Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.712 [Categoria DeCS]
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[PMID]:28573243
[Au] Autor:Ndhlovu DN; Masika PJ
[Ad] Endereço:Department of Livestock and Pasture Science, University of Fort Hare, P. Bag X 1314, Alice, 5700 RSA, Faculty of Veterinary Science, University of Zimbabwe, MP 167 Mount Pleasant, Harare, Zimbabwe.
[Ti] Título:IN VITRO EFFICACY OF EXTRACTS FROM PLANTS USED BY SMALL-HOLDER FARMERS IN THE TREATMENT OF DERMATOPHILOSIS IN CATTLE.
[So] Source:Afr J Tradit Complement Altern Med;14(2):263-272, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bovine dermatophilosis, an important skin disease of cattle caused by , negatively impacts the livelihoods of small-holder farmers in Zimbabwe. This impact is through, morbidity, loss of draught animal power, costs incurred to manage the disease, losses associated with devalued damaged hides and the resultant culling of some of the affected cattle. Due to the inaccessibility of conventional drugs to manage bovine dermatophilosis, farmers have been reported to use local medicinal plants to manage the disease. The aim of the study was to evaluate the antimicrobial activities of three plants that small-holder farmers in Zimbabwe used to manage bovine dermatophilosis. METHODS: Dried plant materials were ground into powder and extracted individually using, water, 80 % acetone and 80 % methanol. The antimicrobial properties of the plants were evaluated against two Gram-negative and and one Gram-positive reference bacterial strains. They were further evaluated against a field isolate of . The assays used were the disc diffusion, minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). RESULTS: Acetone and methanol extracts had superior inhibitory activities than did those of water. DC extracts had better inhibitory properties with absolute MIC values of 0.156 - 5 mg/ml, L had MIC values in the range 0.156 - 5 mg/ml while that of Thunb, Terveng was 0.156 - 10 mg/ml. was more sensitive to DC average MIC = 0.63 mg/ml than to L average MIC = 1.25 mg/ml and Thunb, Terveng average MIC = 2.08 mg/ml. CONCLUSION: These results suggest the potential antibacterial activities of extracts of the three plants and hence farmers are, in a way, justified in using the plants. Better results (lower MIC) could be obtained by extracting and evaluating pure active compounds of the plants.
[Mh] Termos MeSH primário: Actinobacteria/efeitos dos fármacos
Doenças dos Bovinos/microbiologia
Cissus
Extratos Vegetais/farmacologia
Pterocarpus
Rubiaceae
Dermatopatias/microbiologia
[Mh] Termos MeSH secundário: Actinobacteria/crescimento & desenvolvimento
Criação de Animais Domésticos
Animais
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Etnobotânica
Extratos Vegetais/uso terapêutico
Plantas Medicinais
Dermatopatias/tratamento farmacológico
Dermatopatias/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.28


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[PMID]:28480397
[Au] Autor:Noufou O; Anne-Emmanuelle H; Claude W OJ; Richard SW; André T; Marius L; Jean-Baptiste N; Jean K; Marie-Genevieve DF; Pierre GI
[Ad] Endereço:Département de médecine-pharmacopée traditionnelle/pharmacie (IRSS/CNRST) 03 BP 7192 Ouagadougou 03, Burkina Faso.
[Ti] Título:BIOLOGICAL AND PHYTOCHEMICAL INVESTIGATIONS OF EXTRACTS FROM POIR (FABACEAE) ROOT BARKS.
