Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.401.327 [Categoria DeCS] Referências encontradas : 33 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 27058600 [Au] Autor: Santana GM; Deus MS; Sousa JM; Ferreira PM; Fernandes HB; Peron AP [Ad] Endereço: Departamento de Ciências Biológicas, Universidade Federal do Piauí, Picos, PI, Brazil. [Ti] Título: Antimitotic and antimutagenic action of the Hymenaea stigonocarpa bark on dividing cells. [So] Source: Braz J Biol;76(2):520-5, 2016 Jun. [Is] ISSN: 1678-4375 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: The objective of this study was to evaluate the action of Hymenaea stigonocarpa bark hydroalcoholic extract against a mutagenic compound using A. cepa meristematic root cells as a test system. The treatment groups were: Negative Control (NC) - distilled water; Positive Control (PC) - paracetamol at a concentration of 0.008 mg/mL, Jatoba Control (JC) - aqueous fraction jatobá-do-cerrado at 0.5 or 1.0 or 1.5 mg/mL, and Simultaneous Treatment (ST) - jatobá-do-cerrado aqueous fraction at a concentration of 0.5 or 1.0 or 1.5 mg/mL associated with paracetamol solution at a concentration of 0.008 mg/mL. All groups were analyzed at 24 and 48 h. Five onion bulbs (five replications) were used for each treatment group. The root tips were fixed in Carnoy and slides prepared by the crush technique. Cells were analyzed throughout the cell cycle, totaling 5,000 for each treatment group at each exposure time. Mitotic indices were subjected to statistical analysis using the chi-square test (p<0.05). From the results it was found that the ST group, at the three concentrations, significantly potentiated the antiproliferative effect of the test system cells when compared to PC, NC and TJ at the three concentrations. Furthermore, the three ST concentrations significantly reduced the number of cell aberrations when compared to the number of aberrant cells obtained for the PC, demonstrating antimutagenic action on the A. cepa test system cells. [Mh] Termos MeSH primário: Acetaminofen/farmacologia Hymenaea Cebolas Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Antimitóticos/farmacologia Antipiréticos/farmacologia Ciclo Celular/efeitos dos fármacos Meristema Índice Mitótico/métodos Mutagênicos/metabolismo Mutagênicos/farmacologia Cebolas/citologia Cebolas/fisiologia Casca de Planta Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antimitotic Agents); 0 (Antipyretics); 0 (Mutagens); 0 (Plant Extracts); 362O9ITL9D (Acetaminophen) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160409 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 26337089 [Au] Autor: Castro e Silva DM; Santos DC; Martins MA; Oliveira L; Szeszs MW; Melhem MS [Ad] Endereço: Instituto Adolfo Lutz, Secretariat of Health, Government of São Paulo State, Brazil dulmatos.ial@gmail.com. [Ti] Título: First isolation of Cryptococcus neoformans genotype VNI MAT-alpha from wood inside hollow trunks of Hymenaea courbaril. [So] Source: Med Mycol;54(1):97-102, 2016 Jan. [Is] ISSN: 1460-2709 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Cryptococcal infection is transmitted by the inhalation of Cryptococcus spp. propagules. Information about the Cryptococcus species inhabiting plants might be clinically relevant due to the epidemiological role of these habitats as possible sources of human infection. The aim of this study was to increase the knowledge about the environmental occurrence of cryptococcosis agents. Hollow tree vegetal debris of nine plant species was sampled quarterly over a 12-month period. Melanized colonies were screened for Cryptococcus neoformans and C. gattii by biochemical tests, followed by URA5-RFLP molecular analysis, M13 fingerprinting assays, and mating-typing with the specific a and α primers. The susceptibility to fluconazole of all of the confirmed species colonies was determined using the AFST-EUCAST broth dilution method. We found that the typical Brazilian flora tree Hymenaea courbaril yielded a high cryptococcal burden (median, 10(2) CFU/g) during the summer, autumn and winter seasons. C. neoformans VNI molecular type MAT alpha was identified