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[PMID]:28865459
[Au] Autor:Cheng HM; Wu YC; Wang Q; Song M; Wu J; Chen D; Li K; Wadman E; Kao ST; Li TC; Leon F; Hayden K; Brodmerkel C; Chris Huang C
[Ad] Endereço:Department of Integration of Traditional Chinese and Western Medicine, China Medical University Hospital, Taichung, Taiwan.
[Ti] Título:Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis.
[So] Source:BMC Complement Altern Med;17(1):439, 2017 Sep 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unknown due to lack of knowledge about the responsible chemical entity. We took a different approach to this challenge by investigating the molecular profile of Indigo naturalis treatment and impacted pathways. METHODS: A randomized, double-blind, placebo-controlled clinical study was conducted using Indigo naturalis as topical monotherapy to treat moderate plaque psoriasis in a Chinese cohort (n = 24). Patients were treated with Indigo naturalis ointment (n = 16) or matched placebo (n = 8) twice daily for 8 weeks, with 1 week of follow-up. RESULTS: At week 8, significant improvements in Psoriasis Area and Severity Index (PASI) scores from baseline were observed in Indigo naturalis-treated patients (56.3% had 75% improvement [PASI 75] response) compared with placebo (0.0%). A gene expression signature of moderate psoriasis was established from baseline skin biopsies, which included the up-regulation of the interleukin (IL)-17 pathway as a key component; Indigo naturalis treatment resulted in most of these signature genes returning toward normal, including down-regulation of the IL-17 pathway. Using an in vitro keratinocyte assay, an IL-17-inhibitory effect was observed for tryptanthrin, a component of Indigo naturalis. CONCLUSIONS: This study demonstrated the clinical efficacy of Indigo naturalis in moderate psoriasis, and exemplified a novel experimental medicine approach to understand TCM targeting mechanisms. TRIAL REGISTRATION: NCT01901705 .
[Mh] Termos MeSH primário: Indigofera/química
Interleucina-17/imunologia
Extratos Vegetais/administração & dosagem
Psoríase/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Interleucina-17/genética
Masculino
Meia-Idade
Psoríase/genética
Psoríase/imunologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Interleukin-17); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1947-1


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[PMID]:28787565
[Au] Autor:Tan ETT; Al Jassim R; D'Arcy BR; Fletcher MT
[Ad] Endereço:Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Health and Food Sciences Precinct , Coopers Plains, Queensland 4108, Australia.
[Ti] Título:In Vitro Biodegradation of Hepatotoxic Indospicine in Indigofera spicata and Its Degradation Derivatives by Camel Foregut and Cattle Rumen Fluids.
[So] Source:J Agric Food Chem;65(34):7528-7534, 2017 Aug 30.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The known accumulation of the hepatotoxin indospicine in tissues of camels and cattle grazing Indigofera pasture plants is unusual in that free amino acids would normally be expected to be degraded during the fermentation processes in these foregut fermenters. In this study, in vitro experiments were carried out to examine the degradability of indospicine of Indigofera spicata by camel and cattle foregut microbiota. In the first experiment, a 48 h in vitro incubation was carried out using foregut fluid samples that were collected from 15 feral camels and also a fistulated cow. Degradability of indospicine ranged between 97% and 99%, with the higher value of 99% for camels. A pooled sample of foregut fluids from three camels that were on a roughage diet was used in a second experiment to examine the time-dependent degradation of indospicine present in the plant materials. Results indicated that camels' foregut fluids have the ability to biodegrade ∼99% of the indospicine in I. spicata within 48 h of incubation and produced 2-aminopimelamic acid and 2-aminopimelic acid. The time-dependent degradation analysis showed rapid indospicine degradation (65 nmol/h) during the first 8-18 h of incubation followed by a slower degradation rate (12 nmol/h) between 18 and 48 h. Indospicine degradation products were also degraded toward the end of the experiment. The results of these in vitro degradation studies suggest that dietary indospicine may undergo extensive degradation in the foregut of the camel, resulting in trace levels after 48 h. The retention time for plant material in the camel foregut varies depending on feed quality, and the results of this study together with the observed accumulation of indospicine in camel tissues suggest that, although indospicine can be degraded by foregut fermentation, this degradation is not complete before the passage of the digesta into the intestine.
[Mh] Termos MeSH primário: Ração Animal/análise
Camelus/metabolismo
Bovinos/metabolismo
Sistema Digestório/metabolismo
Indigofera/metabolismo
Norleucina/análogos & derivados
[Mh] Termos MeSH secundário: Ração Animal/toxicidade
Animais
Indigofera/química
Indigofera/toxicidade
Modelos Biológicos
Norleucina/química
Norleucina/metabolismo
Norleucina/toxicidade
Rúmen/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
832C8OV84S (Norleucine); X29Q4D9671 (indospicine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02492


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[PMID]:27509381
[Au] Autor:Tan ET; Materne CM; Silcock RG; D'Arcy BR; Al Jassim R; Fletcher MT
[Ad] Endereço:Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland , Health and Food Sciences Precinct, Coopers Plains, QLD 4108, Australia.
[Ti] Título:Seasonal and Species Variation of the Hepatotoxin Indospicine in Australian Indigofera Legumes As Measured by UPLC-MS/MS.
[So] Source:J Agric Food Chem;64(34):6613-21, 2016 Aug 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Livestock industries have maintained a keen interest in pasture legumes because of the high protein content and nutritive value. Leguminous Indigofera plant species have been considered as having high feeding values to be utilized as pasture, but the occurrence of the toxic constituent indospicine in some species has restricted this utility. Indospicine has caused both primary and secondary hepatotoxicosis and also reproductive losses, but has only previously been determined in a small number of Indigofera species. This paper validates a high-throughput ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to determine the indospicine content of various Indigofera species found in Australian pasture. Twelve species of Indigofera together with Indigastrum parviflorum plants were collected and analyzed. Of the 84 samples analyzed, *I. spicata (the asterisk indicates a naturalized species) contained the highest indospicine level (1003 ± 328 mg/kg DM, n = 4) followed by I. linnaei (755 ± 490 mg/kg DM, n = 51). Indospicine was not detected in 9 of the remaining 11 species and at only low levels (<10 mg/kg DM) in 2 of 8 I. colutea specimens and in 1 of 5 I. linifolia specimens. Indospicine concentrations were below quantitation levels for other Indigofera spp. (I. adesmiifolia, I. georgei, I. hirsuta, I. leucotricha, *I. oblongifolia, I. australis, and I. trita) and Indigastrum parviflorum. One of the more significant findings to emerge from this study is that the indospicine content of I. linnaei is highly variable (from 159 to 2128 mg/kg DM, n = 51) and differs across both regions and seasons. Its first regrowth after spring rain has a higher (p < 0.01) indospicine content than growth following more substantial summer rain. The species collected include the predominant Indigofera in Australia pasture, and of these, only *I. spicata and I. linnaei contain high enough levels of indospicine to pose a potential toxic threat to grazing herbivores.
[Mh] Termos MeSH primário: Indigofera/química
Norleucina/análogos & derivados
Toxinas Biológicas/análise
[Mh] Termos MeSH secundário: Austrália
Cromatografia Líquida de Alta Pressão
Indigofera/toxicidade
Norleucina/análise
Estações do Ano
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toxins, Biological); 832C8OV84S (Norleucine); X29Q4D9671 (indospicine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b02437


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[PMID]:27492007
[Au] Autor:Birru EM; Asrie AB; Adinew GM; Tsegaw A
[Ad] Endereço:Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Chechela street, Lideta subcity kebele 16, Gondar, Ethiopia. meshetie21@gmail.com.
[Ti] Título:Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae).