[So] Source:Afr J Tradit Complement Altern Med;14(1):187-195, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Poir. belonging to Fabacae familly is used as medicinal plant in Burkina Faso's folk medicine. Roots of are used to treat ulcer, stomach ache and inflammatory diseases. The objective of the present study was to carry out phytochemical composition of methanol (MeOH) and dichloromethane (DCM) extracts from roots, to isolate pure compounds, and to evaluate their pharmacological activities. METHODS: Chromatographic fractionation led to the isolation of active components of the extracts. The structures were established by NMR analysis and comparison with data from literature. The anti-inflammatory activity was evaluated using croton oil-induced edema of mice ear as well as the effect of extracts against lipoxygenase and lipid peroxidation was evaluated. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Cupric-reducing antioxidant capacity (CUPRAC) methods were used to evaluate the antioxidant activity of the extracts. RESULTS: Friedelin (1), 3a-hydroxyfriedelan-2-one (2), a-sophoradiol (3) and stigmasterol (4) were isolated from DCM extract and maltol-6- -apiofuranoside-glucopyranoside (5) isolated from MeOH. DCM extract and friedelin, 3a-hydroxyfriedelan-2-one, a-sophoradiol showed a significant anti-inflammatory effect against ear edema. Friedelin (1), α-sophoradiol (3) and maltol-6- -apiofuranoside-glucopyranoside (5) exhibited lipoxygenase inhibition. MeOH extract (100 µg/mL) inhibited lipoxygenase and lipid peroxidation activities at 45.1 ± 3% and 30.7 ± 0.5% respectively. MeOH extract, ethyl acetate fraction and butanol fraction exhibited antioxidant property with both two methods used. CONCLUSION: The results suggested that the extracts and compounds from roots of possessed local anti-inflammatory effect, antioxidant properties and inhibitor effect against lipoxygenase and lipid peroxidation activities.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Compostos Fitoquímicos/administração & dosagem
Extratos Vegetais/administração & dosagem
Pterocarpus/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/administração & dosagem
Antioxidantes/química
Antioxidantes/isolamento & purificação
Edema/tratamento farmacológico
Seres Humanos
Masculino
Camundongos
Estrutura Molecular
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Casca de Planta/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i1.21


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[PMID]:28257483
[Au] Autor:Majeed M; Bani S; Natarajan S; Pandey A; S N
[Ad] Endereço:Sami Labs Limited, Bangalore, Karnataka, India.
[Ti] Título:Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals.
[So] Source:PLoS One;12(3):e0172770, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as per OECD guidelines. 90 day toxicity was conducted in sixty Sprague Dawley rats of each sex (120 rats), grouped into six dosage groups of 0 (control), 0 (control recovery), 20 (low dose), 80 (mid dose), 200 (high dose) and 200 (high dose recovery) mg/kg bwt/day (body weight/day) respectively. For the reproductive toxicity study forty Wistar rats of each sex (80 rats) divided into four dosage groups received 0 (vehicle control), 20 (low dose), 100 (mid dose) and 200 (high dose) mg/kg bwt/day of 3'-HPT respectively for a period of two weeks while pre-mating, mating, on the day before sacrifice, in females during pregnancy and four days of lactation period. Results showed no significant differences in body weight, food intake, absolute organ weight, haematology, with no adverse effects (toxicity) on biochemical values nor any abnormal clinical signs or behavioural changes were observed in any of the control/treatment groups, including reproductive and developmental parameters, gross and histopathological changes. In conclusion, the results suggested a No-Observed-Adverse-Effect-Level (NOAEL) of 200 mg/kg bwt/day in rats after oral administration, implying 3'-HPT did not exhibit any toxicity under the study conditions employed.
[Mh] Termos MeSH primário: Lactação/efeitos dos fármacos
Extratos Vegetais/efeitos adversos
Reprodução/efeitos dos fármacos
Estilbenos/efeitos adversos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal
Relação Dose-Resposta a Droga
Ingestão de Alimentos/efeitos dos fármacos
Feminino
Seres Humanos
Lactação/fisiologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Gravidez
Pterocarpus/química
Ratos
Reprodução/fisiologia
Estilbenos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3'-hydroxypterostilbene); 0 (Plant Extracts); 0 (Stilbenes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172770


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[PMID]:27836749
[Au] Autor:Singh P; Arora D; Shukla Y
[Ad] Endereço:Environmental Carcinogenesis & Proteomics Laboratory, Food, Drug & Chemical Toxicology Area, Vishvigyan Bhawan 31, Mahatma Gandhi Marg, PO Box 80, Lucknow, 226001, Uttar Pradesh, India.
[Ti] Título:Enhanced chemoprevention by the combined treatment of pterostilbene and lupeol in B[a]P-induced mouse skin tumorigenesis.
