologia
Pele/efeitos dos fármacos
Chá/química
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Citometria de Fluxo
Técnicas In Vitro
Pele/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Tea)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


  10 / 117 MEDLINE  
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[PMID]:27871602
[Au] Autor:Reddy S; Mishra P; Qureshi S; Nair S; Straker T
[Ad] Endereço:Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: shreddy@montefiore.org.
[Ti] Título:Hepatotoxicity due to red bush tea consumption: a case report.
[So] Source:J Clin Anesth;35:96-98, 2016 Dec.
[Is] ISSN:1873-4529
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many conventional drugs used today, including isoniazid, dapsone, and acetaminophen, are well recognized culprits of hepatotoxicity. With increasing use of complementary and alternative medical therapies, several herbal medicines, such as Ma-Huang, kava, and chaparral leaf, have been implicated as hepatotoxins. Hepatotoxicity may be the most frequent adverse reaction to these herbal remedies when taken in excessive quantities. A myriad of liver dysfunctions may occur including transient liver enzyme abnormalities due to acute and chronic hepatitis. These herbal products are often overlooked as the causal etiologic agent during the evaluation of a patient with elevated liver function tests. We describe a case of hepatotoxicity due to ingestion of red bush tea diagnosed during preoperative assessment of a patient scheduled for laparoscopic appendectomy. Elevated liver enzymes and thrombocytopenia detected in the patient's laboratory work up confounded the initial diagnosis of acute appendicitis and additional investigations were required to rule out cholecystitis and other causes of hepatitis. Open appendectomy was done uneventfully under spinal anesthesia without any further deterioration of hepatic function.
[Mh] Termos MeSH primário: Aspalathus/química
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Chás de Ervas/efeitos adversos
Trombocitopenia/induzido quimicamente
Transaminases/sangue
[Mh] Termos MeSH secundário: Adulto
Raquianestesia
Apendicectomia
Apendicite/cirurgia
Doença Hepática Induzida por Substâncias e Drogas/sangue
Seres Humanos
Laparoscopia
Testes de Função Hepática
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Teas, Herbal); EC 2.6.1.- (Transaminases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE



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