Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.710 [Categoria DeCS]
Referências encontradas : 199 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 20 ir para página                         

  1 / 199 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28825980
[Au] Autor:Chen CH; Hwang TL; Chen LC; Chang TH; Wei CS; Chen JJ
[Ad] Endereço:Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Department of Pharmacy, Tajen University, Pingtung, 907, Taiwan.
[Ti] Título:Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia.
[So] Source:Phytochemistry;143:186-193, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The fruits of Psoralea corylifolia, known as Psoraleae Fructus (Buguzhi in Chinese), are traditionally used for the treatment of spermatorrhea, nephritis, asthma, pollakiuria, and various inflammatory diseases. Three previously undescribed isoflavone derivatives, 7-O-methylcorylifol A, 7-O-isoprenylcorylifol A, and 7-O-isoprenylneobavaisoflavone, have been isolated from the fruits of P. corylifolia, together with 9 known compounds. The structures of these compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 7-O-methylcorylifol A and psoralen exhibited potent inhibition (IC values ≤ 10.89 µM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). 7-O-Isoprenylcorylifol A, 7-O-isoprenylneobavaisoflavone, and 12,13-dihydro-12,13-epoxybakuchiol inhibited fMLP/CB-induced elastase release with IC values ≤ 14.30 µM. In addition, 7-O-isoprenylcorylifol A, bakuchiol, 12,13-dihydro-12,13-epoxybakuchiol, and psoralidin showed potent inhibition with IC values ≤ 36.65 µM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Isoflavonas/isolamento & purificação
Isoflavonas/farmacologia
Psoralea/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Benzofuranos
Cumarínicos
Frutas
Seres Humanos
Isoflavonas/química
Lipopolissacarídeos/farmacologia
Camundongos
N-Formilmetionina Leucil-Fenilalanina
Neutrófilos/efeitos dos fármacos
Óxido Nítrico/biossíntese
Ressonância Magnética Nuclear Biomolecular
Elastase Pancreática/antagonistas & inibidores
Fenóis
Fenilalanina
Superóxidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Benzofurans); 0 (Coumarins); 0 (Isoflavones); 0 (Lipopolysaccharides); 0 (Phenols); 11062-77-4 (Superoxides); 31C4KY9ESH (Nitric Oxide); 47E5O17Y3R (Phenylalanine); 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine); EC 3.4.21.36 (Pancreatic Elastase); G16ZUQ069L (psoralidin); OT12HJU3AR (bakuchiol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  2 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28639266
[Au] Autor:Li ZJ; Abulizi A; Zhao GL; Wang T; Zhou F; Jiang ZZ; Aibai S; Zhang LY
[Ad] Endereço:Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China.
[Ti] Título:Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats.
[So] Source:Phytother Res;31(8):1265-1272, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and bakukiol. Bakuchiol (BAK) has antiinflammatory, antipyretic, antibacterial antiviral, anticancer, and estrogenic activity but appears to be hepatotoxic in in vitro tests. This study investigated the hepatotoxicity in vivo in rats. Using intragastrically administered bakuchiol at doses of 52.5 and 262.5 mg/kg for 6 weeks. Bodyweight, relative liver weight, biochemical indicators, histopathology, mRNA expression of CYP7A1, HMG-CoA reductase, BSEP, PPARα, SREBP-2, and MRP3 were measured. Many abnormalities were observed in the bakuchiol-treated groups including suppression of weight gain and food intake, change of some parameters in serum biochemistry, and increased weight of liver. The mRNA expression of CYP7A1, HMG-CoA reductase, PPARα, and SREBP-2 decreased in bakuchiol-treated group, the expression of BSEP increased in bakuchiol-treated low dosage, and the expression of BSEP decreased in bakuchiol-treated high dosage. In conclusion, we provide evidence for the first time that bakuchiol can induce cholestatic hepatotoxicity, suggesting potential hepatotoxicity. The mechanism may be related to effects on liver lipid metabolism, but further investigation is necessary. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia
Fenóis/toxicidade
Extratos Vegetais/toxicidade
Psoralea/toxicidade
[Mh] Termos MeSH secundário: Animais
Colestase/induzido quimicamente
Fabaceae/química
Frutas/química
Fígado/efeitos dos fármacos
Fígado/fisiopatologia
Masculino
Estrutura Molecular
Extratos Vegetais/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts); OT12HJU3AR (bakuchiol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5851


  3 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28602940
[Au] Autor:Jo JH; Kim JH; Lee HS; Jeong GS; Lee JM; Lee S
[Ad] Endereço:BK21 Plus KNU Multi-Omics based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
[Ti] Título:Investigation of pharmacokinetic parameters of bakuchicin isolated from Psoralea corylifolia in mice.
