Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.098 [Categoria DeCS]
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  1 / 135 MEDLINE  
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[PMID]:28927568
[Au] Autor:Zeng Z; Ji Z; Hu N; Bai B; Wang H; Suo Y
[Ad] Endereço:Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, 810008, China; University of Chinese Academy of Science, Beijing, 100049, China.
[Ti] Título:A sensitive pre-column derivatization method for the analysis of free fatty acids by RP-HPLC with fluorescence detector and its application to Caragana species.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1064:151-159, 2017 Oct 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Caragana korshinskii Kom. (CK), one of afforestation tree species, is widely planted in northwest region of China. To compare the constituents as references for further utilization of CK, C. microphyll Lam. (CM) and C. jubata L. (CJ), been used as traditional Chinese medicine, were taken into consideration. To obtain more information on CK for further utilization, a sensitive and stable pre-column derivatization method for the analysis of fatty acids (FAs) was established using a novel labeling reagent 2-(5H-benzo[a]-carbazol-11(6H)-yl)ethyl hydrazine-carboxylate (BCEHC) by HPLC with fluorescence detector. The derivatives exhibit predominant fluorescence property at excitation and emission wavelengths of 330nm and 380nm, respectively. 16 derivatives of FAs including 13 saturated FAs and 3 unsaturated FAs are separated on a reversed-phase column with gradient elution within 30min. The validation of method indicated that all FAs were given excellent linear responses with good linear coefficient of correlation being equal to or greater than 0.9985. The limits of detection (LODs) at a signal-to-noise ratio of 3 varied from 63.12 to 116.21ngL . The developed method was successfully applied to determine the contents of free FAs (FFAs) in flowers, leaves and bark of CK and the samples were extracted by a green and simple method of gas purge microsyringe extraction. The results show that the contents of linoleic acid and linolenic acid are high in flowers and leaves while the bark is rich in linoleic acid. The total content of FFAs in all parts of CK is higher than that of CM. The distribution of FFAs in plants is obviously different even in the congeneric among different species.
[Mh] Termos MeSH primário: Caragana/química
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia de Fase Reversa/métodos
Ácidos Graxos não Esterificados/análise
[Mh] Termos MeSH secundário: Ácidos Graxos não Esterificados/química
Limite de Detecção
Modelos Lineares
Extratos Vegetais/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Nonesterified); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


  2 / 135 MEDLINE  
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[PMID]:28911817
[Au] Autor:Song Y; Pan L; Li W; Si Y; Zhou D; Zheng C; Hao X; Jia X; Jia Y; Shi M; Jia X; Li N; Hou Y
[Ad] Endereço:Traditional Chinese Materia Medica Academy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
[Ti] Título:Natural neuro-inflammatory inhibitors from Caragana turfanensis.
[So] Source:Bioorg Med Chem Lett;27(20):4765-4769, 2017 10 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Because of the critical role of over-activated microglia in the progress of neurodegenerative diseases, it has been selected as a potential therapeutic target for drug discovery. In order to find natural neuroinflammatory inhibitors, we carried out a bioactivity-oriented phytochemical research of Caragana turfanensis Kom. (Krassn.), which is a folk medicine widely distributed in Xinjiang. As a result, a new coumarin lactone caraganolide A (1) and 35 known components were characterized from the effective extract of C. turfanensis. Furthermore, their anti-neuroinflammatory effects were evaluated in LPS-induced BV2 microglial cells using Griess assay to determine the release of nitric oxide (NO). Compounds 1, 2, 4-6, 9, 13-15, 20, 29 and 30 exhibited significant inhibitory activities and no obvious cytotoxicities were observed at their effective concentrations. It is noteworthy, the new compound caraganolide A (1) (IC 1.01±1.57µM) and 3',7,8-trihydroxy-4'-methoxyisoflavone (5) (IC 6.87±2.23µM) exhibited more excellent action than that of positive control minocycline (IC 9.07±0.86µM).
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Caragana/química
Cumarínicos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Caragana/metabolismo
Linhagem Celular
Cumarínicos/isolamento & purificação
Cumarínicos/metabolismo
Concentração Inibidora 50
Lipopolissacarídeos/toxicidade
Espectroscopia de Ressonância Magnética
Microglia/citologia
Microglia/efeitos dos fármacos
Microglia/metabolismo
Conformação Molecular
Óxido Nítrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Coumarins); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (caraganolide A); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


