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[PMID]: 29179542 [Au] Autor: Zhao Y; Lv B; Feng X; Li C [Ad] Endereço: Institute for Biotransformation and Synthetic Biosystem, Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China. [Ti] Título: Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents. [So] Source: J Agric Food Chem;65(51):11147-11156, 2017 Dec 27. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Licorice, an important herbal medicine, is derived from the dried roots and rhizomes of Glycyrrhiza genus plants. It has been widely used in food, pharmaceutical, tobacco, and cosmetics industries with high economic value. However, overexploitation of licorice resources has severely destroyed the local ecology. Therefore, producing bioactive compounds of licorice through the biotransformation and bioengineering methods is a hot spot in recent years. In this perspective, we comprehensively summarize the biotransformation of licorice constituents into high-value-added derivatives by biocatalysts. Furthermore, successful cases and the strategies for de novo biosynthesizing compounds of licorice in microbes have been summarized. This paper will provide new insights for the further research of licorice. [Mh] Termos MeSH primário: Bactérias/metabolismo Fungos/metabolismo Glycyrrhiza/química Extratos Vegetais/síntese química [Mh] Termos MeSH secundário: Bactérias/genética Bioengenharia Biotransformação Fungos/genética Glycyrrhiza/genética Glycyrrhiza/metabolismo Extratos Vegetais/química Extratos Vegetais/metabolismo Proteínas de Plantas/genética Proteínas de Plantas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Plant Extracts); 0 (Plant Proteins) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180108 [Lr] Data última revisão: 180108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171129 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b04470

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[PMID]: 29224994 [Au] Autor: Kuang Y; Li B; Fan J; Qiao X; Ye M [Ad] Endereço: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. [Ti] Título: Antitussive and expectorant activities of licorice and its major compounds. [So] Source: Bioorg Med Chem;26(1):278-284, 2018 01 01. [Is] ISSN: 1464-3391 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30-78% (p < .01). The antitussive effects could be partially antagonized by the pretreatment of methysergide or glibenclamide, but not naloxone. Moreover, compounds 1-3 showed potent expectorant activities after 3 days treatment (p < .05). The water and ethanol extracts of licorice, which contain abundant 1 and 2, could decrease cough frequency at 200 mg/kg by 25-59% (p < .05), and enhance the phenol red secretion (p < .05), while the ethyl acetate extract showed little effect. These results indicate liquiritin apioside and liquiritin are the major antitussive and expectorant compounds of licorice. Their antitussive effects depend on both peripheral and central mechanisms. [Mh] Termos MeSH primário: Antitussígenos/farmacologia Tosse/tratamento farmacológico Expectorantes/farmacologia Glycyrrhiza/química Fenolsulfonaftaleína/metabolismo Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Administração Oral Amônia Animais Antitussígenos/antagonistas & inibidores Antitussígenos/química Tosse/induzido quimicamente Modelos Animais de Doenças Relação Dose-Resposta a Droga Expectorantes/química Expectorantes/isolamento & purificação Glibureto/farmacologia Masculino Metisergida/farmacologia Camundongos Camundongos Endogâmicos ICR Estrutura Molecular Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antitussive Agents); 0 (Expectorants); 0 (Plant Extracts); 7664-41-7 (Ammonia); I6G9Y0J1OJ (Phenolsulfonphthalein); SX6K58TVWC (Glyburide); XZA9HY6Z98 (Methysergide) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180106 [Lr] Data última revisão: 180106 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171212 [St] Status: MEDLINE

