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Pesquisa : B01.650.940.800.575.912.250.401.606 [Categoria DeCS]
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  1 / 92 MEDLINE  
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[PMID]:28284660
[Au] Autor:Jiao J; Wang S; Zhang R; Ma Z; Du G; Chen X; Tao D; Zhao J
[Ad] Endereço:Yingkou Institute of Technology, 115014, China; College of Animal Science, Tarim University, Alar, Xinjiang, 843300, China.
[Ti] Título:iTRAQ-based quantitative proteomics discovering potential serum biomarkers in locoweed poisoned rabbits.
[So] Source:Chem Biol Interact;268:111-118, 2017 Apr 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Locoism threatens the sustainable development of animal husbandry in areas around the world with intensified desertification, especially in the western United States, western China, Canada, and Mexico, among other countries. This study was conducted to discover potential serum biomarkers in locoweed-poisoned rabbits and lay a foundation for early diagnosis of locoism. We performed iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS), comparing locoweed-poisoned rabbits and healthy controls. A total of 78 differentially-expressed proteins (fold change > 1.5 or < 0.67) were identified in the locoweed-poisoned rabbits compared to healthy controls. We found that 57.70% of differentially-expressed proteins were functionally related, and through bioinformatics analysis, we were able to construct a network mainly in complement and coagulation cascades. Significant differences in thrombospondin 4 (THBS4), kininogen 1 (KNG1), hemoglobin (HBB), and complement factor I (CFI) between locoweed poisoned animals and controls were found (P < 0.05) and validated by western blotting. These results suggested that locoweed could damage neurocytes, lower immunity, and form thrombi in rabbits. Our study proposes potential biomarkers for locoism diagnosis and also provides a new experimental basis to understand the pathogenesis of locoism.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/análise
Oxytropis/envenenamento
Proteoma/análise
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Feminino
Masculino
Proteômica
Coelhos
Swainsonina/farmacologia
alfa-Manosidase/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Proteins); 0 (Proteome); EC 3.2.1.24 (alpha-Mannosidase); RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  2 / 92 MEDLINE  
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[PMID]:27939530
[Au] Autor:Ampomah OY; Mousavi SA; Lindström K; Huss-Danell K
[Ad] Endereço:Department of Agricultural Research for Northern Sweden, Swedish University of Agricultural Sciences (SLU), SE-90183, Umeå, Sweden. Electronic address: oseiampomah@yahoo.com.
[Ti] Título:Diverse Mesorhizobium bacteria nodulate native Astragalus and Oxytropis in arctic and subarctic areas in Eurasia.
[So] Source:Syst Appl Microbiol;40(1):51-58, 2017 Jan.
[Is] ISSN:1618-0984
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Rhizobia nodulating native Astragalus and Oxytropis spp. in Northern Europe are not well-studied. In this study, we isolated bacteria from nodules of four Astragalus spp. and two Oxytropis spp. from the arctic and subarctic regions of Sweden and Russia. The phylogenetic analyses were performed by using sequences of three housekeeping genes (16S rRNA, rpoB and recA) and two accessory genes (nodC and nifH). The results of our multilocus sequence analysis (MLSA) of the three housekeeping genes tree showed that all the 13 isolates belonged to the genus Mesorhizobium and were positioned in six clades. Our concatenated housekeeping gene tree also suggested that the isolates nodulating Astragalus inopinatus, Astragalus frigidus, Astragalus alpinus ssp. alpinus and Oxytropis revoluta might be designated as four new Mesorhizobium species. The 13 isolates were grouped in three clades in the nodC and nifH trees. N analysis suggested that the legumes in association with these isolates were actively fixing nitrogen.
[Mh] Termos MeSH primário: Astrágalo (Planta)/microbiologia
Variação Genética
Mesorhizobium/classificação
Mesorhizobium/isolamento & purificação
Oxytropis/microbiologia
Nodulação
Nódulos Radiculares de Plantas/microbiologia
[Mh] Termos MeSH secundário: Regiões Árticas
Proteínas de Bactérias/genética
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Ribossômico/química
DNA Ribossômico/genética
RNA Polimerases Dirigidas por DNA/genética
Mesorhizobium/genética
Tipagem de Sequências Multilocus
N-Acetilglucosaminiltransferases/genética
Oxirredutases/genética
Filogenia
RNA Ribossômico 16S/genética
Recombinases Rec A/genética
Federação Russa
Suécia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S); EC 1.- (Oxidoreductases); EC 1.18.6.1 (nitrogenase reductase); EC 2.4.1.- (N-Acetylglucosaminyltransferases); EC 2.4.1.- (NodC protein, Rhizobiales); EC 2.7.7.- (Rec A Recombinases); EC 2.7.7.6 (DNA-Directed RNA Polymerases); EC 2.7.7.6 (RNA polymerase beta subunit)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  3 / 92 MEDLINE  
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[PMID]:27999809
[Au] Autor:Wu C; Feng K; Lu D; Yan D; Han T; Zhao B
[Ad] Endereço:College of Animal Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.