[So] Source:Fitoterapia;120:194-198, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bakuchicin is a furanocoumarin isolated from the seeds of Psoralea corylifolia, which is used in oriental medicine. However, limited information on the pharmacokinetics of bakuchicin is available and in addition, no determined method has been devised to quantify bakuchicin levels in the plasma. In the present study, we developed and validated a quantification method using liquid chromatography (LC) coupled with tandem mass spectrometry (LC-MS/MS), which was applied to a pharmacokinetic investigation in mouse plasma. LC was performed using an ACE 5 C18 column, and a mixture of acetonitrile and water containing 0.1% formic acid was used as the mobile phase at a flow rate of 220µL/min. Bakuchicin transition ions in multiple reaction-monitoring modes using positive ionization were observed at m/z 187.0 to m/z 131.0. Bakuchicin and the internal standard (reserpine) had retention times of 4.5 and 4.3min, respectively. Acceptable linearity (r =0.996) was observed over the concentration range of 20-1000ng/mL, with a lower quantification limit of 20ng/mL in mouse plasma. This method was successfully applied to determine the pharmacokinetic parameters of bakuchicin in mouse plasma and showed that the bioavailability of bakuchicin was 58.3% at 5mg/kg oral administration.
[Mh] Termos MeSH primário: Compostos Heterocíclicos com 3 Anéis/farmacocinética
Plasma/química
Psoralea/química
[Mh] Termos MeSH secundário: Administração Intravenosa
Administração Oral
Animais
Disponibilidade Biológica
Cromatografia Líquida
Masculino
Camundongos
Camundongos Endogâmicos ICR
Sementes/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heterocyclic Compounds, 3-Ring); 0 (bakuchicin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  4 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28069007
[Au] Autor:Zarmouh NO; Eyunni SK; Soliman KF
[Ad] Endereço:College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, 32307, USA.
[Ti] Título:The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor.
[So] Source:BMC Complement Altern Med;17(1):34, 2017 Jan 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Monoamine oxidase-B (MAO-B) inhibitors are widely used in the treatment of Parkinson's disease. They increase vital monoamine neurotransmitters in the brain. However, there is a need for safer natural reversible MAO inhibitors with MAO-B selectivity. Our previous studies showed that Psoralea corylifolia seeds (PCS) extract contains compounds that inhibit monoamine oxidase-B. METHODS: In this study, six of PCS constituents sharing a benzopyrone structure were investigated. The compounds Biochanin-A (BIO-A), isopsoralen, 6-prenylnaringenin, neobavaisoflavone, psoralen, and psoralidin, were tested for their ability to inhibit recombinant human MAO-A and B (hMAO-A and hMAO-B) isozymes. The ability of these compounds to inhibit MAO-A and MAO-B were compared to that of PCS ethanolic extract (PCSEE) using spectrophotometric assays and confirmed by luminescence assays. The highly potent and selective MAO-B inhibitor, BIO-A, was further investigated for both isozymes reversibility and enzyme kinetics. Molecular docking studies were used to predict the bioactive conformation and molecular interactions of BIO-A with both isozymes. RESULTS: The data obtained indicate that benzopyrones inhibited hMAO-A and hMAO-B with different degrees as confirmed with the luminescence assay. BIO-A inhibited hMAO-B with high potency and selectivity in the present study (IC = 0.003 µg/mL) and showing 38-fold more selectivity than PCSEE (hMAO-B IC = 3.03 µg/mL, 17-fold selectivity) without affecting hydrogen peroxide. Furthermore, BIO-A reversibly and competitively inhibited both hMAOs with significantly lower inhibitory constant (K ) in hMAO-B (3.8 nM) than hMAO-A (99.3 nM). Our docking studies indicated that the H-bonds and hydrophobic interactions at the human MAO-A and MAO-B active sites contributed to the reversibility and selectivity of BIO-A. CONCLUSIONS: The data obtained indicate that BIO-A is a potent, reversible and selective MAO-B inhibitor and may be recommended for further investigation in its possible use in the therapeutic management of Parkinson's and Alzheimer's diseases.
