Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.598 [Categoria DeCS]
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[PMID]:29447189
[Au] Autor:Saleem AR; Brunetti C; Khalid A; Della Rocca G; Raio A; Emiliani G; De Carlo A; Mahmood T; Centritto M
[Ad] Endereço:Department of Earth and Environmental Sciences, Bahria University Islamabad Campus, Islamabad, Pakistan.
[Ti] Título:Drought response of Mucuna pruriens (L.) DC. inoculated with ACC deaminase and IAA producing rhizobacteria.
[So] Source:PLoS One;13(2):e0191218, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drought is one of the major constraints limiting agricultural production worldwide and is expected to increase in the future. Limited water availability causes significant effects to plant growth and physiology. Plants have evolved different traits to mitigate the stress imposed by drought. The presence of plant growth-promoting rhizobacteria (PGPR) could play an important role in improving plant performances and productivity under drought. These beneficial microorganisms colonize the rhizosphere of plants and increase drought tolerance by lowering ethylene formation. In the present study, we demonstrate the potential to improve the growth of velvet bean under water deficit conditions of two different strains of PGPR with ACCd (1-Aminocyclopropane-1-Carboxylate deaminase) activity isolated from rainfed farming system. We compared uninoculated and inoculated plants with PGPR to assess: a) photosynthetic performance and biomass; b) ACC content and ethylene emission from leaves and roots; c) leaf isoprene emission. Our results provided evidence that under drought conditions inoculation with PGPR containing the ACCd enzyme could improve plant growth compared to untreated plants. Ethylene emission from roots and leaves of inoculated velvet bean plants was significantly lower than uninoculated plants. Moreover, isoprene emission increased with drought stress progression and was higher in inoculated plants compared to uninoculated counterparts. These findings clearly illustrate that selected PGPR strains isolated from rainfed areas could be highly effective in promoting plant growth under drought conditions by decreasing ACC and ethylene levels in plants.
[Mh] Termos MeSH primário: Mucuna/metabolismo
Reguladores de Crescimento de Planta/metabolismo
Rhizobiaceae/metabolismo
[Mh] Termos MeSH secundário: Biomassa
Carbono-Carbono Liases/metabolismo
Secas
Etilenos/biossíntese
Mucuna/fisiologia
Fotossíntese
Desenvolvimento Vegetal
Reguladores de Crescimento de Planta/fisiologia
Raízes de Plantas/crescimento & desenvolvimento
Rhizobiaceae/genética
Rizosfera
Microbiologia do Solo
Água/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ethylenes); 0 (Plant Growth Regulators); 059QF0KO0R (Water); 91GW059KN7 (ethylene); EC 3.5.99.7 (1-aminocyclopropane-1-carboxylate deaminase); EC 4.1.- (Carbon-Carbon Lyases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191218


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[PMID]:29175636
[Au] Autor:Ferreira PAA; Tiecher T; Tiecher TL; Rangel WM; Soares CRFS; Deuner S; Tarouco CP; Giachini AJ; Nicoloso FT; Brunetto G; Coronas MV; Ceretta CA
[Ad] Endereço:Department of Soil Science, Federal University of Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil. Electronic address: paulo.ferreira@ufsm.br.
[Ti] Título:Effects of Rhizophagus clarus and P availability in the tolerance and physiological response of Mucuna cinereum to copper.
[So] Source:Plant Physiol Biochem;122:46-56, 2018 Jan.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Arbuscular mycorrhizal fungi (AMF) improve plant ability to uptake P and tolerate heavy metals. This study aimed to evaluate the effect of available P and the inoculation of Rhizophagus clarus in a Cu-contaminated soil (i) on the activity of acid phosphatases (soil and plant), the presence of glomalin, and (ii) in the biochemical and physiological status of Mucuna cinereum. A Typic Hapludalf soil artificially contaminated by adding 60 mg kg Cu was used in a 3 × 2 factorial design with three replicates. Treatments consisted of three P levels: 0, 40, and 100 mg kg P. Each P treatment level was inoculated (+AMF)/non-inoculated (-AMF) with 200 spores of R. clarus per pot, and plants grown for 45 days. The addition of at least 40 mg kg P and the inoculation of plants with R. clarus proved to be efficient to reduce Cu phytotoxicity and increase dry matter yield. Mycorrhization and phosphate fertilization reduced the activity of enzymes regulating oxidative stress (SOD and POD), and altered the chlorophyll a fluorescence parameters, due to the lower stress caused by available Cu. These results suggest a synergism between the application of P and the inoculation with R. clarus, favoring the growth of M. cinereum in a Cu-contaminated soil. This study shows that AMF inoculation represents an interesting alternative to P fertilization to improve plant development when exposed to excess Cu.
