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Pesquisa : B01.650.940.800.575.912.250.401.300.500 [Categoria DeCS]
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[PMID]:29246138
[Au] Autor:Ayeka PA; Bian Y; Githaiga PM; Zhao Y
[Ad] Endereço:International College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, 312 Anshan Western Road, Nankai District, Tianjin, 300193, People's Republic of China.
[Ti] Título:The immunomodulatory activities of licorice polysaccharides (Glycyrrhiza uralensis Fisch.) in CT 26 tumor-bearing mice.
[So] Source:BMC Complement Altern Med;17(1):536, 2017 Dec 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The increasing use of complementary and alternative medicine (CAM) has kindled the need for scientific evaluation of the mechanism of action of CAMs. Although, licorice, a common ingredient in many Traditional Chinese medicine (TCM) has attracted great attention for its antitumor and immunomodulatory activities, the mechanism of action of its polysaccharides is still unclear. Here we report the immunomodulatory activity of licorice polysaccharides in vivo. METHODS: The differential anticancer activities of licorice polysaccharides by tumorigenesis and immunomodulation was evaluated in vivo. Six weeks old, 120 CT-26 tumor bearing BALB/c mice, weighing 20 ± 2 g were used. They were randomly divided into six groups, three groups receiving high molecular weight (fraction A), low molecular weight (fraction B) polysaccharides and crude extract (fraction C); positive, negative and normal groups receiving cytoxin, saline and normal diet respectively. Weight of mice and tumors was determined and tumorigenicity assay calculated to determine the anticancer effects. Immunomodulatory potential was determined by immune organ indices, immune cell population and serum cytokine levels using immune organ weight and index, flow cytometry and cytokine/chemokine bead panel kit respectively. RESULTS: Licorice polysaccharides exhibited immunomodulatory activities in CT 26 tumor bearing BALB/c mice. The polysaccharides significantly suppressed tumor growth and increased immune organ index. Furthermore, the immunomodulatory effect was evident with activation of CD4 and CD8 immune cells population. The polysaccharides also affected the production of various cytokines, by increasing IL 2, IL 6, IL 7 levels and a decreasing TNFα levels. CONCLUSION: In summary, licorice polysaccharide especially of low molecular weight exhibit anticancer and immunomodulatory activities by suppressing tumor growth and improving general health of mice. They also augment the thymus/spleen index and population of T lymphocytes. Furthermore, the polysaccharides enhance the levels of serum antitumor cytokines, IL 2, IL 6 and IL 7 while decreasing pro-tumor cytokine TNFα.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Glycyrrhiza uralensis
Fatores Imunológicos/farmacologia
Extratos Vegetais/farmacologia
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Linhagem Celular Tumoral
Citocinas/sangue
Fatores Imunológicos/química
Camundongos
Camundongos Endogâmicos BALB C
Neoplasias Experimentais
Extratos Vegetais/química
Polissacarídeos/química
Baço/química
Baço/efeitos dos fármacos
Timo/química
Timo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Cytokines); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (Polysaccharides)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2030-7


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[PMID]:28404983
[Au] Autor:Chen J; Li WC; Gu XL
[Ad] Endereço:Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China (mainland).
[Ti] Título:Optimized Extraction, Preliminary Characterization, and In Vitro Antioxidant Activity of Polysaccharides from Glycyrrhiza Uralensis Fisch.
[So] Source:Med Sci Monit;23:1783-1791, 2017 Apr 13.
[Is] ISSN:1643-3750
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND This study performed optimized extraction, preliminary characterization, and in vitro antioxidant activities of polysaccharides from Glycyrrhiza uralensis Fisch. MATERIAL AND METHODS Three parameters (extraction temperature, ratio of water to raw material, and extraction time) were optimized for yields of G. uralensis polysaccharides (GUP) using response surface methodology with Box-Behnken design (BBD). The GUP was purified using DEAE cellulose 32-column chromatography. The main fraction obtained from G. uralensis Fisch was GUP-II, which was composed of rhamnose, arabinose, galactose, and glucose monosaccharide, was screened for antioxidant properties using DP Hand hydroxyl radical scavenging assays. In addition, immunological activity of GUP-II was determined by nitric oxide and lymphocyte proliferation assays. RESULTS Optimization revealed maximum GUP yields with an extraction temperature of 99°C, water: raw material ratio of 15: 1, and extraction duration of 2 h. GUP-II purified from G. uralensis Fisch had good in vitro DPPH and hydroxyl radical scavenging abilities. Immunologically, GUP-II significantly stimulated NO production in RAW 264.7 macrophages, and significantly enhanced LPS-induced lymphocyte proliferation. CONCLUSIONS Extraction of GUP from G. uralensis Fisch can be optimized with respect to temperature, extraction period, and ratio of water to material, using response surface methodology. The purified product (GUP-II) possesses excellent antioxidant and immunological activities.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Glycyrrhiza uralensis/química
Macrófagos/efeitos dos fármacos
Polissacarídeos/química
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Radical Hidroxila/química
Macrófagos/metabolismo
Camundongos
Oxirredução
Polissacarídeos/isolamento & purificação
Células RAW 264.7
Temperatura Ambiente
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Polysaccharides); 059QF0KO0R (Water); 3352-57-6 (Hydroxyl Radical)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28361161
[Au] Autor:Fung FY; Linn YC
[Ad] Endereço:Traditional Medicine Information Service, Department of Pharmacy, Singapore General Hospital, Singapore.
[Ti] Título:Steroids in traditional Chinese medicine: what is the evidence?
[So] Source:Singapore Med J;58(3):115-120, 2017 Mar.
[Is] ISSN:0037-5675
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Local healthcare providers often question the possible steroidal activity of traditional Chinese medicine (TCM) herbs or herbal products and implicate them as a cause for adrenal insufficiency or Cushing's syndrome in patients with a history of TCM intake. We conducted a comprehensive database search for evidence of potential glucocorticoid, mineralocorticoid, androgenic or oestrogenic activity of herbs or herbal products. Overall, there are not many herbs whose steroidal activity is well established; among these, most cases were based on preclinical studies. Liquorice root may cause pseudoaldosteronism through interference with the steroidogenesis pathway. Although ginseng and cordyceps have some in vitro glucocorticoid activities, the corroborating clinical data is lacking. Deer musk and deer antler contain androgenic steroids, while epimedium has oestrogenic activity. On the other hand, adulteration of herbal products with exogenous glucocorticoids is a recurrent problem encountered locally in illegal products masquerading as TCM. Healthcare providers should stay vigilant and report any suspicion to the relevant authorities for further investigations.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/análise
Medicina Tradicional Chinesa/efeitos adversos
Esteroides/análise
[Mh] Termos MeSH secundário: Androgênios/análise
Animais
Cordyceps
Bases de Dados Factuais
Cervos
Medicamentos de Ervas Chinesas/efeitos adversos
Epimedium
Estrogênios/análise
Ácidos Graxos Monoinsaturados
Glucocorticoides/análise
Glycyrrhiza uralensis
Seres Humanos
Mineralocorticoides/análise
Panax
Preparações de Plantas/análise
Risco
Singapura
Esteroides/efeitos adversos
Extratos de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgens); 0 (Drugs, Chinese Herbal); 0 (Estrogens); 0 (Fatty Acids, Monounsaturated); 0 (Glucocorticoids); 0 (Mineralocorticoids); 0 (Plant Preparations); 0 (Steroids); 0 (Tissue Extracts); 0 (lu rong); 095I377U8F (musk)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.11622/smedj.2017016


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[PMID]:28290079
[Au] Autor:Zhang W; Xie Z; Wang L; Li M; Lang D; Zhang X
[Ad] Endereço:College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
[Ti] Título:Silicon alleviates salt and drought stress of Glycyrrhiza uralensis seedling by altering antioxidant metabolism and osmotic adjustment.
[So] Source:J Plant Res;130(3):611-624, 2017 May.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study was conducted to determine effect and mechanism of exogenous silicon (Si) on salt and drought tolerance of Glycyrrhiza uralensis seedling by focusing on the pathways of antioxidant defense and osmotic adjustment. Seedling growth, lipid peroxidation, antioxidant metabolism, osmolytes concentration and Si content of G. uralensis seedlings were analyzed under control, salt and drought stress [100 mM NaCl with 0, 10 and 20% of PEG-6000 (Polyethylene glycol-6000)] with or without 1 mM Si. Si addition markedly affected the G. uralensis growth in a combined dose of NaCl and PEG dependent manner. In brief, Si addition improved germination rate, germination index, seedling vitality index and biomass under control and NaCl; Si also increased radicle length under control, NaCl and NaCl-10% PEG, decreased radicle length, seedling vitality index and germination parameters under NaCl-20% PEG. The salt and drought stress-induced-oxidative stress was modulated by Si application. Generally, Si application increased catalase (CAT) activity under control and NaCl-10% PEG, ascorbate peroxidase (APX) activity under all treatments and glutathione (GSH) content under salt combined drought stress as compared with non-Si treatments, which resisted to the increase of superoxide radicals and hydrogen peroxide caused by salt and drought stress and further decreased membrane permeability and malondialdehyde (MDA) concentration. Si application also increased proline concentration under NaCl and NaCl-20% PEG, but decreased it under NaCl-10% PEG, indicating proline play an important role in G. uralensis seedling response to osmotic stress. In conclusion, Si could ameliorate adverse effects of salt and drought stress on G. uralensis likely by reducing oxidative stress and osmotic stress, and the oxidative stress was regulated through enhancing of antioxidants (mainly CAT, APX and GSH) and osmotic stress was regulated by proline.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Secas
Glycyrrhiza uralensis/efeitos dos fármacos
Glycyrrhiza uralensis/crescimento & desenvolvimento
Plântulas/efeitos dos fármacos
Plântulas/crescimento & desenvolvimento
Silício/farmacologia
Cloreto de Sódio/metabolismo
[Mh] Termos MeSH secundário: Ascorbato Peroxidases/efeitos dos fármacos
Biomassa
Catalase/efeitos dos fármacos
Catalase/metabolismo
Germinação/efeitos dos fármacos
Glutationa/efeitos dos fármacos
Glycyrrhiza uralensis/enzimologia
Glycyrrhiza uralensis/metabolismo
Peróxido de Hidrogênio/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Modelos Biológicos
Pressão Osmótica/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Polietilenoglicóis/farmacologia
Prolina/efeitos dos fármacos
Tolerância a Sal/efeitos dos fármacos
Estresse Fisiológico
Superóxidos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 11062-77-4 (Superoxides); 30IQX730WE (Polyethylene Glycol 6000); 30IQX730WE (Polyethylene Glycols); 451W47IQ8X (Sodium Chloride); 4Y8F71G49Q (Malondialdehyde); 9DLQ4CIU6V (Proline); BBX060AN9V (Hydrogen Peroxide); EC 1.11.1.11 (Ascorbate Peroxidases); EC 1.11.1.6 (Catalase); GAN16C9B8O (Glutathione); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-017-0927-3


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[PMID]:28263754
[Au] Autor:Wu L; Fan Y; Fan C; Yu Y; Sun L; Jin Y; Zhang Y; Ye RD
[Ad] Endereço:School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
[Ti] Título:Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages.
[So] Source:Eur J Pharmacol;801:46-53, 2017 Apr 15.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The effects of licocoumarone (LC) isolated from Glycyrrhiza uralensis were studied in LPS-stimulated RAW 264.7 macrophages. Our study demonstrated that LC dose-dependently attenuated LPS-induced NO production by down-regulating iNOS expression. Additionally, the treatment with LC inhibited LPS-induced expression of cytokines including IL-1ß, IL-6 and IL-10, but not TNF-α, at both mRNA and protein levels. Similar suppressive effects of LC were observed on LPS-stimulated murine peritoneal macrophages as well. Furthermore, LC significantly reduced LPS-stimulated NF-κB activation by inhibition of IκBα degradation and p65 phosphorylation. The results from NF-κB-luc reporter gene assay further support the inhibitory effect of LC on NF-κB activation. Further studies showed that LC also interfered with the MAPKs and STAT3 signaling pathways, which are typical inflammatory signaling pathways triggered by LPS. Taken together, these results show that LC attenuates LPS-induced cytokine gene expression in RAW 264.7 macrophages through mechanisms that involve NF-κB, MAPKs and STAT3 signaling pathways, but the pattern of inhibition differs from that of a global immunosuppresant. Our study indicates that LC is a functional constituent of Glycyrrhiza uralensis with potential implications in infectious and immune-related diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Benzofuranos/isolamento & purificação
Benzofuranos/farmacologia
Glycyrrhiza uralensis/química
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Resorcinóis/isolamento & purificação
Resorcinóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Benzofuranos/uso terapêutico
Sobrevivência Celular/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Inflamação/metabolismo
Inflamação/patologia
Interleucina-10/metabolismo
Interleucina-1beta/metabolismo
Interleucina-6/metabolismo
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Macrófagos/citologia
Camundongos
NF-kappa B/metabolismo
Óxido Nítrico/biossíntese
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Células RAW 264.7
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Resorcinóis/uso terapêutico
Fator de Transcrição STAT3/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzofurans); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (RNA, Messenger); 0 (Resorcinols); 0 (STAT3 Transcription Factor); 0 (Tumor Necrosis Factor-alpha); 0 (licocoumarone); 130068-27-8 (Interleukin-10); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


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[PMID]:28161542
[Au] Autor:Tan CS; Ch'ng YS; Loh YC; Zaini Asmawi M; Ahmad M; Yam MF
[Ad] Endereço:School of Pharmaceutical Sciences, Universiti Sains Malaysia, USM 11800 Minden, Pulau Pinang, Malaysia.