[Mh] Termos MeSH primário: Benzoquinonas/química
Genisteína/química
Inibidores da Monoaminoxidase/química
Monoaminoxidase/química
Extratos Vegetais/química
Psoralea/química
[Mh] Termos MeSH secundário: Ligação Competitiva
Seres Humanos
Cinética
Simulação de Acoplamento Molecular
Estrutura Molecular
Monoaminoxidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Monoamine Oxidase Inhibitors); 0 (Plant Extracts); 3T006GV98U (quinone); DH2M523P0H (Genistein); EC 1.4.3.4 (Monoamine Oxidase); U13J6U390T (biochanin A)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1525-y


  5 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27587300
[Au] Autor:Luo XM; Xie CJ; Wang; Wei YM; Cai J; Cheng SS; Yang X-; Sui A-
[Ad] Endereço:The School of Life Science, Southwest University, Chongqing, 400715, China.
[Ti] Título:Psc-AFP from Psoralea corylifolia L. overexpressed in Pichia pastoris increases antimicrobial activity and enhances disease resistance of transgenic tobacco.
[So] Source:Appl Microbiol Biotechnol;101(3):1073-1084, 2017 Feb.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Psc-AFP, isolated from the seeds of Psoralea corylifolia L., is an antimicrobial protein with trypsin inhibitor activity. Its encoding gene was cloned by 3'- rapid amplification of cDNA ends (RACE) combined with Y-shaped adaptor-dependent extension (YADE) method. The gene Psc-AFP encodes a protein of 203 amino acids with a deduced signal peptide of 24 residues. The growth inhibition effect exerted by the heterologously expressed Psc-AFP in Pichia pastoris revealed that the recombinant Psc-AFP inhibited mycelium growth of Aspergillus niger, Rhizoctonia solani, and Alternaria brassicae and conidial germination of Alternaria alternata. The recombinant Psc-AFP also showed protease inhibitor activity manifested by the inhibition of trypsin. The transgenic tobacco bioassays confirmed that overexpressing Psc-AFP significantly enhanced the disease resistance of tobacco and that some of the transgenic lines were almost fully tolerant to Ralstonia solanacearum and A. alternata, whereas no apparent alteration in plant growth and development was observed. Collectively, these results indicate that the recombinant Psc-AFP is an active antimicrobial protein, with protease inhibitor activity that can be successfully produced in the yeast and tobacco and, therefore, maybe a potential antimicrobial candidate for practical use.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Pichia/genética
Doenças das Plantas/prevenção & controle
Proteínas de Plantas/genética
Proteínas de Plantas/farmacologia
Psoralea/genética
Tabaco/microbiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Antifúngicos/química
Antifúngicos/isolamento & purificação
Aspergillus niger/efeitos dos fármacos
Clonagem Molecular
Biologia Computacional
Resistência à Doença
Plantas Geneticamente Modificadas/genética
Plantas Geneticamente Modificadas/microbiologia
Psoralea/anatomia & histologia
Psoralea/química
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Proteínas Recombinantes/farmacologia
Rhizoctonia/efeitos dos fármacos
Análise de Sequência de Proteína
Tabaco/genética
Tabaco/crescimento & desenvolvimento
Inibidores da Tripsina/química
Inibidores da Tripsina/isolamento & purificação
Inibidores da Tripsina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Proteins); 0 (Recombinant Proteins); 0 (Trypsin Inhibitors)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-016-7768-1


  6 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26669320
[Au] Autor:Kanu SA; Dakora FD
[Ad] Endereço:Crop Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa.
[Ti] Título:Symbiotic functioning, structural adaptation, and subcellular organization of root nodules from Psoralea pinnata (L.) plants grown naturally under wetland and upland conditions in the Cape Fynbos of South Africa.
[So] Source:Protoplasma;254(1):137-145, 2017 Jan.