[Mh] Termos MeSH primário: Cobre/farmacologia
Resistência à Doença/efeitos dos fármacos
Glomeromycota/crescimento & desenvolvimento
Mucuna
Fósforo/metabolismo
Poluentes do Solo/farmacologia
[Mh] Termos MeSH secundário: Mucuna/metabolismo
Mucuna/microbiologia
Estresse Oxidativo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 27YLU75U4W (Phosphorus); 789U1901C5 (Copper)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28685548
[Au] Autor:Yousaf F; Shahid M; Riaz M; Atta A; Fatima H
[Ad] Endereço:Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.
[Ti] Título:Immunomodulatory potential of Anacyclus pyrethrum (L.) and Mucuna pruriens (L.) In male albino rats.
[So] Source:J Biol Regul Homeost Agents;31(2):425-429, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the immunomodulatory potential of Anacyclus pyrethrum roots and Mucuna pruriens seeds in male albino rats. The roots of A. pyrethrum and seeds of M. pruriens were extracted with methanolic solvent (70:30) and administered at dose concentrations of 50, 100 and 200 mg/Kg body weight to healthy male rats. The immune system of rats was suppressed by injecting carbon tetrachloride to animals in the toxic control group and test group animals. Cell-mediated immune response of animals was examined by performing neutrophil adhesion test and the humoral immune response was evaluated by determining serum immunoglobulin levels of the animals under study. The administration of methanolic extracts of A. pyrethrum roots and M. pruriens seeds significantly (p less than 0.05) increased the neutrophil adhesion to the nylon fiber. Increase in % neutrophil adhesion was observed in animals treated with 200 mg of each plant extract. Significant (p less than 0.05) improvement in immunoglobulin levels was recorded in the extract treated group animals, showing that the root extract of A. pyrethrum and seed extract of M. pruriens have immunomodulatory potential. We therefore conclude that the tested extracts can be used as immunomodulatory agents to stimulate the immune system.
[Mh] Termos MeSH primário: Asteraceae/química
Imunidade Humoral/efeitos dos fármacos
Fatores Imunológicos/farmacologia
Mucuna/química
Neutrófilos/imunologia
Extratos Vegetais/química
Raízes de Plantas/química
Sementes/química
[Mh] Termos MeSH secundário: Animais
Adesão Celular/efeitos dos fármacos
Adesão Celular/imunologia
Fatores Imunológicos/química
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunologic Factors); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28679598
[Au] Autor:Cilia R; Laguna J; Cassani E; Cereda E; Pozzi NG; Isaias IU; Contin M; Barichella M; Pezzoli G
[Ad] Endereço:From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplan
[Ti] Título: in Parkinson disease: A double-blind, randomized, controlled, crossover study.
[So] Source:Neurology;89(5):432-438, 2017 Aug 01.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate whether (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations. METHODS: We investigated efficacy and safety of single-dose intake of MP powder from roasted seeds obtained without any pharmacologic processing. Eighteen patients with advanced PD received the following treatments, whose sequence was randomized: (1) dispersible levodopa at 3.5 mg/kg combined with the dopa-decarboxylase inhibitor benserazide (LD+DDCI; the reference treatment); (2) high-dose MP (MP-Hd; 17.5 mg/kg); (3) low-dose MP (MP-Ld; 12.5 mg/kg); (4) pharmaceutical preparation of LD without DDCI (LD-DDCI; 17.5 mg/kg); (5) MP plus benserazide (MP+DDCI; 3.5 mg/kg); (6) placebo. Efficacy outcomes were the change in motor response at 90 and 180 minutes and the duration of on state. Safety measures included any adverse event (AE), changes in blood pressure and heart rate, and the severity of dyskinesias. RESULTS: When compared to LD+DDCI, MP-Ld showed similar motor response with fewer dyskinesias and AEs, while MP-Hd induced greater motor improvement at 90 and 180 minutes, longer ON duration, and fewer dyskinesias. MP-Hd induced less AEs than LD+DDCI and LD-DDCI. No differences in cardiovascular response were recorded. CONCLUSION: Single-dose MP intake met all noninferiority efficacy and safety outcome measures in comparison to dispersible levodopa/benserazide. Clinical effects of high-dose MP were similar to levodopa alone at the same dose, with a more favorable tolerability profile. CLINICALTRIALSGOV IDENTIFIER: NCT02680977.
[Mh] Termos MeSH primário: Antiparkinsonianos/uso terapêutico
Mucuna
Doença de Parkinson/tratamento farmacológico
Fitoterapia
[Mh] Termos MeSH secundário: Antiparkinsonianos/efeitos adversos
Antiparkinsonianos/farmacocinética
Benserazida/efeitos adversos
Benserazida/uso terapêutico
Pressão Sanguínea/efeitos dos fármacos
Estudos Cross-Over
Relação Dose-Resposta a Droga
Método Duplo-Cego
Discinesia Induzida por Medicamentos
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Levodopa/efeitos adversos
Levodopa/farmacocinética
Levodopa/uso terapêutico
Masculino
Meia-Idade
Atividade Motora/efeitos dos fármacos
Fitoterapia/efeitos adversos
Pós
Sementes
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antiparkinson Agents); 0 (Powders); 46627O600J (Levodopa); 762OS3ZEJU (Benserazide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004175


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[PMID]:27897091
[Au] Autor:Singh SK; Yadav D; Lal RK; Gupta MM; Dhawan SS
[Ad] Endereço:a Council of Scientific and Industrial Research (CSIR), Central Institute of Medicinal and Aromatic Plants (CIMAP) , Lucknow , India.
[Ti] Título:Inducing mutations through γ-irradiation in seeds of Mucuna pruriens for developing high L-DOPA-yielding genotypes.
[So] Source:Int J Radiat Biol;93(4):426-432, 2017 Apr.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To develop elite genotypes in Mucuna pruriens (L.) DC with high L-DOPA (L-3, 4 dihydroxyphenylalanine) yields, with non-itching characteristics and better adaptability by applying γ-irradiation. Molecular and chemical analysis was performed for screening based on specific characteristics desired for developing suitable genotypes. MATERIALS AND METHODS: Developed, mutant populations were analyzed for L-DOPA % in seeds through TLC (thin layer chromatography), and the results obtained were validated with the HPLC (High performance liquid chromatography). The DNA (Deoxyribonucleic acid) was isolated from the leaf at the initial stage and used for DNA polymorphism. RNA (Ribonucleic acid) was isolated from the leaf during maturity and used for expression analysis. RESULTS: The selected mutant T-I-7 showed 5.7% L-DOPA content compared to 3.18% of parent CIM-Ajar. The total polymorphism obtained was 57% with the molecular marker analysis. The gene expression analysis showed higher fold change expression of the dopadecarboxylase gene (DDC) in control compared to selected mutants (T-I-7, T-II-23, T-IV-9, T-VI-1). CONCLUSION: DNA polymorphism was used for the screening of mutants for efficient screening at an early stage. TLC was found suitable for the large-scale comparative chemical analysis of L-DOPA. The expression profile of DDC clearly demonstrated the higher yields of L-DOPA in selected mutants developed by γ-irradiation in the seeds of the control.
[Mh] Termos MeSH primário: Levodopa/biossíntese
Mucuna/fisiologia
Mucuna/efeitos da radiação
Mutação/efeitos da radiação
Sementes/fisiologia
Sementes/efeitos da radiação
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Raios gama
Melhoramento Genético/métodos
Levodopa/isolamento & purificação
Mutação/genética
Dose de Radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
46627O600J (Levodopa)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1080/09553002.2016.1254832


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[PMID]:27893308
[Au] Autor:Chel-Guerrero L; Galicia-Martínez S; Acevedo-Fernández JJ; Santaolalla-Tapia J; Betancur-Ancona D
[Ad] Endereço:1 Facultad de Ingeniería Química, Universidad Autónoma de Yucatán , Mérida, México .
[Ti] Título:Evaluation of Hypotensive and Antihypertensive Effects of Velvet Bean (Mucuna pruriens L.) Hydrolysates.
[So] Source:J Med Food;20(1):37-45, 2017 Jan.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertension could cause significant worldwide health problems that affect 15-20% of all adults; according to National Health and Nutrition Examination Survey, about 29% of the adult population in the United States are hypertensive. Recent research has shown that peptides derived from the hydrolysis of food proteins can decrease blood pressure. This study was carried out to evaluate the hypotensive and antihypertensive potential of Mucuna pruriens protein hydrolysates in in vitro and in vivo models. M. pruriens protein concentrate was prepared by wet fractionation and enzymatically hydrolyzed using Alcalase , Flavourzyme , and the sequential system Alcalase-Flavourzyme at different times (5-120 min). The biological potential was measured in vitro based on the IC value as well as in vivo effect, measuring the systolic (SBP) and diastolic (DBP) blood pressure in normotensive and antihypertensive Wistar-Kyoto rats by the tail-cuff method. Hydrolysis of M. pruriens protein concentrates with commercial enzymes generated extensive hydrolysates with angiotensin-converting enzyme (ACE-I) inhibitory activity (IC : 0.589-0.993 mg/mL) and hypotensive (SBP: 0.6-47.43%, DBP: 1.94-43.47%) and antihypertensive (SBP: 8.84-27.29% DBP: 16.1-29.37%) effect. These results indicate that Mucuna pruriens protein hydrolysate (MPPH) could be used as a functional ingredient to prevent blood pressure increase.
[Mh] Termos MeSH primário: Inibidores da Enzima Conversora de Angiotensina/administração & dosagem
Anti-Hipertensivos/administração & dosagem
Hipertensão/tratamento farmacológico
Mucuna/química
Extratos Vegetais/administração & dosagem
Hidrolisados de Proteína/administração & dosagem
[Mh] Termos MeSH secundário: Inibidores da Enzima Conversora de Angiotensina/química
Animais
Anti-Hipertensivos/química
Pressão Sanguínea/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
Hipertensão/enzimologia
Hipertensão/fisiopatologia
Peptidil Dipeptidase A/metabolismo
Hidrolisados de Proteína/química
Ratos
Ratos Endogâmicos WKY
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Antihypertensive Agents); 0 (Plant Extracts); 0 (Protein Hydrolysates); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0080


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[PMID]:27868137
[Au] Autor:Jones O; Schindler IC; Holle H
[Ad] Endereço:Department of Psychology, University of Hull, Cottingham Road, Hull, HU6 7RX, United Kingdom.
[Ti] Título:Assessing Acute Itch Intensity: General Labelled Magnitude Scale is More Reliable than Classic Visual Analogue Scale.
[So] Source:Acta Derm Venereol;97(3):375-376, 2017 03 10.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Mh] Termos MeSH primário: Prurido/diagnóstico
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adolescente
Adulto
Inglaterra
Feminino
Seres Humanos
Masculino
Mucuna
Extratos Vegetais/toxicidade
Valor Preditivo dos Testes
Prurido/induzido quimicamente
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.2340/00015555-2584


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[PMID]:27854061
[Au] Autor:Boechat CL; Giovanella P; Amorim MB; de Sá EL; de Oliveira Camargo FA
[Ad] Endereço:Cinobelina Elvas, Agronomy Department, Federal University of Piauí, BR 135, km 3, Planalto Horizonte, Bom Jesus, PI, Brazil. cacioboechat@gmail.com.
[Ti] Título:Metal-resistant rhizobacteria isolates improve Mucuna deeringiana phytoextraction capacity in multi-metal contaminated soils from a gold mining area.
[So] Source:Environ Sci Pollut Res Int;24(3):3063-3073, 2017 Jan.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phytoremediation consists of biological techniques for heavy metal remediation, which include exploring the genetic package of vegetable species to remove heavy metals from the environment. The goals of this study were to investigate heavy metal and bioaugmentation effects on growth and nutrient uptake by Mucuna deeringiana; to determine the metal translocation factor and bioconcentration factor and provide insight for using native bacteria to enhance heavy metal accumulation. The experiment was conducted under greenhouse conditions using a 2 × 4 factorial scheme with highly and slightly contaminated soil samples and inoculating M. deeringiana with three highly lead (Pb )-resistant bacteria Kluyvera intermedia (Ki), Klebsiella oxytoca (Ko), and Citrobacter murliniae (Cm) isolated from the rhizosphere of native plants identified as Senecio brasiliensis (Spreng.) Less., Senecio leptolobus DC., and Baccharis trimera (Less) DC., respectively. The increased heavy metal concentrations in soil samples do not decrease the root dry mass of M. deeringiana, concerning the number and dry weight of nodules. The shoot dry mass is reduced by the increasing concentration of heavy metals in soil associated with Kluyvera intermedia and Klebsiella oxytoca bacteria. The number of nodules is affected by heavy metals associated with Citrobacter murliniae bacteria. The bacteria K. intermedia, C. murliniae, and K. oxytoca increase the lead and cadmium available in the soil and enhanced metal uptake by Mucuna deeringiana. The M. deeringiana specie has characteristics that make it hyperaccumulate copper and zinc. The translocation and bioconcentration factors for M. deeringiana characterize it as a promising candidate to phytostabilize multi-metal contaminated soils.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Ouro
Metais Pesados
Mineração
Mucuna
[Mh] Termos MeSH secundário: Cádmio
Cobre
Raízes de Plantas/química
Plantas
Rizosfera
Solo
Poluentes do Solo/análise
Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 7440-57-5 (Gold); 789U1901C5 (Copper); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-8103-1


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[PMID]:27377123
[Au] Autor:Andersen HH; Sørensen AR; Nielsen GA; Mølgaard MS; Stilling P; Boudreau SA; Elberling J; Arendt-Nielsen L
[Ad] Endereço:SMI®, Department of Health science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
[Ti] Título:A Test-Retest Reliability Study of Human Experimental Models of Histaminergic and Non-histaminergic Itch.
