Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.525 [Categoria DeCS]
Referências encontradas : 82 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 9 ir para página                      

  1 / 82 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29223588
[Au] Autor:Baek J; Lee D; Lee TK; Song JH; Lee JS; Lee S; Yoo SW; Kang KS; Moon E; Lee S; Kim KH
[Ad] Endereço:School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
[Ti] Título:(-)-9'-O-(α-l-Rhamnopyranosyl)lyoniresinol from Lespedeza cuneata suppresses ovarian cancer cell proliferation through induction of apoptosis.
[So] Source:Bioorg Med Chem Lett;28(2):122-128, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lespedeza cuneata (Dum. Cours.) G. Don. (Fabaceae), known as Chinese bushclover or sericea lespedeza, has been used in traditional medicine to treat diabetes, hematuria, and insomnia, and it has been reported that bioactive compounds from L. cuneata possess various pharmacological properties. However, there has been no study to determine the active compounds from L. cuneata with potential activity against ovarian cancer. This study aimed to isolate cytotoxic compounds from L. cuneata and identify the molecular mechanisms underlying the apoptosis pathway in ovarian cancer cells. Based on cytotoxic activity identified in the screening test, chemical investigation of the active fraction of L. cuneata led to the isolation of nine compounds including four lignanosides (1-4), three flavonoid glycosides (5-7), and two phenolics (8-9). Cytotoxicity and the molecular mechanism were examined by methyl thiazolyl tetrazolium (MTT) assay and Western blot analysis. Of the isolated compounds, (-)-9'-O-(α-l-rhamnopyranosyl)lyoniresinol (3) demonstrated the strongest effect in suppressing A2780 human ovarian carcinoma cell proliferation in a dose-dependent manner, with an IC value of 35.40 ±â€¯2.78 µM. Control A2780 cells had normal morphology, whereas cell blebbing, shrinkage, and condensation were observed after treatment with compound 3. Western blotting analysis showed that compound 3 inhibited A2780 human ovarian cancer cell viability by activating caspase-8, caspase-3, and PARP, which contributed to apoptotic cell death. These results suggest that (-)-9'-O-(α-l-rhamnopyranosyl)lyoniresinol (3) has potent anticancer activities against A2780 human ovarian carcinoma cells through the extrinsic apoptotic pathway. Therefore, (-)-9'-O-(α-l-rhamnopyranosyl)lyoniresinol is an excellent candidate for the development of novel chemotherapeutics.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Lespedeza/química
Monossacarídeos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Estrutura Molecular
Monossacarídeos/química
Monossacarídeos/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Monosaccharides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


  2 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28275986
[Au] Autor:Qu H; Zhao HL; Zhao XY; Zuo XA; Wang SK; Chen M
[Ad] Endereço:Naiman Desertification Research Station, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, 320# Donggang West Road, Lanzhou, 730000, China. quhao@lzb.ac.cn.
[Ti] Título:Effects of sand burial on the survival and growth of two shrubs dominant in different habitats of northern China.
[So] Source:Environ Monit Assess;189(4):149, 2017 Apr.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Plants that grow in dune ecosystems always suffer from sand burial. Shrubs play implications on the healthy functioning of dune ecosystems due to control blowing sand. However, the survival and growth responses of shrubs to sand burial remain poorly understood. The survival rate and seedling height of two shrubs (Artemisia halodendron and Lespedeza davurica) along with the soil properties under different burial depths were examined in order to reveal the causing ecophysiological attributes of sand burial on shrubs in the desertified region. It was found that A. halodendron can survive a burial depth of 6 cm greater than its seedling height, which is a dominant shrub in mobile dunes with intense burial, whereas a burial depth equivalent to three fourths of its seedling height is detrimental to L. davurica, which is dominant in fixed dunes with less burial. The reasons for the shrub death under sand burial were associated with the physical barrier to vertical growth and the reduction in photosynthetic area. In conclusion, A. halodendron can facilitate the stabilization of mobile dunes because of their high tolerance to the frequent and intensive sand burial, while L. davurica can be beneficial for the recovery process because of their higher survival rates under shallow burial following restoration of mobile dunes.
[Mh] Termos MeSH primário: Artemisia/fisiologia
Ecossistema
Monitoramento Ambiental
Lespedeza/fisiologia
Plântulas/fisiologia
[Mh] Termos MeSH secundário: China
Fotossíntese
Plântulas/crescimento & desenvolvimento
Dióxido de Silício
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5866-x