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[PMID]:28482219
[Au] Autor:Reddy SD; Siva B; Phani Babu VS; Vijaya M; Nayak VL; Mandal R; Tiwari AK; Shashikala P; Babu KS
[Ad] Endereço:Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
[Ti] Título:New cycloartane type-triterpenoids from the areal parts of Caragana sukiensis and their biological activities.
[So] Source:Eur J Med Chem;136:74-84, 2017 Aug 18.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A comprehensive re-investigation of aerial parts of Caragana sukiensis resulted in the isolation of twelve compounds (1-12) including three new cycloartane type triterpenoids (3-5) respectively. Chemical structures of the isolated compounds were established by analysis of their IR, HRMSESI, 1D and 2D NMR spectroscopic data. In addition, these compounds were evaluated for their cytotoxic activity against cancer lines (HeLa, A549, MCF-7, DU-145) and Human embryonic kidney cell line (HEK-293). The results indicated that compound 8 showed potent cytotoxic activity against A549 with IC value of 1.54 µM which is comparable to standard drug, doxorubicin. Further, flow cytometric analysis showed that compound 8 arrested the cell cycle in the Go/G1 phase leading to apoptotic cell death. In addition, Hoechst 33258 staining, Annexin V-FITC assay and measurement of mitochondrial membrane potential also suggested that 8 induced cell death by apoptosis. Further, all the isolates were also screened for their antifeedant and insecticidal activity against tobacco caterpillar (Spodoptera litura), using no-choice leaf disk method. Among screened compounds 1, 3, 4, and 6 showed potent antifeedancy with ED values of 0.59, 1.19, 0.67, and 1.68 µg/cm . Overall, this study identified a novel class of cycloartane tritepenoids as potent cyotoxic agents as well as antifeedants.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Caragana/química
Inseticidas/farmacologia
Componentes Aéreos da Planta/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Borboletas
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Células HEK293
Seres Humanos
Inseticidas/química
Inseticidas/isolamento & purificação
Estrutura Molecular
Spodoptera/efeitos dos fármacos
Relação Estrutura-Atividade
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Insecticides); 0 (Triterpenes); 511-64-8 (cycloartane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


  4 / 135 MEDLINE  
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[PMID]:28398659
[Au] Autor:Luan G; Tie F; Yuan Z; Li G; He J; Wang Z; Wang H
[Ad] Endereço:Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, 23 Xin'ning Road, Xining, 810008, P. R. China.
[Ti] Título:Hypaphorine, an Indole Alkaloid Isolated from Caragana korshinskii Kom., Inhibites 3T3-L1 Adipocyte Differentiation and Improves Insulin Sensitivity in Vitro.
[So] Source:Chem Biodivers;14(7), 2017 Jul.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Obesity, a major health problem worldwide, is a complex multifactorial chronic disease that increases the risk for insulin resistance, type 2 diabetes, coronary heart disease, and hypertension. In this study, we assessed methods to isolate hypaphorine, a potent drug candidate for obesity and insulin resistance. Semi-preparative reversed-phase liquid chromatography (semi-preparative RPLC) was established as a method to separate three compounds, adenosine, l-tryptophan, and hypaphorine, from the crude extracts of Caragana korshinskii Kom. Due to its specific chemical structure, the effect of hypaphorine on differentiation and dexamethasone (DXM) induced insulin resistance of 3T3-L1 cells was investigated. The structures of the three compounds were confirmed by UV, H-NMR, and C-NMR analysis and compared with published data. The activity results indicated that hypaphorine prevented the differentiation of 3T3-L1 preadipocytes into adipocytes by down-regulating hormone-stimulated protein expression of peroxisome proliferator activated receptor γ (PPARγ) and CCAAT/enhancer binding protein (C/EBPα), and their downstream targets, sterol regulatory element binding protein 1 c (SREBP1c) and fatty acid synthase (FAS). Hypaphorine also alleviated DXM-induced insulin resistance in differentiated 3T3-L1 adipocytes via increasing the phosphorylation level of Akt2, a key protein in the insulin signaling pathway. Taken together, we suggest that the method can be applied to large-scale extraction and large-quantity preparation of hypaphorine for treatment of obesity and insulin resistance.
[Mh] Termos MeSH primário: Adipogenia/efeitos dos fármacos
Caragana/química
Indóis/farmacologia
Resistência à Insulina
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/citologia
Animais
Diferenciação Celular/efeitos dos fármacos
Alcaloides de Indol/isolamento & purificação
Alcaloides de Indol/farmacologia
Indóis/isolamento & purificação
Camundongos
Obesidade/tratamento farmacológico
Extratos Vegetais/química
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indole Alkaloids); 0 (Indoles); 0 (Plant Extracts); GJ3358U63L (lenticin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700038