[So] Source:BMC Complement Altern Med;16:272, 2016 Aug 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Till now many of medicinal plants having claimed therapeutic value traditionally are waiting scientific verification of their efficacy and safety. Accordingly this study is conducted to evaluate the antidiarrheal activity of hydromethanolic root extract of Indigofera spicata Forssk. in castor oil induced diarrhea model, misoprostol induced secretion model and its antimotility activity using charcoal as a marker. METHODS: In all the three models the animals were randomly allocated into five groups of six animals each and then group I mice were received 1 ml/100 g normal saline, group II were treated with standard drug as a positive control whereas group III, IV and V were treated with 100, 200 and 400 mg/kg extract doses, respectively. Statistical significance of differences in the mean of number of defecations, fluid content of faces, intestinal fluid accumulation ratio, intestinal fluid weight and distance travelled by charcoal between groups was analyzed by SPSS version-21 using one way ANOVA followed by Tukey's post hoc multiple comparison. RESULT: The hydromethanolic crude extract of Indigofera spicata at 200 and 400 mg/kg mg/kg doses showed statistically significant (p < 0.05) inhibition of the frequency of defecation and weight difference of the fluid content of the faces compared to the negative controls. For those doses the percentage inhibition of diarrheal feces was 43.62 and 53.51 %, respectively. The antisecretary activity of the extract in terms of fluid accumulation ratio was not found significant but in terms of intestinal fluid weight, all the extract doses revealed significant (p < 0.05) inhibition. Unlike the standard drug, the antimotility activity of the extract was not found statistically significant compared to the negative control. CONCLUSION: Root of Indigofera spicata Forssk. has shown promising antidiarrheal activity which validates its traditional use. Further studies are needed and possibly the plant may serve as a potential source of new agent in the therapeutic armamentarium of diarrhea.
[Mh] Termos MeSH primário: Antidiarreicos/farmacologia
Indigofera/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Antidiarreicos/química
Antidiarreicos/toxicidade
Motilidade Gastrointestinal/efeitos dos fármacos
Masculino
Camundongos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidiarrheals); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1252-4


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[PMID]:27477889
[Au] Autor:Tan ET; Al Jassim R; Cawdell-Smith AJ; Ossedryver SM; D'Arcy BR; Fletcher MT
[Ad] Endereço:Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Health and Food Sciences Precinct , Coopers Plains, QLD, Australia.
[Ti] Título:Accumulation, Persistence, and Effects of Indospicine Residues in Camels Fed Indigofera Plant.
[So] Source:J Agric Food Chem;64(34):6622-9, 2016 Aug 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Indospicine (l-2-amino-6-amidinohexanoic acid) is a natural hepatotoxin found in all parts of some Indigofera plants such as Indigofera linnaei and Indigofera spicata. Several studies have documented a susceptibility to this hepatotoxin in different species of animals, including cattle, sheep, dogs, and rats, which are associated with mild to severe liver disease after prolonged ingestion. However, there is little published data on the effects of this hepatotoxin in camels, even though Indigofera plants are known to be palatable to camels in central Australia. The secondary poisoning of dogs after prolonged dietary exposure to residual indospicine in camel muscle has raised additional food safety concerns. In this study, a feeding experiment was conducted to investigate the in vivo accumulation, excretion, distribution, and histopathological effects of dietary indospicine on camels. Six young camels (2-4 years old), weighing 270-390 kg, were fed daily a roughage diet consisting of Rhodes grass hay and lucerne chaff, supplemented with Indigofera and steam-flaked barley. Indigofera (I. spicata) was offered at 597 mg DM/kg body weight (bw)/day, designed to deliver 337 µg indospicine/kg bw/day, and fed for a period of 32 days. Blood and muscle biopsies were collected over the period of the study. Concentrations of indospicine in the plasma and muscle biopsy samples were quantitated by validated ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The highest concentrations in plasma (1.01 mg/L) and muscle (2.63 mg/kg fresh weight (fw)) were found at necropsy (day 33). Other tissues were also collected at necropsy, and analysis showed ubiquitous distribution of indospicine, with the highest indospicine accumulation detected in the pancreas (4.86 ± 0.56 mg/kg fw) and liver (3.60 ± 1.34 mg/kg fw), followed by the muscle, heart, and kidney. Histopathological examination of liver tissue showed multiple small foci of predominantly mononuclear inflammatory cells. After cessation of Indigofera intake, indospicine present in plasma in the remaining three camels had a longer terminal elimination half-life (18.6 days) than muscle (15.9 days), and both demonstrated monoexponential decreases.
[Mh] Termos MeSH primário: Ração Animal/análise
Camelus/metabolismo
Indigofera/metabolismo
Norleucina/análogos & derivados
Toxinas Biológicas/metabolismo
[Mh] Termos MeSH secundário: Ração Animal/toxicidade
Animais
Austrália
Camelus/sangue
Cães
Feminino
Indigofera/química
Rim/química
Rim/metabolismo
Fígado/química
Fígado/metabolismo
Masculino
Carne/análise
Músculo Esquelético/química
Músculo Esquelético/metabolismo
Norleucina/sangue
Norleucina/metabolismo
Toxinas Biológicas/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toxins, Biological); 832C8OV84S (Norleucine); X29Q4D9671 (indospicine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b02707


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[PMID]:27464528
[Au] Autor:Mahajan P; Gnana Oli R; Jachak SM; Bharate SB; Chaudhuri B
[Ad] Endereço:Leicester School of Pharmacy, De Montfort University, Leicester, UK.
[Ti] Título:Antioxidant and antiproliferative activity of indigocarpan, a pterocarpan from Indigofera aspalathoides.
[So] Source:J Pharm Pharmacol;68(10):1331-9, 2016 Oct.
[Is] ISSN:2042-7158
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study aimed to investigate the anticancer potential of indigocarpan (1), a pterocarpan isolated from Indigofera aspalathoides, a plant found in India which has been used in Ayurveda for centuries for the treatment of oedematous tumours. METHODS: The antiproliferative activity in a panel of four human cancer cell lines was studied. The mechanism of its antiproliferative activity in human colorectal adenocarcinoma LS174T cells was investigated in detail. KEY FINDINGS: Indigocarpan (1) showed antiproliferative activity in a panel of four human cancer cell lines with IC50 s ranging from 180 to 250 µm. Indigocarpan induces p53-dependent p21 upregulation and apoptosis in LS174T cells, upregulates p53 and p21(WAF1) protein levels, enhances cleavage of caspase-3 and downregulates cyclin D1, cyclin B1 and PCNA protein levels, indicating its role in modulating cell cycle progression. Indigocarpan also exhibited a strong antioxidative effect in LS174T cells. CONCLUSIONS: Along with the antiproliferative capacity, the strong antioxidative property of the compound makes it a promising candidate for further development as an anticancer and chemopreventive compound.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Proliferação Celular/efeitos dos fármacos
Indigofera/química
Extratos Vegetais/farmacologia
Pterocarpanos/farmacologia
[Mh] Termos MeSH secundário: Adenocarcinoma/tratamento farmacológico
Adenocarcinoma/metabolismo
Apoptose/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Proteínas de Ciclo Celular/metabolismo
Linhagem Celular Tumoral
Neoplasias Colorretais/tratamento farmacológico
Neoplasias Colorretais/metabolismo
Ciclina B1/metabolismo
Ciclina D1/metabolismo
Inibidor de Quinase Dependente de Ciclina p21/metabolismo
Regulação para Baixo/efeitos dos fármacos
Seres Humanos
Índia
Extratos Vegetais/química
Antígeno Nuclear de Célula em Proliferação/metabolismo
Proteína Supressora de Tumor p53/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cell Cycle Proteins); 0 (Cyclin B1); 0 (Cyclin-Dependent Kinase Inhibitor p21); 0 (Plant Extracts); 0 (Proliferating Cell Nuclear Antigen); 0 (Pterocarpans); 0 (Tumor Suppressor Protein p53); 136601-57-5 (Cyclin D1)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1111/jphp.12609


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[PMID]:27391413
[Au] Autor:Abdel Moneim AE
[Ad] Endereço:Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
[Ti] Título:Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats.
[So] Source:PLoS One;11(7):e0158965, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The current study was aimed to evaluate the preventive effects of Indigofera oblongifolia leaf extract (IOLE) on lead acetate (PbAc)-induced hepatotoxicity in adult male Wistar rats. PbAc was intraperitoneally injected at a dose of 20 mg/kg body weight for 5 days alone or in combination with the IOLE (100 mg/kg). Liver lead concentration and oxidative stress markers such as lipid peroxidation, hydrogen peroxide, nitric oxide, and glutathione content were investigated in addition to the enzymatic antioxidant activities. PbAc injection caused a significant elevation in the liver function parameters, lead level, lipid peroxidation, hydrogen peroxide, and nitric oxide, with a concomitant decline in the glutathione content compared with the control, accompanied by a significant inhibition of antioxidant enzyme activities. The induction of oxidative stress, lead accumulation, and histological alterations in the liver were successfully minimized by pre-administration of IOLE. In addition, the PbAc group showed increase in the levels of Bax, caspase-3, and matrix metalloproteinase-9 proteins, while the expression of Bcl-2 protein was decreased. Prior administration of IOLE significantly mitigated apoptosis and fibrosis in the liver. Finally, the major components in I. oblongifolia extract were identified as polyphenols, flavonoids, and organic acids using liquid chromatography coupled mass spectroscopy. Thus, the findings of the current study revealed that I. oblongifolia had protective, anti-fibrotic, antioxidant, and anti-apoptotic activities on PbAc-induced hepatotoxicity. The beneficial effects of I. oblongifolia were in part mediated by Nrf2/HO-1 pathway.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Indigofera/química
Cirrose Hepática/prevenção & controle
Compostos Organometálicos/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Cirrose Hepática/metabolismo
Cirrose Hepática/patologia
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 0 (Plant Extracts); RX077P88RY (lead acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0158965


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[PMID]:27330278
[Au] Autor:Dkhil MA; Al-Khalifa MS; Al-Quraishy S; Zrieq R; Abdel Moneim AE
[Ad] Endereço:Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
[Ti] Título:Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model.
[So] Source:Drug Des Devel Ther;10:1847-56, 2016.
[Is] ISSN:1177-8881
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:This study was conducted to appraise the protective effect of Indigofera oblongifolia leaf extract on lead acetate (PbAc)-induced nephrotoxicity in rats. PbAc was intraperitoneally injected at a dose of 20 mg/kg body weight for 5 days, either alone or together with the methanol extract of I. oblongifolia (100 mg/kg). Kidney lead (Pb) concentration; oxidative stress markers including lipid peroxidation, nitrite/nitrate, and glutathione (GSH); and antioxidant enzyme activities, namely superoxide dismutase, catalase, GSH peroxidase, and GSH reductase were all determined. The PbAc injection elicited a marked elevation in Pb concentration, lipid peroxidation, and nitrite/nitrate, with a concomitant depletion in GSH content compared with the control and a remarkable decrease in antioxidant enzymes. Oxidant/antioxidant imbalance, Pb accumulation, and histological changes in the kidneys were successfully prevented by the pre-administration of I. oblongifolia extract. In addition, the elevated expression of proapoptotic protein, Bax, in the kidneys of the PbAc-injected rats was reduced as a result of I. oblongifolia pre-administration, while the hitherto reduced expression of the anti-apoptotic protein Bcl-2 was elevated. Based on the current findings, it can be concluded that I. oblongifolia successfully minimizes the deleterious effects in kidney function and histological coherence associated with nephrotoxicity by strengthening the antioxidant defense system, suppressing oxidative stress, and mitigating apoptosis.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Catalase/metabolismo
Glutationa Peroxidase/metabolismo
Indigofera/química
Indigofera/metabolismo
Rim/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Nitrilos/química
Compostos Organometálicos/química
Estresse Oxidativo/efeitos dos fármacos
Superóxido Dismutase/metabolismo
[Mh] Termos MeSH secundário: Animais
Catalase/química
Glutationa Peroxidase/química
Nefropatias/induzido quimicamente
Ratos
Ratos Wistar
Superóxido Dismutase/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Nitriles); 0 (Organometallic Compounds); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); RX077P88RY (lead acetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.2147/DDDT.S105511


  9 / 84 MEDLINE  
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[PMID]:27052307
[Au] Autor:Dkhil MA; Moneim AE; Al-Quraishy S
[Ad] Endereço:Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
[Ti] Título:Indigofera oblongifolia Ameliorates Lead Acetate-Induced Testicular Oxidative Damage and Apoptosis in a Rat Model.
[So] Source:Biol Trace Elem Res;173(2):354-61, 2016 Oct.
[Is] ISSN:1559-0720
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lead (Pb) enhances the production of reactive oxygen species and depletes the antioxidant molecules that cause tissue damage. In the current study, we investigated the protective effect of Indigofera oblongifolia (hasr in Arabic) against lead acetate-induced reproductive toxicity in rats. Exposure of rats to lead acetate (PbAc; 20 mg/kg body weight; intraperitoneal injection) induced a significant change in both of body weight loss and the relative testis weight. Furthermore, a significant increase in lipid peroxidation and nitric oxide and a marked depletion of glutathione were evident in the testis of the PbAc group compared to the control group. Also, PbAc significantly reduced the activity of antioxidant enzymes. Pre-administration of I. oblongifolia leaves extract (IOLE; 100 mg/kg body weight) to the PbAc-treated rats restored most of the parameters mentioned above to near-normal levels. Additionally, pretreatment of animals with IOLE accompanied with a significant decrease in the toxic effects of PbAc as shown by caspase-3 and Bax expressions and prevented the histological injury in the testis. On the basis of the above results, I. oblongifolia appeared to be a promising agent for protection against lead-induced oxidative damage and apoptosis in the testis of rat.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Indigofera/química
Compostos Organometálicos/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Testículo/metabolismo
[Mh] Termos MeSH secundário: Animais
Caspase 3/biossíntese
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Extratos Vegetais/química
Ratos
Ratos Wistar
Testículo/patologia
Proteína X Associada a bcl-2/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bax protein, rat); 0 (Organometallic Compounds); 0 (Plant Extracts); 0 (bcl-2-Associated X Protein); EC 3.4.22.- (Casp3 protein, rat); EC 3.4.22.- (Caspase 3); RX077P88RY (lead acetate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE
[do] DOI:10.1007/s12011-016-0689-0


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[PMID]:26954317
[Au] Autor:McDermott L; Madan R; Rupani R; Siegel D
[Ti] Título:A Review of Indigo Naturalis as an Alternative Treatment for Nail Psoriasis.
[So] Source:J Drugs Dermatol;15(3):319-23, 2016 Mar.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Nail psoriasis is challenging to treat. The few currently available therapies are limited in efficacy, and often produce unfavorable side effects. A plant extract widely used in Traditional Chinese Medicine, indigo naturalis (Qing Dai), is presented in this review as an alternative topical treatment for skin and nail psoriasis. The purpose of this article is to present information on a viable alternative treatment with a favorable side effect profile for a difficult disease to treat. METHODS: A PubMed search for the term "indigo naturalis" was performed, and literature from 2006 to the present relevant to indigo naturalis and treatment of psoriasis and nail psoriasis was reviewed. RESULTS: Indigo naturalis shares several therapeutic mechanisms with current psoriasis treatments, such as regulation of keratinocyte proliferation and differentiation, restoration of epidermal barrier function, and reduction of inflammatory processes. Clinically, it is well tolerated. CONCLUSION: Recent research of indigo naturalis suggests that it is a safe, inexpensive, and effective alternative topical treatment for skin and nail psoriasis.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Doenças da Unha/tratamento farmacológico
Fitoterapia/métodos
Psoríase/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Tópica
Proliferação Celular/efeitos dos fármacos
Citocinas/efeitos dos fármacos
Citocinas/metabolismo
Medicamentos de Ervas Chinesas/efeitos adversos
Medicamentos de Ervas Chinesas/economia
Epiderme/efeitos dos fármacos
Seres Humanos
Indigofera
Indóis/efeitos adversos
Indóis/uso terapêutico
Queratinócitos/efeitos dos fármacos
Óleos/efeitos adversos
Óleos/uso terapêutico
Pomadas/efeitos adversos
Pomadas/uso terapêutico
Fitoterapia/efeitos adversos
Fitoterapia/economia
Ensaios Clínicos Controlados Aleatórios como Assunto
Índice de Gravidade de Doença
Transdução de Sinais/efeitos dos fármacos
Pele/efeitos dos fármacos
Resultado do Tratamento
Molécula 1 de Adesão de Célula Vascular/efeitos dos fármacos
Molécula 1 de Adesão de Célula Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Drugs, Chinese Herbal); 0 (Indoles); 0 (Oils); 0 (Ointments); 0 (Qingdai compound); 0 (Vascular Cell Adhesion Molecule-1); V86L8P74GI (indirubin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE



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