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[PMID]: | 27663949 |
[Au] Autor: | Wang W; Li N; Wang J; Chen G; Huang R; Zhao W; Li J; Si Y |
[Ad] Endereço: | School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, PR China. |
[Ti] Título: | Bioactive benzofuran-chalcanes as potential NQO1 inducers from Millettia pulchra (Benth) kurzvar-laxior (Dunn) Z.Wei. |
[So] Source: | Phytochemistry;131:107-114, 2016 Nov. | [Is] ISSN: | 1873-3700 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | Five chalcanes ((α'R)-2, α'-dimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, ßR)-2', α', ß-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, ßR)-2', α', ß-trimethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'R, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane) and a flavonoid glycoside (3', 7-dihydroxy-6-methoxy-4', 5'-methylenedioxyisoflavone 6-O-ß-D- glucopyranoside), together with 15 known components, were isolated from the leaves of Millettia pulchra (Benth) Kurzvar-laxior (Dunn) Z. Wei, a traditional Zhuang medicine. Their chemical structures were established by extensive analysis of NMR, mass spectrometry and ECD spectra. Furthermore compounds (α'R, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, (α'S, ßR)-2', ß-dimethoxy-α'-hydroxyethoxy-furano-[4″, 5'': 3', 4'] chalcane, quercetin, methyl 2-O-ß-D-glucopyranosylbenzoate, 6,7-dimethoxy-3',4'-methylenedioxyisoflavone and lyoniresinol were suggested to be potential chemopreventive agents because of their significant activity in inducing NQO1 ([NAD(P)H quinine oxidoreductase 1], a phase II metabolism enzyme). |
[Mh] Termos MeSH primário: |
Anticarcinógenos/isolamento & purificação Anticarcinógenos/farmacologia Benzofuranos/isolamento & purificação Benzofuranos/farmacologia Chalconas/isolamento & purificação Chalconas/farmacologia Millettia/química NAD(P)H Desidrogenase (Quinona)/antagonistas & inibidores
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[Mh] Termos MeSH secundário: |
Anticarcinógenos/química Benzofuranos/análise Benzofuranos/química Chalconas/química Glicosídeos/análise Seres Humanos Medicina Tradicional Estrutura Molecular Folhas de Planta/química Raízes de Plantas/química
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Anticarcinogenic Agents); 0 (Benzofurans); 0 (Chalcones); 0 (Glycosides); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (NQO1 protein, human) |
[Em] Mês de entrada: | 1703 |
[Cu] Atualização por classe: | 170310 |
[Lr] Data última revisão:
| 170310 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 160925 |
[St] Status: | MEDLINE |
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