[So] Source:Acta Derm Venereol;97(2):198-207, 2017 Feb 08.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:Numerous exploratory, proof-of-concept and interventional studies have used histaminergic and non-histaminergic human models of itch. However, no reliability studies for such surrogate models have been conducted. This study investigated the test-retest reliability for the response to histamine- and cowhage- (5, 15, 25 spiculae) induced itch in healthy volunteers. Cowhage spiculae were individually applied with tweezers and 1% histamine was applied with a skin prick test (SPT) lancet, both on the volar forearm. The intensity of itch was recorded on a visual analogue scale and self-reported area of itch was assessed 5 and 10 min after itch provocation. Reliability of the evoked itch (area under the curve and peak intensity) was assessed by the coefficient of variation (CV), intra-class correlation coefficient (ICC), and sample size estimation for parallel and cross-over designs. Cowhage (ICC = 0.57-0.77, CVbetween = 97%, CVwithin = 41%) and histamine: (ICC = 0.83-0.93, CVbetween = 97%, CVwithin = 20%) exhibited moderate-to-excellent intra-individual reliability and moderate inter-individual reliability for the itch intensity. For a test-retest observation period of one week, SPT-delivered histamine and application of cowhage-spiculae are reproducible human models of itch. The high inter-individual and low intra-individual variability suggests cross-over designed studies when applicable.
[Mh] Termos MeSH primário: Histamina/efeitos adversos
Mucuna
Componentes Aéreos da Planta/efeitos adversos
Prurido/etiologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Modelos Biológicos
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Escala Visual Analógica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
820484N8I3 (Histamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE
[do] DOI:10.2340/00015555-2502


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[PMID]:27721538
[Au] Autor:Barua AG; Raj H; Konch P; Hussain P; Barua CC
[Ad] Endereço:Department of Veterinary Public Health, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India.
[Ti] Título:Evaluation of antimycobacterial activity of some folklore medicinal plants and enumeration of colony forming unit in murine model.
[So] Source:Indian J Pharmacol;48(5):526-530, 2016 Sep-Oct.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The present study was carried out to investigate the antimycobacterial activity of methanol extract of and in murine model. MATERIALS AND METHODS: Female BALB/c mice were infected with the H Rv suspension. Extracts were administered orally for 2 weeks from 7 day postinfection at a dose of 200 mg/kg and rifampicin at 20 mg/kg as standard. The synergistic groups were 10 and 100 mg/kg for rifampicin and extract, respectively. RESULTS: The final body weight of mycobacteria-infected group was significantly reduced (15.41 ± 0.42, < 0.01), but following treatment with the plant extract plus rifampicin could elevate the body weight. Colony forming unit (CFU) count of lung (8.71 ± 0.01) and spleen (8.59 ± 0.01) was significantly higher in infected and untreated group ( < 0.01). It was observed that activity of the synergistic group displayed powerful and maximum response against tuberculosis (TB) infection with lower CFU counts. Histopathology study showed cells such as lymphocytes, epithelioid, Langhans giant cell, and fibrous tissue proliferation in lungs; depletion of lymphocytes in the spleen. CONCLUSIONS: The data indicate that methanol extract of has potential antimycobacterial activity, and the synergistic group consisting of rifampicin and could be a rational choice for the treatment of TB.
[Mh] Termos MeSH primário: Alstonia
Antituberculosos/uso terapêutico
Mucuna
Extratos Vegetais/uso terapêutico
Tuberculose/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Contagem de Colônia Microbiana
Feminino
Folclore
Pulmão/efeitos dos fármacos
Pulmão/microbiologia
Pulmão/patologia
Camundongos Endogâmicos BALB C
Mycobacterium tuberculosis/isolamento & purificação
Fitoterapia
Plantas Medicinais
Baço/efeitos dos fármacos
Baço/microbiologia
Tuberculose/microbiologia
Tuberculose/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE



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