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[PMID]: 28862446 [Au] Autor: Aiello F; Armentano B; Polerà N; Carullo G; Loizzo MR; Bonesi M; Cappello MS; Capobianco L; Tundis R [Ad] Endereço: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria , Via P. Bucci 87036, Rende, Cosenza, Italy. [Ti] Título: From Vegetable Waste to New Agents for Potential Health Applications: Antioxidant Properties and Effects of Extracts, Fractions and Pinocembrin from Glycyrrhiza glabra L. Aerial Parts on Viability of Five Human Cancer Cell Lines. [So] Source: J Agric Food Chem;65(36):7944-7954, 2017 Sep 13. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Glycyrrhiza glabra cultivation and harvesting produces substantial quantities of aerial parts as waste. With the aim to prospect an innovative valorization of these byproducts, the aerial parts were harvested in May and October and analyzed for their chemical profile, antioxidant properties, and effects on viability of five cancer cell lines. Pinocembrin was the main constituent. A significant protection of lipid peroxidation was observed with the May total extract (IC of 4.2 ± 0.4 µg/mL at 30 min of incubation). The effects on viability of HeLa, MCF-7, MDA-MB-231, Caco-2, and PC3 human cancer cells were investigated. All samples shown a remarkable activity with IC values below 25 µg/mL. Samples from plants harvested in May exhibited greater activity than those harvested in October. MCF-7 and HeLa were the most sensitive cells with IC in the range 2.73-3.01 and 3.28-5.53 µg/mL, respectively. G. glabra aerial parts represent a good source of valuable products. [Mh] Termos MeSH primário: Antioxidantes/farmacologia Sobrevivência Celular/efeitos dos fármacos Flavanonas/farmacologia Glycyrrhiza/química Extratos Vegetais/farmacologia Verduras/química [Mh] Termos MeSH secundário: Antioxidantes/química Antioxidantes/isolamento & purificação Linhagem Celular Tumoral Flavanonas/química Flavanonas/isolamento & purificação Seres Humanos Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Resíduos/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Flavanones); 0 (Plant Extracts); 0 (Waste Products); 8T7C8CH791 (pinocembrin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170902 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b03045

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[PMID]: 28835349 [Au] Autor: Lin Y; Kuang Y; Li K; Wang S; Ji S; Chen K; Song W; Qiao X; Ye M [Ad] Endereço: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, People's Republic of China. [Ti] Título: Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl -induced liver injury in mice. [So] Source: Bioorg Med Chem;25(20):5522-5530, 2017 Oct 15. [Is] ISSN: 1464-3391 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Glycyrrhiza inflata (licorice) has been used to treat liver diseases for a long history. However, the bioactive compounds are still not clear. In this work, 77 compounds, including 9 new ones, were isolated from the EtOAc extract of the roots and rhizomes of G. inflata. The Nrf2 activation activities of all compounds were screened using ARE-luciferase reporter assay on HepG2C8 cells. The results indicated a number of chalcones were potent Nrf2 activators, including 11 (licochalcone A, 4.07-fold), 12 (licochalcone B, 5.17-fold), and 19 (echinatin, 4.09-fold). Further studies indicated that 11, 12 and 19 remarkably attenuated CCl -induced acute liver injury in mice (10 or 50mg/kg, 7days, ig.). These compounds could be promising hepatoprotective natural agents. [Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle Glycyrrhiza/química Fator 2 Relacionado a NF-E2/metabolismo Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Administração Oral Animais Tetracloreto de Carbono Sobrevivência Celular/efeitos dos fármacos Modelos Animais de Doenças Relação Dose-Resposta a Droga Células Hep G2 Seres Humanos Masculino Camundongos Camundongos Endogâmicos ICR Estrutura Molecular Extratos Vegetais/administração & dosagem Extratos Vegetais/isolamento & purificação Raízes de Plantas/química Ratos Ratos Sprague-Dawley [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Plant Extracts); CL2T97X0V0 (Carbon Tetrachloride) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171108 [Lr] Data última revisão: 171108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170825 [St] Status: MEDLINE