[Is] ISSN:1615-6102
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:In the Cape Fynbos of South Africa, Psoralea pinnata (L.) plants occur naturally in both wetland and well-drained soils and yet effectively fix N under the two contrasting conditions. In this study, nodule structure and functioning in P. pinnata plants from the two habitats were evaluated using light and transmission electron microscopy (TEM), as well as the N natural abundance technique. The results showed that, structurally, fully developed P. pinnata nodules were spherical in shape with six components (namely, lenticels, periderm, outer cortex, middle cortex, inner cortex, and a central bacteria-infected medulla region). Morphometric analysis revealed 44 and 84 % increase in cell area and volume of wetland nodules compared to those from upland. The percentage area of nodules occupied by the middle cortex in wetland nodules was twice that of upland nodules. As a result, the size of the medulla region in wetland nodules was significantly reduced compared to upland nodules. Additionally, the average area of medulla occupied by intercellular air spaces in wetland nodules was about five times that of upland nodules (about 431 % increase in wetland over upland nodules). TEM data also showed more bacteroids in symbiosomes of upland nodules when compared to wetland nodules. However, isotopic analysis of above-ground plant parts revealed no differences in symbiotic parameters such as N concentration, ∂ N and %Ndfa between wetland and upland P. pinnata plants. These results suggest that, under limiting O conditions especially in wetlands, nodules make structural and functional adjustments to meet the O demands of N -fixing bacteroids.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Psoralea/crescimento & desenvolvimento
Psoralea/microbiologia
Nódulos Radiculares de Plantas/fisiologia
Simbiose
Zonas Úmidas
[Mh] Termos MeSH secundário: Isótopos de Nitrogênio
Psoralea/ultraestrutura
Nódulos Radiculares de Plantas/citologia
Nódulos Radiculares de Plantas/microbiologia
Nódulos Radiculares de Plantas/ultraestrutura
Solo
África do Sul
Frações Subcelulares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Isotopes); 0 (Soil)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151217
[St] Status:MEDLINE
[do] DOI:10.1007/s00709-015-0922-2


  7 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27920496
[Au] Autor:Hussain I; Hussain N; Manan A; Rashid A; Khan B; Bakhsh S
[Ad] Endereço:Department of Dermatology; Department of Pharmacy, SMBB Medical University, Larkana.
[Ti] Título:Fabrication of anti-vitiligo ointment containing : in vitro and in vivo characterization.
[So] Source:Drug Des Devel Ther;10:3805-3816, 2016.
[Is] ISSN:1177-8881
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vitiligo is a repugnant and odious dermatological malady of the time. It has an detrimental impact on the pigmentation of the human skin as a result of the destruction of cutaneous melanocytes. It affects 1%-2% of the population worldwide. Different therapeutic regimens have been deployed to treat vitiligo, but none of them could stand alone to be stated as a perfect cure. Recently, a change has been observed through novel experimental-designed optimization leading to the development of an anti-vitiligo ointment containing (PC) seed powder. AIM: The aim of this study was to explore the clinical outcomes of ointment containing powdered seeds of PC. MATERIALS AND METHODS: Guided by the protocol Response Surface Methodology, 13 formulations of concentration variance of permeation enhancers were prepared. The formulation fulfilling the required criteria (pH; temperature stability tests at 8°C±0.1°C, 25°C±0.1°C and 40°C±0.1°C; and the physical properties such as color, bleeding and rheology) was selected for clinical trials. Fourier transform infrared spectroscopy studies of seed powder of PC and selected formulation of the seed powder were performed. After obtaining informed consents and with prior approval of university and hospital ethical review boards, 20 patients (age range 25-65 years) were included in the present study. Formulations were applied on the affected body parts of patients, and some affected portion of the same patient was taken as control (self-control study design). The pigmentation of white spots of vitiligo was photographically evaluated before, during and after 12 weeks of treatment. Analysis of the measured values was performed using GraphPad Prism version 5 statistical software. A paired sample -test was performed to observe variation between repigmented patches and white patches of self-control. RESULTS: Hydrophilic ointment (10% w/w) prepared with seed powder of PC was fabricated. The ointment was found effective for small circular white lesions of vitiligo as compared to self-control. Pre- and post-treatment differences in the levels of pigmentation were statistically significant ( ≤0.05). CONCLUSION: Ointment containing seed powder of PC could be an effective monotherapy for small circular white lesions of vitiligo.