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[PMID]:28207805
[Au] Autor:Ning P; Zhou Y; Gao L; Sun Y; Zhou W; Liu F; Yao Z; Xie L; Wang J; Gong C
[Ad] Endereço:College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
[Ti] Título:Unraveling the microRNA of Caragana korshinskii along a precipitation gradient on the Loess Plateau, China, using high-throughput sequencing.
[So] Source:PLoS One;12(2):e0172017, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drought remains one of the main factors that negatively affect plant growth and development. Caragana korshinskii is widely distributed on the Loess Plateau, China, where it mediates soil and water loss and helps prevent desertification. However, little is known about the stress response mechanisms of C. korshinskii in water-starved environments. MicroRNAs (miRNAs) have been implicated in the regulation of plant responses to several types of biotic and abiotic stress. Here, we describe the miRNAs of wild C. korshinskii from Huangling, Yulin, and Dalad Banner, which occur along a precipitation gradient. Using next-generation sequencing technology, we obtained a total of 13 710 681, 15 048 945, and 15 198 442 reads for each location, respectively; after filtering and BLAST analysis, 490 conserved miRNAs and 96 novel miRNAs were characterized from the sRNAome data, with key functions determined using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. We also designed stem-loop qRT-PCR to validate the expression patterns of 5 conserved miRNAs (miR390, miR398, miR530, miR2119, and miR5559) that obviously responded to water stress in plants grown both under natural and experimental water stress conditions and found that the expression levels of miR2119 and miR5559 were negatively correlated with their predicted target genes. This study is the first to identify miRNAs from wild C. korshinskii and provides a basis for future studies of miRNA-mediated gene regulation of stress responses in C. korshinskii.
[Mh] Termos MeSH primário: Caragana/genética
Secas
Regulação da Expressão Gênica de Plantas
Sequenciamento de Nucleotídeos em Larga Escala/métodos
MicroRNAs/genética
RNA de Plantas/genética
Chuvas
[Mh] Termos MeSH secundário: Análise de Sequência de RNA/métodos
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (RNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172017


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[PMID]:28076357
[Au] Autor:Zeng Q; Lal R; Chen Y; An S
[Ad] Endereço:College of Natural Resources and Environment, Northwest A&F University, Yangling, P.R. China.
[Ti] Título:Soil, Leaf and Root Ecological Stoichiometry of Caragana korshinskii on the Loess Plateau of China in Relation to Plantation Age.
[So] Source:PLoS One;12(1):e0168890, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Caragana korshinskii, a leguminous shrub, a common specie, is widely planted to prevent soil erosion on the Loess Plateau. The objective of this study was to determine how the plantation ages affected soil, leaf and root nutrients and ecological stoichiometry. The chronosequence ages of C. korshinskii plantations selected for this study were 10, 20 and 30 years. Soil organic carbon (SOC) and soil total nitrogen (STN) of C. korshinskii plantations significantly increased with increase in the chronosequence age. However, soil total phosphorous (STP) was not affected by the chronosequence age. The soil C: N ratio decreased and the soil C: P and N: P ratios increased with increasing plantation age. The leaf and root concentrations of C, N, and P increased and the ratios C: N, C: P, and N: P decreased with age increase. Leaf N: P ratios were >20, indicating that P was the main factor limiting the growth of C. korshinskii. This study also demonstrated that the regeneration of natural grassland (NG) effectively preserved and enhanced soil nutrient contents. Compared with NG, shrub lands (C. korshinskii) had much lower soil nutrient concentrations, especially for long (>20 years) chronosequence age. Thus, the regeneration of natural grassland is an ecologically beneficial practice for the recovery of degraded soils in this area.
[Mh] Termos MeSH primário: Caragana/crescimento & desenvolvimento
Ecossistema
Folhas de Planta/crescimento & desenvolvimento
Raízes de Plantas/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Caragana/metabolismo
China
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168890