[So] Source:Food Chem Toxicol;99:182-189, 2017 Jan.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study is aimed to evaluate the inhibitory effect of the combination of two phytochemicals; pterostilbeneand lupeol (generally obtained from blue berries, grapes, white cabbage, green pepper, olive and mangoes) on mouse skin tumorigenesis. We hypothesized that the concomitant topical treatment of selected phytochemicals would lead to improved impediment of skin cancer. Swiss albino mice (n = 25) received a topical dose of Benzo[a]pyrene (B[a]P, 5 µg/animal) with pre/post application of pterostilbene (16 µM/0.2 ml acetone/animal) and/or lupeol (500 µM/0.2 ml acetone/animal) for 32 weeks. Results showed that pterostilbene and/or lupeol treatment resulted in a significant delay in onset of tumorigenesis. However, a more promising effect on tumor suppression was noted with the combination of both the phytochemicals. A significant reduction in average tumor volume, cumulative number of tumors and tumor multiplicity was recorded in combination treated group. The histopathological analysis illustrated the marked suppression in epidermal hyperplasia and necrotic cells in combination treated groups. Our study suggests that the combination of pterostilbene and lupeol was more effective in prevention of skin cancer as compared to either of the phytochemical alone. Therefore, the combined treatment of phytochemicals has better potential to prevent skin carcinogenesis.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Benzo(a)pireno/toxicidade
Transformação Celular Neoplásica/efeitos dos fármacos
Triterpenos Pentacíclicos/farmacologia
Neoplasias Cutâneas/prevenção & controle
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Anti-Inflamatórios/administração & dosagem
Benzo(a)pireno/administração & dosagem
Ciclo Celular/efeitos dos fármacos
Transformação Celular Neoplásica/induzido quimicamente
Transformação Celular Neoplásica/patologia
Dano ao DNA/efeitos dos fármacos
Citometria de Fluxo
Técnicas Imunoenzimáticas
Masculino
Camundongos
Triterpenos Pentacíclicos/administração & dosagem
Pterocarpus/química
Neoplasias Cutâneas/induzido quimicamente
Neoplasias Cutâneas/patologia
Estilbenos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Pentacyclic Triterpenes); 0 (Stilbenes); 26R60S6A5I (pterostilbene); 3417WMA06D (Benzo(a)pyrene); O268W13H3O (lupeol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


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[PMID]:27788477
[Au] Autor:Saliu JA; Oboh G; Omojokun OS; Rocha JBT; Schetinger MR; Guterries J; Stefanello N; Carvalho F; Schmatz R; Morsch VM; Boligon A
[Ad] Endereço:Department of Biochemistry, Adekunle Ajasin University, P.M.B. 001, Akungba Akoko, Ondo State, Nigeria; Functional Foods, Nutraceuticals and Phytomedine Unit, Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria.
[Ti] Título:Effect of dietary supplementation of Padauk (Pterocarpus soyauxii) leaf on high fat diet/streptozotocin induced diabetes in rats' brain and platelets.
[So] Source:Biomed Pharmacother;84:1194-1201, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study investigated the effects of Padauk leaf on brain malondialdehyde (MDA) content, acetylcholinesterase (AChE) activities, ectonucleotidases and adenosine deaminase (ADA) activities in the platelet of high fat diet and streptozotocin (STZ)-induced diabetic rats. METHODS: The animals were divided into six groups (n=7): normal control rats; diabetic rats+high fat diet (HFD); diabetic rats+HFD+Metformin; diabetic rats+HFD+acarbose; diabetic rats+HFD+10% Padauk leaf; normal rats+basal diet+10% Padauk leaf. After 30days of experiment comprising of acclimatization, dietary manipulation, pre-treatment with STZ and supplementation with Padauk leaf, the animals were sacrificed and the rats' brain and blood were collected for subsequent analysis. RESULTS: The results demonstrated that the elevated MDA content and AChE activity in the diabetic rats were significantly reduced when compared with the control rats. Furthermore, the increased NTPDases, 5'-nucleotidase and ADA activities in the diabetic rats were significantly reduced when compared with the control rats. CONCLUSION: This study demonstrated that Padauk leaf exhibited modulatory effects on purinergic and cholinergic enzymes involved in the prevention of platelet abnormality and consequent vascular complications in diabetic state.