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[PMID]: 28754101 [Au] Autor: Park JY; Kwon YW; Lee SC; Park SD; Lee JH [Ad] Endereço: College of Korean Medicine, Dongguk University, Goyang, 10326, Republic of Korea. [Ti] Título: Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages. [So] Source: BMC Complement Altern Med;17(1):374, 2017 Jul 28. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: SC-E1 is a novel herbal formula consisting of five oriental medicinal herbs used frequently in traditional herbal medicine for the treatment of inflammatory diseases in Korea. This study examined the effects of SC-E1 on lipopolysaccharide (LPS)-stimulated macrophages and the molecular mechanism involved. METHODS: The cytotoxic effect of the SC-E1 extract was evaluated in RAW 264.7 cells by MTT assay. The effects of SC-E1 on the free radical scavenging and generation of intracellular reactive oxygen species were measured using DPPH and DCFH-DA, respectively. The effects of SC-E1 on the production of pro-inflammatory cytokines, inflammatory mediators, and related products were determined by ELISA and western blotting. The molecular mechanism and the nuclear translocation of nuclear factor-kappa B (NF-κB) and NF-E2-related factor 2 (Nrf2) were examined by western blot analysis and immunocytochemistry. RESULTS: SC-E1 exhibited strong anti-oxidant activity and inhibited LPS-induced NO secretion as well as iNOS expression and the production of pro-inflammatory cytokines, without affecting the cell viability. SC-E1 also suppressed the LPS-induced NF-κB activation and the mitogen-activated protein kinase (MAPK) pathway. Moreover, SC-E1 induced heme oxygenase-1 (HO-1) expression via the nuclear translocation of Nrf2. The inhibitory effects of SC-E1 on the production of pro-inflammatory cytokines were abrogated by treatment with SnPP, an HO-1 inhibitor. CONCLUSION: These results suggest that SC-E1 exerts its anti-oxidant and anti-inflammatory effects through the inhibition of NF-κB and MAPK as well as Nrf2-mediated HO-1 induction in macrophages. These findings provide evidences for SC-E1 to be considered as a new prescription for treating inflammatory diseases. [Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia Antioxidantes/farmacologia Heme Oxigenase-1/metabolismo Inflamação/metabolismo Magnoliopsida Proteínas de Membrana/metabolismo Fator 2 Relacionado a NF-E2/metabolismo Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Animais Anti-Inflamatórios/uso terapêutico Antioxidantes/uso terapêutico Compostos de Bifenilo/metabolismo Citocinas/metabolismo Fluoresceínas/metabolismo Gardenia Glycyrrhiza Inflamação/induzido quimicamente Inflamação/tratamento farmacológico Lipopolissacarídeos Medicina Tradicional Coreana Camundongos NF-kappa B/metabolismo Óxido Nítrico/metabolismo Óxido Nítrico Sintase Tipo II/metabolismo Picratos/metabolismo Extratos Vegetais/uso terapêutico Platycodon Pueraria Células RAW 264.7 Transdução de Sinais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Cytokines); 0 (Fluoresceins); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, mouse); 0 (Picrates); 0 (Plant Extracts); 2044-85-1 (diacetyldichlorofluorescein); 31C4KY9ESH (Nitric Oxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170730 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-1874-1

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[PMID]: 28735827 [Au] Autor: Ryuk JA; Lixia M; Cao S; Ko BS; Park S [Ad] Endereço: Korean Institutes of Oriental Medicine, Daejeon, South Korea. [Ti] Título: Efficacy and safety of Gegen Qinlian decoction for normalizing hyperglycemia in diabetic patients: A systematic review and meta-analysis of randomized clinical trials. [So] Source: Complement Ther Med;33:6-13, 2017 Aug. [Is] ISSN: 1873-6963 [Cp] País de publicação: Scotland [La] Idioma: eng [Ab] Resumo: OBJECTIVES: A systematic review and meta-analysis was conducted to evaluate the efficacy and safety of Gegen Qinlian decoction (GQD) for normalizing hyperglycemia in T2DM patients by pooling all available RCTs. METHODS: All relevant RCTs were searched using the keywords: "GQD", "T2DM", "hyperglycemia" and "insulin" from the electronic databases including PubMed, EMBASE, Cochrane Library, Korean databases, Chinese medical databases, and Indian