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Pesquisa : B01.650.940.800.575.912.250.401.594 [Categoria DeCS]
Referências encontradas : 167 [refinar]
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[PMID]:28893216
[Au] Autor:Satish PVV; Sunita K
[Ad] Endereço:Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar 522510, Guntur district, Andhra Pradesh, India.
[Ti] Título:Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA).
[So] Source:BMC Complement Altern Med;17(1):458, 2017 Sep 11.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cytotoxicity against Brine shrimp larvae and THP-1 cell line. For in vivo study, the plant extract which has shown potent in vitro antimalarial activity was tested against Plasmodium berghei (ANKA strain). METHODS: The plant Pongamia pinnata was collected from the herbal garden of Acharya Nagarjuna University of Guntur district, Andhra Pradesh, India. Sequentially crude extracts of methanol (polar), chloroform (non-polar), hexane (non-polar), ethyl acetate (non-polar) and aqueous (polar) of dried leaves, bark, flowers and roots of Pongamia pinnata were prepared using Soxhlet apparatus. The extracts were screened for in vitro antimalarial activity against P. falciparum 3D7 strain. The cytotoxicity studies of crude extracts were conducted against Brine shrimp larvae and THP-1 cell line. Phytochemical analysis of the plant extracts was carried out by following the standard methods. The chemical injury to erythrocytes due to the plant extracts was checked. The in vivo study was conducted on P. berghei (ANKA) infected BALB/c albino mice by following 4-Day Suppressive, Repository, and Curative tests. RESULTS: Out of all the tested extracts, the methanol extract of the bark of Pongamia pinnata had shown an IC value of 11.67 µg/mL with potent in vitro antimalarial activity and cytotoxicity evaluation revealed that this extract was not toxic against Brine shrimp and THP-1 cells. The injury to erythrocytes analysis had not shown any morphological alterations and damage to the erythrocytes after 48 h of incubation. Because methanolic bark extract of Pongamia pinnata has shown good antimalarial activity in vitro, it was also tested in vivo. So the extract had exhibited an excellent activity against P. berghei malaria parasite while decrement of parasite counts was moderately low and dose-dependent (P < 0.05) when compared to the control groups, which shown a daily increase of parasitemia, unlike the CQ-treated groups. The highest concentration of the extract (1000 mg/kg b.wt./day) had shown 83.90, 87.47 and 94.67% of chemo-suppression during Suppressive, Repository, and Curative tests respectively which is almost nearer to the standard drug Chloroquine (5 mg/kg b.wt./day). Thus, the study has revealed that the methanolic bark extract had shown promisingly high ((P < 0.05) and dose-dependent chemo-suppression. The phytochemical screening of the crude extracts had shown the presence of alkaloids, flavonoids, triterpenes, tannins, carbohydrates, phenols, coumarins, saponins, phlobatannins and steroids. CONCLUSIONS: The present study is useful to develop new antimalarial drugs in the scenario of the growing resistance to the existing antimalarials. Thus, additional research is needed to characterize the bioactive molecules of the extracts of Pongamia pinnata that are responsible for inhibition of malaria parasite.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Millettia/química
Extratos Vegetais/farmacologia
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimaláricos/química
Antimaláricos/toxicidade
Artemia/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Eritrócitos/efeitos dos fármacos
Seres Humanos
Malária/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Parasitemia/parasitologia
Casca de Planta/química
Extratos Vegetais/química
Extratos Vegetais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1958-y


  2 / 167 MEDLINE  
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[PMID]:28665590
[Au] Autor:Deyou T; Marco M; Heydenreich M; Pan F; Gruhonjic A; Fitzpatrick PA; Koch A; Derese S; Pelletier J; Rissanen K; Yenesew A; Erdélyi M
[Ad] Endereço:Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
[Ti] Título:Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis.
[So] Source:J Nat Prod;80(7):2060-2066, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH Cl /CH OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC values of 33.3 and 93.8 µM, respectively.
[Mh] Termos MeSH primário: Isoflavonas/isolamento & purificação
Millettia/química
Folhas de Planta/química
Rotenona/isolamento & purificação
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Concentração Inibidora 50
Isoflavonas/química
Isoflavonas/farmacologia
Quênia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Rotenona/química
Rotenona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoflavones); 03L9OT429T (Rotenone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00255


  3 / 167 MEDLINE  
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[PMID]:28330553
[Au] Autor:Marriboina S; Sengupta D; Kumar S; Reddy AR
[Ad] Endereço:Photosynthesis and Stress Biology Laboratory, Department of Plant Sciences, University of Hyderabad, Hyderabad 500046, India.
[Ti] Título:Physiological and molecular insights into the high salinity tolerance of Pongamia pinnata (L.) pierre, a potential biofuel tree species.
[So] Source:Plant Sci;258:102-111, 2017 May.
[Is] ISSN:1873-2259
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Soil salinity is gradually becoming a threat to the global economy by affecting agricultural productivity worldwide. Here, we analyze the salinity tolerance of Pongamia pinnata with an insight into the underlying physiological and molecular responses. Despite a reduction in net photosynthetic rate, P. pinnata efficiently maintained its leaf water potentials even at 500mM NaCl for 15days and displayed no visible stress symptoms. Na localization analysis using CoroNa-Green AM revealed effective Na sequestration in the roots when compared to leaves. Elemental analysis demonstrated that roots accumulated more of Na while K content was higher in leaves. At the molecular level, salt stress significantly induced the expression levels of salt overly sensitive1 (SOS1), SOS2, SOS3, high affinity K transporter (HKT1), ABA biosynthetic and receptor genes (NCED and PYL4), guaiacol peroxidase (POD) exclusively in roots while tonoplast localized Na /H exchanger (NHX1) was significantly enhanced in leaves. Our results clearly demonstrate that leaves and roots of Pongamia exhibit differential responses under salt stress although roots are more efficient in sequestering the Na ions. The present study provides crucial inputs for understanding salt tolerance in a tree species which can be further utilized for developing salt tolerance in higher plants.
[Mh] Termos MeSH primário: Millettia/fisiologia
Plantas Tolerantes a Sal/fisiologia
Árvores/fisiologia
[Mh] Termos MeSH secundário: Biocombustíveis
Clorofila/metabolismo
Microscopia Confocal
Microscopia Eletrônica de Varredura
Millettia/metabolismo
Millettia/ultraestrutura
Fotossíntese/fisiologia
Complexo de Proteína do Fotossistema II/fisiologia
Folhas de Planta/fisiologia
Folhas de Planta/ultraestrutura
Transpiração Vegetal/fisiologia
Reação em Cadeia da Polimerase
Espectrometria por Raios X
Árvores/metabolismo
Árvores/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Photosystem II Protein Complex); 1406-65-1 (Chlorophyll)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


  4 / 167 MEDLINE  
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[PMID]:28273835
[Au] Autor:Yin H; Wei Y; Chen R; Zhang S; Long L; Yin H; Tian X; He W
[Ad] Endereço:Key Laboratory of Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. yinhao@scsio.ac.cn.
[Ti] Título:Identifying Natural syNergist from Pongamia pinnata Using High-Speed Counter-Current Chromatography Combined with Isobolographic Analysis.
[So] Source:Molecules;22(3), 2017 Mar 03.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:For identifying the synergistic compounds from Pongamia pinnata, an approach based on high-speed counter-current chromatography (HSCCC) combined with isobolographic analysis was designed to detect the synergistic effects in the complex mixture [...].
[Mh] Termos MeSH primário: Millettia/química
Compostos Fitoquímicos/análise
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Distribuição Contracorrente
Sinergismo Farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


