Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.275 [Categoria DeCS]
Referências encontradas : 74 [refinar]
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[PMID]:28813687
[Au] Autor:Harauchi Y; Kajimoto T; Ohta E; Kawachi H; Imamura-Jinda A; Ohta S
[Ad] Endereço:Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan.
[Ti] Título:Prenylated purine alkaloids from seeds of Gleditsia japonica.
[So] Source:Phytochemistry;143:145-150, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three previously undescribed isoguanine glycosides with an N -prenyl group, designated locustoside B, saikachinoside B, and saikachinoside C, have been isolated from the seed of Gleditsia japonica Miquel (Fabaceae) along with two known compounds, locustoside A and saikachinoside A. Their structures were determined from spectroscopic data and X-ray crystallographic analysis. The inhibitory activity against acid phosphatase was evaluated.
[Mh] Termos MeSH primário: Gleditsia/química
Sementes/química
[Mh] Termos MeSH secundário: Fosfatase Ácida/antagonistas & inibidores
Alcaloides
Cristalografia por Raios X
Fabaceae/química
Glicosídeos/química
Japão
Conformação Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Glycosides); EC 3.1.3.2 (Acid Phosphatase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


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[PMID]:27690627
[Au] Autor:Yu J; Xian Y; Li G; Wang D; Zhou H; Wang X
[Ad] Endereço:a Shandong Key Laboratory of TCM Quality Control Technology , Shandong Analysis and Test Center , Jinan , P.R. China.
[Ti] Título:One new flavanocoumarin from the thorns of Gleditsia sinensis.
[So] Source:Nat Prod Res;31(3):275-280, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new flavanocoumarin (1), as well as six known flavonoids (2-7), was isolated from the ethyl acetate extract of the thorns of Gleditsia sinensis. The structures of these compounds were elucidated by extensive spectroscopic measurements and comparison with data reported in literatures. Cytotoxic activities of compounds 1-6 were evaluated against human liver cancer SK-hep-1 cells in vitro by the MTT method, with compound 1 displaying moderate activity (IC of 62.53 µM). Furthermore, compound 1 could increase the number of apoptosis cells in a concentration-dependent manner.
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Cumarínicos/farmacologia
Gleditsia/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Cumarínicos/química
Cumarínicos/isolamento & purificação
Flavonoides/química
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Seres Humanos
Neoplasias Hepáticas/tratamento farmacológico
Estrutura Molecular
Extratos Vegetais/química
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coumarins); 0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27999373
[Au] Autor:Liu Y; Xu Z; Zhang W; Duan J; Jiang J; Sun D
[Ad] Endereço:MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing Forestry University, Beijing 100083, China. liuyt0321@163.com.
[Ti] Título:Characterization of Fractional Polysaccharides from Gleditsia sinensis and Gleditsia microphylla Gums.
[So] Source:Molecules;21(12), 2016 Dec 19.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The seeds of and , widespread in China, are an important source of galactomannans. gum (GSG) and gum (GMG) were purified and precipitated using different concentrations of ethanol and isopropanol. The GSG and GMG, precipitated in different stages, presented different characteristics, including polymer recovery, mannose/galactose ratio, chemical composition, molecular weight, and morphological appearance. The galactomannan recovery of GSG and GMG in 33.3% ethanol was 81.7% and 82.5%, respectively, while that in 28.8% isopropanol was 81.3% and 82.9%, respectively. To achieve similar precipitation efficiency, the amount of isopropanol should be lower than that of ethanol because of the lower dielectric constant of isopropanol (20 vs. 25 for ethanol). The precipitation behavior of galactomannans in polar organic solvents was dependent on the molecular structures and properties of the solvent. A higher mannose/galactose ratio and a higher molecular weight was obtained in a lower concentration of alcohols.
[Mh] Termos MeSH primário: Gleditsia/química
Mananas/química
Gomas Vegetais/química
Sementes/química
[Mh] Termos MeSH secundário: 2-Propanol/química
Cromatografia em Gel
Etanol/química
Galactose/análise
Manose/análise
Peso Molecular
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mannans); 0 (Plant Gums); 11078-30-1 (galactomannan); 3K9958V90M (Ethanol); ND2M416302 (2-Propanol); PHA4727WTP (Mannose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE


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[PMID]:27401288
[Au] Autor:Li KK; Zhou X; Wong HL; Ng CF; Fu WM; Leung PC; Peng G; Ko CH
[Ad] Endereço:Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Shenzhen Research Institute
[Ti] Título:In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action.
[So] Source:J Ethnopharmacol;192:192-200, 2016 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Zao-Jiao-Ci (ZJC), as the spine of Chinese Honey locust (Gleditsia sinensis Lam.), is traditionally used as Chinese medicine to reduce inflammation. AIM OF THE STUDY: The present study aimed to investigate an anti-inflammatory effect of ZJC aqueous extract both in vitro and in vivo, as well as its underlying mechanisms. MATERIALS AND METHODS: Anti-inflammatory effect of ZJC aqueous extract was evaluated by using carrageenan-induced paw edema in rats. In addition, the inhibitory effects of ZJC on nitric oxide production, intracellular reactive oxygen species production, pro-inflammatory mediator expression and prostaglandin E (PGE ) production were determined by using LPS-activated RAW 264.7 cells. The anti-oxidant activity of ZJC was assessed using 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid assay. RESULTS: ZJC aqueous extract showed significant suppressive effect on paw edema in rats at 100mg/kg. Moreover, ZJC aqueous extract decreased the expression of cyclooxygenase (COX)-2 and significantly decreased the PGE2, tumor necrosis factor-α, interleukin (IL)-1ß and IL-6 production in LPS-activated macrophages in dose-dependent manners. ZJC aqueous extract inhibited the mRNA expression of these inflammatory cytokines as well. Furthermore, ZJC aqueous extract was found as an anti-oxidant and could inhibit ROS production in the LPS-induced cells. CONCLUSIONS: These findings show the potential of ZJC aqueous extract as a naturally occurring COX-2 inhibitor to reduce inflammation.
[Mh] Termos MeSH primário: Benzopiranos/farmacologia
Inibidores de Ciclo-Oxigenase 2/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Edema/prevenção & controle
Gleditsia/química
Macrófagos/efeitos dos fármacos
Caules de Planta/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Benzopiranos/isolamento & purificação
Carragenina
Ciclo-Oxigenase 2/metabolismo
Inibidores de Ciclo-Oxigenase 2/isolamento & purificação
Citocinas/genética
Citocinas/metabolismo
Dinoprostona/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Medicamentos de Ervas Chinesas/isolamento & purificação
Edema/induzido quimicamente
Edema/genética
Edema/metabolismo
Regulação da Expressão Gênica
Mediadores da Inflamação/metabolismo
Macrófagos/metabolismo
Masculino
Camundongos
Fitoterapia
Plantas Medicinais
Células RAW 264.7
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Solventes/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzopyrans); 0 (Cyclooxygenase 2 Inhibitors); 0 (Cytokines); 0 (Drugs, Chinese Herbal); 0 (Inflammation Mediators); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 0 (Solvents); 0 (Zao-Jiao-Ci); 059QF0KO0R (Water); 9000-07-1 (Carrageenan); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE


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[PMID]:27352387
[Au] Autor:Wang S; Wang Q; Qiao X; Song W; Zhong L; Guo DA; Ye M
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
[Ti] Título:Separation and Characterization of Triterpenoid Saponins in Gleditsia sinensis by Comprehensive Two-Dimensional Liquid Chromatography Coupled with Mass Spectrometry.
[So] Source:Planta Med;82(18):1558-1567, 2016 Dec.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A comprehensive two-dimensional liquid chromatography coupled with mass spectrometry method was established to separate and characterize triterpenoid saponins in , the Chinese herbal medicine Zhu-Ya-Zao used for the treatment of apoplexy. The saponins were separated on an Agilent Zorbax Eclipse plus C column (2.1 mm × 150 mm, 1.8 µm) for the first dimension, and a Poroshell 120 phenyl-hexyl column (3.0 mm × 50 mm, 2.7 µm) for the second dimension. Methanol and acetonitrile were used as the organic mobile phase for D and D, respectively. The theoretical peak capacity was 640, and the orthogonality was 57 %. Particularly, saponins with different numbers of monoterpene groups could be well separated on the second dimension. The structures were characterized by electrospray ionization tandem mass spectrometry in both positive and negative ion modes. In the MS/MS spectra, the relative abundances for [B + Na] and [Y + Na] were closely correlated with the number of sugar residues of the -chain and -chain, respectively, which facilitated the differentiation of isomers. Finally, a total of 72 saponins with molecular weights greater than 1500 Da were characterized. Among them, 49 compounds, including 2 acetylated saponins, were detected from for the first time.
[Mh] Termos MeSH primário: Gleditsia/química
Saponinas/química
Triterpenos/química
[Mh] Termos MeSH secundário: Fracionamento Químico
Extratos Vegetais/química
Saponinas/isolamento & purificação
Espectrometria de Massas em Tandem
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE


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[PMID]:27259229
[Au] Autor:El Awdan SA; Abdel Jaleel GA; Saleh DO; Abdel Basset M; Melek FR; Kassem IA; Badawi M
[Ti] Título:Hypoglycemic activity of Gleditsia caspica extract and its saponin-containing fraction in streptozotocin-induced diabetic rats.
[So] Source:Z Naturforsch C;71(7-8):253-60, 2016.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The fruits of Gleditsia species (Fabaceae) have been known in traditional medicine as a saponin-rich herbal medicine. The present study aimed to investigate the effects of the total methanolic extract of Gleditsia caspica (MEGC) and its saponin-containing fractions (SFGC) on hyperglycemia in streptozotocin (STZ)-induced diabetic rats. A single intraperitoneal injection of STZ (55 mg/kg body weight) was used to induce hyperglycemia in male albino rats. MEGC (15, 30 and 60 mg/kg, p.o.) and SFGC (15, 30 and 60 mg/kg, p.o.) were administered to the diabetic rats daily for 14 days. The anti-diabetic drug gliclazide (10 mg/kg, p.o.) was used as a positive control. Blood samples were collected from overnight fasted rats for the evaluation of the antihyperglycemic, antihyperlipidemic and antioxidant activities. The levels of glucose, triglycerides (TG), cholesterol (TC) and malondialdehyde (MDA) were increased significantly, whereas the levels of α-amylase, insulin and reduced glutathione (GSH) were decreased in the experimental diabetic rats. Pancreas and liver of the diabetic rats exhibited significant changes in the histopathology, morphology and DNA content. Administration of MEGC or SFGC led to a decrease in the levels of glucose, TG, TC and MDA. In addition, the levels of α-amylase, insulin and GSH were increased in MEGC and SFGC treated diabetic rats. Also, the histopathological and morphological changes, as well the changes in DNA were significantly reversed by the extracts. Thus, MEGC and SFGC exhibited potent hypoglycemic and hypolipidemic activities in STZ- induced diabetic rats.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Frutas/química
Gleditsia/química
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Glicemia/análise
Colesterol/sangue
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Relação Dose-Resposta a Droga
Glutationa/sangue
Hipoglicemiantes/química
Insulina/sangue
Fígado/efeitos dos fármacos
Fígado/patologia
Masculino
Malondialdeído/sangue
Metanol/química
Pâncreas/efeitos dos fármacos
Pâncreas/patologia
Fitoterapia
Extratos Vegetais/química
Ratos Wistar
Estreptozocina
Resultado do Tratamento
Triglicerídeos/sangue
alfa-Amilases/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 0 (Saponins); 0 (Triglycerides); 4Y8F71G49Q (Malondialdehyde); 5W494URQ81 (Streptozocin); 97C5T2UQ7J (Cholesterol); EC 3.2.1.1 (alpha-Amylases); GAN16C9B8O (Glutathione); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE


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[PMID]:26950116
[Au] Autor:Ryu S; Park KM; Lee SH
[Ad] Endereço:Department of Nano-Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 406-772, Korea. lovedbtnwls@naver.com.
[Ti] Título:Gleditsia sinensis Thorn Attenuates the Collagen-Based Migration of PC3 Prostate Cancer Cells through the Suppression of α2ß1 Integrin Expression.
[So] Source:Int J Mol Sci;17(3):328, 2016 Mar 02.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Gleditsia sinensis thorns (GST) have been used as a traditional medicine for carbuncles and skin diseases. The purpose of this study was to decide whether non-toxicological levels of water extract of GST (WEGST) are effective in inhibiting the progress of prostate cancer formation and to identify the target molecule involved in the WEGST-mediated inhibitory process of prostate cancer cell migration and in vivo tumor formation. Through the Boyden chamber migration assay, we found that non-toxic levels of WEGST could not attenuate the PC3 migration to the bottom area coated with serum but significantly inhibited PC3 cell migration to the collagen-coated bottom area. We also found that non-toxic levels of WEGST significantly attenuated collagen against adhesion. Interestingly, ectopic administration of WEGST could not affect the expression of α2ß1 integrin, which is known as a receptor of collagen. However, when the PC3 cells adhered to a collagen-coated plate, the expression of α2 integrin but not that of ß1 integrin was significantly inhibited by the administration of non-toxic levels of WEGST, leading to the inhibition of focal adhesion kinase (FAK) phosphorylation. Furthermore, oral administration of WEGST (25 mg/kg/day) significantly inhibited the size of a PC3 cell-xenografted tumor. Taken together, these results suggest a novel molecular mechanism for WEGST to inhibit prostate cancer progression at particular stages, such as collagen-mediated adhesion and migration, and it might provide further development for the therapeutic use of WEGST in the treatment of prostate cancer progression.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Movimento Celular/efeitos dos fármacos
Gleditsia/química
Integrina alfa2beta1/metabolismo
Extratos Vegetais/uso terapêutico
Próstata/efeitos dos fármacos
Neoplasias da Próstata/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Colágeno/metabolismo
Proteína-Tirosina Quinases de Adesão Focal/metabolismo
Seres Humanos
Masculino
Camundongos Nus
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Próstata/metabolismo
Próstata/patologia
Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/patologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Integrin alpha2beta1); 0 (Plant Extracts); 9007-34-5 (Collagen); EC 2.7.10.2 (Focal Adhesion Protein-Tyrosine Kinases)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE


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[PMID]:26909943
[Au] Autor:Han S; Wu Z; Wang X; Huang K; Jin Y; Yang W; Shi H
[Ad] Endereço:Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China.
[Ti] Título:De novo assembly and characterization of Gleditsia sinensis transcriptome and subsequent gene identification and SSR mining.
[So] Source:Genet Mol Res;15(1), 2016 Jan 29.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Gleditsia sinensis is a Chinese native deciduous tree with a high economic and medicinal value. However, there is limited knowledge on the molecular processes responsible for the medical properties of this species owing to lack of bioinformatic resources such as available whole-genome sequences. In the present study, RNA sequencing data were used to analyze the transcriptome of G. sinensis, and a series of bioinformatic tools was used to explore the main genes involved in important molecular processes. A total of 75.57 million paired-end reads, with a length of 101 bp, were acquired from G. sinensis. Using the assembly tool Trinity, 233,751 transcripts were discovered. Among these, 85,795 were identified as unique transcripts and 59,326 unique transcripts were found to contain coding regions. Gene ontology analysis identified 27,637 unique transcripts that were clustered into 56 functional groups. Genes involved in flavonoid and terpenoid backbone biosynthesis and those encoding transcription factors were further analyzed. Sequence analysis revealed four putative G. sinensis chalcone isomerase genes (GsCHI) encoding the enzymes for flavonoid biosynthesis. GsCHI1 was found to be phylogenetically related to the chalcone isomerase of the family Leguminosae, and its transcript levels in different tissues were higher than those of GsCHI2, GsCHI3, and GsCHI4. Furthermore, 15,014 simple sequence repeat (SSR) markers were discovered in the transcript library, and 5170 primers were generated for the SSR loci. The genetic and genomic information presented in this study will be helpful for future studies on gene discovery and molecular processes in G. sinensis.
[Mh] Termos MeSH primário: Genes de Plantas
Loci Gênicos
Gleditsia/genética
Repetições de Microssatélites
Filogenia
Transcriptoma
[Mh] Termos MeSH secundário: Biologia Computacional
Mineração de Dados
Flavonoides/biossíntese
Ontologia Genética
Gleditsia/classificação
Liases Intramoleculares/genética
Isoenzimas/genética
Anotação de Sequência Molecular
Fases de Leitura Aberta
Análise de Sequência de DNA
Terpenos/metabolismo
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Isoenzymes); 0 (Terpenes); EC 5.5.- (Intramolecular Lyases); EC 5.5.1.6 (chalcone isomerase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15017740


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[PMID]:26718865
[Au] Autor:Zhou ZY; Zhang WA; Duan JF; Zhang WM; Sun DF; Jiang JX
[Ad] Endereço:Department of Chemistry and Chemical Engineering, Beijing Forestry University, Beijing 100083, China.
[Ti] Título:Enhancement of Gleditsia sinensis gum rheological properties with pressure cell treatment in semi-solid state.
[So] Source:Int J Biol Macromol;84:254-60, 2016 Mar.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The apparent viscosity, molecular weight, and molecular weight distribution are important physical properties that determine the functional properties of galactomannan gum. Gleditsia sinensis gum (GSG) in semi-solid state was pressure cell treated over a range of temperature (30-110 °C) under nitrogen maintained at a pressure of 1.0-4.0 MPa. Physicochemical properties of GSG samples both before and after the pressure cell treatment were characterized. These include measurements of rheological properties by LVDV-III Ultra Rheometer, molecular weight and radius of gyration by light scattering, and changes in surface morphology by scanning electron microscopy. GSG had the highest apparent viscosity at a treatment temperature of 30 °C; further increase in temperature led to decrease in apparent viscosity. The apparent viscosity of GSG can be efficiently improved at room temperature and low pressure. The process of pressure cell treatment of GSG in semi-solid state could be industrialized for enhancement of rheological properties of galactomannan gum.
[Mh] Termos MeSH primário: Gleditsia/química
Fenômenos Mecânicos
Gomas Vegetais/química
Reologia
[Mh] Termos MeSH secundário: Peso Molecular
Solubilidade
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Gums)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160101
[St] Status:MEDLINE


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[PMID]:26643065
[Au] Autor:Zhang JP; Tian XH; Yang YX; Liu QX; Wang Q; Chen LP; Li HL; Zhang WD
[Ad] Endereço:School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
[Ti] Título:Gleditsia species: An ethnomedical, phytochemical and pharmacological review.
[So] Source:J Ethnopharmacol;178:155-71, 2016 Feb 03.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The plants in the genus Gleditsia, mainly distributed in central and Southeast Asia and North and South America, have been used as local and traditional medicines in many regions, especially in China, for the treatment of measles, indigestion, whooping, smallpox, arthrolithiasis, constipation, diarrhea, hematochezia, dysentery, carbuncle, etc. This present paper systemically reviews the miscellaneous information surrounding its traditional use, phytochemistry and pharmacology to provide opportunities and recommendations for the future research. MATERIALS AND METHODS: The scientific literatures were systematically searched from scientific databases (PubMed, Scopus, Elsevier, SpringerLink, SciFinder, Google Scholar and others). In addition, the ethnopharmacological information on this genus was mainly acquired from Chinese and Korean herbal classics, and library catalogs. RESULTS: More than 60 compounds including triterpenes, sterols, flavonoids, alkaloids, phenolics and their derivatives were isolated from Gleditsia japonica Miq., Gleditsia sinensis Lam., Gleditsia caspica Desf. and Gleditsia triacanthos L. Among these compounds, triterpenoid saponins were the main constituents of Gleditsia species. Moreover, the crude extracts and purified molecules were tested, revealing diverse biological activities such as anti-tumor, anti-inflammatory, anti-allergic, anti-hyperlipidemic, analgesic, antimutagenic, antioxidant, anti-HIV, antibacterial, antifungal activities, etc. Among these biological studies, the possible mechanisms of antitumor action are stressed in this review, and these include causing cytotoxicity to cancer cells, inhibition of proliferation of cancer cells by affecting their growth, regeneration and apoptosis, inhibition of basic fibroblast growth factor (bFGF) and nitric oxide (NO), modulation of the oncogenic expression and telomerase activity results, inhibition of the expression of pro-angiogenic proteins, as well as down-regulation of intra/extracellular proangiogenic modulators, etc. CONCLUSIONS: On the basis of preliminary research on Gleditsia genus it could be stated that saponins investigations may be more promising in future. Although 32 compounds of 67 identified compounds were saponins, modern pharmacological research on saponins were not a priority in Gleditsia species. Therefore, more bioactive experiments and in-depth mechanisms of action are required for elucidating their roles in physiological systems. Moreover, the present review also highlights that analgesic, anti-tumor and anti-HIV activities should have priority in saponins research. Additionally, it is imperative to explore more structure-activity relationships and possible synergistic actions of triterpenoid saponins for revaluating their pharmacological activities.
[Mh] Termos MeSH primário: Gleditsia/química
Compostos Fitoquímicos/farmacologia
Compostos Fitoquímicos/uso terapêutico
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Etnofarmacologia/métodos
Seres Humanos
Medicina Tradicional/métodos
Fitoterapia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151209
[St] Status:MEDLINE



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