  3 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27309187
[Au] Autor:Zhang CF; Zhou J; Yang JZ; Li CJ; Ma J; Zhang D; Li L; Zhang DM
[Ad] Endereço:a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
[Ti] Título:Three new lignanosides from the aerial parts of Lespedeza cuneata.
[So] Source:J Asian Nat Prod Res;18(10):913-20, 2016 Oct.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new lignanosides (+)-(8S,7'S,8'S)-burselignan-9'-O-ß-d-glucopyrano side (1), (+)-(8R,7'S,8'R)-isolariciresinol-9'-O-ß-d-fucopyranoside (2), (-)-(8S, 7'R,8'R)-methoxyisoariciresinol-9'-O-α-l-rhamnoside (3), along with four known compounds, were isolated from the aerial parts of Lespedeza cuneata (Dum.Cours.) G.Don. The fucopyranoside has not been reported in this genus previously. Their structures and absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with known analogues in the literature. Compounds 2 and 6 showed moderate hepatoprotective activities.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Glicosídeos/isolamento & purificação
Lespedeza/química
Lignanas/isolamento & purificação
Componentes Aéreos da Planta/química
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Glicosídeos/farmacologia
Lignanas/química
Lignanas/farmacologia
Fígado/efeitos dos fármacos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 ((8R,7'S,8'R)-isolariciresinol-9'-O-beta-D-fucopyranoside); 0 ((8S,7'R,8'R)-methoxyisoariciresinol-9'-O-alpha-L-rhamnoside); 0 ((8S,7'S,8'S)-burselignan-9'-O-beta-D-glucopyranoside); 0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Lignans)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1187603


  4 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27206725
[Au] Autor:Jin DP; Lee JH; Xu B; Choi BH
[Ad] Endereço:Department of Biological Sciences, Inha University, Incheon, 22212, Republic of Korea.
[Ti] Título:Phylogeography of East Asian Lespedeza buergeri (Fabaceae) based on chloroplast and nuclear ribosomal DNA sequence variations.
[So] Source:J Plant Res;129(5):793-805, 2016 Sep.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The dynamic changes in land configuration during the Quaternary that were accompanied by climatic oscillations have significantly influenced the current distribution and genetic structure of warm-temperate forests in East Asia. Although recent surveys have been conducted, the historical migration of forest species via land bridges and, especially, the origins of Korean populations remains conjectural. Here, we reveal the genetic structure of Lespedeza buergeri, a warm-temperate shrub that is disjunctively distributed around the East China Sea (ECS) at China, Korea, and Japan. Two non-coding regions (rpl32-trnL, psbA-trnH) of chloroplast DNA (cpDNA) and the internal transcribed spacer of nuclear ribosomal DNA (nrITS) were analyzed for 188 individuals from 16 populations, which covered almost all of its distribution. The nrITS data demonstrated a genetic structure that followed geographic boundaries. This examination utilized AMOVA, comparisons of genetic differentiation based on haplotype frequency/genetic mutations among haplotypes, and Mantel tests. However, the cpDNA data showed contrasting genetic pattern, implying that this difference was due to a slower mutation rate in cpDNA than in nrITS. These results indicated frequent migration by this species via an ECS land bridge during the early Pleistocene that then tapered gradually toward the late Pleistocene. A genetic isolation between western and eastern Japan coincided with broad consensus that was suggested by the presence of other warm-temperate plants in that country. For Korean populations, high genetic diversity indicated the existence of refugia during the Last Glacial Maximum on the Korean Peninsula. However, their closeness with western Japanese populations at the level of haplotype clade implied that gene flow from western Japanese refugia was possible until post-glacial processing occurred through the Korea/Tsushima Strait land bridge.
[Mh] Termos MeSH primário: Núcleo Celular/genética
DNA de Cloroplastos/genética
DNA de Plantas/genética
DNA Ribossômico/genética
Variação Genética
Lespedeza/genética
Filogeografia
[Mh] Termos MeSH secundário: Sequência de Bases
Teorema de Bayes
Extremo Oriente
Haplótipos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Plant); 0 (DNA, Ribosomal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-016-0831-2


  5 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27136018
[Au] Autor:Acharya M; Burke JM; Coffey KP; Kegley EB; Miller JE; Smyth E; Welborn MG; Terrill TH; Mosjidis JA; Rosenkrans C
[Ti] Título:Changes in concentrations of trace minerals in lambs fed sericea lespedeza leaf meal pellets with or without dietary sodium molybdate.
[So] Source:J Anim Sci;94(4):1592-9, 2016 Apr.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prolonged feeding of sericea lespedeza (SL) previously led to reduced serum concentrations of Mo, a cofactor in an enzyme complex that may be involved in weight gain. The current objective was to determine the effect of Mo supplementation on changes in serum, fecal, urine, and liver concentrations of trace minerals in lambs fed SL leaf meal pellets. Thirty ram lambs weaned in May (84 ± 1.5 d of age and 27 ± 1.1 kg; D 0) were blocked by BW, breed type (full or three-fourths Katahdin), and EBV of parasite resistance and randomly assigned to be fed 900 g/d of an alfalfa-based supplement (CON; = 10) or a SL-based supplement ( = 20) for 103 d. Supplements were formulated to be isonitrogenous and isocaloric and to meet trace mineral requirements. Within the SL group, individual lambs were administered either 5 mL water or 5 mL of water with 163.3 mg of sodium molybdate (SLMO). Serum was collected on d 28, 56, and 104; a liver sample was collected by biopsy on d 104 to determine concentrations of trace minerals. Data were analyzed using a mixed model and orthogonal contrasts. Serum concentrations of Mo increased in response to the drench and were greatest in SLMO lambs and then CON lambs and lowest in SL lambs ( < 0.001). Concentrations of Mo in the liver ( < 0.001) were similar between CON and SLMO lambs and were lower in SL lambs than other groups. Serum ( < 0.001) and liver ( = 0.013) concentrations of zinc (Zn) were reduced in both SL and SLMO lambs compared with CON lambs. Serum concentrations of cobalt (Co) increased in CON lambs compared with SL and SLMO lambs between d 0 and 56 but were similar on d 104 (diet × day, < 0.005) as with concentrations in the liver. Serum and liver concentrations of copper (Cu) were greatest ( < 0.001 and < 0.001, respectively) in CON lambs followed by SL lambs and then SLMO lambs. Serum concentrations of selenium (Se) tended ( = 0.10) to be reduced in SL lambs compared with CON and SLMO lambs, but concentrations in the liver were reduced in SL lambs compared with CON lambs and even more so in SLMO lambs ( < 0.003). Although the dietary Mo did increase stores of Mo in the animal and reduced copper, trace minerals associated with metalloproteins-Mo, copper, selenium, and zinc-were reduced in the liver of SL- and/or SLMO-fed lambs. These reductions could be associated with the lower weight gains previously observed after prolonged feeding of SL.
[Mh] Termos MeSH primário: Ração Animal/análise
Lespedeza
Molibdênio/farmacologia
Ovinos
Oligoelementos/sangue
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Cobre
Dieta/veterinária
Suplementos Nutricionais
Fezes/parasitologia
Masculino
Molibdênio/administração & dosagem
Selênio
Sódio na Dieta
Oligoelementos/química
Oligoelementos/urina
Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium, Dietary); 0 (Trace Elements); 789U1901C5 (Copper); 81AH48963U (Molybdenum); 948QAQ08I1 (sodium molybdate(VI)); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2015-9910


  6 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26507574
[Au] Autor:Cornara L; Xiao J; Burlando B
[Ad] Endereço:a Dipartimento di Scienze della Terra dell'Ambiente e della Vita , Università degli Studi di Genova , Genova , Italy.
[Ti] Título:Therapeutic Potential of Temperate Forage Legumes: A Review.
[So] Source:Crit Rev Food Sci Nutr;56 Suppl 1:S149-61, 2016 Jul 29.
[Is] ISSN:1549-7852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The discovery of bioactive molecules from botanical sources is an expanding field, preferentially oriented to plants having a tradition of use in medicine and providing high yields and availability. Temperate forage legumes are Fabaceae species that include worldwide-important crops. These plants possess therapeutic virtues that have not only been used in veterinary and folk medicine, but have also attracted the interest of official medicine. We have examined here Medicago sativa (alfalfa), Trifolium pratense and T. repens (clovers), Melilotus albus and M. officinalis (sweet clovers), Lotus corniculatus (birdsfoot trefoil), Onobrychis viciifolia (sainfoin), Lespedeza capitata (roundhead lespedeza), and Galega officinalis (goat's rue). The phytochemical complexes of these species contain secondary metabolites whose pharmacological potentials deserve investigation. Major classes of compounds include alkaloids and amines, cyanogenic glycosides, flavonoids, coumarins, condensed tannins, and saponins. Some of these phytochemicals have been related to antihypercholesterolemia, antidiabetic, antimenopause, anti-inflammatory, antiedema, anthelmintic, and kidney protective effects. Two widely prescribed drugs have been developed starting from temperate forage legumes, namely, the antithrombotic warfarin, inspired from sweet clover's coumarin, and the antidiabetic metformin, a derivative of sainfoin's guanidine. Available evidence suggests that temperate forage legumes are a potentially important resource for the extraction of active principles to be used as nutraceuticals and pharmaceuticals.
[Mh] Termos MeSH primário: Fabaceae/química
Compostos Fitoquímicos/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/análise
Anti-Inflamatórios/farmacologia
Ensaios Clínicos como Assunto
Cumarínicos/análise
Cumarínicos/farmacologia
Modelos Animais de Doenças
Fibrinolíticos/análise
Fibrinolíticos/farmacologia
Flavonoides/análise
Flavonoides/farmacologia
Galega/química
Seres Humanos
Hipoglicemiantes/análise
Hipoglicemiantes/farmacologia
Lespedeza/química
Loteae/química
Medicago/química
Medicago sativa/química
Melilotus/química
Compostos Fitoquímicos/análise
Proantocianidinas/análise
Proantocianidinas/farmacologia
Saponinas/análise
Saponinas/farmacologia
Trifolium/química
Varfarina/análise
Varfarina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Coumarins); 0 (Fibrinolytic Agents); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Phytochemicals); 0 (Proanthocyanidins); 0 (Saponins); 5Q7ZVV76EI (Warfarin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.1080/10408398.2015.1038378


  7 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26475664
[Au] Autor:Zhou J; Li CJ; Yang JZ; Ma J; Wu LQ; Wang WJ; Zhang DM
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University,
[Ti] Título:Phenylpropanoid and lignan glycosides from the aerial parts of Lespedeza cuneata.
[So] Source:Phytochemistry;121:58-64, 2016 Jan.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four phenylpropanoid glucosides (1-4) and five lignan glycosides (5-9) were isolated from the aerial parts of Lespedeza cuneata, together with three known lignan glycosides (10-12). Their structures were elucidated on the basis of spectroscopic analyses, and the absolute configurations of compounds 5-9 were determined from the CD spectra. In addition, the compounds were tested for their ability to activate the transcription effect on xbp1 promoter. Compounds 4, 5, 7, 9, 10, and 12 could activate the transcription of xbp1 to varying degrees, with EC50 values ranging from 0.18 to 0.64 µM.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Glicosídeos/isolamento & purificação
Lespedeza/química
Lignanas/isolamento & purificação
Fenilpropionatos/isolamento & purificação
[Mh] Termos MeSH secundário: Dicroísmo Circular
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Glicosídeos/química
Glicosídeos/farmacologia
Lignanas/química
Lignanas/farmacologia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fenilpropionatos/química
Fenilpropionatos/farmacologia
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Lignans); 0 (Phenylpropionates)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151128
[Lr] Data última revisão:
151128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151018
[St] Status:MEDLINE


  8 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26243444
[Au] Autor:Jiang W; Ye J; Xie YG; Pan YP; Zheng Y; Qian XP; Jin HZ
[Ad] Endereço:a School of Pharmacy, Shanghai Jiao Tong University , Shanghai 200240 , China.
[Ti] Título:A new phenyldilactone from Lespedeza cuneata.
[So] Source:J Asian Nat Prod Res;18(2):200-5, 2016.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new phenyldilactone, maysedilactone B (1), together with twenty known compounds, were isolated from the aerial parts of Lespedeza cuneata. The structural elucidation of the isolated compounds was primarily based on HR-ESI-MS, IR and 1D and 2D NMR analyses. Compounds 1-8 and 15-21 were tested for cytotoxicity against four human tumor cell lines (A549, HCT116, SKOV3, and HepG2) using MTT method in vitro, while no significant activities were observed for the evaluated compounds.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Lactonas/isolamento & purificação
Lactonas/farmacologia
Lespedeza/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Células HCT116
Células Hep G2
Seres Humanos
Lactonas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (Lactones); 0 (maysedilactone B)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160219
[Lr] Data última revisão:
160219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150806
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2015.1061510


  9 / 82 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26345477
[Au] Autor:Kim Nk; Park HM; Lee J; Ku KM; Lee CH
[Ad] Endereço:Department of Bioscience and Biotechnology, Konkuk University , 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
[Ti] Título:Seasonal Variations of Metabolome and Tyrosinase Inhibitory Activity of Lespedeza maximowiczii during Growth Periods.
[So] Source:J Agric Food Chem;63(38):8631-9, 2015 Sep 30.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lespedeza species are useful for pasture and energy crops as well as medical plants. We determined the metabolites discriminated from the each growth period (3, 4, 6, 8, 15, and 18 months) after germination in leaves and stems of Lespedeza maximowizii by a metabolomics technique. Specifically, levels of sugars and luteolin-dominated derivatives were significantly elevated in samples harvested in November. This may be related to the cold tolerance mechanism against the low temperatures of the winter season. The concentrations of secondary metabolites, isoflavones and flavanones, as well as tyrosinase inhibitory activity were the highest in the 6 month samples, which were harvested in September, during the fall season. The tyrosinase inhibitory activity in leaves was higher than that in stems irrespective of the growth period. This study suggests that mass spectrometry-based metabolite profiling could be used as a tool to examine quantitative or qualitative metabolite changes related to seasonal variations and to understand the correlation between activity and metabolites.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/análise
Lespedeza/química
Lespedeza/crescimento & desenvolvimento
Monofenol Mono-Oxigenase/antagonistas & inibidores
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Agaricales/química
Agaricales/enzimologia
Inibidores Enzimáticos/metabolismo
Lespedeza/metabolismo
Metaboloma
Monofenol Mono-Oxigenase/análise
Extratos Vegetais/metabolismo
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150930
[Lr] Data última revisão:
150930
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150909
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b03566


  10 / 82 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:26236898
[Au] Autor:Schlatter DC; Bakker MG; Bradeen JM; Kinkel LL
[Ti] Título:Plant community richness and microbial interactions structure bacterial communities in soil.
[So] Source:Ecology;96(1):134-42, 2015 Jan.
[Is] ISSN:0012-9658
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plant species, plant community diversity and microbial interactions can significantly impact soil microbial communities, yet there are few data on the interactive effects of plant species and plant community diversity on soil bacterial communities. We hypothesized that plant species and plant community diversity affect soil bacterial communities by setting the context in which bacterial interactions occur. Specifically, we examined soil bacterial community composition and diversity in relation to plant "host" species, plant community richness, bacterial antagonists, and soil edaphic characteristics. Soil bacterial communities associated with four different prairie plant species (Andropogon gerardii, Schizachyrium scoparium, Lespedeza capitata, and' Lupinus perennis) grown in plant communities of increasing species richness (1, 4, 8, and 16 species) were sequenced. Additionally, soils were evaluated for populations of antagonistic bacteria and edaphic characteristics. Plant species effects on soil bacterial community composition were small and depended on plant community richness. In contrast, increasing plant community richness significantly altered soil bacterial community composition and was negatively correlated with bacterial diversity. Concentrations of soil carbon, organic matter, nitrogen, phosphorus, and potassium were similarly negatively correlated with bacterial diversity, whereas the proportion of antagonistic bacteria was positively correlated with soil bacterial diversity. Results suggest that plant species influences on soil bacterial communities depend on plant community diversity and are mediated through the effects of plant-derived resources on antagonistic soil microbes.
[Mh] Termos MeSH primário: Biodiversidade
Consórcios Microbianos
Plantas
Microbiologia do Solo
[Mh] Termos MeSH secundário: Andropogon
Lespedeza
Lupinus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150803
[Lr] Data última revisão:
150803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150804
[St] Status:MEDLINE



página 1 de 9 ir para página                      
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde