Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.112 [Categoria DeCS]
Referências encontradas : 7 [refinar]
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  1 / 7 MEDLINE  
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[PMID]:25583438
[Au] Autor:Kato A; Hirokami Y; Kinami K; Tsuji Y; Miyawaki S; Adachi I; Hollinshead J; Nash RJ; Kiappes JL; Zitzmann N; Cha JK; Molyneux RJ; Fleet GW; Asano N
[Ad] Endereço:Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan. Electronic address: kato@med.u-toyama.ac.jp.
[Ti] Título:Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors.
[So] Source:Phytochemistry;111:124-31, 2015 Mar.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report the isolation and structural determination of fourteen iminosugars, containing five pyrrolizidines and five indolizidines, from Castanospermum australe. The structure of a new alkaloid was elucidated by spectroscopic methods as 6,8-diepi-castanospermine (13). Our side-by-side comparison between bicyclic and corresponding monocyclic iminosugars revealed that inhibition potency and spectrum against each enzyme are clearly changed by their core structures. Castanospermine (10) and 1-deoxynojirimycin (DNJ) have a common d-gluco configuration, and they showed the expected similar inhibition potency and spectrum. In sharp contrast, 6-epi-castanospermine (12) and 1-deoxymannojirimycin (manno-DNJ) both have the d-manno configuration but the α-mannosidase inhibition of 6-epi-castanospermine (12) was much better than that of manno-DNJ. 6,8-Diepi-castanospermine (13) could be regarded as a bicyclic derivative of talo-DNJ, but it showed a complete loss of α-galactosidase A inhibition. This behavior against α-galactosidase A is similar to that observed for 1-epi-australine (6) and altro-DMDP.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Castanospermum/química
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/farmacologia
Glicosídeo Hidrolases/antagonistas & inibidores
Imino Açúcares/isolamento & purificação
Imino Açúcares/farmacologia
Indolizinas/isolamento & purificação
Indolizinas/farmacologia
[Mh] Termos MeSH secundário: 1-Desoxinojirimicina/análogos & derivados
1-Desoxinojirimicina/química
1-Desoxinojirimicina/farmacologia
Alcaloides/química
Inibidores Enzimáticos/química
Glucosamina/análogos & derivados
Glucosamina/química
Hipoglicemiantes/química
Hipoglicemiantes/farmacologia
Imino Açúcares/química
Indolizinas/química
Piperidinas/farmacologia
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1-deoxy-nojirimycin); 0 (Alkaloids); 0 (Enzyme Inhibitors); 0 (Hypoglycemic Agents); 0 (Imino Sugars); 0 (Indolizines); 0 (Piperidines); 0V5436JAQW (miglitol); 19130-96-2 (1-Deoxynojirimycin); EC 3.2.1.- (Glycoside Hydrolases); N08U5BOQ1K (Glucosamine); Q0I3184XM7 (castanospermine)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:150217
[Lr] Data última revisão:
150217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150114
[St] Status:MEDLINE


  2 / 7 MEDLINE  
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[PMID]:24909952
[Au] Autor:Ballesteros D; Sershen; Varghese B; Berjak P; Pammenter NW
[Ad] Endereço:Plant Germplasm Conservation Research, School of Life Sciences, University of KwaZulu-Natal, South Ring Road, Westville Campus, Durban 4001, South Africa. Electronic address: daniel.ballesteros@uv.es.
[Ti] Título:Uneven drying of zygotic embryos and embryonic axes of recalcitrant seeds: challenges and considerations for cryopreservation.
[So] Source:Cryobiology;69(1):100-9, 2014 Aug.
[Is] ISSN:1090-2392
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cryopreservation is the most promising option for the long-term germplasm conservation of recalcitrant-seeded species. However, the variable post-cryo success achieved with the excised zygotic explants traditionally used for cryopreservation has been a concern for some time. Differential drying rates amongst explants of different species, uneven drying amongst explants within a batch of seeds and uneven drying across tissues within individual embryos could be contributory factors to this variable success and these phenomena form the foci of the present study. Using zygotic explants from a range of recalcitrant-seeded species, which included sub-tropical dicotyledonous trees and sub-tropical monocotyledonous geophytes, the study showed that embryo morphology and anatomy are critical determinants of the drying characteristics of the different tissues composing the explant and hence, post-cryo survival. The results suggest that the rates of drying of explants to water contents (WCs) in the theoretically optimal range for successful cryopreservation are species-specific, and that more rapid drying rates may promote post-cryo survival. However, the large variation in WC amongst individual explants in bulk samples challenges the selection of the theoretically optimum WC for cryopreservation. As a consequence of differential drying rates across the different tissues composing explants, either lethal ice crystal damage or desiccation damage may sometimes be likely in tissues responsible for the onwards development of the embryo. Drying times for cryopreservation of such explants should, therefore, be selected on the basis of WC of segments containing root or shoot meristem, rather than embryo bulk WC. Drying intensity and duration also interact with explant morphology and embryo/axis size and anatomy to bring about - or preclude - post-cryo survival.
[Mh] Termos MeSH primário: Criopreservação/métodos
Dessecação
Sementes/citologia
[Mh] Termos MeSH secundário: Calorimetria
Castanospermum/embriologia
Conservação dos Recursos Naturais/métodos
Crioprotetores
Liliaceae/embriologia
Meliaceae/embriologia
Strychnos/embriologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cryoprotective Agents); 059QF0KO0R (Water)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:140815
[Lr] Data última revisão:
140815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140610
[St] Status:MEDLINE


  3 / 7 MEDLINE  
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[PMID]:24672339
[Au] Autor:Sajeesh T; Parimelazhagan T
[Ad] Endereço:Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore,Tamil Nadu 641 046, India.
[Ti] Título:Analgesic, anti-inflammatory, and GC-MS studies on Castanospermum australe A. Cunn. & C. Fraser ex Hook.
[So] Source:ScientificWorldJournal;2014:587807, 2014.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was aimed to evaluate the analgesic and anti-inflammatory properties of Castanospermum australe and to profile phytochemicals by GC-MS. The ethanolic extracts were prepared by successive solvent extraction using Soxhlet apparatus. The analgesic activity was analyzed by hot plate method and acetic acid-induced writhing test whereas anti-inflammatory study was done by carrageenan induced paw oedema model. The acute toxicity study revealed that ethanol extracts of leaf and bark of C. australe were safe even at a higher dose of 2000 mg/kg whereas ethanol extract of seed was toxic at the same dose. In both hot plate method (5.85 s) and acetic acid-induced writhing test (57%), the leaf ethanol extract exhibited significant analgesic activity (P < 0.001) at a dose of 400 mg/kg. The anti-inflammatory activity of leaf extract was exhibited by the reduction in paw linear diameter by 64.76% at 400 mg/kg in carrageenan induced paw oedema. The GC-MS analysis of the ethanol extract of leaf revealed sixteen major compounds of which 1,7-dimethyl-4,10-dioxa-1,7-diazacyclododecane, (+)-N-methylephedrine, and permethylspermine were found to be pharmaceutically and the most important. These findings justify that C. australe can be a valuable natural analgesic and anti-inflammatory source which seemed to provide potential phytotherapeutics against various ailments.
[Mh] Termos MeSH primário: Analgésicos/química
Anti-Inflamatórios/química
Castanospermum/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Feminino
Camundongos
Extratos Vegetais/farmacologia
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140328
[St] Status:MEDLINE
[do] DOI:10.1155/2014/587807


  4 / 7 MEDLINE  
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[PMID]:24043848
[Au] Autor:Delahaie J; Hundertmark M; Bove J; Leprince O; Rogniaux H; Buitink J
[Ad] Endereço:Université d'Angers, UMR 1345 Institut de Recherche en Horticulture et Semences, SFR 4207 QUASAV, PRES L'UNAM, 49045 Angers, France.
[Ti] Título:LEA polypeptide profiling of recalcitrant and orthodox legume seeds reveals ABI3-regulated LEA protein abundance linked to desiccation tolerance.
[So] Source:J Exp Bot;64(14):4559-73, 2013 Nov.
[Is] ISSN:1460-2431
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In contrast to orthodox seeds that acquire desiccation tolerance during maturation, recalcitrant seeds are unable to survive drying. These desiccation-sensitive seeds constitute an interesting model for comparative analysis with phylogenetically close species that are desiccation tolerant. Considering the importance of LEA (late embryogenesis abundant) proteins as protective molecules both in drought and in desiccation tolerance, the heat-stable proteome was characterized in cotyledons of the legume Castanospermum australe and it was compared with that of the orthodox model legume Medicago truncatula. RNA sequencing identified transcripts of 16 homologues out of 17 LEA genes for which polypeptides are detected in M. truncatula seeds. It is shown that for 12 LEA genes, polypeptides were either absent or strongly reduced in C. australe cotyledons compared with M. truncatula seeds. Instead, osmotically responsive, non-seed-specific dehydrins accumulated to high levels in the recalcitrant cotyledons compared with orthodox seeds. Next, M. truncatula mutants of the abscisic acid insensitive3 (ABI3) gene were characterized. Mature Mtabi3 seeds were found to be desiccation sensitive when dried below a critical water content of 0.4 g H2O g DW(-1). Characterization of the LEA proteome of the Mtabi3 seeds revealed a subset of LEA proteins with severely reduced abundance that were also found to be reduced or absent in C. australe cotyledons. Transcripts of these genes were indeed shown to be ABI3 responsive. The results highlight those LEA proteins that are critical to desiccation tolerance and suggest that comparable regulatory pathways responsible for their accumulation are missing in both desiccation-sensitive genotypes, revealing new insights into the mechanistic basis of the recalcitrant trait in seeds.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Castanospermum/fisiologia
Medicago truncatula/fisiologia
Peptídeos/metabolismo
Proteínas de Plantas/metabolismo
Sementes/fisiologia
[Mh] Termos MeSH secundário: Castanospermum/genética
Cotilédone/metabolismo
Dessecação
Eletroforese em Gel Bidimensional
Regulação da Expressão Gênica de Plantas
Medicago truncatula/genética
Mutação/genética
Proteoma/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Sementes/genética
Análise de Sequência de DNA
Transcriptoma/genética
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Peptides); 0 (Plant Proteins); 0 (Proteome); 0 (RNA, Messenger); 0 (late embryogenesis abundant protein, plant); 059QF0KO0R (Water)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130918
[St] Status:MEDLINE
[do] DOI:10.1093/jxb/ert274


  5 / 7 MEDLINE  
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[PMID]:23063145
[Au] Autor:Bharti SK; Krishnan S; Kumar A; Rajak KK; Murari K; Bharti BK; Gupta AK
[Ad] Endereço:Department of Biochemistry, Patna University, Patna 800005, Bihar, India. sudhanshu_bharti@rediffmail.com
[Ti] Título:Antihyperglycemic activity with DPP-IV inhibition of alkaloids from seed extract of Castanospermum australe: Investigation by experimental validation and molecular docking.
[So] Source:Phytomedicine;20(1):24-31, 2012 Dec 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The antidiabetic actions of Castanospermum australe Cunn., seed (CAS) extract were evaluated in Poloxamer-407 (PX-407) induced T2DM rats. The CAS extract (100 and 150 mg/kg body weight) was administered orally once a day for 5 weeks after the animals were confirmed diabetic. A significant increase in blood glucose, HbA1c and serum insulin levels were observed in T2DM rats in comparison to citrate control rats. Treatment with CAS extract in T2DM rats reduced the elevated levels of blood glucose, HbA1c and insulin with significant (p≤0.001) improvement in OGT. The CAS extract treatment also increased (p≤0.001) the K(ITT) and prevented increase in HOMA-R level in T2DM rats. The DPP-IV inhibitory potential of CAS extract showed IC50 value of 13.96 µg/ml whilst the standard Diprotin A displayed the IC50 value of 1.543 µg/ml. Molecular docking of the three reported alkaloids from the seeds of C. australe showed comparable DPP-IV inhibition with berberine. Our data suggest that CAS extract (150 mg/kg body weight) normalizes hyperglycemia in T2DM rats with strong DPP-IV inhibitory potential. The molecular docking showed that among the three alkaloids of seed extract 7-Deoxy-6-epi-castanospermine is a potent DPP-IV inhibitor similar to berberine.
[Mh] Termos MeSH primário: Alcaloides/uso terapêutico
Castanospermum/química
Diabetes Mellitus Tipo 2/tratamento farmacológico
Dipeptidil Peptidase 4/metabolismo
Inibidores da Dipeptidil Peptidase IV/uso terapêutico
Hipoglicemiantes/uso terapêutico
Indolizinas/uso terapêutico
[Mh] Termos MeSH secundário: Alcaloides/farmacologia
Animais
Berberina/farmacologia
Glicemia/metabolismo
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Inibidores da Dipeptidil Peptidase IV/farmacologia
Intolerância à Glucose/sangue
Intolerância à Glucose/tratamento farmacológico
Hemoglobina A Glicada/metabolismo
Hipoglicemiantes/farmacologia
Indolizinas/farmacologia
Insulina/sangue
Resistência à Insulina
Simulação de Acoplamento Molecular
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Poloxâmero
Ratos
Ratos Wistar
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Blood Glucose); 0 (Dipeptidyl-Peptidase IV Inhibitors); 0 (Glycated Hemoglobin A); 0 (Hypoglycemic Agents); 0 (Indolizines); 0 (Insulin); 0 (Plant Extracts); 0I8Y3P32UF (Berberine); 106392-12-5 (Poloxamer); 129724-72-7 (7-deoxycastanospermine); EC 3.4.14.5 (Dipeptidyl Peptidase 4)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121016
[St] Status:MEDLINE


  6 / 7 MEDLINE  
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[PMID]:20698123
[Au] Autor:Hrga I; Mitic B; Alegro A; Dragojlovic D; Stjepanovic B; Puntaric D
[Ad] Endereço:Department of Ecology, "Dr. Andrija Stampar" Institute of Public Health, Zagreb, Croatia.
[Ti] Título:Aerobiology of sweet chestnut (Castanea sativa Mill.) in north-west Croatia.
[So] Source:Coll Antropol;34(2):501-7, 2010 Jun.
[Is] ISSN:0350-6134
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:The aims of the study were to analyse characteristics of the Castanea airborne pollen and to compare aeropalynological data obtained from two sampling stations in north-west Croatia. The study was conducted in Zagreb and Samobor during the 2003-2006 periods, using the seven-day volumetric samplers of the Hirst design. In both study areas, the seasons of chestnut pollination were similar and lasted from June to the end of July, which is comparable to other European cities. A general rule was noticed--the shorter the main pollen season, the higher the pollen peak concentration. Although the pollen season of Fagales pollen is prolonged to summer in the area of inland west-north Croatia due to the genus Castanea summer pollination, the number of days with pollen air concentration higher than 50 per m3 was low and was not likely to have any major effects in allergic individuals. Airborne pollen concentration of Castanea showed positive statistically significant correlation with air temperature and negative non-significant correlation with precipitation. Because of the non-significant differences between the two stations, for a possible long-term forecast model for Fagales airborne pollen for this part of north-west Croatia, aerobiological data obtained from only one station are sufficient.
[Mh] Termos MeSH primário: Acer/fisiologia
Pólen/fisiologia
[Mh] Termos MeSH secundário: Aerobiose/fisiologia
Castanospermum/fisiologia
Croácia
Geografia
Estações do Ano
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1009
[Cu] Atualização por classe:100811
[Lr] Data última revisão:
100811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100812
[St] Status:MEDLINE


  7 / 7 MEDLINE  
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[PMID]:15957923
[Au] Autor:Cronin L; Murphy PV
[Ad] Endereço:Department of Chemistry, Centre for Synthesis and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
[Ti] Título:Novel synthesis of castanospermine and 1-epicastanospermine.
[So] Source:Org Lett;7(13):2691-3, 2005 Jun 23.
[Is] ISSN:1523-7060
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:[reaction: see text] Polyhydroxylated indolizidines have potential for treatment of HIV, hepatitis C and HSV infection, multiple sclerosis, angiogenesis, cancer, and diabetes. A new synthetic approach to the title compounds from a 5-C-methoxypyranosyl azide has been developed. The route incorporates the aldol reaction and a novel catalytic reductive amination cascade to generate the indolizidine ring.
[Mh] Termos MeSH primário: Indolizinas/síntese química
[Mh] Termos MeSH secundário: Aminação
Castanospermum/química
Catálise
Estrutura Molecular
Plantas Medicinais/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indolizines); Q0I3184XM7 (castanospermine)
[Em] Mês de entrada:0604
[Cu] Atualização por classe:121115
[Lr] Data última revisão:
121115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050617
[St] Status:MEDLINE



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