in all of the samples. The fingerprinting analyses showed great molecular variability with no correlation with the susceptibility profile to fluconazole (MIC range 4 to ≥64 mg/l). To our knowledge, this study is the first describing the association between C. neoformans and Hymenaea courbaril. These observations extend the known geographic distribution of and substantiate a new urban environmental niche for C. neoformans and also emphasize the genetic diversity of the environmental C. neoformans VNI molecular type isolates. [Mh] Termos MeSH primário: Cryptococcus neoformans/classificação Cryptococcus neoformans/isolamento & purificação Genes Fúngicos Tipo Acasalamento Genótipo Hymenaea/microbiologia Madeira/microbiologia [Mh] Termos MeSH secundário: Antifúngicos/farmacologia Brasil Contagem de Colônia Microbiana Cryptococcus neoformans/genética Cryptococcus neoformans/fisiologia Fluconazol/farmacologia Variação Genética Testes de Sensibilidade Microbiana Tipagem Molecular Técnicas de Tipagem Micológica Polimorfismo de Fragmento de Restrição Estações do Ano [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antifungal Agents); 8VZV102JFY (Fluconazole) [Em] Mês de entrada: 1610 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150905 [St] Status: MEDLINE [do] DOI: 10.1093/mmy/myv066

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[PMID]: 26050908 [Au] Autor: de Freitas RA; Spier VC; Sierakowski MR; Nicolai T; Benyahia L; Chassenieux C [Ad] Endereço: LUNAM Université, Université du Maine, CNRS UMR 6283, IMMM, Avenue Olivier Messiaen, 72085 LE MANS Cedex 9, France; BioPol, Chemistry Department, Federal University of Paraná, 81531-980 Curitiba, PR, Brazil. Electronic address: rilton@ufpr.br. [Ti] Título: Transient and quasi-permanent networks in xyloglucan solutions. [So] Source: Carbohydr Polym;129:216-23, 2015 Sep 20. [Is] ISSN: 1879-1344 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Viscoelastic properties of aqueous solutions of xyloglucan extracted from Hymenaea courbaril seeds (Jatobá gum) were investigated by rheology over a wide range of concentrations and temperatures. The polymer was characterized in dilute solutions by light scattering measurements and size exclusion chromatography. Xyloglucan formed, in semi-dilute solutions (C 0.3 wt%), a transient network with cross-links characterized by a broad distribution of lifetimes, independent of the temperature and concentration. Progressively, at higher temperatures (>60°C), a second much weaker quasi-permanent network was formed and attributed to the exchange of intra- to inter-chain bonds. The stiffness of the second network increased with decreasing temperature, but it could be easily broken by applying a relatively weak shear stress and is readily reversible on re-heating, and partially reversible on resting at 20°C. [Mh] Termos MeSH primário: Glucanos/química Hymenaea/química Xilanos/química [Mh] Termos MeSH secundário: Configuração de Carboidratos Oligossacarídeos/química Soluções Viscosidade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Glucans); 0 (Oligosaccharides); 0 (Solutions); 0 (Xylans); 37294-28-3 (xyloglucan) [Em] Mês de entrada: 1603 [Cu] Atualização por classe: 150608 [Lr] Data última revisão: 150608 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150609 [St] Status: MEDLINE

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[PMID]: 26039872 [Au] Autor: Monteiro AF; Batista JM; Machado MA; Severino RP; Blanch EW; Bolzani VS; Vieira PC; Severino VG [Ad] Endereço: †Unidade Acadêmica Especial de Física e Química, Universidade Federal de Goiás, Avenida Dr. Lamartine Pinto de Avelar, 1120, 75704-020, Catalão, GO, Brazil. [Ti] Título: Structure and Absolute Configuration of Diterpenoids from Hymenaea stigonocarpa. [So] Source: J Nat Prod;78(6):1451-5, 2015 Jun 26. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Chemical investigations of the ethanolic extracts from the flowers and leaves of Hymenaea stigonocarpa Mart. ex Hayne afforded one new ent-halimane diterpenoid, 18-hydroxy-ent-halima-1(10),13-(E)-dien-15-oic acid (1), together with five known compounds (2-6). The structural elucidation was performed by means of NMR (COSY, HSQC, HMBC, and NOESY) and MS analyses. Complete (1)H and (13)C NMR data assignments are also reported for labd-13-en-8ß-ol-15-oic (2) and labd-7,13-dien-15-oic (3) acids. The absolute configurations of 1 and 2 were established by comparison of experimental and calculated Raman optical activity spectra. [Mh] Termos MeSH primário: Diterpenos/química Diterpenos/isolamento & purificação Hymenaea/química [Mh] Termos MeSH secundário: Brasil Flores/química Estrutura Molecular Ressonância Magnética Nuclear Biomolecular Folhas de Planta/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (18-hydroxy-ent-halima-1(10),13-(E)-dien-15-oic acid); 0 (Diterpenes) [Em] Mês de entrada: 1509 [Cu] Atualização por classe: 150626 [Lr] Data última revisão: 150626 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150604 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.5b00166

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[PMID]: 25450047 [Au] Autor: Arruda IR; Albuquerque PB; Santos GR; Silva AG; Mourão PA; Correia MT; Vicente AA; Carneiro-da-Cunha MG [Ad] Endereço: Departamento de Bioquímica, Universidade Federal de Pernambuco-UFPE, Av. Prof. Moraes Rego s/n, CEP: 50.670-420, Recife, PE, Brasil. [Ti] Título: Structure and rheological properties of a xyloglucan extracted from Hymenaea courbaril var. courbaril seeds. [So] Source: Int J Biol Macromol;73:31-8, 2015 Feb. [Is] ISSN: 1879-0003 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Hymenaea courbaril var courbaril seed xyloglucan was efficiently extracted with 0.1M NaCl, followed by ethanol precipitation (yield=72±5% w/w). Its amorphous structure was identified by the pattern of X-ray diffraction. The monosaccharide composition was determined by GC/MS analysis of the alditol acetates and showed the occurrence of glucose:xylose:galactose:arabinose (40:34:20:6). One-(1D) and two-dimensional-(2D) NMR spectra confirmed a central backbone composed by 4-linked ß-glucose units partially branched at position 6 with non-reducing terminal units of α-xylose or ß-galactose-(1→2)-α-xylose disaccharides. The xyloglucan solution was evaluated by dynamic light scattering and presents a polydisperse and practically neutral profile, and at 0.5 and 1.0% (w/v) the solutions behave as a viscoelastic fluid. The polysaccharide did not show significant antibacterial or hemolytic activities. Overall our results indicate that xyloglucan from H. courbaril is a promising polysaccharide for food and pharmaceutical industries. [Mh] Termos MeSH primário: Glucanos/química Hymenaea/química Extratos Vegetais/química Sementes/química Xilanos/química [Mh] Termos MeSH secundário: Antibacterianos/química Antibacterianos/farmacologia Cromatografia em Gel Glucanos/farmacologia Hemolíticos/química Hemolíticos/farmacologia Metilação Estrutura Molecular Ressonância Magnética Nuclear Biomolecular Extratos Vegetais/farmacologia Reologia Difração de Raios X Xilanos/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Glucans); 0 (Hemolytic Agents); 0 (Plant Extracts); 0 (Xylans); 37294-28-3 (xyloglucan) [Em] Mês de entrada: 1509 [Cu] Atualização por classe: 150110 [Lr] Data última revisão: 150110 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141203 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 25482765 [Au] Autor: Gupta D; Eldakak M; Rohila JS; Basu C [Ad] Endereço: a Department of Biology ; California State University Northridge ; Northridge , CA USA. [Ti] Título: Biochemical analysis of 'kerosene tree' Hymenaea courbaril L. under heat stress. [So] Source: Plant Signal Behav;9(10):e972851, 2014. [Is] ISSN: 1559-2324 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Hymenaea courbaril or jatoba is a tropical tree known for its medically important secondary metabolites production. Considering climate change, the goal of this study was to investigate differential expression of proteins and lipids produced by this tree under heat stress conditions. Total lipid was extracted from heat stressed plant leaves and various sesquiterpenes produced by the tree under heat stress were identified. Gas chromatographic and mass spectrometric analysis were used to study lipid and volatile compounds produced by the plant. Several volatiles, isoprene, 2-methyl butanenitrile, ß ocimene and a numbers of sesquiterpenes differentially produced by the plant under heat stress were identified. We propose these compounds were produced by the tree to cope up with heat stress. A protein gel electrophoresis (2-D DIGE) was performed to study differential expression of proteins in heat stressed plants. Several proteins were found to be expressed many folds different in heat stressed plants compared to the control. These proteins included heat shock proteins, histone proteins, oxygen evolving complex, and photosynthetic proteins, which, we believe, played key roles in imparting thermotolerance in Hymenaea tree. To the best of our knowledge, this is the first report of extensive molecular physiological study of Hymenaea trees under heat stress. This work will open avenues of further research on effects of heat stress in Hymenaea and the findings can be applied to understand how global warming can affect physiology of other plants. [Mh] Termos MeSH primário: Resposta ao Choque Térmico Hymenaea/metabolismo Estresse Fisiológico Árvores/metabolismo [Mh] Termos MeSH secundário: Eletroforese em Gel Bidimensional Cromatografia Gasosa-Espectrometria de Massas Querosene Lipídeos/análise Folhas de Planta/metabolismo Proteínas de Plantas/metabolismo Proteoma/metabolismo Compostos Orgânicos Voláteis/análise [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Kerosene); 0 (Lipids); 0 (Plant Proteins); 0 (Proteome); 0 (Volatile Organic Compounds) [Em] Mês de entrada: 1508 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141209 [St] Status: MEDLINE [do] DOI: 10.4161/15592316.2014.972851

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[PMID]: 25263863 [Au] Autor: de Souza CF; Riegel-Vidotti IC; Cardoso MB; Ono L; Lucyszyn N; Lubambo AF; Sens CV; Grein-Iankovski A; Sierakowski MR [Ad] Endereço: Laboratório de Biopolímeros-BioPol, Departamento de Química, Universidade Federal do Paraná (UFPR), PO 19081, Curitiba 81531-990, PR, Brazil; Curso de Licenciatura em Química, Escola de Educação e Humanidades, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil. [Ti] Título: Nanometric organisation in blends of gellan/xyloglucan hydrogels. [So] Source: Carbohydr Polym;114:48-56, 2014 Dec 19. [Is] ISSN: 1879-1344 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Mixtures of gellan gum (GL) and a xyloglucan (XGJ) extracted from Hymenaea courbaril seeds were prepared in a solution of 0.15 mol L(-1) NaCl. Rheology measurements revealed that 2.4 g L(-1) pure GL formed a brittle hydrogel, and GL-XGJ blends showed improved pseudoplastic character with higher XGJ contents. SAXS analyses showed that the Rg dimensions ranged from 1.3 to 4.9 nm, with larger values occurring as the amount of XGJ increased, and diffusion tests indicated that better diffusion of methylene blue dye was obtained in the network with a higher XGJ content. AFM topographic images of the films deposited onto mica revealed fewer heterogeneous surfaces with increased XGJ contents. The water contact angle revealed more hydrophobic character on all of the films, and the wettability decreased with increasing amounts of XGJ. Therefore, the demonstrated benefit of using XGJ blends is the production of a soft material with improved interface properties. [Mh] Termos MeSH primário: Glucanos/isolamento & purificação Hidrogéis/isolamento & purificação Nanotecnologia/métodos Polissacarídeos Bacterianos/isolamento & purificação Xilanos/isolamento & purificação [Mh] Termos MeSH secundário: Glucanos/química Hidrogéis/química Hymenaea Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Polissacarídeos Bacterianos/química Difração de Raios X Xilanos/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Glucans); 0 (Hydrogels); 0 (Plant Extracts); 0 (Polysaccharides, Bacterial); 0 (Xylans); 37294-28-3 (xyloglucan); 7593U09I4D (gellan gum) [Em] Mês de entrada: 1510 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140930 [St] Status: MEDLINE