[Ti] Título:Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice.
[So] Source:Biomed Res Int;2016:6824374, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Swainsonine is the primary toxin in locoweeds. It causes intention tremors, reproductive dysfunction, emaciation, and death. The objective of the present study was to evaluate the potential reproductive and developmental toxicities caused by swainsonine in mice. The treatment groups consisting of three generations of mice were given a range of concentrations of swainsonine by intraperitoneal injection (2.50 mg/kg body weight (BW), 1.20 mg/kg BW, 0.60 mg/kg BW, and 0 mg/kg BW). The 0 mg/kg BW group exhibited significantly fewer estrous cycles and an increased number of estrous ones compared to the 2.50 mg/kg BW, 1.20 mg/kg BW, and 0.60 mg/kg BW groups ( < 0.05). All three generations of mice treated with swainsonine had significantly higher spleen, liver, and kidney indices and significantly lower body weights compared to the 0 mg/kg BW group ( < 0.05). For the first and second generations of treatment group, the copulation indices and the numbers of live pups on postnatal days (PND) 0, 4, and 15 were significantly decreased compared to those of the 0 mg/kg BW group ( < 0.05). The fertility and gestation indices of the treatment group of the first generation were significantly increased compared to the 2.50 mg/kg BW, 1.20 mg/kg BW, and 0.60 mg/kg BW groups of the second generation ( < 0.05). Cumulatively, these results indicate that swainsonine may cause reproductive and developmental toxicities in mice in both parents and offspring.
[Mh] Termos MeSH primário: Fertilidade/efeitos dos fármacos
Oxytropis/química
Efeitos Tardios da Exposição Pré-Natal
Swainsonina/toxicidade
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Camundongos
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Efeitos Tardios da Exposição Pré-Natal/patologia
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Swainsonina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1155/2016/6824374


  4 / 92 MEDLINE  
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[PMID]:27797518
[Au] Autor:Banzragchgarav O; Murata T; Odontuya G; Buyankhishig B; Suganuma K; Davaapurev BO; Inoue N; Batkhuu J; Sasaki K
[Ad] Endereço:Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University , 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
[Ti] Título:Trypanocidal Activity of 2,5-Diphenyloxazoles Isolated from the Roots of Oxytropis lanata.
[So] Source:J Nat Prod;79(11):2933-2940, 2016 Nov 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eleven 2,5-diphenyloxazole derivatives (1-11), together with six known isoflavonoid derivatives, were isolated from the roots of Oxytropis lanata. The 2,5-diphenyloxazole (1) obtained proved to be identical to a standard sample used as a scintillator and liquid laser dye. The other oxazole derivatives isolated were found to have one to four hydroxy and/or O-methyl groups in their phenyl rings. Seven of the oxazole derivatives obtained are new (3-9). The inhibitory activity of the isolated compounds was evaluated against Trypanosoma congolense, the causative agent of African trypanosomosis in animals. Oxazoles with di- and trihydroxy groups showed trypanocidal activity, and 2-(2',3'-dihydroxyphenyl)-5-(2″-hydroxyphenyl)oxazole (4) exhibited the most potent inhibitory activity (IC 1.0 µM).
[Mh] Termos MeSH primário: Oxazóis/isolamento & purificação
Oxazóis/farmacologia
Oxytropis/química
Raízes de Plantas/química
Tripanossomicidas/isolamento & purificação
Tripanossomicidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Concentração Inibidora 50
Estrutura Molecular
Mongólia
Ressonância Magnética Nuclear Biomolecular
Oxazóis/química
Tripanossomicidas/química
Trypanosoma congolense/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-(2',3'-dihydroxyphenyl)-5-(2'-hydroxyphenyl)oxazole); 0 (Oxazoles); 0 (Trypanocidal Agents); 92-71-7 (2,5-diphenyloxazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE


  5 / 92 MEDLINE  
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[PMID]:27644899
[Au] Autor:Cook D; Gardner DR; Roper JM; Ransom CV; Pfister JA; Panter KE
[Ad] Endereço:USDA/ARS Poisonous Plant Research Laboratory, 1150 East 1400 North, Logan, UT 84341, United States. Electronic address: daniel.cook@ars.usda.gov.