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[PMID]:27626111
[Au] Autor:Yang X; Huang M; Cai J; Lv D; Lv J; Zheng S; Ma X; Zhao P; Wang Q
[Ad] Endereço:a School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan , China.
[Ti] Título:Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR.
[So] Source:Nat Prod Res;31(10):1150-1155, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An EtOAc fraction from the roots of Caragana tangutica Maxim. (CTEA) displayed promising anti-hepatocellular carcinoma (HCC) activity during screening of a traditional Chinese ethnic herb library against HepG2 and Hep3B cell lines. HPLC-based activity profiling of CTEA by combination of MS-guided large-scale semi-preparative HPLC and NMR methods led to the identification of a new pterocarpan glycoside, (-)-maackiain 3-O-6'-O-methyl malonyl-ß-d-glucopyranoside (1), together with three known pterocarpan glycosides, (-)-maackiain 3-O-ß-d-glucopyranoside (2), 3-O-6'-O-acrylyl-ß-d-galactopyranoside (3), and (-)-maackiain 3-O-6'-O-acetyl-ß-d-glucopyranoside (4). Compound 1 was isolated during a drug discovery programme aimed at identifying new anti-HCC leads from a natural product library. Anti-HCC study showed that all four compounds exhibited cytotoxic activity with IC values range of 29.1-53.5 µg/mL against HepG2 and Hep3B cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Caragana/química
Carcinoma Hepatocelular/tratamento farmacológico
Glucosídeos/química
Glucosídeos/farmacologia
Neoplasias Hepáticas/tratamento farmacológico
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Cromatografia Líquida de Alta Pressão
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Espectroscopia de Ressonância Magnética
Extratos Vegetais/química
Raízes de Plantas/química
Tibet
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glucosides); 0 (Plant Extracts); 0 (maackiain 3-O-6'-O-methyl malonyl-beta-D-glucopyranoside)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1230118


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[PMID]:27632407
[Au] Autor:Zhou W; Xu H; Luan G; Wang H; Wang X; Ji M
[Ad] Endereço:Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.
[Ti] Título:In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caraganakorshinskii Kom.
[So] Source:Skin Pharmacol Physiol;29(5):243-249, 2016.
[Is] ISSN:1660-5535
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:AIM: The objective of this study was to evaluate the effects of seed oil of Caragana korshinskii Kom. against Trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis. METHODS: The skin of albino guinea pigs was infected with T. mentagrophytes, and the animals were divided into five groups: negative control (NC group), positive control (PC group), vehicle control, CK50% group (received topical 50% seed oil of C.korshinskii), and CK100% group (received topical 100% seed oil of C.korshinskii). Evaluation of clinical efficacy was performed 72 h after the completion of a 10-day treatment regimen. Skin biopsy samples were processed for histopathological examination. RESULTS: The infected untreated control guinea pigs showed patches of hair loss and ulcerated or scaly skin. Lower clinical scores indicate improved efficacy compared with NC. The lesion scores significantly declined in the CK50%, CK100%, and PC groups in comparison with the NC group. The CK50% group (45.31%) and the CK100% group (75%) showed clinical efficacy compared with the PC group (78.13%). In addition, no fungal elements, inflammation, or tissue destruction was observed in any of the PAS-stained sections of the infected skin in the groups treated with CK100% or 1% terbinafine. CONCLUSION: Seed oil of C.korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Caragana
Óleos Vegetais/uso terapêutico
Tinha/tratamento farmacológico
Trichophyton
[Mh] Termos MeSH secundário: Animais
Cobaias
Masculino
Fitoterapia
Sementes
Pele/efeitos dos fármacos
Pele/patologia
Tinha/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Oils)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1159/000448739


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[PMID]:27593445
[Au] Autor:Peng W; Wang L; Qiu XH; Jiang YP; Pan L; Jia XG; Qin LP; Zheng CJ
[Ad] Endereço:Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
[Ti] Título:Flavonoids from Caragana pruinosa roots.
[So] Source:Fitoterapia;114:105-109, 2016 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A new pterocarpan derivative, pruinosanone D (1), a new isoflavonoid, pruinosanone E (2), and a new chalcone, pruinosanone F (3), were isolated from Caragana pruinosa roots, along with four known analogues (4-7), identified as 2,4-dihydroxy-3'-methoxy-4'-ethoxychalcone, 7,4-dihydroxyflavanone, butin and scutellaprostin C, respectively. Their structures were elucidated by detailed analyses of NMR, IR, and MS data. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages was also studied. Compound 1 were among the most potent NO production inhibitor, with IC value of 0.62µM.
[Mh] Termos MeSH primário: Caragana/química
Flavonoides/química
Macrófagos/efeitos dos fármacos
Raízes de Plantas/química
Pterocarpanos/química
[Mh] Termos MeSH secundário: Animais
Flavonoides/isolamento & purificação
Camundongos
Estrutura Molecular
Óxido Nítrico/antagonistas & inibidores
Pterocarpanos/isolamento & purificação
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Pterocarpans); 0 (pruinosanone D); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE


  10 / 135 MEDLINE  
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[PMID]:27292194
[Au] Autor:Peng W; Wang L; Qiu X; Jiang Y; Han T; Pan L; Jia X; Qin L; Zheng C
[Ad] Endereço:Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China.
[Ti] Título:Therapeutic effects of Caragana pruinosa Kom. roots extract on type II collagen-induced arthritis in rats.
[So] Source:J Ethnopharmacol;191:1-8, 2016 Sep 15.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Caragana pruinosa Kom. is a deciduous shrub belonging to the genus of Caragana (Leguminosae), and Caragana plants exhibit a wide range of interesting pharmacological properties including anti-inflammatory, analgesic, and anti-arthritis activity, etc. AIM OF THE STUDY: This study was aimed to investigate the anti-arthritic effect of 80% EtOH extract from the roots of C. pruinosa (ERCP) on arthritis and explore the potential pharmacological mechanism. MATERIALS AND METHODS: After collagen induced arthritis (CIA) were established in rats, the animals were orally administered with ERCP (130, 260 and 520mg/kg) for 30 days. During the treatment, the rats' body weights, arthritis indices and paw volumes were measured every 5 days. Subsequently, rats' blood samples were collected to determine TNF-α, IL-1ß, IL-6, IL-10, and C-reactive protein (CRP) contents in serum. Then, rats were sacrificed and the hind paws and knee joints were collected for histopathological examination. RESULTS: Our results indicated that ERCP significantly suppressed the inflammatory reactions and destructions in joints and synovial tissues. ERCP inhibited the paw swelling and arthritis index in CIA rats. Additionally, it decreased the levels of pro-inflammatory cytokines (TNF-α, IL-1ß and IL-6) and CRP, whereas increased that of IL-10. CONCLUSION: Our results suggested ERCP has significant anti-arthritic effect on CIA rats, and the pharmacological mechanisms are related to the down-regulation of TNF-α, IL-1ß, IL-6 and CRP and the up-regulation of IL-10.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Artrite Experimental/prevenção & controle
Caragana/química
Colágeno
Articulações/efeitos dos fármacos
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Artrite Experimental/sangue
Artrite Experimental/induzido quimicamente
Artrite Experimental/imunologia
Biomarcadores/sangue
Proteínas de Transporte/sangue
Cromatografia Líquida de Alta Pressão
Citocinas/sangue
Regulação para Baixo
Ensaio de Imunoadsorção Enzimática
Mediadores da Inflamação/sangue
Interleucina-10/sangue
Articulações/imunologia
Articulações/metabolismo
Articulações/patologia
Masculino
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Ratos Wistar
Espectrometria de Massas por Ionização por Electrospray
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Carrier Proteins); 0 (Crp protein, rat); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Plant Extracts); 130068-27-8 (Interleukin-10); 9007-34-5 (Collagen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE



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