[Mh] Termos MeSH primário: Candidíase Cutânea/tratamento farmacológico
Candidíase Cutânea/fisiopatologia
Pomadas/farmacologia
Psoralea/química
Vitiligo/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ointments)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


  8 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27548120
[Au] Autor:Kim YJ; Lim HS; Lee J; Jeong SJ
[Ad] Endereço:Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. jinjin0228@kiom.re.kr.
[Ti] Título:Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia.
[So] Source:Molecules;21(8), 2016 Aug 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The seeds of Psoralea corylifolia L. (P. corylifolia), also known as "Bo-Gol-Zhee" in Korea, are used in a traditional herbal medicine for treating various skin diseases. In the present study, we performed quantitative analyses of the seven standard components of P. corylifolia: psoralen, angelicin, neobavaisoflavone, psoralidin, isobavachalcone, bavachinin, and bakuchiol, using high-performance liquid chromatography. We also investigated the neuroprotective and anti-neuroinflammation effects of P. corylifolia and its standard components in the hippocampal cell line HT22 and microglia cell line BV-2. A 70% ethanol extract of P. corylifolia was prepared and the seven standard components were separated using C-18 analytical columns by gradient solvents with acetonitrile and water, and ultraviolet detection at 215, 225 and 275 nm. The analytical method showed high linearity, with a correlation coefficient of ≥0.9999. The amounts of the standard components ranged from 0.74 to 11.71 mg/g. Among the components, bakuchiol (11.71 mg/g) was the most potent phytochemical component of P. corylifolia. Furthermore, we analyzed the inhibitory effects of the components from P. corylifolia to determine the bioactive compound needed to regulate neuronal cell changes. Angelicin, isobavachalcone, and bakuchiol suppressed lipopolysaccharide (LPS)-stimulated nitric oxide production in LPS-treated BV-2 microglia more significantly than did the other components. In HT22 hippocampal cells, neobavaisoflavone and bakuchiol had more potent inhibitory activity against hydrogen peroxide-induced cell death. Taken together of the quantification and efficacy analyses, bakuchiol appeared to be the most potent bioactive phytochemical component of P. corylifolia for the potential treatment of neurodegenerative diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Hipocampo/efeitos dos fármacos
Microglia/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
Psoralea/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Linhagem Celular
Cromatografia Líquida de Alta Pressão/métodos
Hipocampo/citologia
Lipopolissacarídeos/efeitos adversos
Camundongos
Estrutura Molecular
Fármacos Neuroprotetores/química
Óxido Nítrico/metabolismo
Fenóis/química
Fenóis/isolamento & purificação
Fenóis/farmacologia
Extratos Vegetais/química
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Neuroprotective Agents); 0 (Phenols); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); OT12HJU3AR (bakuchiol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


  9 / 199 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27215915
[Au] Autor:Sorty AM; Meena KK; Choudhary K; Bitla UM; Minhas PS; Krishnani KK
[Ad] Endereço:School of Edaphic Stress Management, ICAR-National Institute of Abiotic Stress Management, Baramati, Pune, 413115, Maharashtra, India.
[Ti] Título:Effect of Plant Growth Promoting Bacteria Associated with Halophytic Weed (Psoralea corylifolia L) on Germination and Seedling Growth of Wheat Under Saline Conditions.
[So] Source:Appl Biochem Biotechnol;180(5):872-882, 2016 Nov.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Halotolerant bacteria associated with Psoralea corylifolia L., a luxuriantly growing annual weed in salinity-affected semi-arid regions of western Maharashtra, India were evaluated for their plant growth-promoting activity in wheat. A total of 79 bacteria associated with different parts viz., root, shoot and nodule endophytes, rhizosphere, rhizoplane, and leaf epiphytes, were isolated and grouped based on their habitat. Twelve bacteria isolated for their potential in plant growth promotion were further selected for in vitro studies. Molecular identification showed the presence of the genera Bacillus, Pantoea, Marinobacterium, Acinetobacter, Enterobacter, Pseudomonas, Rhizobium, and Sinorhizobium (LC027447-53; LC027455; LC027457, LC027459, and LC128410). The phylogenetic studies along with carbon source utilization profiles using the Biolog® indicated the presence of novel species and the in planta studies revealed promising results under salinity stress. Whereas the nodule endophytes had minute plant growth-promoting (PGP) activity, the cell free culture filtrates of these strains enhanced seed germination of wheat (Triticum aestivum L). The maximum vigor index was monitored in isolate Y7 (Enterobacter sp strain NIASMVII). Indole acetic acid (IAA) production by the isolates ranged between 0.22 and 25.58 µg mL . This signifies the need of exploration of their individual metabolites for developing next-generation bio-inoculants through co-inoculation with other compatible microbes. This study has potential in utilization of the weed-associated microbiome in terms of alleviation of salinity stress in crop plants.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Germinação
Desenvolvimento Vegetal
Psoralea/microbiologia
Salinidade
Plântulas/crescimento & desenvolvimento
Triticum/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Bactérias/efeitos dos fármacos
Bactérias/isolamento & purificação
Germinação/efeitos dos fármacos
Ácidos Indolacéticos/metabolismo
Desenvolvimento Vegetal/efeitos dos fármacos
Raízes de Plantas/anatomia & histologia
Raízes de Plantas/efeitos dos fármacos
Plantas Daninhas/efeitos dos fármacos
Plantas Daninhas/microbiologia
Plantas Tolerantes a Sal/efeitos dos fármacos
Plantas Tolerantes a Sal/microbiologia
Plântulas/efeitos dos fármacos
Sementes/efeitos dos fármacos
Sementes/crescimento & desenvolvimento
Cloreto de Sódio/farmacologia
Triticum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoleacetic Acids); 451W47IQ8X (Sodium Chloride); 6U1S09C61L (indoleacetic acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE


  10 / 199 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27180332
[Au] Autor:Iannuzzi A; Perucatti A; Genualdo V; Pauciullo A; Melis R; Porqueddu C; Marchetti M; Usai M; Iannuzzi L
[Ad] Endereço:National Research Council (CNR), Institute for Animal Production Systems in Mediterranean Environments (ISPAAM), Laboratory of Animal Cytogenetics and Genetics, Via Argine 1085, 80147 Naples, Italy, alessandra.iannuzzi@cnr.it.
[Ti] Título:Sister chromatid exchange test in river buffalo lymphocytes treated in vitro with furocoumarin extracts.
[So] Source:Mutagenesis;31(5):547-51, 2016 Sep.
[Is] ISSN:1464-3804
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Furocoumarin extracts from Psoralea morisiana, the endemic Sardinian legume species, were tested for their mutagenic potential on river buffalo blood cells. The results obtained performing the sister chromatid exchange (SCE) test in blood cultures of five river buffalo calves (exposure to furocoumarins for 72h) and five cows (exposure to furocoumarins for 3h, in the absence and presence of S9 metabolic activator) are reported. Significant differences in mean values of SCEs were observed in cells of calves compared to control cells (unexposed), but no differences in SCE mean values were found between treated and untreated cells of cows in the presence or absence of S9. SCE mean values were much higher in cells of cows (exposed and control) than in cells of calves. Indeed, in calf cells, SCE mean values/cell (±SD) were 6.66±2.45 in the control and 7.63±3.01, 9.03±3.90, 9.53±3.60 and 9.99±3.41 in treated cells at 50, 100, 200 and 400 µg/ml of furocoumarin extracts, respectively. In cow cells, grown in presence of S9, SCE mean values/cell were 11.49±4.78 and 11.65±5.19 in treated cells at 100 and 200 µg/ml of furocoumarins and 11.66±5.45 in the control. In cow cells grown in absence of S9, SCE mean values were 11.81±6.14 in the control and 12.35±7.09 and 12.01±5.43, respectively, in the presence of 100 and 200 µg/ml of furocoumarins. Despite their higher SCE values in the absence of S9, no statistically significant differences were found when these values were compared with those shown in presence of S9, suggesting no mutagenic action of furocoumarins in cows, at the doses used in this study.
[Mh] Termos MeSH primário: Búfalos/genética
Furocumarinas/toxicidade
Troca de Cromátide Irmã/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Feminino
Furocumarinas/farmacologia
Linfócitos/efeitos dos fármacos
Masculino
Testes de Mutagenicidade
Mutagênicos/farmacologia
Mutagênicos/toxicidade
Psoralea/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furocoumarins); 0 (Mutagens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160516
[St] Status:MEDLINE
[do] DOI:10.1093/mutage/gew022



página 1 de 20 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde