Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.200 [Categoria DeCS]
Referências encontradas : 369 [refinar]
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[PMID]:28614730
[Au] Autor:Zarev Y; Foubert K; Lucia de Almeida V; Anthonissen R; Elgorashi E; Apers S; Ionkova I; Verschaeve L; Pieters L
[Ad] Endereço:Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium; Department of Pharmacognosy, Faculty of Pharmacy, Medical University - Sofia, Str. Dunav 2, 1000, Sofia, Bulgaria.
[Ti] Título:Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima.
[So] Source:Phytochemistry;141:140-146, 2017 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of prenylated flavonoids was obtained from antigenotoxic extracts and fractions of stem bark of Erythrina latissima E. Mey (Leguminosae). In addition to five constituents never reported before, i.e. (2S)-5,7-dihydroxy-2-(4-hydroxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin D), (2S)-5,7-dihydroxy-2-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin E), 5,7-dihydroxy-3-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)-4H-chromen-4-one (erylatissin F), (2S)-5,7,8'-trihydroxy-2',2'-dimethyl-[2,6'-bichroman]-4-one (erylatissin G) and (2S)-5,7-dihydroxy-8'-methoxy-2',2'-dimethyl-[2,6'-bichroman]-4-one (dihydroabyssinin I), 18 known flavonoids were identified. Evaluation of the antigenotoxic properties (against genotoxicity induced by aflatoxin B1, metabolically activated) in the Vitotox assay revealed that most flavonoids were active. Sigmoidin A and B showed the highest activity, with an IC value of 18.7 µg/mL, equivalent to that of curcumin (IC 18.4 µg/mL), used as a reference antigenotoxic compound.
[Mh] Termos MeSH primário: Antimutagênicos/química
Erythrina/química
Flavonoides/química
Casca de Planta/química
[Mh] Termos MeSH secundário: Aflatoxina B1
Antimutagênicos/isolamento & purificação
Flavonoides/isolamento & purificação
Estrutura Molecular
Testes de Mutagenicidade
Prenilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimutagenic Agents); 0 (Flavonoids); 87746-47-2 (sigmoidin B); 87746-48-3 (sigmoidin A); 9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE


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[PMID]:28177773
[Au] Autor:Oliveira de Lima VC; de Araújo Machado RJ; Vieira Monteiro NK; de Lyra IL; da Silva Camillo C; Coelho Serquiz A; Silva de Oliveira A; da Silva Rufino FP; Leal Lima Maciel B; Ferreira Uchôa A; Antunes Dos Santos E; de Araújo Morais AH
[Ad] Endereço:a Biochemistry Department, Biosciences Center, Federal University of Rio Grande do Norte, 59078-970 Natal, RN, Brazil.
[Ti] Título:Gastroprotective and antielastase effects of protein inhibitors from Erythrina velutina seeds in an experimental ulcer model.
[So] Source:Biochem Cell Biol;95(2):243-250, 2017 Apr.
[Is] ISSN:1208-6002
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Trypsin and chymotrypsin inhibitors from Erythrina velutina seeds have been previously isolated by our group. In previous studies using a sepsis model, we demonstrated the antitumor and anti-inflammatory action of these compounds. This study aimed to evaluate the gastroprotective and antielastase effects of protein inhibitors from E. velutina seeds in an experimental stress-induced ulcer model. Two protein isolates from E. velutina seeds, with antitrypsin (PIAT) and antichymotrypsin (PIAQ) activities, were tested. Both protein isolates showed a high affinity and inhibitory effect against human neutrophil elastase, with 84% and 85% inhibition, respectively. Gastric ulcer was induced using ethanol (99%) in 6 groups of animals (female Wistar rats, n = 6). Before ulcer induction, these animals were treated for 5 days with one of the following: (1) PIAT (0.2 mg·kg ), (2) PIAT (0.4 mg·kg ), (3) PIAQ (0.035 mg·kg ), (4) ranitidine hydrochloride (50 mg·kg ), (5) saline solution (0.9%), or (6) no intervention (sham). Both PIAT and PIAQ protected gastric mucosa, preventing hemorrhagic lesions, edema, and mucus loss. No histologic toxic effects of PIAT or PIAQ were seen in liver and pancreatic cells. Our results show that protein isolates from E. velutina seeds have potential gastroprotective effects, placing these compounds as natural candidates for gastric ulcer prevention.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Inibidores Enzimáticos/farmacologia
Erythrina/química
Fármacos Gastrointestinais/farmacologia
Fitoterapia
Úlcera Gástrica/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Modelos Animais de Doenças
Inibidores Enzimáticos/isolamento & purificação
Etanol
Feminino
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/enzimologia
Mucosa Gástrica/patologia
Fármacos Gastrointestinais/isolamento & purificação
Seres Humanos
Elastase de Leucócito/antagonistas & inibidores
Elastase de Leucócito/metabolismo
Extratos Vegetais/química
Ranitidina/farmacologia
Ratos
Ratos Wistar
Sementes/química
Úlcera Gástrica/induzido quimicamente
Úlcera Gástrica/enzimologia
Úlcera Gástrica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Enzyme Inhibitors); 0 (Gastrointestinal Agents); 0 (Plant Extracts); 3K9958V90M (Ethanol); 884KT10YB7 (Ranitidine); EC 3.4.21.37 (Leukocyte Elastase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1139/bcb-2016-0034


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[PMID]:28112509
[Au] Autor:Nyandoro SS; Munissi JJ; Kombo M; Mgina CA; Pan F; Gruhonjic A; Fitzpatrick P; Lu Y; Wang B; Rissanen K; Erdélyi M
[Ad] Endereço:Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.
[Ti] Título:Flavonoids from Erythrina schliebenii.
[So] Source:J Nat Prod;80(2):377-383, 2017 Feb 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2-4), and nineteen known natural products (5-23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32-64 µg mL and 36.9-101.8 µM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC values of 13.0-290.6 µM (pure compounds) and 38.3 to >100 µg mL (crude extracts).
[Mh] Termos MeSH primário: Antituberculosos/isolamento & purificação
Erythrina/classificação
Flavonoides/isolamento & purificação
[Mh] Termos MeSH secundário: Antituberculosos/química
Antituberculosos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Flavonoides/química
Flavonoides/farmacologia
Seres Humanos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Mycobacterium tuberculosis/efeitos dos fármacos
Ressonância Magnética Nuclear Biomolecular
Casca de Planta/química
Raízes de Plantas/química
Tanzânia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents); 0 (Flavonoids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00839


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[PMID]:27555226
[Au] Autor:Muthukrishnan S; Palanisamy S; Subramanian S; Selvaraj S; Mari KR; Kuppulingam R
[Ad] Endereço:Department of Biochemistry, School of Biosciences, Periyar University, Salem, Tamil Nadu, India. Electronic address: suriyaveda@yahoo.co.in.
[Ti] Título:Phytochemical Profile of Erythrina variegata by Using High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectroscopy Analyses.
[So] Source:J Acupunct Meridian Stud;9(4):207-12, 2016 Aug.
[Is] ISSN:2093-8152
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Natural products derived from plant sources have been utilized to treat patients with numerous diseases. The phytochemical constituents present in ethanolic leaf extract of Erythrina variegata (ELEV) were identified by using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GC-MS) analyses. Shade dried leaves were powdered and extracted with ethanol for analyses through HPLC to identify selected flavonoids and through GC-MS to identify other molecules. The HPLC analysis of ELEV showed the presence of gallic and caffeic acids as the major components at concentrations of 2.0 ppm and 0.1 ppm, respectively, as well as other components. GC-MS analysis revealed the presence of 3-eicosyne; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; butanoic acid, 3-methyl-3,7-dimethyl-6-octenyl ester; phytol; 1,2-benzenedicarboxylic acid, diundecyl ester; 1-octanol, 2-butyl-; squalene; and 2H-pyran, 2-(7-heptadecynyloxy) tetrahydro-derivative. Because pharmacopuncture is a new evolving natural mode that uses herbal extracts for treating patients with various ailments with minimum pain and maximum effect, the results of this study are particularly important and show that ELEV possesses a wide range of phytochemical constituents, as indicated above, as effective active principle molecules that can be used individually or in combination to treat patients with various diseases.
[Mh] Termos MeSH primário: Erythrina/química
Compostos Fitoquímicos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cromatografia Gasosa-Espectrometria de Massas
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


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[PMID]:27534115
[Au] Autor:Intiquilla A; Jiménez-Aliaga K; Zavaleta AI; Arnao I; Peña C; Chávez-Hidalgo EL; Hernández-Ledesma B
[Ti] Título:Erythrina edulis (Pajuro) Seed Protein: A New Source of Antioxidant Peptides.
[So] Source:Nat Prod Commun;11(6):781-6, 2016 Jun.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Erythrina edulis Triana ex Micheli is a protein-enriched legume traditionally used for both dietary and medicinal purposes. In this paper, protein concentrate was obtained from the seed flour. SDS-PAGE analysis revealed a high number and intensity of bands in the range between 10 and 90 kDa. Neutrase, Flavourzyme, and Alcalase were used to hydrolyze the protein concentrate at different times. By SDS-PAGE, the lower resistance of proteins to Alcalase action was observed, providing hydrolyzates with higher radical scavenging activity. The 120 min-hydrolyzate showed ORAC and TEAC values of 2.51 and 0.91 µmol Trolox equivalents/mg of protein, respectively. A fraction lower than 3 kDa and rich in hydrophobic and aromatic amino acids was demonstrated to be mainly responsible for the observed activity. E. edulis could be a new alternative in the formulation of functional foods not only for its high protein content but also for the potential biological properties of its hydrolyzates.
[Mh] Termos MeSH primário: Antioxidantes/química
Erythrina/química
Peptídeos/química
Proteínas de Plantas/química
Sementes/química
[Mh] Termos MeSH secundário: Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Peptides); 0 (Plant Proteins)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160818
[Lr] Data última revisão:
160818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


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[PMID]:27323200
[Au] Autor:Souza EM; Pereira GS; Silva-Mann R; Álvares-Carvalho SV; Ferreira RA
[Ad] Endereço:Programa de Pós-Graduação em Agricultura e Biodiversidade, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.
[Ti] Título:A comparative framework of the Erythrina velutina tree species in reforested land and native populations.
[So] Source:Genet Mol Res;15(2), 2016 Jun 17.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Erythrina velutina Willd. (Fabaceae: Papillionoideae) is a pioneer species found in tropical and subtropical regions of the world that has medicinal properties and that is used in reforestation projects. This species is rare in some areas of northeastern Brazil. This study aimed to characterize and compare genetic structures of natural and restored populations of E. velutina, with a focus on the selection of tree seeds. A total of 108 individuals from five natural populations and one restored population were analyzed using ISSR markers, resulting in 407 polymorphic fragments. A high rate of polymorphism was observed in the restored population. The highest genetic variability was identified within populations (82%). Genetic bottleneck tests were significant for the Carmópolis/Rosário do Catete and Laranjeiras natural populations along with the Laranjeiras restored population. Genetic distances significantly correlated with spatial distance. Only the restored population retained unique alleles. Similarly, increased genetic distance was observed in individuals of the restored populations compared to the other populations. Observed genetic variation in both natural and restored populations of E. velutina was moderate, thus enabling selection of divergent trees from those trees supplying seeds. Environmental protection and management of these areas is necessary for the maintenance of these individuals and subsequent reproduction. We recommend suggestions for E. velutina conservation, since the restoration model adopted in this study did not promote the development of the specimens until the reproductive stage in a fashion that aims to augment the soil seed bank supply, as is suggested for pioneer species.
[Mh] Termos MeSH primário: Erythrina/genética
[Mh] Termos MeSH secundário: Brasil
Conservação dos Recursos Naturais
DNA de Plantas
Florestas
Marcadores Genéticos
Variação Genética
Repetições de Microssatélites
Polimorfismo Genético
Banco de Sementes
Sementes
Árvores/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Genetic Markers)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15028534


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[PMID]:27271580
[Au] Autor:Ashmawy NS; Ashour ML; Wink M; El-Shazly M; Chang FR; Swilam N; Abdel-Naim AB; Ayoub N
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt. naglaa.saad@pharma.asu.edu.eg.
[Ti] Título:Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity.
[So] Source:Molecules;21(6), 2016 Jun 03.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The current study aimed at exploring the secondary metabolites content of Erythrina crista-galli aqueous methanol extract and assessing its phytoestrogenic and cytoprotective activities. METHODS: Isolation of the compounds was carried out using conventional chromatographic techniques. The structures of the isolated compounds were elucidated based on the UV, NMR spectral data along with their mass-spectrometric analyses. The phytoestrogenic activity was evaluated in-silico and in vitro using the Arabidopsis thaliana pER8: GUS reporter assay and the proliferation-enhancing activity of MCF-7 cells. KEY FINDINGS: Phytochemical investigation of E. crista-galli aqueous methanol extract resulted in the isolation and identification of five flavonoids. The plant extract and its fractions showed significant estrogenic activities compared to controls. CONCLUSION: Five flavonoids were identified from E. crista-galli aqueous methanol extract. To the best of our knowledge, among these flavonoids, apigenin-7-O-rhamnosyl-6-C-glucoside was isolated for the first time from nature. Moreover, luteolin-6-C-glucoside was isolated for the first time from this plant. The plant revealed promising phytoestrogenic activities. This gives rationale to some of its pharmacological properties and suggests additional phytoestrogenic effects, which have not been reported yet.
[Mh] Termos MeSH primário: Erythrina/química
Fitoestrógenos/química
Extratos Vegetais/química
Polifenóis/química
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Seres Humanos
Células MCF-7
Espectroscopia de Ressonância Magnética
Simulação de Acoplamento Molecular
Estrutura Molecular
Fitoestrógenos/administração & dosagem
Extratos Vegetais/administração & dosagem
Polifenóis/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytoestrogens); 0 (Plant Extracts); 0 (Polyphenols)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:27076115
[Au] Autor:Andreev IA; Ratmanova NK; Novoselov AM; Belov DS; Seregina IF; Kurkin AV
[Ad] Endereço:Department of Chemistry, Lomonosov Moscow State University, Leninsky Gory 1/3, 119991, Moscow, Russia.
[Ti] Título:Oxidative Dearomatization of 4,5,6,7-Tetrahydro-1H-indoles Obtained by Metal- and Solvent-Free Thermal 5-endo-dig Cyclization: The Route to Erythrina and Lycorine Alkaloids.
[So] Source:Chemistry;22(21):7262-7, 2016 05 17.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A facile one-pot approach based on a thermally induced metal- and solvent-free 5-endo-dig cyclization reaction of the amino propargylic alcohols in combination with Dess-Martin periodinane-promoted oxidative dearomatization of 4,5,6,7-tetrahydroindole intermediates provides an efficient and robust access to 5,6-dihydro-1H-indol-2(4H)ones. Green, relatively mild and operationally simple characteristics of the synthetic sequence are the major advantages, which greatly amplify the developed methodology. The utility of obtained indolones as unified key precursors is demonstrated by the application of these products to the formal total syntheses of a whole pleiad of Erythrina- and Lycorine-type alkaloids, namely (±)-erysotramidine, (±)-erysotrine, (±)-erythravine, (±)-γ-lycorane, and abnormal erythrinanes (±)-coccoline and (±)-coccuvinine.
[Mh] Termos MeSH primário: Alcaloides/síntese química
Alcaloides de Amaryllidaceae/síntese química
Erythrina/química
Indóis/química
Fenantridinas/síntese química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides de Amaryllidaceae/química
Ciclização
Química Verde/métodos
Hidrocarbonetos Iodados/síntese química
Hidrocarbonetos Iodados/química
Indóis/síntese química
Oxirredução
Fenantridinas/química
Estereoisomerismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one); 0 (Alkaloids); 0 (Amaryllidaceae Alkaloids); 0 (Hydrocarbons, Iodinated); 0 (Indoles); 0 (Phenanthridines); I9Q105R5BU (lycorine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201600273


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[PMID]:27010846
[Au] Autor:Mello TJ; Oliveira AA
[Ad] Endereço:Departamento de Ecologia, Universidade de São Paulo, São Paulo-SP, Brazil.
[Ti] Título:Making a Bad Situation Worse: An Invasive Species Altering the Balance of Interactions between Local Species.
[So] Source:PLoS One;11(3):e0152070, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biological invasions pose a significant threat to biodiversity, especially on oceanic islands. One of the primary explanations for the success of plant invaders is direct suppression of competitors. However, indirect interactions can also be important, although they are often overlooked in studies on biological invasion. The shrub Leucaena leucocephala is a widespread island invader with putative allelopathic effects on the germination and growth of other species. We quantified the impact of Leucaena on plant communities richness on an oceanic Brazilian island and, through nursery experiments, investigated the potential for allelopathic effects on the germination of Erythrina velutina, a native species that is often absent from stands of Leucaena. Additionally, in a manipulative field experiment, we examined the direct and indirect effects (mediated by the native species Capparis flexuosa) of the invader on the development of Erythrina. The species richness in invaded sites was lower than in uninvaded sites, and Capparis was the only native species that was frequently present in invaded sites. In the nursery experiments, we found no evidence that Leucaena affects the germination of Erythrina. In the field experiments, the odds of Erythrina germination were lower in the presence of Leucaena litter, but higher in the presence of Leucaena trees. However, the survival and growth of Erythrina were considerably inhibited by the presence of Leucaena trees. The isolated effect of native Capparis on the germination and growth of Erythrina varied from positive to neutral. However, when Capparis and Leucaena were both present, their combined negative effects on Erythrina were worse than the effect of Leucaena alone, which may be attributed to indirect effects. This study provides the first empirical evidence that the balance of the interactions between native species can shift from neutral/positive to negative in the presence of an exotic species.
[Mh] Termos MeSH primário: Capparis/crescimento & desenvolvimento
Ecossistema
Erythrina/crescimento & desenvolvimento
Fabaceae/crescimento & desenvolvimento
Espécies Introduzidas
Ilhas
[Mh] Termos MeSH secundário: Biodiversidade
Brasil
Ecologia
Germinação
Modelos Estatísticos
Razão de Chances
Sementes
Especificidade da Espécie
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160325
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0152070


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[PMID]:26969405
[Au] Autor:Akter K; Barnes EC; Loa-Kum-Cheung WL; Yin P; Kichu M; Brophy JJ; Barrow RA; Imchen I; Vemulpad SR; Jamie JF
[Ad] Endereço:Indigenous Bioresources Research Group, Faculty of Science and Engineering, Macquarie University, North Ryde, Sydney 2109, Australia.
[Ti] Título:Antimicrobial and antioxidant activity and chemical characterisation of Erythrina stricta Roxb. (Fabaceae).
[So] Source:J Ethnopharmacol;185:171-81, 2016 Jun 05.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Erythrina stricta Roxb. (Fabaceae) has been used in Indian indigenous systems as a remedy for rheumatism, stomach-ache, asthma, dysentery, contact dermatitis, eczema and skin infections. However, there have been limited phytochemical or biological studies on the bark of E. stricta and there are no studies that align with its traditional medicinal uses. AIM OF THE STUDY: The aim of this study was to assess the antimicrobial and antioxidant activity of the stem bark of E. stricta to support its topical use in the treatment of contact dermatitis, eczema and skin infections and to isolate and identify any bioactive compounds. MATERIALS AND METHODS: MTT microdilution and disc diffusion assays were used to determine the antimicrobial activities of n-hexane, dichloromethane, ethyl acetate, methanol and water extracts of the bark of E. stricta. Column and preparative thin layer chromatography were used for the purification of the dichloromethane extract. The structures of the compounds isolated were elucidated by extensive 1D and 2D NMR spectroscopic techniques and comparison with published data. The antioxidant activities of the extracts were determined by DPPH free radical scavenging and FRAP assays and the antioxidant activity of the pure compounds by dot-blot and DPPH staining methods. RESULTS: The dichloromethane, ethyl acetate, and n-hexane extracts showed the most significant activity with MIC values of 7.8µg/mL, 125µg/mL, and 125µg/mL against a sensitive strain of Staphylococcus aureus. The dichloromethane and ethyl acetate extracts also showed significant activity against Candida albicans with MIC values of 125µg/mL and 1mg/mL respectively. GC-MS analysis of the n-hexane extract showed the presence of the antibacterial and antifungal compounds ß-caryophyllene, caryophyllene oxide, α-selinene, ß-selinene, selin-11-en-4-α-ol, α-copaene and δ-cadenine. Phytochemical studies of the dichloromethane extract led to the isolation of the novel compound erynone (1), together with six known compounds; wighteone (2), alpinum isoflavone (3), luteone (4), obovatin (5), erythrinassinate B (6) and isovanillin (7). Luteone (4) exhibited the most significant antibacterial activity with minimum inhibitory quantity (MIQ) values of 1.88µg, 1.88µg and 3.75µg, respectively, against sensitive (MSSA) and resistant strains (MRSA and MDRSA) of S. aureus using a TLC bioautography assay. Erynone (1) exhibited the greatest DPPH free radical scavenging activity. CONCLUSIONS: Seven compounds, including a new chromanone, were isolated from the antimicrobial dichloromethane extract of the stem bark of E. stricta. Six of the seven compounds showed antibacterial and/or antioxidant activities. These findings provide support for the customary (traditional and contemporary) use of E. stricta bark for the treatment of skin and wound infections.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Antioxidantes/farmacologia
Erythrina/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antifúngicos/química
Antioxidantes/química
Bactérias/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Estrutura Molecular
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE



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