  5 / 167 MEDLINE  
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[PMID]:28115262
[Au] Autor:Malaikozhundan B; Vaseeharan B; Vijayakumar S; Pandiselvi K; Kalanjiam MA; Murugan K; Benelli G
[Ad] Endereço:Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Alagappa University, Karaikudi 630004, Tamil Nadu, India.
[Ti] Título:Biological therapeutics of Pongamia pinnata coated zinc oxide nanoparticles against clinically important pathogenic bacteria, fungi and MCF-7 breast cancer cells.
[So] Source:Microb Pathog;104:268-277, 2017 Mar.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The overuse of antimicrobics and drugs has led to the development of resistance in a number of pathogens and parasites, which leads to great concerns for human health and the environment. Furthermore, breast cancer is the second most common cause of cancer death in women. MCF-7 is a widely used epithelial cancer cell line, derived from breast adenocarcinoma for in vitro breast cancer studies, since the cell line has retained several ideal characteristics particular to the mammary epithelium. In this scenario, the development of novel and eco-friendly drugs are of timely importance. Green synthesis of nanoparticles is cost effective, environmental friendly and does not involve the use of toxic chemicals or elevate energy inputs. This research focused on the anticancer activity of Pongamia pinnata seed extract-fabricated zinc oxide nanoparticles (Pp-ZnO NPs) on human MCF-7 breast cancer cells, antibiofilm activity against bacteria and fungi was also investigated. Nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Energy dispersive X-ray spectroscopy (EDX). Pp-ZnO NPs effectively inhibited the growth of Gram positive Bacillus licheniformis (zone of inhibition: 17.3 mm) at 25 µg ml followed by Gram negative Pseudomonas aeruginosa (14.2 mm) and Vibrio parahaemolyticus (12.2 mm). Pp-ZnO NPs also effectively inhibited the biofilm formation of C. albicans at 50 µg ml . Cytotoxicity studies revealed that a single treatment with Pp-ZnO NPs significantly reduced the cell viability of breast cancer MCF-7 cells at doses higher than 50 µg ml . Morphological changes in the Pp-ZnO NPs treated MCF-7 breast cancer cells were observed using phase contrast microscopy. This study concludes that the green synthesized Pp-ZnO NPs may be used as an effective antimicrobial and antibreast cancer agents.
[Mh] Termos MeSH primário: Bactérias/efeitos dos fármacos
Biofilmes/efeitos dos fármacos
Materiais Revestidos Biocompatíveis/metabolismo
Células Epiteliais/efeitos dos fármacos
Fungos/efeitos dos fármacos
Nanopartículas/metabolismo
Óxido de Zinco/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Células Epiteliais/citologia
Células Epiteliais/fisiologia
Seres Humanos
Millettia/química
Nanopartículas/química
Nanopartículas/ultraestrutura
Extratos Vegetais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28025099
[Au] Autor:Rajakumar G; Gomathi T; Thiruvengadam M; Devi Rajeswari V; Kalpana VN; Chung IM
[Ad] Endereço:Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 143 701, South Korea.
[Ti] Título:Evaluation of anti-cholinesterase, antibacterial and cytotoxic activities of green synthesized silver nanoparticles using from Millettia pinnata flower extract.
[So] Source:Microb Pathog;103:123-128, 2017 Feb.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to develop an easy and eco-friendly method for the synthesis of Ag-NPs using extracts from the medicinal plant, Millettia pinnata flower extract and investigate the effects of Ag-NPs on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), antibacterial and cytotoxicity activity. UV-Vis peak at 438 nm confirmed the Ag-NPs absorbance. The SEM analysis results confirmed the presence of spherical shaped Ag-NPs by a huge disparity in the particle size distribution with an average size of 49 ± 0.9 nm. TEM images revealed the formation of Ag-NPs with spherical shape and sizes in the range between 16 and 38 nm. The Ag-NPs showed an excellent inhibitory efficacy against AChE and BChE. The highest antibacterial activity was found against Escherichia coli (20.25 ± 0.91 mm). These nanoparticles showed the cytotoxic effects against brine shrimp (artemia saliana) nauplii with a LD value of 33.92.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Inibidores da Colinesterase/farmacologia
Flores/química
Nanopartículas Metálicas
Millettia/química
Extratos Vegetais/farmacologia
Prata
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Inibidores da Colinesterase/química
Ativação Enzimática/efeitos dos fármacos
Química Verde
Nanopartículas Metálicas/administração & dosagem
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Testes de Sensibilidade Microbiana
Espectroscopia Fotoeletrônica
Extratos Vegetais/química
Prata/química
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cholinesterase Inhibitors); 0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE


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[PMID]:27988713
[Au] Autor:Gupta A; Joshi S
[Ad] Endereço:. drankitagupta7@gmail.com.
[Ti] Título:The first record of the genus Tanaostigma (Hymenoptera: Tanaostigmatidae) in the Old World, with the description of a new species from India.
[So] Source:Zootaxa;4193(1):zootaxa.4193.1.13, 2016 Nov 15.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Tanaostigma Howard (Hymenoptera: Tanaostigmatidae) is recorded for the first time in the fauna of the Old World, with T. indica Gupta sp. n.  described and illustrated from southern India, reared from Millettia (=Pongamia) pinnata (Fabaceae).
[Mh] Termos MeSH primário: Vespas/classificação
[Mh] Termos MeSH secundário: Estruturas Animais/anatomia & histologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Tamanho Corporal
Feminino
Índia
Millettia/parasitologia
Tamanho do Órgão
Vespas/anatomia & histologia
Vespas/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4193.1.13


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[PMID]:27784319
[Au] Autor:Zingue S; Tchoumtchoua J; Ntsa DM; Sandjo LP; Cisilotto J; Nde CBM; Winter E; Awounfack CF; Ndinteh DT; Clyne C; Njamen D; Halabalaki M; Creczynski-Pasa TB
[Ad] Endereço:Laboratory of Physiology and Natural Products Research, Department of Live and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon. stephanezingue@gmail.com.
[Ti] Título:Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms.
[So] Source:BMC Complement Altern Med;16(1):421, 2016 Oct 26.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Millettia macrophylla was previously reported to have estrogenic effects and to prevent postmenopausal osteoporosis in Wistar rats. So, the study deals with the identification of its secondary metabolites and the evaluation of their estrogenicity and cytotoxicity toward tumoural cells. Thus, 13 known compounds were obtained from successive chromatographic columns and identified by NMR data compared to those previously reported. METHODS: In vitro estrogenicity of the isolates and the phenolic fraction (PF) of M. macrophylla were performed by E-screen and reporter gene assays, while their cytotoxicity was evaluated by Alamar Blue (resazurin) assay. A 3-days uterotrophic assay and the ability of PF to alleviate hot flushes in ovariectomized adult rats were tested in vivo. RESULTS: Seven of the 13 secondary metabolites turned to be estrogenic. Only two exhibited cytotoxic effects on MCF-7 and MDA-MB-231 with CC values of 110 µM and 160 µM, respectively. PF induced a significant (p < 0.01) MCF-7 cells proliferation and transactivated both ERα and ERß in the reported gene assay at 10 µg/mL. In vivo, PF acted more efficiently than the methanol crude extract, resulting to a significant (p < 0.01) increase in the uterine wet weight, uterine protein level, uterine and vaginal epithelial height at the dose of 10 mg/kg BW. In addition, PF reduced the average duration and frequency of hot flushes induced in rat. CONCLUSION: These aforementioned results indicate that PF is a good candidate for the preparation of an improved traditional medicine able to alleviate some menopausal complaints such as vaginal dryness and hot flushes. Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth. (Fabaceae): towards a better understanding of its underlying mechanism.
[Mh] Termos MeSH primário: Estrogênios/farmacologia
Estrogênios/toxicidade
Millettia/química
Extratos Vegetais/farmacologia
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Estrogênios/química
Feminino
Seres Humanos
Células MCF-7
Ovariectomia
Extratos Vegetais/química
Ratos
Útero/química
Útero/efeitos dos fármacos
Vagina/citologia
Vagina/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170708
[Lr] Data última revisão:
170708
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1385-5


  9 / 167 MEDLINE  
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[PMID]:27754464
[Au] Autor:Ayine-Tora DM; Kingsford-Adaboh R; Asomaning WA; Harrison JJ; Mills-Robertson FC; Bukari Y; Sakyi PO; Kaminta S; Reynisson J
[Ad] Endereço:School of Chemical Sciences, University of Auckland, 23 Symonds Street, 1142 Auckland, New Zealand. dayi479@aucklanduni.ac.nz.
[Ti] Título:Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action.
[So] Source:Molecules;21(10), 2016 Oct 15.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Fungal pathogens continue to pose challenges to humans and plants despite efforts to control them. Two coumarins, robustic acid and thonningine-C isolated from , show promising activity against the fungus with minimum fungicidal concentration of 1.0 and 0.5 mg/mL, respectively. Molecular modelling against the putative bio-molecular target, lanosterol 14α-demethylase (CYP51), revealed a plausible binding mode for the active compounds, in which the hydroxyl group binds with a methionine backbone carboxylic group blocking access to the iron catalytic site. This binding disrupts the synthesis of several important sterols for the survival of fungi.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida albicans/efeitos dos fármacos
Cumarínicos/farmacologia
Millettia/química
Esterol 14-Desmetilase/química
[Mh] Termos MeSH secundário: Antifúngicos/química
Domínio Catalítico/efeitos dos fármacos
Cumarínicos/química
Proteínas Fúngicas/química
Proteínas Fúngicas/metabolismo
Isoflavonas/química
Isoflavonas/farmacologia
Testes de Sensibilidade Microbiana
Modelos Moleculares
Simulação de Acoplamento Molecular
Estrutura Molecular
Ligação Proteica
Esterol 14-Desmetilase/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Coumarins); 0 (Fungal Proteins); 0 (Isoflavones); 5307-59-5 (robustic acid); EC 1.14.13.70 (Sterol 14-Demethylase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


  10 / 167 MEDLINE  
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[PMID]:27663949
[Au] Autor:Wang W; Li N; Wang J; Chen G; Huang R; Zhao W; Li J; Si Y
[Ad] Endereço:School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, PR China.
[Ti] Título:Bioactive benzofuran-chalcanes as potential NQO1 inducers from Millettia pulchra (Benth) kurzvar-laxior (Dunn) Z.Wei.
[So] Source:Phytochemistry;131:107-114, 2016 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five chalcanes ((α'R)-2, α'-dimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, ßR)-2', α', ß-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, ßR)-2', α', ß-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane) and a flavonoid glycoside (3', 7-dihydroxy-6-methoxy-4', 5'-methylenedioxyisoflavone 6-O-ß-D- glucopyranoside), together with 15 known components, were isolated from the leaves of Millettia pulchra (Benth) Kurzvar-laxior (Dunn) Z. Wei, a traditional Zhuang medicine. Their chemical structures were established by extensive analysis of NMR, mass spectrometry and ECD spectra. Furthermore compounds (α'R, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, quercetin, methyl 2-O-ß-D-glucopyranosylbenzoate, 6,7-dimethoxy-3',4'-methylenedioxyisoflavone and lyoniresinol were suggested to be potential chemopreventive agents because of their significant activity in inducing NQO1 ([NAD(P)H quinine oxidoreductase 1], a phase II metabolism enzyme).
[Mh] Termos MeSH primário: Anticarcinógenos/isolamento & purificação
Anticarcinógenos/farmacologia
Benzofuranos/isolamento & purificação
Benzofuranos/farmacologia
Chalconas/isolamento & purificação
Chalconas/farmacologia
Millettia/química
NAD(P)H Desidrogenase (Quinona)/antagonistas & inibidores
[Mh] Termos MeSH secundário: Anticarcinógenos/química
Benzofuranos/análise
Benzofuranos/química
Chalconas/química
Glicosídeos/análise
Seres Humanos
Medicina Tradicional
Estrutura Molecular
Folhas de Planta/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Benzofurans); 0 (Chalcones); 0 (Glycosides); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (NQO1 protein, human)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE



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