Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.262 [Categoria DeCS]
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[PMID]:28402389
[Au] Autor:Hogg BN; Moran PJ; Smith L
[Ad] Endereço:USDA-ARS, Exotic and Invasive Weeds Research Unit, 800 Buchanan St., Albany, CA (brian.hogg@ars.usda.gov; patrick.moran@ars.usda.gov; link.smith@ars.usda.gov).
[Ti] Título:Impacts of the Psyllid Arytinnis hakani (Homoptera: Psyllidae) on Invasive French Broom in Relation to Plant Size and Psyllid Density.
[So] Source:Environ Entomol;46(3):552-558, 2017 06 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The impacts of weed biological control agents may vary with plant ontogeny. As plants grow, structural and chemical changes can alter plant resistance, which may reduce herbivory via chemical or structural defenses, and plant tolerance, which may enable plants to maintain fitness despite attack. Resistance and tolerance generally increase as plants grow. Nonetheless, prerelease tests of agent efficacy often overlook plant ontogeny. Here, we assess the performance and impacts of a candidate biocontrol agent, the psyllid Arytinnis hakani (Loginova), in relation to the age of its host plant, the invasive shrub French broom, Genista monspessulana. We also examined whether the psyllid can consistently kill plants when its densities are sufficiently high. Survival of psyllids to adulthood and the timing of adult emergence did not differ between plant sizes, indicating that performance of nymphs was not influenced by plant size. However, adult psyllid survival was reduced on small plants, suggesting that nymphs and adults responded differently to ontogenetic changes in plant quality. Psyllids affected the growth of small and large plants similarly; all measured plant growth parameters were lower in the presence of psyllids regardless of plant size. In a separate experiment, effects on plant survival depended on psyllid density, as higher realized densities of ∼9 psyllids per cm stem length were necessary to consistently kill plants. Thus, results suggest that the psyllid would be equally effective on a range of plant sizes, particularly at high densities, and show the potential of the psyllid to help control French broom in California.
[Mh] Termos MeSH primário: Genista/crescimento & desenvolvimento
Hemípteros/fisiologia
Espécies Introduzidas
[Mh] Termos MeSH secundário: Animais
California
Hemípteros/crescimento & desenvolvimento
Ninfa/crescimento & desenvolvimento
Ninfa/fisiologia
Controle Biológico de Vetores
Densidade Demográfica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx074


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[PMID]:28379400
[Au] Autor:Hogg BN; Mills NJ; Daane KM
[Ad] Endereço:Department of Environmental Science Policy and Management, University of California, Berkeley, CA 94720-3114 ( brian.hogg@ars.usda.gov ; nmills@berkeley.edu ; kdaane@ucanr.edu ).
[Ti] Título:Temporal Patterns in the Abundance and Species Composition of Spiders on Host Plants of the Invasive Moth Epiphyas postvittana (Lepidoptera: Tortricidae).
[So] Source:Environ Entomol;46(3):502-510, 2017 06 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Generalist predators such as spiders may help mitigate the spread and impact of exotic herbivores. The lack of prey specificity and long generation times of spiders may allow them to persist when pests are scarce, and to limit the growth of pest populations before they reach damaging levels. We examined whether resident spiders are likely to play a role in maintaining populations of the invasive light brown apple moth, Epiphyas postvittana (Walker) (Lepidoptera: Tortricidae), below outbreak levels in California. We surveyed the spider community on two E. postvittana host plants, the ornamental Australian tea tree, Leptospermum laevigatum, and the weed French broom, Genista monspessulana, to characterize spider and larval E. postvittana abundance and spider species composition throughout the year. Spider densities and species composition showed slight seasonal changes. Spiders were present during periods of high and low E. postvittana abundance. Anyphaenid hunting spiders, Anyphaena aperta Banks in Australian tea tree and Anyphaena pacifica Banks in French broom, dominated spider species composition at four of five sampled sites, and underwent only slight seasonal variation in abundance. Adult A. aperta were rare at all times of the year, suggesting that high mortality among juvenile A. aperta limits the potential of this species as a predator of E. postvittana. Nevertheless, the continued presence of spiders throughout the year indicates that the resident spider community is likely to play a key role in reducing E. postvittana populations in California.
[Mh] Termos MeSH primário: Cadeia Alimentar
Genista/fisiologia
Leptospermum/fisiologia
Mariposas/fisiologia
Aranhas/fisiologia
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal
California
Espécies Introduzidas
Larva/crescimento & desenvolvimento
Larva/fisiologia
Mariposas/crescimento & desenvolvimento
Controle Biológico de Vetores
Dinâmica Populacional
Estações do Ano
Especificidade da Espécie
Aranhas/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx065


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[PMID]:27190990
[Au] Autor:Aires A; Marrinhas E; Carvalho R; Dias C; Saavedra MJ
[Ad] Endereço:Centre for the Research and Technology for Agro-Environment and Biological Sciences, CITAB, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5001-801 Vila Real, Portugal.
[Ti] Título:Phytochemical Composition and Antibacterial Activity of Hydroalcoholic Extracts of Pterospartum tridentatum and Mentha pulegium against Staphylococcus aureus Isolates.
[So] Source:Biomed Res Int;2016:5201879, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders and inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the current work is to evaluate its benefits and phytochemicals related to those beneficial properties. A distinct polyphenol profile between P. tridentatum and M. pulegium was found. Taxifolin, myricetin, ginestin, ginestein, and ginestein derivatives, biochanin A-glucoside, and biochanin A were identified in P. tridentatum, whilst in M. pulegium the luteolin-7-rutinoside, diosmin, and apigenin and respective derivatives were most representative polyphenols. These variations had implications in the antiradical and antibacterial activity and the P. tridentatum exhibited the highest antibacterial activity against methicillin-resistant and methicillin-sensitive Staphylococcus aureus MSSA, which was mainly dose-dependent. This antibacterial activity seems to be related to high content of flavonols, flavones, and isoflavones, which can act synergistically with each other against this type of bacteria. Our results showed consistent evidence that Pterospartum tridentatum and Mentha pulegium are an important reservoir of phytochemicals with antiradical activity and antibacterial capacity and thus they might be used in a preventive way or in a combined pharmaceutical and antibiotic therapy against pathogenic bacteria.
[Mh] Termos MeSH primário: Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Extratos Vegetais/farmacologia
Polifenóis/farmacologia
Infecções Estafilocócicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Flavonas/química
Flavonas/farmacologia
Flavonóis/química
Flavonóis/farmacologia
Genista/química
Seres Humanos
Isoflavonas/química
Isoflavonas/farmacologia
Mentha pulegium/química
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Extratos Vegetais/química
Polifenóis/química
Polifenóis/isolamento & purificação
Infecções Estafilocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones); 0 (Flavonols); 0 (Isoflavones); 0 (Plant Extracts); 0 (Polyphenols); 4737-27-3 (isoflavanone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE
[do] DOI:10.1155/2016/5201879


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[PMID]:27043622
[Au] Autor:Baali N; Belloum Z; Baali S; Chabi B; Pessemesse L; Fouret G; Ameddah S; Benayache F; Benayache S; Feillet-Coudray C; Cabello G; Wrutniak-Cabello C
[Ad] Endereço:UMR 866 Dynamique Musculaire et Métabolisme, Institut National de la Recherche Agronomique (INRA), Université de Montpellier, F-34060 Montpellier, France. nacirabek@hotmail.com.
[Ti] Título:Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats.
[So] Source:Nutrients;8(4):193, 2016 Apr 01.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Oxidative stress is a major cause of drug-induced hepatic diseases and several studies have demonstrated that diet supplementation with plants rich in antioxidant compounds provides a variety of health benefits in these circumstances. Genista quadriflora Munby (Gq) and Teucrium polium geyrii Maire (Tp) are known to possess antioxidant and numerous biological properties and these endemic plants are often used for dietary or medicinal applications. Herein, we evaluated the beneficial effect of rich-polyphenol fractions of Gq and Tp to prevent Acetaminophen-induced liver injury and investigated the mechanisms involved in this protective action. Rats were orally administered polyphenolic extracts from Gq or Tp (300 mg/kg) or N-acetylcysteine (NAC: 200 mg/kg) once daily for ten days prior to the single oral administration of Acetaminophen (APAP: 1 g/kg). The results show that preventive administration of polyphenolic extracts from Gq or Tp exerts a hepatoprotective influence during APAP treatment by improving transaminases leakage and liver histology and stimulating antioxidant defenses. Besides, suppression of liver CYP2E1, GSTpi and TNF-α mRNA levels, with enhancement of mitochondrial bioenergetics may contribute to the observed hepatoprotection induced by Gq and Tp extracts. The effect of Tp extract is significantly higher (1.5-2 fold) than that of Gq extract and NAC regarding the enhancement of mitochondrial functionality. Overall, this study brings the first evidence that pretreatment with these natural extracts display in vivo protective activity against APAP hepatotoxicity through improving mitochondrial bioenergetics, oxidant status, phase I and II enzymes expression and inflammatory processes probably by virtue of their high total polyphenols content.
[Mh] Termos MeSH primário: Acetaminofen/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Genista/química
Polifenóis/farmacologia
Teucrium/química
[Mh] Termos MeSH secundário: Animais
Cromatografia em Camada Delgada
Citocromo P-450 CYP2E1/genética
Citocromo P-450 CYP2E1/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Mitocôndrias Hepáticas/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Polifenóis/química
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Wistar
Transaminases/sangue
Transaminases/metabolismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Polyphenols); 0 (RNA, Messenger); 0 (Tumor Necrosis Factor-alpha); 362O9ITL9D (Acetaminophen); EC 1.14.13.- (Cytochrome P-450 CYP2E1); EC 2.6.1.- (Transaminases)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


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[PMID]:27005507
[Au] Autor:Hanganu D; Olah NK; Benedec D; Mocan A; Crisan G; Vlase L; Popica I; Oniga I
[Ad] Endereço:Department of Pharmacognosy "Iuliu Hatieganu" University of Medicine and Pharmacy, Creanga Street, Cluj-Napoca, Romania.
[Ti] Título:Comparative polyphenolic content and antioxidant activities of Genista tinctoria L. and Genistella sagittalis (L.) Gams (Fabaceae).
[So] Source:Pak J Pharm Sci;29(1 Suppl):301-7, 2016 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The aim of this study was focused on the polyphenolic composition and antioxidant capacity of Genista tinctoria L. and Genistella sagittalis (L.) Gams. A qualitative and quantitative characterization of the main phenolic compounds from the extracts were carried out using a HPLC-MS method. The total polyphenolic and flavonoid content was spectrophotometrically determined. The antioxidant activity towards various radicals generated in different systems was evaluated usingDPPH bleaching method, Trolox equivalent antioxidant capacity assay (TEAC) and Oxygen radical absorbance capacity (ORAC), and all indicated that G. tinctoria extract was more antioxidant than G. sagittalis extract.That was in good agreement with the total polyphenolic and flavonoidic content.Chlorogenic acid, p-coumaric acid, isoquercitrin and apigenin were identified in bothspecies. Caffeic acid, ferulic acid, hyperoside, rutin, quercitrin and luteolin were found only in G. tinctoria, while quercetin was determined in G. sagittalis.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Fabaceae/química
Genista/química
Polifenóis/química
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Compostos de Bifenilo/química
Cromanos/farmacologia
Cromatografia Líquida de Alta Pressão
Flavonas/química
Flavonas/farmacologia
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Radicais Livres/metabolismo
Espectrometria de Massas
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Chromans); 0 (Flavones); 0 (Free Radical Scavengers); 0 (Free Radicals); 0 (Picrates); 0 (Plant Extracts); 0 (Polyphenols); 0 (Reactive Oxygen Species); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); S18UL9710X (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE


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[PMID]:26879932
[Au] Autor:Fernández Prieto JA; Sanna M; Bueno Á; Pérez M
[Ad] Endereço:Departamento de Biología de Organismos y Sistemas, Universidad de Oviedo, Área de Botánica, Catedrático Rodrigo Uría s/n, 33071, Oviedo, Spain.
[Ti] Título:Genista anglica (Fabaceae): One very diverse species or one species complex?
[So] Source:J Plant Res;129(3):411-22, 2016 May.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Genista anglica represents a widely distributed group of shrubs in the Iberian Peninsula, as well as in the North of the Moroccan Mountains, the South of Italy and in most oceanic territories of Western Europe, with its northern limit in Sweden. Up to five different species within the group have been described in these territories: Genista ancistrocarpa, G. acutifolia, G. brutia and G. silana, as well as G. anglica sensu stricto. The diversity of Genista anglica sensu lato as well as the phylogenetic patterns that have generated this diversity have been analyzed through the use of nuclear (ITS, ETS) and chloroplastic (trnL, trnL-F, rbcL, matK) DNA sequences. Our results show that the group probably originated in the West of the Iberian Peninsula and subsequently spread to the rest of the European oceanic territories. Additionally, the results support the idea that the presence of a group of plants in the South of Italy, where G. brutia and G. silana were previously described, has been the consequence of the introduction of seeds collected in the Northwest of the Iberian Peninsula. Our results also indicate that, in contrast to some authors, the populations from the West of the Iberian Peninsula are not isolated and, consequently, they should be grouped into one species with high diversity, therefore differentiation into different taxa is no longer adequate.
[Mh] Termos MeSH primário: Biodiversidade
Genista/fisiologia
[Mh] Termos MeSH secundário: Sequência de Bases
Núcleo Celular/genética
DNA de Cloroplastos/genética
Geografia
Filogenia
Análise de Sequência de DNA
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160217
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-016-0793-4


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[PMID]:26123661
[Au] Autor:Mejri O; Beji O; Ben Salem C; Hmouda H
[Ad] Endereço:Faculty of Medicine of Sousse, Medical Intensive Care Unit, Sahloul University Hospital, Sousse, Tunisia.
[Ti] Título:A case-based discussion from the Medical Intensive Care Unit of Sahloul University Hospital of Tunisia: an unusual cause of alveolar hypoventilation in a patient with COPD.
[So] Source:Thorax;70(10):1004-6, 2015 Oct.
[Is] ISSN:1468-3296
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Genista/efeitos adversos
Hipoventilação/etiologia
Doença Pulmonar Obstrutiva Crônica/complicações
Chás de Ervas/efeitos adversos
[Mh] Termos MeSH secundário: Hospitais Universitários
Seres Humanos
Hipoventilação/diagnóstico
Hipoventilação/terapia
Unidades de Terapia Intensiva
Masculino
Meia-Idade
Tunísia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Teas, Herbal)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150915
[Lr] Data última revisão:
150915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE
[do] DOI:10.1136/thoraxjnl-2015-207034


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[PMID]:25952836
[Au] Autor:Roriz CL; Barros L; Carvalho AM; Santos-Buelga C; Ferreira IC
[Ad] Endereço:Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal.
[Ti] Título:Scientific validation of synergistic antioxidant effects in commercialised mixtures of Cymbopogon citratus and Pterospartum tridentatum or Gomphrena globosa for infusions preparation.
[So] Source:Food Chem;185:16-24, 2015 Oct 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pterospartum tridentatum (L.) Willk., Gomphrena globosa L. and Cymbopogon citratus (DC) Stapf. are examples of medicinal plants with antioxidant properties on their own, but that can be improved when mixed. In the present work, the antioxidant activity and phenolic compounds were determined in the infusions prepared from the individual plants, and from mixtures of these plants in different proportions. P. tridentatum > C. citratus > G. globosa was the order observed for antioxidant efficacy, which can be related to their different composition in phenolic compounds. Synergism was the main effect observed among the tested mixtures, mainly for the infusions prepared from the plants in proportion 40%:60% (either P. tridentatum and C. citratus; or G. globosa and C. citratus). The infusion obtained with 40% of P. tridentatum and 60% of C. citratus gave the highest antioxidant properties. The present study validates the commercialisation of the studied plants combined in specific proportions.
[Mh] Termos MeSH primário: Amaranthaceae/química
Antioxidantes/análise
Cymbopogon/química
Genista/química
Fenóis/análise
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Betacianinas/análise
Sinergismo Farmacológico
Plantas Medicinais/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Antioxidants); 0 (Betacyanins); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150508
[Lr] Data última revisão:
150508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150509
[St] Status:MEDLINE


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[PMID]:25835015
[Au] Autor:Stinca A; Chirico GB; Incerti G; Bonanomi G
[Ad] Endereço:Department of Agriculture, University of Naples Federico II, via Università 100, Portici (Naples), Italy.
[Ti] Título:Regime shift by an exotic nitrogen-fixing shrub mediates plant facilitation in primary succession.
[So] Source:PLoS One;10(4):e0123128, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ecosystem invasion by non-native, nitrogen-fixing species is a global phenomenon with serious ecological consequences. However, in the Mediterranean basin few studies addressed the impact of invasion by nitrogen-fixing shrubs on soil quality and hydrological properties at local scale, and the possible effects on succession dynamics and ecosystem invasibility by further species. In this multidisciplinary study we investigated the impact of Genista aetnensis (Biv.) DC., an exotic nitrogen-fixing shrub, on the Vesuvius Grand Cone (Southern Italy). Specifically, we tested the hypotheses that the invasion of G. aetnensis has a significant impact on soil quality, soil hydrological regime, local microclimate and plant community structure, and that its impact increases during the plant ontogenetic cycle. We showed that G. aetnensis, in a relatively short time-span (i.e. ~ 40 years), has been able to build-up an island of fertility under its canopy, by accumulating considerable stocks of C, N, and P in the soil, and by also improving the soil hydrological properties. Moreover, G. aetnensis mitigates the daily range of soil temperature, reducing the exposure of coexisting plants to extremely high temperatures and water loss by soil evaporation, particularly during the growing season. Such amelioration of soil quality, coupled with the mitigation of below-canopy microclimatic conditions, has enhanced plant colonization of the barren Grand Cone slopes, by both herbaceous and woody species. These results suggest that the invasion of G. aetnensis could eventually drive to the spread of other, more resource-demanding exotic species, promoting alternative successional trajectories that may dramatically affect the local landscape. Our study is the first record of the invasion of G. aetnensis, an additional example of the regime shifts driven by N-fixing shrubs in Mediterranean region. Further studies are needed to identity specific management practices that can limit the spread and impacts of this species.
[Mh] Termos MeSH primário: Fenômenos Ecológicos e Ambientais
Genista/metabolismo
Espécies Introduzidas
Fixação de Nitrogênio/fisiologia
Solo/química
[Mh] Termos MeSH secundário: Clima
Ecossistema
Inundações
Itália
Região do Mediterrâneo
Microclima
Estações do Ano
Solo/classificação
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Soil); 059QF0KO0R (Water)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150404
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0123128


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[PMID]:25347820
[Au] Autor:Jesus AR; Dias C; Matos AM; de Almeida RF; Viana AS; Marcelo F; Ribeiro RT; Macedo MP; Airoldi C; Nicotra F; Martins A; Cabrita EJ; Jiménez-Barbero J; Rauter AP
[Ad] Endereço:Center of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, Faculdade de Ciências, Universidade de Lisboa , Ed C8, Piso 5, Campo Grande, 1749-016 Lisboa, Portugal.
[Ti] Título:Exploiting the therapeutic potential of 8-ß-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid ß-peptide (1-42).
[So] Source:J Med Chem;57(22):9463-72, 2014 Nov 26.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:8-ß-d-Glucopyranosylgenistein (1), the major component of Genista tenera, was synthesized and showed an extensive therapeutical impact in the treatment of STZ-induced diabetic rats, producing normalization of fasting hyperglycemia and amelioration of excessive postprandial glucose excursions and and increasing ß-cell sensitivity, insulin secretion, and circulating insulin within 7 days at a dose of 4 (mg/kg bw)/day. Suppression of islet amyloid polypeptide (IAPP) fibril formation by compound 1 was demonstrated by thioflavin T fluorescence and atomic force microscopy. Molecular recognition studies with IAPP and Aß1-42 employing saturation transfer difference (STD) confirmed the same binding mode for both amyloid peptides as suggested by their deduced epitope. Insights into the preferred conformation in the bound state and conformers' geometry resulting from interaction with Aß1-42 were also given by STD, trNOESY, and MM calculations. These studies strongly support 8-ß-d-glucopyranosylgenistein as a promising molecular entity for intervention in amyloid events of both diabetes and the frequently associated Alzheimer's disease.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/química
Genisteína/análogos & derivados
Glucosídeos/química
Hipoglicemiantes/química
Polipeptídeo Amiloide das Ilhotas Pancreáticas/química
Inibidores de Proteínas Quinases/química
[Mh] Termos MeSH secundário: Doença de Alzheimer/tratamento farmacológico
Animais
Diabetes Mellitus Experimental/tratamento farmacológico
Desenho de Drogas
Epitopos/química
Genista/metabolismo
Genisteína/química
Seres Humanos
Hiperglicemia/tratamento farmacológico
Insulina/sangue
Espectroscopia de Ressonância Magnética
Microscopia de Força Atômica/métodos
Microscopia de Fluorescência/métodos
Oxigênio/química
Ligação Proteica
Conformação Proteica
Ratos
Ratos Wistar
Estreptozocina
Tiazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Epitopes); 0 (Glucosides); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Islet Amyloid Polypeptide); 0 (Protein Kinase Inhibitors); 0 (Thiazoles); 0 (genistein-8-c-glucoside); 2390-54-7 (thioflavin T); 5W494URQ81 (Streptozocin); DH2M523P0H (Genistein); S88TT14065 (Oxygen)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:141126
[Lr] Data última revisão:
141126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141028
[St] Status:MEDLINE
[do] DOI:10.1021/jm501069h



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