Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.694 [Categoria DeCS]
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[PMID]:15556497
[Au] Autor:Zhao B; Moochhala SM; Tham SY
[Ad] Endereço:Centre for Biomedical Sciences, Defence Medical and Environmental Research Institute, DSO National Laboratories (DMERI @ DSO), 27 Medical Drive, #09-01, Singapore 117510, Republic of Singapore. zbin@dso.org.sg
[Ti] Título:Biologically active components of Physostigma venenosum.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;812(1-2):183-92, 2004 Dec 05.
[Is] ISSN:1570-0232
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Physostigmine is a major alkaloid found in the seeds of the fabaceous plant Physostigma venenosum. It is a powerful and reversible acetylcholine esterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. It exerts its cholinesterase inhibitor effect in both the periphery and central nervous system. Many studies on physostigmine have involved the reliance on techniques that extract and quantify physostigmine in biological samples. This paper presents an overview of the currently applied methodologies for the determination of physostigmine and its metabolites in various biological samples. Papers published from January 1980 to December 2003 were taken into consideration for the discussion of the metabolism and analytical method of physostigmine. HPLC methods have been discussed and used in most of the references cited in this review. A few CE and RIA methods that have been recently reported are also mentioned in this paper. Basic information about the sample assayed, sample preparation, chromatographic column, mobile phase, detection mode and validation data are summarized in a table.
[Mh] Termos MeSH primário: Physostigma/química
[Mh] Termos MeSH secundário: Cromatografia em Camada Delgada/métodos
Eletroforese/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:0504
[Cu] Atualização por classe:051116
[Lr] Data última revisão:
051116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041124
[St] Status:MEDLINE


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[PMID]:11858744
[Au] Autor:Morales-Ríos MS; Santos-Sánchez NF; Joseph-Nathan P
[Ad] Endereço:Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado 14-740, México, DF, 07000 México.
[Ti] Título:Efficient formal total synthesis of physostigmine and physovenine: conformational analysis of key intermediates.
[So] Source:J Nat Prod;65(2):136-41, 2002 Feb.
[Is] ISSN:0163-3864
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An efficient route for the formal total synthesis of physostigmine (1) and physovenine (2), alkaloids from 5-methoxyindole-3-acetonitrile, through a Grignard reagent 1,4-addition, is described. 2-Hydroxyindolenine 5, the key advanced intermediate for the synthetic targets, was converted either to esermethole (12) via a high-yielding (28%) seven-step sequence or to the C-ring oxygenated analogue 15 in a five-step sequence and 23% overall yield. (1)H NMR and molecular modeling analyses of esermethole (12) and the furoindolines 13 and 15 were used to deconvolute weighted time-average vicinal coupling constants to provide definite solution-state conformational preferences in CD(2)Cl(2) solvent.
[Mh] Termos MeSH primário: Alcaloides de Indol/isolamento & purificação
Physostigma/química
Fisostigmina/análogos & derivados
Fisostigmina/síntese química
[Mh] Termos MeSH secundário: Fabaceae/química
Alcaloides de Indol/química
Modelos Químicos
Conformação Molecular
Ressonância Magnética Nuclear Biomolecular
Fisostigmina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indole Alkaloids); 6091-05-0 (physovenine); 9U1VM840SP (Physostigmine)
[Em] Mês de entrada:0204
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020223
[St] Status:MEDLINE



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