scientific database. Each RCT included the control (metformin) and experimental (GQD+metformin) groups. The outcome measures were the assessments of changes in the severity of diabetic symptoms such as "markedly effective" and "effective" (fasting plasma glucose levels: <7 and 7-9, respectively; 2h postprandial glucose levels: <8.3 and 8.3-10.5mmol/L, respectively) after 8 weeks of treatment in each RCT. RESULTS: There were 186 articles selected from the initial searches and 181 irrelevant and duplicate articles were removed. Finally, 5 relevant RCTs involving 499 patients were included in this review. The meta-analysis showed the odds ratio of favorable GQD effect on the marked effectiveness of glycemia (n=499, OR: 2.34, 95% CI: 1.63-3.37, P<0. In a subgroup analysis by GQD composition, 4 RCTs with original GQD composition also showed the odds ratio of the original GQD effect on the marked effectiveness of glycemia (n=339, OR: 2.58; 95% CI=1.65-4.02, P<0.0001) in comparison to the control group. All five studies used an appropriate method for randomization of the subjects but some of them included allocation concealment and blinding of patients and practitioners. There was no significant publication bias in the meta-analysis. CONCLUSION: The GQD and metformin had a synergistic effect on glycemic control in comparison to metformin alone as a T2DM therapy. More rigorous and larger studies are needed to confirm the therapeutic efficacy of GQD for hyperglycemia due to the moderate to high risk of bias in the 5 RCTs. [Mh] Termos MeSH primário: Glicemia/metabolismo Diabetes Mellitus Tipo 2/tratamento farmacológico Medicamentos de Ervas Chinesas/uso terapêutico Hiperglicemia/tratamento farmacológico Hipoglicemiantes/uso terapêutico Magnoliopsida Fitoterapia [Mh] Termos MeSH secundário: Adulto Idoso Coptis Diabetes Mellitus Tipo 2/sangue Diabetes Mellitus Tipo 2/complicações Medicamentos de Ervas Chinesas/farmacologia Feminino Glycyrrhiza Seres Humanos Hiperglicemia/sangue Hiperglicemia/etiologia Hipoglicemiantes/farmacologia Masculino Meia-Idade Pueraria Scutellaria baicalensis [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Nm] Nome de substância: 0 (Blood Glucose); 0 (Drugs, Chinese Herbal); 0 (Hypoglycemic Agents) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170725 [St] Status: MEDLINE

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[PMID]: 28647482 [Au] Autor: Simmler C; Lankin DC; Nikolic D; van Breemen RB; Pauli GF [Ad] Endereço: UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, College of Pharmacy, 833 S. Wood Street, Chicago, IL 60612, USA. Electronic address: simmler@uic.edu. [Ti] Título: Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A. [So] Source: Fitoterapia;121:6-15, 2017 Sep. [Is] ISSN: 1873-6971 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: In an effort to explore the residual complexity of naturally occurring chalcones from the roots of Glycyrrhiza inflata (Fabaceae), two new licochalcone A (LicA) derivatives were isolated as trace metabolites from enriched fractions. Both constituents contain a dihydrofuran moiety linked to carbons C-4 and C-5 of the retrochalcone core. Compound 1 (LicAF1) represents a new chemical entity, whereas compound 2 (LicAF2) has previously been reported as a Lewis acid catalyzed rearrangement of LicA. Evaluation of chirality revealed that both dihydrofuran derivatives existed as a mixture of R and S enantiomers. Interestingly, when solutions were exposed to sunlight, both dihydrofuran retrochalcones, initially isolated as trans isomers, were found to rapidly isomerize yielding trans and cis isomers. Analysis of the 1D H NMR spectra of the photolysis products revealed the presence of two sets of proton resonances ascribed to each of the geometric isomers. An up-field shift of all proton resonances arising from the cis isomer was observed, suggesting that anisotropic shielding effects were introduced through an overall perturbation of the 3-dimensional structure upon photoisomerization. Similar up-field shifts were observed in the C spectrum of the cis isomer, except for the CO, C-α, and C-6 carbons, which experienced downfield shifts. Analogous NMR results were observed for LicA. Hence, the results presented herein encompass the isolation and full characterization of LicAF analogs 1 and 2, and observations of their trans-to-cis photoisomerization through the systematic analysis of their NMR spectra. [Mh] Termos MeSH primário: Amidinas/química Benzofuranos/química Chalconas/química Glycyrrhiza/química [Mh] Termos MeSH secundário: Amidinas/isolamento & purificação Benzofuranos/isolamento & purificação Chalconas/isolamento & purificação Estrutura Molecular Extratos Vegetais/química Raízes de Plantas/química Espectroscopia de Prótons por Ressonância Magnética Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amidines); 0 (Benzofurans); 0 (Chalcones); 0 (Plant Extracts); 0 (benzofuran-2-carboxamidine); JTV5467968 (licochalcone A) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170626 [St] Status: MEDLINE

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[PMID]: 28638869 [Au] Autor: Zhang Y; Yu L; Jin W; Fan H; Li M; Zhou T; Wan H; Yang J [Ad] Endereço: Zhejiang Chinese Medical University, Hangzhou 310053, P.R. China. [Ti] Título: REDUCING TOXICITY AND INCREASING EFFICIENCY: ACONITINE WITH LIQUIRITIN AND GLYCYRRHETINIC ACID REGULATE CALCIUM REGULATORY PROTEINS IN RAT MYOCARDIAL CELL. [So] Source: Afr J Tradit Complement Altern Med;14(4):69-79, 2017. [Is] ISSN: 2505-0044 [Cp] País de publicação: Nigeria [La] Idioma: eng [Ab] Resumo: BACKGROUND: Compatibility of and is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of and could result in regulating intracellular calcium homeostasis and calcium cycling, and thereby verifies the therapeutic material basis. MATERIALS AND METHODS: The myocardial cells were divided into twelve groups randomly as control group, Aconitine group, nine different dose groups that orthogonal combined with Aconitine, Liquiritin and Glycyrrhetinic Acid, and Verapamil group. The myocardial cellular survival rate and morphology were assessed. The expression of calcium regulation protein(RyR2, NCX1, DHPR-a1) in the myocardial cell by Western-blotting. RESULTS: The results exhibited that Aconitine (120 uM) significantly damaged on myocardial cell, decreased the survival rate and expression of Na /Ca exchangers (NCX1) and dihydropteridine reducta-α1 (DHPR-a1), and increased the expression of ryanodine receptor type2 (RyR2) obviously. The compatibility groups (Aconitine, Liquiritin and Glycyrrhetinic Acid) all could against the damage on the myocardial cell by Aconitine at different levels. CONCLUSION: Aconitine with Liquiritin and Glycyrrhetinic Acid may regulate the expression of calcium-regulated proteins to protect myocardial cells from damage. [Mh] Termos MeSH primário: Aconitina/farmacologia Aconitum/química Cálcio/metabolismo Medicamentos de Ervas Chinesas/farmacologia Flavanonas/farmacologia Glucosídeos/farmacologia Ácido Glicirretínico/farmacologia Glycyrrhiza/química Miócitos Cardíacos/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Linhagem Celular Miócitos Cardíacos/metabolismo Ratos Canal de Liberação de Cálcio do Receptor de Rianodina/genética Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo Trocador de Sódio e Cálcio/genética Trocador de Sódio e Cálcio/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drugs, Chinese Herbal); 0 (Flavanones); 0 (Glucosides); 0 (RyR2 protein, rat); 0 (Ryanodine Receptor Calcium Release Channel); 0 (Sodium-Calcium Exchanger); 0 (sodium-calcium exchanger 1); P540XA09DR (Glycyrrhetinic Acid); SY7Q814VUP (Calcium); T0O79T74CD (liquiritin); X8YN71D5WC (Aconitine) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170623 [St] Status: MEDLINE [do] DOI: 10.21010/ajtcam.v14i4.9

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[PMID]: 28573236 [Au] Autor: Alam P; Foudah AI; Zaatout HH; T KY; Abdel-Kader MS [Ad] Endereço: Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia. [Ti] Título: QUANTIFICATION OF GLYCYRRHIZIN BIOMARKER IN GLYCYRRHIZA GLABRA RHIZOME AND BABY HERBAL FORMULATIONS BY VALIDATED RP-HPTLC METHODS. [So] Source: Afr J Tradit Complement Altern Med;14(2):198-205, 2017. [Is] ISSN: 2505-0044 [Cp] País de publicação: Nigeria [La] Idioma: eng [Ab] Resumo: BACKGROUND: A simple and sensitive thin-layer chromatographic method has been established for quantification of glycyrrhizin in rhizome and baby herbal formulations by validated Reverse Phase HPTLC method. MATERIALS AND METHODS: RP-HPTLC Method was carried out using glass coated with RP-18 silica gel 60 F254S HPTLC plates using methanol-water (7: 3 v/v) as mobile phase. RESULTS: The developed plate was scanned and quantified densitometrically at 256 nm. Glycyrrhizin peaks from rhizome and baby herbal formulations were identified by comparing their single spot at R = 0.63 ± 0.01. Linear regression analysis revealed a good linear relationship between peak area and amount of glycyrrhizin in the range of 2000-7000 ng/band. CONCLUSION: The method was validated, in accordance with ICH guidelines for precision, accuracy, and robustness. The proposed method will be useful to enumerate the therapeutic dose of glycyrrhizin in herbal formulations as well as in bulk drug. [Mh] Termos MeSH primário: Cromatografia em Camada Delgada/métodos Glycyrrhiza/química Ácido Glicirrízico/análise Extratos Vegetais/química [Mh] Termos MeSH secundário: Química Farmacêutica Seres Humanos Lactente Reprodutibilidade dos Testes Rizoma/química [Pt] Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES [Nm] Nome de substância: 0 (Plant Extracts); 6FO62043WK (Glycyrrhizic Acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170816 [Lr] Data última revisão: 170816 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170603 [St] Status: MEDLINE [do] DOI: 10.21010/ajtcam.v14i2.21

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[PMID]: 28570935 [Au] Autor: Wang J; Zheng D; Wang Y; Zhang C; Sun X [Ad] Endereço: College of Life Sciences, Zaozhuang University, Zaozhuang 277160, China. Electronic address: jlwang8121@163.com. [Ti] Título: Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1059:35-42, 2017 Aug 01. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: To study the pharmacokinetics of Erhuang decoction extracts, a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established for the determination of effective substances in rat plasma. The extracts prepared by water extraction (WE) method were given to rats by oral administration. After collected from the orbital venous plexus, plasma was treated by protein precipitation method. Then, the concentration of index components, including baicalin, liquiritin, berberine, palmatine and glycyrrhetinic acid, were determined by HPLC-MS/MS. Gradient elution mode was used to the chromatographic separation with an Inertsil ODS-SP column (100 mm×2.1mm, 5µm), with acetonitrile and 0.1% formic acid containing 10mmolL ammonium acetate as the mobile phase. MS analysis was conducted by multiple reactions monitoring (MRM) with Electrospray Ionization (ESI). The extraction recoveries of the five active ingredients from plasma were greater than 86.04%, and the intra- and inter-day precisions were less than 16.57%. Results indicated that active ingredients in plasma of rats with oral administration of extracts showed certain difference in the pharmacokinetic parameters, which proved that the active ingredients were effectively absorbed. The established HPLC-MS/MS analytical method was sensitive and accurate, suitable for the pharmacokinetic study of active ingredients in Erhuang decoction. [Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos Medicamentos de Ervas Chinesas/farmacocinética Espectrometria de Massas em Tandem/métodos [Mh] Termos MeSH secundário: Administração Oral Animais Berberina/sangue Alcaloides de Berberina/sangue Medicamentos de Ervas Chinesas/administração & dosagem Flavanonas/sangue Glucosídeos/sangue Ácido Glicirretínico/sangue Glycyrrhiza/química Glycyrrhiza/metabolismo Ratos Ratos Sprague-Dawley Reprodutibilidade dos Testes Scutellaria baicalensis/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Berberine Alkaloids); 0 (Coptidis rhizoma extract); 0 (Drugs, Chinese Herbal); 0 (Flavanones); 0 (Glucosides); 0I8Y3P32UF (Berberine); 49QAH60606 (baicalein); G50C034217 (palmatine); P540XA09DR (Glycyrrhetinic Acid); T0O79T74CD (liquiritin) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170602 [St] Status: MEDLINE

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