[Ti] Título:Vasorelaxation effect of Glycyrrhizae uralensis through the endothelium-dependent Pathway.
[So] Source:J Ethnopharmacol;199:149-160, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Glycyrrhiza uralensis (G. uralensis) is one of the herbs used in traditional Chinese medicine (TCM) and serves as an envoy medicinal. Since G. uralensis plays a major role in the anti-hypertensive TCM formulae, we believe that G. uralensis might possess vasorelaxation activity. AIM OF THE STUDY: This study is designed to investigate the vasorelaxation effect of G. uralensis from various extracts and to study its pharmacology effect. MATERIALS AND METHODS: The vasorelaxation effect of G. uralensis extracts were evaluated on thoracic aortic rings isolated from Sprague Dawley rats. RESULTS: Among these three extracts of G. uralensis, 50% ethanolic extract (EFG) showed the strongest vasorelaxation activity. EFG caused the relaxation of the aortic rings pre-contracted with phenylephrine either in the presence or absence of endothelium and pre-contracted with potassium chloride in endothelium-intact aortic ring. Nω-nitro-L-arginine methyl ester, methylene blue, or 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one inhibit the vasorelaxation effect of EFG in the presence of endothelium. On the other hand, in the presence of the potassium channel blockers (tetraethylammonium and barium chloride), the vasorelaxation effect of EFG was not affected, but glibenclamide and 4-aminopyridine did inhibit the vasorelaxation effect of EFG. With indomethacin, atropine and propranolol, the vasorelaxation effect by EFG was significantly reduced. EFG was also found to be effective in reducing Ca release from sarcoplasmic reticulum and the blocking of calcium channels. CONCLUSIONS: The results obtained suggest that EFG is involved in the NO/sGC/cGMP pathway.
[Mh] Termos MeSH primário: Endotélio Vascular/efeitos dos fármacos
Glycyrrhiza uralensis
Extratos Vegetais/farmacologia
Vasodilatação/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Aorta Torácica/efeitos dos fármacos
Aorta Torácica/fisiologia
Relação Dose-Resposta a Droga
Endotélio Vascular/fisiologia
Masculino
Técnicas de Cultura de Órgãos
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Sprague-Dawley
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/fisiologia
Vasodilatação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:28159726
[Au] Autor:Yang Y; Wang S; Bao YR; Li TJ; Yang GL; Chang X; Meng XS
[Ad] Endereço:School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. Electronic address: yy741412697@163.com.
[Ti] Título:Anti-ulcer effect and potential mechanism of licoflavone by regulating inflammation mediators and amino acid metabolism.
[So] Source:J Ethnopharmacol;199:175-182, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Glycyrrhiza is the dry root and rhizome of the leguminous plant, Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., which was firstly cited in Shennong's Herbal Classic in Han dynasty and was officially listed in the Chinese Pharmacopoeia, has been widely used in China during the past millennia. Licoflavone is the major component of Glycyrrhiza with anti-ulcer activity. The present study is based on clarifying the anti-ulcer effect of licoflavone, aiming at elucidating the possible molecule mechanisms of its action for treating gastric ulcer rats induced by acetic acid. MATERIALS AND METHODS: Rats were divided into 7 groups, and drugs were administered from on the day after the onset of gastric ulcer (day 3) until day 11 of the experiment once daily continuously. The plasma were analyzed by high-performance liquid chromatography combined with time-of-flight mass spectrometry (HPLC/ESI-TOF-MS), significant different metabolites were investigated to explain its therapeutic mechanism. Furthermore, quantitative real time polymerase chain reaction (RT-PCR) analysis was performed to detect the expression of RNA in stomach tissue for verifying the above results. RESULTS: Licoflavone can effectively cure the gastric ulcer, particularly the middle dose group. According to the statistical analysis of the plasma different metabolites from each groups and the expression of genes in tissues, sixteen significant different metabolites, including histamine, tryptophan, arachidonic acid, phingosine-1-phosphate etc., contributing to the treatment of gastric ulcer were discovered and identified. In RT-PCR analysis, the results of the expression of RNA were corresponded with what we discovered. CONCLUSIONS: Our study indicated licoflavone plays the role of treating gastric ulcer by regulating inflammation mediators and amino acid metabolism. We demonstrated that metabolomics technology combined with gene technology is a useful tool to search different metabolites and to dissect the potential mechanisms of traditional Chinese medicine (TCM) in treating gastric ulcer.
[Mh] Termos MeSH primário: Aminoácidos/metabolismo
Antiulcerosos/uso terapêutico
Flavonas/uso terapêutico
Glycyrrhiza uralensis
Mediadores da Inflamação/metabolismo
Úlcera Gástrica/metabolismo
[Mh] Termos MeSH secundário: Aminoácidos/antagonistas & inibidores
Animais
Antiulcerosos/isolamento & purificação
Antiulcerosos/farmacologia
Relação Dose-Resposta a Droga
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Medicamentos de Ervas Chinesas/uso terapêutico
Flavonas/isolamento & purificação
Flavonas/farmacologia
Mediadores da Inflamação/antagonistas & inibidores
Masculino
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Úlcera Gástrica/tratamento farmacológico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Anti-Ulcer Agents); 0 (Drugs, Chinese Herbal); 0 (Flavones); 0 (Inflammation Mediators)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28105652
[Au] Autor:Wang J; Li J; Li J; Li J; Liu S; Gao W
[Ad] Endereço:Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
[Ti] Título:LSP1, a responsive protein from Meyerozyma guilliermondii, elicits defence response and improves glycyrrhizic acid biosynthesis in Glycyrrhiza uralensis Fisch adventitious roots.
[So] Source:J Cell Physiol;232(12):3510-3519, 2017 Dec.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This research explored the effects of protein and polysaccharide in Meyerozyma guilliermondii on active compounds in Glycyrrhiza uralensis Fisch adventitious roots. In this study, a responsive protein LSP1 was purified from the Meyerozyma guilliermondii since the excellent induction. The contents of total flavonoids (3.46 mg · g ), glycyrrhizic acid (0.41 mg · g ), glycyrrhetinic acid (0.41 mg · g ), and polysaccharide (94.49 mg · g ) in adventitious root peaked at LSP1 group, which were 1.6, 3.4, 2.4, 2.0-fold that of control, respectively. Besides, the responsive protein LSP1 significantly activated the defense signaling, mitogen-activated protein kinases and extremely up-regulated the expression of defense-related genes and functional genes involved in glycyrrhizic acid biosynthesis.
[Mh] Termos MeSH primário: Proteínas Fúngicas/metabolismo
Glycyrrhiza uralensis/metabolismo
Glycyrrhiza uralensis/microbiologia
Ácido Glicirrízico/metabolismo
Raízes de Plantas/metabolismo
Raízes de Plantas/microbiologia
Saccharomycetales/metabolismo
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Glycyrrhiza uralensis/genética
Interações Hospedeiro-Patógeno
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Transdução de Sinais/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray
Fatores de Tempo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 6FO62043WK (Glycyrrhizic Acid); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.25811


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[PMID]:28102022
[Au] Autor:Liu C; Yang N; Chen X; Tversky J; Zhan J; Chehade M; Miller RL; Li XM
[Ad] Endereço:Department of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
[Ti] Título:The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts.
[So] Source:Phytother Res;31(3):449-458, 2017 Mar.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eotaxin/CCL-11 is a major chemoattractant that contributes to eosinophilic inflammation in asthma. Glucocorticoids inhibit inflammation, but long-time exposure may cause paradoxical adverse effects by augmenting eotaxin/CCL-11production. The aim of this study was to determine if 7,4'-dihydroxyflavone (7,4'-DHF), the eotaxin/CCL11 inhibitor isolated from Glycyrrhiza uralensis, reduces in vitro eotaxin production induced by long-time dexamethasone (Dex) exposure, and if so, to elucidate the mechanisms of this inhibition. Human lung fibroblast-1 cells were used to identify the potency of 7,4'-DHF compared with other compounds from G. uralensis, to compare 7,4'-DHF with Dex on eotaxin production following 24-h short-time culture and 72-h longer-time (LT) culture, and to determine the effects of the 7,4'-DHF on Dex LT culture augmented eotaxin production and molecule mechanisms. 7,4'-DHF was the most potent eotaxin/CCL-11 inhibitor among the ten compounds and provided continued suppression. In contrast to short-time culture, Dex LT culture increased constitutively, and IL-4/TNF-α stimulated eotaxin/CCL11 production by human lung fibroblast-1 cells. This adverse effect was abrogated by 7,4'-DHF co-culture. 7,4'-DHF significantly inhibited Dex LT culture augmentation of p-STAT6 and impaired HDAC2 expression. This study demonstrated that 7,4'-DHF has the ability to consistently suppress eotaxin production and prevent Dex-paradoxical adverse effects on eotaxin production. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Quimiocina CCL11/metabolismo
Dexametasona/efeitos adversos
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Flavonas/farmacologia
Flavonoides/farmacologia
[Mh] Termos MeSH secundário: Asma/metabolismo
Células Cultivadas
Interações Medicamentosas
Glucocorticoides/efeitos adversos
Glycyrrhiza uralensis/química
Histona Desacetilase 2/metabolismo
Seres Humanos
Interleucina-4/metabolismo
Pulmão/metabolismo
Fator de Transcrição STAT6/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7,4'-dihydroxyflavone); 0 (CCL11 protein, human); 0 (Chemokine CCL11); 0 (Flavones); 0 (Flavonoids); 0 (Glucocorticoids); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human); 0 (Tumor Necrosis Factor-alpha); 207137-56-2 (Interleukin-4); 7S5I7G3JQL (Dexamethasone); EC 3.5.1.98 (Histone Deacetylase 2)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5767


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[PMID]:28019719
[Au] Autor:Ye R; Fan YH; Ma CM
[Ad] Endereço:School of Life Sciences, Inner Mongolia University , Huhhot, China 010021.
[Ti] Título:Identification and Enrichment of α-Glucosidase-Inhibiting Dihydrostilbene and Flavonoids from Glycyrrhiza uralensis Leaves.
[So] Source:J Agric Food Chem;65(2):510-515, 2017 Jan 18.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To exploit Glycyrrhiza uralensis resources, we examined the bioactive constituents of G. uralensis leaves. Seven chemical components were isolated by repeat column chromatography, and using spectroscopic methods, their structures were determined to be a novel prenylated dihydrostilbene, α,α'-dihydro-3,5,3',4'-tetrahydroxy-2,5'-diprenylstilbene (1); a methylated flavonoid, quercetin-3-Me ether (4); and 5 prenylated flavonoids: 5'-prenylquercetin (3), 8-[(E)-3-hydroxymethyl-2-butenyl]eriodictyol (7), 6-prenyleriodictyol (5), 5'-prenyleriodictyol (6), and 6-prenylquercetin-3-Me ether (2). Compounds 1-7 and their unprenylated counterparts, glycosides, and other related compounds (8-13) were quantitatively analyzed. Using a macroporous resin column, most of these compounds could be enriched in the 40% to 60% ethanol-eluted fractions. Compounds 1-7 showed strong radical scavenging activity toward DPPH, and most of them demonstrated greater inhibitory activity against α-glucosidase than their unprenylated counterparts.
[Mh] Termos MeSH primário: Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Glycyrrhiza uralensis/química
[Mh] Termos MeSH secundário: Flavanonas/isolamento & purificação
Flavanonas/farmacologia
Flavonoides/química
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Hemiterpenos/isolamento & purificação
Hemiterpenos/farmacologia
Estrutura Molecular
Extratos Vegetais/análise
Extratos Vegetais/química
Folhas de Planta/química
Estilbenos/isolamento & purificação
Estilbenos/farmacologia
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-(3-hydroxymethyl-2-butenyl)eriodictyol); 0 (Flavanones); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Glycoside Hydrolase Inhibitors); 0 (Hemiterpenes); 0 (Plant Extracts); 0 (Stilbenes); 0 (alpha,alpha'-dihydro-3,5,3',4'-tetrahydroxy-2,5'-diprenylstilbene); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04155



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