[Mh] Termos MeSH primário: Plaquetas/patologia
Encéfalo/patologia
Diabetes Mellitus Experimental/tratamento farmacológico
Suplementos Nutricionais
Extratos Vegetais/sangue
Extratos Vegetais/uso terapêutico
Folhas de Planta/química
Pterocarpus/química
[Mh] Termos MeSH secundário: 5'-Nucleotidase/metabolismo
Acetilcolinesterase/metabolismo
Adenosina Desaminase/metabolismo
Animais
Plaquetas/efeitos dos fármacos
Plaquetas/enzimologia
Encéfalo/efeitos dos fármacos
Encéfalo/enzimologia
Cromatografia Líquida de Alta Pressão
Diabetes Mellitus Experimental/patologia
Dieta Hiperlipídica
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Malondialdeído/metabolismo
Fenóis/análise
Extratos Vegetais/farmacologia
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 4Y8F71G49Q (Malondialdehyde); 5W494URQ81 (Streptozocin); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.3.5 (5'-Nucleotidase); EC 3.5.4.4 (Adenosine Deaminase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE


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[PMID]:27710898
[Au] Autor:Bulle S; Reddy VD; Hebbani AV; Padmavathi P; Challa C; Puvvada PK; Repalle E; Nayakanti D; Aluganti Narasimhulu C; Nallanchakravarthula V
[Ad] Endereço:Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515 003, Andhra Pradesh, India.
[Ti] Título:Nephro-protective action of P. santalinus against alcohol-induced biochemical alterations and oxidative damage in rats.
[So] Source:Biomed Pharmacother;84:740-746, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats. A significant decrease in plasma electrolytes and mineral levels with increased kidney thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx) levels was also observed. PSE treatment to alcohol-administered rats effectively prevented the elevation in TBARS and NOx levels. Decreased activity of Na /K -ATPase in alcohol administered rats was brought to near normal levels with treatment of PSE. Chronic alcohol consumption affects antioxidant enzymatic activity and reabsorption function of the kidney which is evident from the decreased level of GSH as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione s-transferase (GST). However, treatment with PSE to alcohol-administered rats significantly enhanced these enzymatic activities and reduced glutathione (GSH) content close to normal level. Alcohol-induced organ damage was evident from morphological changes in the kidney. Nevertheless, administration of PSE effectively restored these morphological changes to normal. The flavonoid and tannoid compounds might have protective activity against alcohol-induced oxidative/nitrosative stress mediated kidney damage.
[Mh] Termos MeSH primário: Etanol/toxicidade
Nefropatias/metabolismo
Nefropatias/prevenção & controle
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Pterocarpus
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Etanol/administração & dosagem
Nefropatias/induzido quimicamente
Masculino
Estresse Oxidativo/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/farmacologia
Substâncias Protetoras/uso terapêutico
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); 0 (Pterocarpus santalinus extract); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE


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[PMID]:27544549
[Au] Autor:Bulle S; Reddy VD; Padmavathi P; Maturu P; N Ch V
[Ad] Endereço:Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515 003, AP, India.
[Ti] Título:Modulatory role of Pterocarpus santalinus against alcohol-induced liver oxidative/nitrosative damage in rats.
[So] Source:Biomed Pharmacother;83:1057-1063, 2016 Oct.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Pterocarpus santalinus, a traditional medicinal plant has shown protective mechanisms against various complications. The aim of the present study is to evaluate therapeutic efficacy of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced oxidative/nitrosative stress leading to hepatotoxicity. In-vitro studies revealed that PSE possess strong DPPH (1,1-diphenyl-2-picryl hydrazyl) and nitric oxide radical scavenging activity. For in vivo studies male albino Wistar rats were treated with 20% alcohol (5g/kg b.wt/day) and PSE (250mg/kg b.wt/day) for 60days. Results showed that alcohol administration significantly altered plasma lipid profile with marked increase in the levels of plasma transaminases (ALT and AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transferase (γGT). Moreover, lipid peroxides, nitric oxide (NOx) levels in plasma and liver were increased with increased iNOS protein expression in liver was noticed in alcohol administered rats and these levels were significantly brought back close to normal level by PSE administration except iNOS protein expression. Alcohol administration also decreased the content of reduced glutathione (GSH) and activities of glutathione peroxidase (GPx), glutathione-s transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) in liver, which were significantly enhanced by administration of PSE. The active compounds pterostilbene, lignan and lupeols present in PSE might have shown protection against alcohol-induced hepatic damage by possibly reducing the rate of lipid peroxidation, NOx levels and increasing the antioxidant defence mechanism in alcohol administered rats. Both biochemical and histopathological results in the alcohol-induced liver damage model emphasize beneficial action of PSE as a hepatoprotective agent.
[Mh] Termos MeSH primário: Fígado/patologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Pterocarpus/química
[Mh] Termos MeSH secundário: Álcoois/administração & dosagem
Animais
Antioxidantes/metabolismo
Aspartato Aminotransferases/sangue
Depuradores de Radicais Livres/farmacologia
Glutationa/metabolismo
Lipídeos/sangue
Lipoproteínas/sangue
Fígado/efeitos dos fármacos
Fígado/enzimologia
Masculino
Nitrosação/efeitos dos fármacos
Oxirredução
Extratos Vegetais/química
Ratos Wistar
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Madeira/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Lipids); 0 (Lipoproteins); 0 (Plant Extracts); 0 (Thiobarbituric Acid Reactive Substances); EC 2.6.1.1 (Aspartate Aminotransferases); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160822
[St] Status:MEDLINE


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[PMID]:27124243
[Au] Autor:Gosetti F; Chiuminatto U; Martinotti S; Bolfi B; Ranzato E; Manfredi M; Marengo E
[Ad] Endereço:University of Piemonte Orientale, Department of Science and Technological Innovation, Alessandria, Italy.
[Ti] Título:Characterization of the Volatile and Nonvolatile Fractions of Heartwood Aqueous Extract from Pterocarpus marsupium and Evaluation of Its Cytotoxicity against Cancer Cell Lines.
[So] Source:Planta Med;82(14):1295-301, 2016 Sep.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pterocarpus marsupium is a well-known plant due to its healing properties, in particular, the use of its aqueous extract is able to reduce blood sugar levels and blood triglyceride concentrations. Although this plant has already been widely studied, a complete characterization of its aqueous extract has not been reported. The present study deals with the characterization of the aqueous extract of P. marsupium in order to obtain a full fingerprint of the volatile and nonvolatile constituents. The volatile constituents were identified by CG-MS, whereas the nonvolatile fraction was characterized by UHPLC-MS/MS using a nontarget approach. Several compounds were identified, in particular, polyphenolic species belonging to the class of proanthocyanidins. Cytotoxicity tests were carried out on four different cancer cell lines and three different non-tumoral cell lines. Preliminary results indicate a selective cytotoxicity of the aqueous extract towards the cancer cells. The potential cytotoxicity due to the presence of metals in the aqueous extract was ruled out by testing an aqueous mixture of the metals at the same concentration found in the P. marsupium extract.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Extratos Vegetais/farmacologia
Pterocarpus/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Células HeLa
Seres Humanos
Camundongos
Extratos Vegetais/química
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-104659


  9 / 93 MEDLINE  
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[PMID]:26943486
[Au] Autor:Cha HS; Kim WJ; Lee MH; Kim SY; Kim SH; Lee KH; Kim TJ
[Ad] Endereço:a Division of Biological Science and Technology , College of Science and Technology, Yonsei University , Wonju , Korea.
[Ti] Título:Inhibitory effect of Pterocarpus indicus Willd water extract on IgE/Ag-induced mast cell and atopic dermatitis-like mouse models.
[So] Source:Biosci Biotechnol Biochem;80(5):911-9, 2016 May.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pterocarpus indicus Willd has been widely used as a traditional medicine to treat edema, cancer, and hyperlipidemia, but its antiallergic properties and underlying mechanisms have not yet been studied. The purpose of this study was to evaluate the antiallergic activity of Pterocarpus indicus Willd water extract (PIW) using activated mast cells and an atopic dermatitis (AD)-like mouse model. PIW decreased IgE/Ag-induced mast cell degranulation and the phosphorylation of Syk and downstream signaling molecules such as PLC-γ, Akt, Erk 1/2, JNK compared to stimulated mast cells. In DNCB-induced AD-like mice, PIW reduced IgE level in serum, as well as AD-associated scratching behavior and skin severity score. These results indicate that PIW inhibits the allergic response by reducing mast cell activation and may have clinical potential as an antiallergic agent for disorders such as AD.
[Mh] Termos MeSH primário: Antialérgicos/farmacologia
Dermatite Atópica/tratamento farmacológico
Imunoglobulina E/sangue
Mastócitos/efeitos dos fármacos
Pterocarpus/química
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Degranulação Celular/efeitos dos fármacos
Dermatite Atópica/induzido quimicamente
Dermatite Atópica/imunologia
Dermatite Atópica/patologia
Dinitroclorobenzeno
Modelos Animais de Doenças
Regulação da Expressão Gênica
Irritantes
MAP Quinase Quinase 4/genética
MAP Quinase Quinase 4/imunologia
Masculino
Mastócitos/imunologia
Mastócitos/patologia
Camundongos
Camundongos Endogâmicos ICR
Proteína Quinase 1 Ativada por Mitógeno/genética
Proteína Quinase 1 Ativada por Mitógeno/imunologia
Proteína Quinase 3 Ativada por Mitógeno/genética
Proteína Quinase 3 Ativada por Mitógeno/imunologia
Fosfolipase C gama/genética
Fosfolipase C gama/imunologia
Fosforilação/efeitos dos fármacos
Extratos Vegetais/química
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/imunologia
Transdução de Sinais
Pele/imunologia
Pele/patologia
Quinase Syk/genética
Quinase Syk/imunologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Irritants); 0 (Plant Extracts); 059QF0KO0R (Water); 37341-29-0 (Immunoglobulin E); EC 2.7.10.2 (Syk Kinase); EC 2.7.10.2 (Syk protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Mapk1 protein, mouse); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3); EC 2.7.12.2 (MAP Kinase Kinase 4); EC 3.1.4.3 (Phospholipase C gamma); GE3IBT7BMN (Dinitrochlorobenzene)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2015.1135044


  10 / 93 MEDLINE  
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[PMID]:26749811
[Au] Autor:Bhata V; Nayak BS
[Ti] Título:Renoprotective Effects, Protein Thiols and Liver Glycogen Content of Alloxan-induced Diabetic Rats Treated with Different Fractions of Heartwood of Pterocarpus marsupium.
[So] Source:Nat Prod Commun;10(11):1843-6, 2015 Nov.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxidative stress is believed to be a pathogenic factor in the development of diabetic complications. In the present study, we aimed to evaluate the effects of different fractions of heart wood of Pterocarpus marsupium on antioxidant enzyme like protein thiols and also check the efficacy of the extract for the protection of the renal function in alloxan induced diabetic rats. The present study also investigates the levels of liver glycogen which are considered as the best biomarker for assaying the hypoglycemic activity of any drug. Diabetes was induced by administering alloxan dissolved in saline, while the normal control group was given propylene glycol. Diabetes induced animals were randomly assigned into different groups. Blood samples were collected from all the experimental and control groups. Estimation of urea, uric acid and creatinine along with protein thiols was made on day 30 only. At the end, all the animals were sacrificed to collect liver tissue to analyze glycogen content. The 30 days treatment with various extracts (75 mg/kg body wt) significantly lowered protein thiol levels, which probably represents increased utilization for neutralizing free radicals. There was no significant increase in the levels of renal parameters in the extract treated groups which revealed that the employed dose of the extract is nontoxic to the kidney. There was also a significant decrease in the glycogen content in insulin and alcohol-extract treated groups and should be encouraging for the treatment of diabetes mellitus. The extract showed a promising antioxidant effect, as well as hypoglycemic activity, and should be encouraged for the treatment of diabetes.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/metabolismo
Diabetes Mellitus Experimental/tratamento farmacológico
Glicogênio Hepático/metabolismo
Extratos Vegetais/administração & dosagem
Pterocarpus/química
[Mh] Termos MeSH secundário: Aloxano/efeitos adversos
Animais
Glicemia/metabolismo
Diabetes Mellitus Experimental/metabolismo
Seres Humanos
Hipoglicemiantes/administração & dosagem
Masculino
Fitoterapia
Ratos
Ratos Wistar
Compostos de Sulfidrila/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Blood Proteins); 0 (Hypoglycemic Agents); 0 (Liver Glycogen); 0 (Plant Extracts); 0 (Sulfhydryl Compounds); 6SW5YHA5NG (Alloxan)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:160111
[Lr] Data última revisão:
160111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160112
[St] Status:MEDLINE



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