[Ti] Título:Fungicide treatment and clipping of Oxytropis sericea does not disrupt swainsonine concentrations.
[So] Source:Toxicon;122:26-30, 2016 Nov.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Swainsonine, an indolizidine alkaloid, is an α-mannosidase and mannosidase II inhibitor that causes lysosomal storage disease and alters glycoprotein processing. Swainsonine is found in a number of plant species worldwide, and is produced by associated endophytic fungi. Prolonged consumption of swainsonine-containing plants by livestock causes a condition characterized by weight loss, depression, altered behavior, decreased libido, infertility, and death. In contrast, Astragalus and Oxytropis that do not contain swainsonine may present a valuable food source for grazing livestock in regions where palatable forage is scarce. This study tested the hypothesis that swainsonine concentrations may be reduced by fungicide treatment or by clipping, thus reducing plant toxicity. Additionally we hypothesized that clipping plants may provide a mechanism for horizontal transmission of the endophyte. To this end, four different fungicides were applied to render the endophyte non-viable, and plant vegetative tissues were periodically clipped. Treatment of Oxytropis sericea with any of four different fungicides did not alter swainsonine concentrations in plants at any of three harvest times. Additionally, we found that individual or multiple clippings had no effect on swainsonine concentrations; plants that contained swainsonine maintained concentrations, and plants low or absent in swainsonine also remained as such at each harvest. These results suggest that there is no evidence of horizontal transmission of the endophyte among individual plants due to clipping.
[Mh] Termos MeSH primário: Fungicidas Industriais/farmacologia
Oxytropis/metabolismo
Swainsonina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


  6 / 92 MEDLINE  
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[PMID]:27606974
[Au] Autor:Wu C; Han T; Lu H; Zhao B
[Ad] Endereço:College of Animal Veterinary Medicine, Northwest A & F University, Yangling 712100, Shaanxi, People's Republic of China. Electronic address: wucen95888@163.com.
[Ti] Título:The toxicology mechanism of endophytic fungus and swainsonine in locoweed.
[So] Source:Environ Toxicol Pharmacol;47:38-46, 2016 Oct.
[Is] ISSN:1872-7077
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Locoweed is a perennial herbaceous plant included in Astragalus spp. and Oxytropis spp. that contains the toxic indolizidine alkaloid swainsonine. The livestock that consume locoweed can suffer from a type of toxicity called locoism. There are aliphaticnitro compounds, selenium, selenium compounds, and alkaloids in locoweed. The toxic component in locoweed has been identified as swainsonine, an indolizidine alkaloid. Swainsonine inhibits lysosomal a-mannosidase and mannosidase II, resulting in altered oligosaccharide degradation and incomplete glycoprotein processing. Corresponding studies on endophytic fungi producing swainsonine have been isolated from a variety of locoweed, and these endophytic fungi and locoweed have a close relationship. Endophytic fungi can promote the growth of locoweed and increase swainsonine production. As a result, livestock that consume locoweed exhibit several symptoms, including dispirited behavior, staggering gait, chromatopsia, trembling, ataxia, and cellular vacuolar degeneration of most tissues by pathological observation. Locoism results in significant annual economic losses. Therefore, in this paper, we review the current research on locoweed, including that on locoweed species distribution in China, endophyte fungus in locoweed, the toxicology mechanism of locoweed, and the swainsonine effect on reproduction.
[Mh] Termos MeSH primário: Ascomicetos/metabolismo
Astrágalo (Planta)/microbiologia
Oxytropis/microbiologia
Swainsonina/toxicidade
[Mh] Termos MeSH secundário: Animais
Ascomicetos/fisiologia
Astrágalo (Planta)/metabolismo
China
Endófitos/metabolismo
Manosidases/antagonistas & inibidores
Oxytropis/metabolismo
Plantas Daninhas/microbiologia
Swainsonina/metabolismo
Swainsonina/farmacocinética
Simbiose
alfa-Manosidase/classificação
alfa-Manosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 3.2.1.- (Mannosidases); EC 3.2.1.114 (mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase); EC 3.2.1.24 (alpha-Mannosidase); RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE


  7 / 92 MEDLINE  
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[PMID]:27436221
[Au] Autor:Gardner DR; Cook D
[Ad] Endereço:Poisonous Plant Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture , 1150 E 1400 N, Logan, Utah 84341, United States.
[Ti] Título:Analysis of Swainsonine and Swainsonine N-Oxide as Trimethylsilyl Derivatives by Liquid Chromatography-Mass Spectrometry and Their Relative Occurrence in Plants Toxic to Livestock.
[So] Source:J Agric Food Chem;64(31):6156-62, 2016 Aug 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There are limited data concerning the occurrence of swainsonine N-oxide in plants known to contain swainsonine and its relative impact on toxicity of the plant material. A liquid chromatography-mass spectrometry method based on a solvent partitioning extraction procedure followed by trimethylsilylation and analysis using reversed phase high-pressure liquid chromatography-mass spectrometry was developed for the analysis of swainsonine and its N-oxide. The concentrations of each were measured in several swainsonine-containing taxa as well as two endophytic isolates that produce swainsonine. In vegetative samples the relative percent of N-oxide to free base ranged from 0.9 to 18%. In seed samples the N-oxide to free base ratio ranged from 0 to 10%. The measured concentrations of swainsonine N-oxide relative to swainsonine only slightly increases the actual toxicity of the various plant samples in a combined assay of both compounds.
[Mh] Termos MeSH primário: Alcaloides/análise
Astrágalo (Planta)/química
Fabaceae/química
Ipomoea/química
Malvaceae/química
Oxytropis/química
Swainsonina/análise
Compostos de Trimetilsilil/química
[Mh] Termos MeSH secundário: Alcaloides/toxicidade
Animais
Astrágalo (Planta)/toxicidade
Cromatografia Líquida
Fabaceae/toxicidade
Ipomoea/toxicidade
Gado
Malvaceae/toxicidade
Espectrometria de Massas
Oxytropis/toxicidade
Swainsonina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Trimethylsilyl Compounds); 81759-44-6 (swainsonine N-oxide); RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b02390


  8 / 92 MEDLINE  
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[PMID]:27085305
[Au] Autor:Cook D; Gardner DR; Lee ST; Pfister JA; Stonecipher CA; Welsh SL
[Ad] Endereço:USDA/ARS Poisonous Plant Research Laboratory, 1150 East 1400 North, Logan, Utah 84341, USA. Electronic address: daniel.cook@ars.usda.gov.
[Ti] Título:A swainsonine survey of North American Astragalus and Oxytropis taxa implicated as locoweeds.
[So] Source:Toxicon;118:104-11, 2016 Aug.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Swainsonine, an indolizidine alkaloid with significant physiological activity, is an α-mannosidase and mannosidase II inhibitor that causes lysosomal storage disease and alters glycoprotein processing. Swainsonine is found in a number of plant species worldwide, and causes severe toxicosis in livestock grazing these plants, leading to a chronic wasting disease characterized by weight loss, depression, altered behavior, decreased libido, infertility, and death. Swainsonine has been detected in 19 Astragalus and 2 Oxytropis species in North America by thin layer chromatography, gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry and a jack bean α-mannosidase inhibition assay. In addition, 5 species in North America are presumed to contain swainsonine based upon reports from field cases. Many of these plant species have not been analyzed for swainsonine using modern instrumentation such as gas or liquid chromatography coupled with mass spectrometry. To provide clarification, 22 Astragalus species representing 93 taxa and 4 Oxytropis species representing 18 taxa were screened for swainsonine using both liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Swainsonine was detected in 48 Astragalus taxa representing 13 species and 5 Oxytropis taxa representing 4 species. Forty of the fifty-three swainsonine-positive taxa had not been determined to contain swainsonine previously using liquid or gas chromatography coupled with mass spectrometry. The list of swainsonine-containing taxa reported here will serve as a reference for risk assessment and diagnostic purposes.
[Mh] Termos MeSH primário: Astrágalo (Planta)/química
Inibidores Enzimáticos/análise
Manosidases/antagonistas & inibidores
Oxytropis/química
Componentes Aéreos da Planta/química
Swainsonina/análise
Toxinas Biológicas/análise
[Mh] Termos MeSH secundário: Animais
Astrágalo (Planta)/classificação
Astrágalo (Planta)/crescimento & desenvolvimento
Astrágalo (Planta)/toxicidade
Canavalia/enzimologia
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Monitoramento Ambiental
Inibidores Enzimáticos/toxicidade
Cromatografia Gasosa-Espectrometria de Massas
Manosidases/metabolismo
América do Norte
Oxytropis/classificação
Oxytropis/crescimento & desenvolvimento
Oxytropis/toxicidade
Componentes Aéreos da Planta/crescimento & desenvolvimento
Componentes Aéreos da Planta/toxicidade
Intoxicação por Plantas/etiologia
Intoxicação por Plantas/veterinária
Proteínas de Plantas/antagonistas & inibidores
Proteínas de Plantas/metabolismo
Plantas Tóxicas/química
Plantas Tóxicas/classificação
Plantas Tóxicas/crescimento & desenvolvimento
Plantas Tóxicas/toxicidade
Especificidade da Espécie
Swainsonina/toxicidade
Espectrometria de Massas em Tandem
Toxinas Biológicas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Proteins); 0 (Toxins, Biological); EC 3.2.1.- (Mannosidases); RSY4RK37KQ (Swainsonine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160418
[St] Status:MEDLINE


  9 / 92 MEDLINE  
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[PMID]:26865176
[Au] Autor:Tan CJ; Zhao Y; Goto M; Hsieh KY; Yang XM; Morris-Natschke SL; Liu LN; Zhao BY; Lee KH
[Ad] Endereço:Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; College of Chemistry and Environment, Guizhou Minzu University, Guiyang 550025, People's Republic of China. Electronic address: tcj1229@163.com.
[Ti] Título:Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
[So] Source:Bioorg Med Chem Lett;26(5):1495-7, 2016 Mar 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ten alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1.
[Mh] Termos MeSH primário: Alcaloides/química
Alcaloides/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Oxytropis/química
Quinolizinas/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Quinolizines); N390W430AC (matrine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170301
[Lr] Data última revisão:
170301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE


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[PMID]:26214748
[Au] Autor:Wei XL; Lin YB; Xu L; Han MS; Dong DH; Chen WM; Wang L; Wei GH
[Ad] Endereço:State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
[Ti] Título:Bacillus radicibacter sp. nov., a new bacterium isolated from root nodule of Oxytropis ochrocephala Bunge.
[So] Source:J Basic Microbiol;55(10):1212-8, 2015 Oct.
[Is] ISSN:1521-4028
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A Gram-positive, facultative anaerobic, rod-shaped, and endospore-forming strain, designated 53-2(T) was isolated from the root nodule of Oxytropis ochrocephala Bunge growing on Qilian mountain, China. The strain can grow at pH 7.0-8.0, 10-50 °C and tolerate up to 11% NaCl. Optimal growth occurred at pH 7.2 and 37 °C. The result of BLASTn search based on 16S rRNA gene sequence revealed that strain 53-2(T) , being closest related to Bacillus acidicola 105-2(T) , possessed remote similarity (less than 95.64%) to the species within genus Bacillus. The DNA G + C content was 37.8%. Chemotaxonomic data (major quinone is MK-7; major polar lipids are diphosphatidylglycerol, phosphatidylglycerol, unknown phospholipid, and aminoglycophospholipid; fatty acids are anteiso-C15: 0 , iso-C15:0 and anteiso-C17: 0 ) supported the affiliation of the isolate to the genus Bacillus. On the basis of physiological, phylogenetic, and biochemical properties, strain 53-2(T) represents a novel species within genus Bacillus, for which the name Bacillus radicibacter is proposed. The type strain is 53-2(T) (=DSM27302(T) =ACCC06115(T) =CCNWQLS5(T) ).
[Mh] Termos MeSH primário: Bacillus/classificação
Bacillus/isolamento & purificação
Oxytropis/microbiologia
Raízes de Plantas/microbiologia
[Mh] Termos MeSH secundário: Bacillus/genética
Técnicas de Tipagem Bacteriana
Composição de Bases/genética
Parede Celular/química
China
DNA Bacteriano/genética
Ácidos Graxos/análise
Fosfatidilgliceróis/análise
Fosfolipídeos/análise
Filogenia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Cloreto de Sódio/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phosphatidylglycerols); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150923
[Lr] Data última revisão:
150923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE
[do] DOI:10.1002/jobm.201400940



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