Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.087.500 [Categoria DeCS]
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[PMID]:26952408
[Au] Autor:Kaya M; Odabasi M; Mujtaba M; Sen M; Bulut E; Akyuz B
[Ad] Endereço:Department of Biotechnology and Molecular Biology, Faculty of Science and Letters Aksaray University, 68100 Aksaray, Turkey. Electronic address: muratkaya3806@yahoo.com.
[Ti] Título:Novel three-dimensional cellulose produced from trunk of Astragalus gummifer (Fabaceae) tested for protein adsorption performance.
[So] Source:Mater Sci Eng C Mater Biol Appl;62:144-51, 2016 May.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This is the first study to produce three-dimensional (3D) cellulose from any plant up to now. This 3D cellulose was produced from Astragalus gummifer(Fabaceae) trunk by using a modified method in which original the shape of cellulose was kept as natural. This novel 3D cellulose was characterized by SEM, TGA, FT-IR, XRD and elemental analysis to evidence the purity and to compare it with commercially available cellulose from cotton. Results from these characterizations were found convincing because almost the same physicochemical properties were observed for both newly obtained 3D cellulose and commercial one. Both fibers and pores on the surface of 3D cellulose were observed. Thanks to its diversified surface morphology, this novel 3D cellulose was tested for its protein adsorption performance and the results were compared with commercial cellulose as follows: maximum adsorption capacity at pH 8.0 was recorded as 59.2 mg/g for 3D cellulose while 29.6 mg/g for commercial cellulose. According to this result, it is clear to say that this sorbent has high affinity for lysozyme. Also this 3D cellulose could be useful for the other areas of separation science.
[Mh] Termos MeSH primário: Astragalus gummifer/metabolismo
Celulose/química
Proteínas/química
[Mh] Termos MeSH secundário: Adsorção
Cobre/química
Microscopia Eletrônica de Varredura
Muramidase/química
Caules de Planta/metabolismo
Porosidade
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins); 789U1901C5 (Copper); 9004-34-6 (Cellulose); EC 3.2.1.17 (Muramidase)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE


  2 / 3 MEDLINE  
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[PMID]:26004718
[Au] Autor:Toseef MU; Saeed A; Mohi-Ud-Din E; Usmanghani K; Nazar H; Nawaz A; Ahmad I; Siddiqui FA
[Ad] Endereço:Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
[Ti] Título:Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease.
[So] Source:Pak J Pharm Sci;28(3):863-70, 2015 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease (GERD). This was multicentre randomized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, Burewala and Shifa-ul-mulk Memorial Hospital, Hamdard University Karachi. The patients were selected according to inclusion and exclusion criteria. In test group-1 the male female ratio was 40%, 60%; test group-2 was 42%, 58% and in control group was 44%, 56% respectively. The observed symptoms in the study were increased appetite (TG-1-95%, TG-2-95% and CG-89%), difficulty in swallowing (TG-1-93%, TG-2-96% and TC-94%), belching/burping (TG-1-97%, TG-2-97% and CG-95%), vomiting (TG-1-90%, TG-2-96% and CG-89%), heart burn (TG-1-100%, TG-2-100% and CG-98%), palpitation (TG-1-100%, TG-2-100% and CG-97%), epigastric pain (TG-1-97%, TG-2-97% and CG-90%), abdominal cramps (TG-1-97%, TG-2-98% and CG-95%), tenesmus (TG-1-100%, TG-2-100% and CG-97%), flatulence (TG-1-100%, TG-2-75% and CG-95%), wakeup during sleep (TG-1-94%, TG-2-87% and CG-94%). The p-value of the results of the symptoms was 0.000 except flatulence where the value was 0.001. The statistical results of the study prescribed that all the drugs studied (Pepsil, Safoof-e-katira and Omeprazole) are highly significant. The herbal coded drug Pepsil showed no side effects and unani herbal drug safoof-e-katira showed minimum result of 75% in the patients while Omeprazole resulted with some side effects. In the result it can be concluded that the herbal coded drug Pepsil is a potent herbal drug for gastro esophageal reflux disease.
[Mh] Termos MeSH primário: Transtornos de Deglutição/tratamento farmacológico
Refluxo Gastroesofágico/tratamento farmacológico
Azia/tratamento farmacológico
Omeprazol/uso terapêutico
Fitoterapia
Preparações de Plantas/uso terapêutico
Inibidores da Bomba de Prótons/uso terapêutico
[Mh] Termos MeSH secundário: Astragalus gummifer
Coriandrum
Transtornos de Deglutição/etiologia
Feminino
Refluxo Gastroesofágico/complicações
Azia/etiologia
Seres Humanos
Masculino
Phyllanthus
Plantago
Tragacanto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Preparations); 0 (Proton Pump Inhibitors); 9000-65-1 (Tragacanth); KG60484QX9 (Omeprazole)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150525
[Lr] Data última revisão:
150525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150526
[St] Status:MEDLINE


  3 / 3 MEDLINE  
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[PMID]:25371592
[Au] Autor:Yusufoglu HS; Alam A; Zaghloul AM; Al-salkini MA; Alam P
[Ad] Endereço:Department of Pharmacognosy, College of Pharmacy, Salman Bin Abdulaziz University, Alkharj-11942, Saudi Arabia.
[Ti] Título:Comparative anti-inflammatory and hepatoprotective activities of Astragalus gummifer Labill herb and roots in rats.
[So] Source:Afr J Tradit Complement Altern Med;11(3):268-74, 2014.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Astragalus gummifer (F. Fabaceae), herb and roots were studied for anti-inflammatory and hepatoprotective activities. MATERIALS AND METHOD: The alcoholic extracts of Astragalus gummifer (F. Fabaceae), herb (AGHE), and roots (AGRE), were used for anti-inflammatory and hepatoprotective activities in Wister rats. The effects of AGHE and AGRE were compared with the standard drugs Phenylbutazone and silymarin, for anti-inflammatory and hepatoprotective activities respectively. RESULT: Both extracts showed significant anti-inflammatory activity (P< 0.001). AGRE showed comparatively more significant hepatoprotective activity (P< 0.001), than AGHE (P< 0.05); at doses of 250 and 500 mg/kg body weight as manifested by lowering the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin. The hepatoprotective activity was, also, supported by total protein (TP), malondialdehyde (MDA), nonprotein sulfhydryls (NP-SH), and histo-pathological studies of liver tissue. DISCUSSION: To the best of our knowledge, this is the first report of the anti-inflammatory and hepatoprotective activities of Astragalus gummifer. The results of present studies indicated that both AGHE and AGRE can be used in inflammatory conditions, while investigation supports the use of AGRE in cases that hepatoprotection are required in the hepatotoxic conditions. More supportive studies are required before clinical recommendation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Astragalus gummifer/química
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Edema/tratamento farmacológico
Fígado/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Aspartato Aminotransferases/sangue
Tetracloreto de Carbono/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/sangue
Doença Hepática Induzida por Substâncias e Drogas/genética
Doença Hepática Induzida por Substâncias e Drogas/imunologia
Edema/imunologia
Feminino
Seres Humanos
Fígado/imunologia
Masculino
Malondialdeído/sangue
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 4Y8F71G49Q (Malondialdehyde); CL2T97X0V0 (Carbon Tetrachloride); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141106
[St] Status:MEDLINE



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