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[PMID]: 25029361 [Au] Autor: Lacerda LP; Malaquias G; Peron AP [Ad] Endereço: Universidade Federal do Piauí (UFPI), Núcleo de Pesquisa Aplicada a Saúde e ao Meio-Ambiente (NUPBSAM), Laboratório de Citogenética Vegetal e Animal, Campus Senador Helvídio Nunes de Barros (CSHNB), Picos, PI, Brasil. [Ti] Título: Antiproliferative action of aqueous extracts of Hymenaea stigonocarpa Mart. (Fabaceae) on the cell cycle of Allium cepa L. [So] Source: An Acad Bras Cienc;86(3):1147-50, 2014 Sep. [Is] ISSN: 1678-2690 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: In this study we evaluated the action of crude aqueous extracts obtained from rhytidome of Hymenaea stigonocarpa (jatobá-do-cerrado) on Allium cepa meristematic root cells in three concentrations: 0.082, 0.164, 0.328g/mL, at exposure times of 24 and 48 h. The slides were prepared by the crushing technique, and cells analyzed throughout the cell cycle, totaling 5000 for each control group and concentration. It was found that all three concentrations, including the lowest which is considered ideal for use, in all exposure times, had significant antiproliferative action on the cell cycle of this test system. For cells under division, we observed a high number of cells in prophase. Therefore, under the conditions studied H. stigonocarpa indicated to be cytotoxic. [Mh] Termos MeSH primário: Ciclo Celular/efeitos dos fármacos Hymenaea/química Cebolas/citologia Cebolas/efeitos dos fármacos Extratos Vegetais/farmacologia Raízes de Plantas/efeitos dos fármacos [Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga Hymenaea/classificação Hymenaea/citologia Raízes de Plantas/citologia Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Extracts) [Em] Mês de entrada: 1501 [Cu] Atualização por classe: 140912 [Lr] Data última revisão: 140912 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140717 [St] Status: MEDLINE

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[PMID]: 25027026 [Au] Autor: da Costa MP; Bozinis MC; Andrade WM; Costa CR; da Silva AL; Alves de Oliveira CM; Kato L; Fernandes Ode F; Souza LK; Silva Mdo R [Ti] Título: Antifungal and cytotoxicity activities of the fresh xylem sap of Hymenaea courbaril L. and its major constituent fisetin. [So] Source: BMC Complement Altern Med;14:245, 2014 Jul 16. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: The great potential of plants as Hymenaea courbaril L (jatoba) has not yet been throughly explored scientifically and therefore it is very important to investigate their pharmacological and toxicological activities to establish their real efficacy and safety. This study investigated the cytotoxicity of xylem sap of Hymenaea courbaril L and its bioactivity against the fungi Cryptococcus neoformans species complex and dermatophytes. METHODS: The fresh xylem sap of H. courbaril was filtered resulting in an insoluble brown color precipitate and was identified as fisetin. In the filtrate was identified the mixture of fisetinediol, fustin, 3-O-methyl-2,3-trans-fustin and taxifolin, which were evaluated by broth microdilution antifungal susceptibility testing against C. neoformans species complex and dermatophytes. The fresh xylem sap and fisetin were screened for cytotoxicity against the 3T3-A31 cells of Balb/c using neutral red uptake (NRU) assay. RESULTS: The fresh xylem sap and the fisetin showed higher in vitro activity than the filtrate. The xylem sap of H. courbaril inhibited the growth of dermatophytes and of C. neoformans with minimal inhibition concentration (MIC) < 256 µg/mL, while the fisetin showed MIC < 128 µg/mL for these fungi. Fisetin showed lower toxicity (IC50 = 158 µg/mL) than the fresh xylem sap (IC50 = 109 µg/mL). CONCLUSION: Naturally occurring fisetin can provide excellent starting points for clinical application and can certainly represent a therapeutic potential against fungal infections, because it showed in vitro antifungal activity and low toxicity on animal cells. [Mh] Termos MeSH primário: Antifúngicos/farmacologia Flavonoides/farmacologia Hymenaea/química Xilema/química [Mh] Termos MeSH secundário: Animais Antifúngicos/química Antifúngicos/isolamento & purificação Arthrodermataceae/efeitos dos fármacos Linhagem Celular Cryptococcus neoformans/efeitos dos fármacos Flavonoides/química Flavonoides/isolamento & purificação Camundongos Testes de Sensibilidade Microbiana [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antifungal Agents); 0 (Flavonoids); OO2ABO9578 (fisetin) [Em] Mês de entrada: 1410 [Cu] Atualização por classe: 150805 [Lr] Data última revisão: 150805 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140717 [St] Status: MEDLINE [do] DOI: 10.1186/1472-6882-14-245

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[PMID]: 24211392 [Au] Autor: Orsi PR; Seito LN; Di Stasi LC [Ad] Endereço: Department of Pharmacology, Institute of Biosciences, Univ. Estadual Paulista, UNESP, Botucatu, SP, CEP 18618-970, Brazil. [Ti] Título: Hymenaea stigonocarpa Mart. ex Hayne: A tropical medicinal plant with intestinal anti-inflammatory activity in TNBS model of intestinal inflammation in rats. [So] Source: J Ethnopharmacol;151(1):380-5, 2014. [Is] ISSN: 1872-7573 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: ETHNOPHARMACOLOGICAL RELEVANCE: Stem bark and fruit pulp of Hymenaea stigonocarpa Mart ex. Hayne (Fabaceae) has been popularly used to treat inflammation and gastrointestinal diseases including ulcers, diarrhea and gastric pain. The aim of this study was to investigate the intestinal anti-inflammatory activity of a methanol extract derived from the stem bark and diet with fruit pulp of Hymenaea stigonocarpa in the TNBS model of intestinal inflammation in rats. MATERIAL AND METHODS: The intestinal anti-inflammatory activity of stem bark extract (100, 200 and 400mg/kg) and fruit pulp (10% and 5% in diet) was measured against the intestinal inflammatory process induced by TNBS (trinitrobenzesulphonic acid) in rats. The protective effects were evaluated as follows: evaluation of intestinal damage (damage score, extension of lesion, colon weight/length ratio), incidence of diarrhea and adherence to adjacent organs, colon glutathione (GSH) and malondialdehyde (MDA) contents, myeloperoxidase (MPO) and alkaline phosphatase (AP) activities. In addition, in vitro studies on lipid peroxidation in rat brain membranes and phytochemical profile were performed with both stem bark and fruit pulp. RESULTS: Treatment with 100, 200 and 400mg/kg of stem bark extract and 10% fruit pulp flour showed protective effects in the TNBS-induced colon damage, which was related to inhibition of MPO and AP activities, reduction in colon MDA content, and counteraction of GSH depletion induced by inflammatory process. A concentration-dependent inhibitory effect on the lipid peroxidation in rat brain membranes for stem bark and fruit pulp was determined, with an IC50 value of 5.25 ± 0.23 µg/mL and 27.33 ± 0.09 µg/mL, respectively. Similar phytochemical composition was observed in fruit and stem bark, including mainly flavonoids, condensed tannins and terpenes. CONCLUSIONS: Stem bark extract and fruit pulp flour of Hymenaea stigonocarpa prevented TNBS-induced colonic damage in rats and this protective effect were associated to an improvement of intestinal oxidative stress. The observed anti-inflammatory and antioxidant effects may be associated to the presence of flavonoids and tannins in the stem bark and fruit pulp of Hymenaea stigonocarpa. [Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico Colite/tratamento farmacológico Hymenaea/química Inflamação/tratamento farmacológico Plantas Medicinais [Mh] Termos MeSH secundário: Animais Anti-Inflamatórios/administração & dosagem Anti-Inflamatórios/química Colite/induzido quimicamente Relação Dose-Resposta a Droga Inflamação/induzido quimicamente Masculino Casca de Planta/química Caules de Planta/química Distribuição Aleatória Ratos Ratos Wistar Ácido Trinitrobenzenossulfônico/toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid) [Em] Mês de entrada: 1409 [Cu] Atualização por classe: 131230 [Lr] Data última revisão: 131230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 131112 [St] Status: MEDLINE

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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