Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.714 [Categoria DeCS]
Referências encontradas : 557 [refinar]
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[PMID]:28886733
[Au] Autor:Chen Z; Yuan Y; Zou X; Hong M; Zhao M; Zhao Y; Liu Y; Li G; Zhu Y; Luo L; Bao B; Bu S
[Ad] Endereço:Division of Nephrology, Ningbo Urology and Nephrology Hospital, 998 Qianhe North Road, Ningbo City, 315192, Zhejiang, People's Republic of China.
[Ti] Título:Radix Puerariae and Fructus Crataegi mixture inhibits renal injury in type 2 diabetes via decreasing of AKT/PI3K.
[So] Source:BMC Complement Altern Med;17(1):454, 2017 Sep 08.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Radix puerariae (RP) is a herbal medicines for diabetes, mainly because of anti-oxidative, insulin resistance and hypoglycemic effect. Fructus crataegi (FC) also possesses strong antioxidant activity in vitro. This study focused on the effects of herbal mixture of RP and FC (RPFC) on renal protection through a diabetic rat model. METHODS: Type 2 Diabetic model was established with high fat diet followed by injecting rats a low dose of STZ (25 mg/kg body weight). Rats were randomly divided into five groups: normal, high fat diet, diabetes mellitus, high fat diet plus RPFC prevention, and RPFC prevention before diabetes mellitus. RPFC was given to rats daily by intragastric gavage. The blood bio-chemical index and renal pathological changes were examined. The later includes hematoxylin and eosin staining, periodic acid schiff staining, and Masson trichrome staining. Protein levels of were determined by Western blot and immunohistochemical staining. mRNA levels were detected by RT-PCR. RESULTS: Rats prevented with RPFC resulted in decreasing blood glucose with corresponding vehicle treated rats. Glomerulus mesangial matrix expansion, renal capsule constriction, and renal tubular epithelial cell edema were less severe following RPFC prevention. Moreover, RPFC prevention reduced protein levels of PI3K, AKT, α-SMA and collagen IV in the kidney of diabetic rats. CONCLUSION: Combined prevention with RPFC may inhibit the PI3K/AKT pathway in the kidney, thereby prevent renal injury in diabetic rats.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/metabolismo
Nefropatias Diabéticas/metabolismo
Medicamentos de Ervas Chinesas/farmacologia
Rim/efeitos dos fármacos
Extratos Vegetais/farmacologia
Pueraria/química
[Mh] Termos MeSH secundário: Animais
Crataegus
Dieta Hiperlipídica
Rim/química
Masculino
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Plant Extracts); 6OM09RPY36 (crataegus extract); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1945-3


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[PMID]:28830209
[Au] Autor:Tan C; Wang A; Liu C; Li Y; Shi Y; Zhou MS
[Ad] Endereço:* Department of Physiology, Jinzhou Medical University, Jinzhou 121001, P. R. China.
[Ti] Título:Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension.
[So] Source:Am J Chin Med;45(6):1169-1184, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Puerarin is an isoflavonoid isolated from the Chinese herb, Kudzu roots (also known as Gegen), which has been widely used for the treatment of hypertensive diseases and diabetic mellitus in traditional Chinese medicine. Dahl salt-sensitive (DS) rat is a genetic model of salt-sensitive hypertension with cardiovascular injury and vascular insulin resistance. Here, we investigated whether puerarin improved vascular insulin resistance and attenuated cardiac and aortic remodeling in salt-sensitive hypertension. DS rats were given a normal (NS) or high salt diet (HS) for five weeks. An additional group of DS rats was pretreated with puerarin and NS for 10 days, then switched to HS plus puerarin for five weeks. HS for five weeks increased systolic blood pressure (SBP), cardiac hypertrophy and fibrosis, and aortic hypertrophy with increased the expression of phosphor-ERK1/2 in the aorta and heart; puerarin attenuated cardiac and aortic hypertrophy, cardiac fibrosis and phosphor-ERK1/2 with a mild reduction in SBP. Hypertensive rats also manifested impairment of acetylcholine- and insulin-mediated vasorelaxation and insulin-mediated Akt and eNOS phosphorylation associated with the activation of NF[Formula: see text]B/TNF[Formula: see text]/JNK pathway. Puerarin improved acetylcholine- and insulin-mediated vasorelaxation and insulin-stimulated Akt/NO signaling with the inhibition of the NF[Formula: see text]B inflammatory pathway. Our results demonstrated that in salt-sensitive hypertension, puerarin improved vascular insulin action with cardiovascular beneficial effects. Our results found that the underlying mechanisms may involve its inhibition of NF[Formula: see text]B/JNK and ERK1/2 pathway. These results suggest that puerarin could be used as a new antihypertensive agent to expand our armamentarium for the prevention and treatment of end-organ damage in individuals with hypertension and metabolic diseases.
[Mh] Termos MeSH primário: Anti-Hipertensivos
Hipertensão/tratamento farmacológico
Hipertensão/fisiopatologia
Resistência à Insulina
Isoflavonas/farmacologia
Isoflavonas/uso terapêutico
Fitoterapia
Pueraria/química
Remodelação Vascular/efeitos dos fármacos
Remodelação Ventricular/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Aorta/patologia
Modelos Animais de Doenças
Fibrose
Hipertensão/patologia
Hipertrofia
Isoflavonas/administração & dosagem
Isoflavonas/isolamento & purificação
Masculino
Miocárdio/patologia
Ratos Endogâmicos Dahl
Cloreto de Sódio na Dieta/administração & dosagem
Sístole/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Isoflavones); 0 (Sodium Chloride, Dietary); Z9W8997416 (puerarin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500641


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[PMID]:28754101
[Au] Autor:Park JY; Kwon YW; Lee SC; Park SD; Lee JH
[Ad] Endereço:College of Korean Medicine, Dongguk University, Goyang, 10326, Republic of Korea.
[Ti] Título:Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages.
[So] Source:BMC Complement Altern Med;17(1):374, 2017 Jul 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: SC-E1 is a novel herbal formula consisting of five oriental medicinal herbs used frequently in traditional herbal medicine for the treatment of inflammatory diseases in Korea. This study examined the effects of SC-E1 on lipopolysaccharide (LPS)-stimulated macrophages and the molecular mechanism involved. METHODS: The cytotoxic effect of the SC-E1 extract was evaluated in RAW 264.7 cells by MTT assay. The effects of SC-E1 on the free radical scavenging and generation of intracellular reactive oxygen species were measured using DPPH and DCFH-DA, respectively. The effects of SC-E1 on the production of pro-inflammatory cytokines, inflammatory mediators, and related products were determined by ELISA and western blotting. The molecular mechanism and the nuclear translocation of nuclear factor-kappa B (NF-κB) and NF-E2-related factor 2 (Nrf2) were examined by western blot analysis and immunocytochemistry. RESULTS: SC-E1 exhibited strong anti-oxidant activity and inhibited LPS-induced NO secretion as well as iNOS expression and the production of pro-inflammatory cytokines, without affecting the cell viability. SC-E1 also suppressed the LPS-induced NF-κB activation and the mitogen-activated protein kinase (MAPK) pathway. Moreover, SC-E1 induced heme oxygenase-1 (HO-1) expression via the nuclear translocation of Nrf2. The inhibitory effects of SC-E1 on the production of pro-inflammatory cytokines were abrogated by treatment with SnPP, an HO-1 inhibitor. CONCLUSION: These results suggest that SC-E1 exerts its anti-oxidant and anti-inflammatory effects through the inhibition of NF-κB and MAPK as well as Nrf2-mediated HO-1 induction in macrophages. These findings provide evidences for SC-E1 to be considered as a new prescription for treating inflammatory diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Heme Oxigenase-1/metabolismo
Inflamação/metabolismo
Magnoliopsida
Proteínas de Membrana/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Compostos de Bifenilo/metabolismo
Citocinas/metabolismo
Fluoresceínas/metabolismo
Gardenia
Glycyrrhiza
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Lipopolissacarídeos
Medicina Tradicional Coreana
Camundongos
NF-kappa B/metabolismo
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/metabolismo
Picratos/metabolismo
Extratos Vegetais/uso terapêutico
Platycodon
Pueraria
Células RAW 264.7
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Cytokines); 0 (Fluoresceins); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, mouse); 0 (Picrates); 0 (Plant Extracts); 2044-85-1 (diacetyldichlorofluorescein); 31C4KY9ESH (Nitric Oxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170730
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1874-1


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[PMID]:28735827
[Au] Autor:Ryuk JA; Lixia M; Cao S; Ko BS; Park S
[Ad] Endereço:Korean Institutes of Oriental Medicine, Daejeon, South Korea.
[Ti] Título:Efficacy and safety of Gegen Qinlian decoction for normalizing hyperglycemia in diabetic patients: A systematic review and meta-analysis of randomized clinical trials.
[So] Source:Complement Ther Med;33:6-13, 2017 Aug.
[Is] ISSN:1873-6963
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: A systematic review and meta-analysis was conducted to evaluate the efficacy and safety of Gegen Qinlian decoction (GQD) for normalizing hyperglycemia in T2DM patients by pooling all available RCTs. METHODS: All relevant RCTs were searched using the keywords: "GQD", "T2DM", "hyperglycemia" and "insulin" from the electronic databases including PubMed, EMBASE, Cochrane Library, Korean databases, Chinese medical databases, and Indian scientific database. Each RCT included the control (metformin) and experimental (GQD+metformin) groups. The outcome measures were the assessments of changes in the severity of diabetic symptoms such as "markedly effective" and "effective" (fasting plasma glucose levels: <7 and 7-9, respectively; 2h postprandial glucose levels: <8.3 and 8.3-10.5mmol/L, respectively) after 8 weeks of treatment in each RCT. RESULTS: There were 186 articles selected from the initial searches and 181 irrelevant and duplicate articles were removed. Finally, 5 relevant RCTs involving 499 patients were included in this review. The meta-analysis showed the odds ratio of favorable GQD effect on the marked effectiveness of glycemia (n=499, OR: 2.34, 95% CI: 1.63-3.37, P<0. In a subgroup analysis by GQD composition, 4 RCTs with original GQD composition also showed the odds ratio of the original GQD effect on the marked effectiveness of glycemia (n=339, OR: 2.58; 95% CI=1.65-4.02, P<0.0001) in comparison to the control group. All five studies used an appropriate method for randomization of the subjects but some of them included allocation concealment and blinding of patients and practitioners. There was no significant publication bias in the meta-analysis. CONCLUSION: The GQD and metformin had a synergistic effect on glycemic control in comparison to metformin alone as a T2DM therapy. More rigorous and larger studies are needed to confirm the therapeutic efficacy of GQD for hyperglycemia due to the moderate to high risk of bias in the 5 RCTs.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Diabetes Mellitus Tipo 2/tratamento farmacológico
Medicamentos de Ervas Chinesas/uso terapêutico
Hiperglicemia/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Magnoliopsida
Fitoterapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Coptis
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/complicações
Medicamentos de Ervas Chinesas/farmacologia
Feminino
Glycyrrhiza
Seres Humanos
Hiperglicemia/sangue
Hiperglicemia/etiologia
Hipoglicemiantes/farmacologia
Masculino
Meia-Idade
Pueraria
Scutellaria baicalensis
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Drugs, Chinese Herbal); 0 (Hypoglycemic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE


  5 / 557 MEDLINE  
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[PMID]:28369558
[Au] Autor:Hoshino K; Adati T; Olson DM; Takasu K
[Ad] Endereço:International Agriculture and Food Studies, Tokyo University of Agriculture, Sakuragaoka 1-1-1, Setagaya-ku, Tokyo 156-8502, Japan (hopppi.jaku23@gmail.com; t3adati@nodai.ac.jp).
[Ti] Título:Seasonal Occurrence and Interspecific Interactions of Egg Parasitoids of Megacopta cribraria (Heteroptera: Plataspidae) in Japan.
[So] Source:Environ Entomol;46(3):487-493, 2017 06 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We conducted a field study to determine seasonal egg parasitism rates of the kudzu bug Megacopta cribraria (F.) on the kudzu plant, Pueraria montana (Lour.) Merr. var. lobata (Willd.) Maesen et Almeida ex Sanjappa and Pradeep, in Tokyo, Japan, during the period from May 2014 to September 2014. The eggs of M. cribraria per 1 m2 of kudzu at four locations in Tokyo were collected weekly and parasitism rates were assessed. Eggs of M. cribraria were laid on the kudzu plant from May to September. Megacopta cribraria eggs were parasitized by two parasitoid species, Paratelenomus saccharalis (Dodd) and Ooencyrtus nezarae Ishii. Paratelenomus saccharalis first appeared in May, and its parasitism rates peaked in July and September. Ooencyrtus nezarae first appeared in June and its parasitism rates peaked in July. Except for one location which could not be statistically analyzed because of the small sample size, occurrence of parasitism by P. saccharalis and O. nezarae in M. cribraria egg masses was independent at one location and positively associated at two locations, suggesting that the use of host egg masses by P. saccharalis and O. nezarae is not mutually exclusive. Parasitism rates by P. saccharalis and O. nezarae were significantly lower for egg masses parasitized by both species than for those parasitized by a single species. The proportion of males among O. nezarae progeny was significantly higher for egg masses parasitized by O. nezarae together with P. saccharalis than for those parasitized by O. nezarae alone. These results suggest that parasitism of host egg masses by the two species is influenced by their interspecific interactions.
[Mh] Termos MeSH primário: Heterópteros/parasitologia
Interações Hospedeiro-Parasita
Vespas/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Heterópteros/crescimento & desenvolvimento
Japão
Masculino
Óvulo/parasitologia
Pueraria/crescimento & desenvolvimento
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx060


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[PMID]:28343876
[Au] Autor:Wang XL; Jiao FR; Yu M; Lin LB; Xiao J; Zhang Q; Wang L; Duan DZ; Xie G
[Ad] Endereço:Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, Shaanxi, PR China. Electronic address: xlwangwang@163.com.
[Ti] Título:Constituents with potent α-glucosidase inhibitory activity from Pueraria lobata (Willd.) ohwi.
[So] Source:Bioorg Med Chem Lett;27(9):1993-1998, 2017 05 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new flavone hydrate named lobatflavate (1), one new chromone named lobatchrosin (2), and one new isoflavone named 3S,4R-tuberosin (3), along with four known isoflavone analogues (4-7), were isolated from the traditional Chinese medicinal plant of Pueraria lobata (Willd.) ohwi. Their structures were elucidated by extensive spectroscopic methods of IR, UV, HR-ESI-MS, 1D and 2D NMR. The absolute configuration of 3 was determined by CD spectrum associated with TD-DFT calculation analysis. All compounds except for 2 were assayed the inhibitory activity against α-glucosidase. Every tested compound was proved to be more active than positive control of acarbose. Of which 1 and 4 showed significant activity with IC value of 1.79µM and 23.01µM (IC of acarbose was 1998.79µM). Enzyme kinetic experiments revealed that 1 was irreversible whereas 4 was reversible and non-competitive α-glucosidase inhibitors. Moreover, structure-activity relationship was discussed and the docking studies of 1, 3 and 4 were also carried out.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Pueraria/química
[Mh] Termos MeSH secundário: Cromonas/química
Cromonas/farmacologia
Flavonas/química
Flavonas/farmacologia
Seres Humanos
Hipoglicemiantes/química
Hipoglicemiantes/farmacologia
Isoflavonas/química
Isoflavonas/farmacologia
Simulação de Acoplamento Molecular
Relação Estrutura-Atividade
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chromones); 0 (Drugs, Chinese Herbal); 0 (Flavones); 0 (Glycoside Hydrolase Inhibitors); 0 (Hypoglycemic Agents); 0 (Isoflavones); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28335679
[Au] Autor:Zhou X; Bai C; Sun X; Gong X; Yang Y; Chen C; Shan G; Yao Q
[Ad] Endereço:a Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
[Ti] Título:Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro.
[So] Source:Ren Fail;39(1):423-431, 2017 Nov.
[Is] ISSN:1525-6049
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Puerarin (PR) is an isoflavonoid isolated from the root of the plant Pueraria lobata and has been widely used in traditional Chinese herbal medicine for the treatment of various diseases. Oxidative stress and epithelial cell apoptosis play important roles in the renal fibrotic process. The present study aimed to determine whether or not PR inhibits renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis. In vivo, unilateral ureteral obstruction (UUO) induced renal fibrosis, and epithelial cell apoptosis. A total of 24 mice were randomly assigned to four experimental groups: sham, UUO alone, UUO +50 mg/kg PR, and UUO +100 mg/kg PR. In vitro, 200 µM hydrogen peroxide (H O ) induced epithelial cell apoptosis. The experiments were dived into four groups: control, H O alone, H O +50 µM PR, and H O +100 µM PR. Tubular injury was measured in the renal cortex of the mice through periodic acid-Schiff (PAS) staining, and the extracellular matrix (ECM) was measured through Sirius red (SR), immunohistochemistry (IHC) staining, and Western blot. Renal epithelial cell apoptosis was measured through terminal deoxynucleotidyl transferase-mediated dUTP Nick-End labeling (TUNEL), flow cytometry (FCM), and Hoechst assays. The protein expression of NOX4, caspase3, ERK, P38, and JNK was assessed through Western blot. PAS staining showed that PR decreased renal tubular injury in UUO mice. SR and IHC staining demonstrated that PR decreased the accumulation of ECM. PR treatment significantly inhibited epithelial cell apoptosis according to the results of TUNEL, FCM, Hoechst, and Western blot. Furthermore, NOX4 increased in UUO mice and decreased with PR treatment. H O -derived oxidative stress activated epithelial apoptosis and mitogen-activated protein kinases (MAPK), and PR treatment significantly reversed it. These results suggest that PR treatment ameliorates renal fibrosis by inhibiting oxidative stress induced-epithelial cell apoptosis through MAPK signaling.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Células Epiteliais/efeitos dos fármacos
Isoflavonas/farmacologia
Rim/efeitos dos fármacos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Caspase 3/metabolismo
Medicamentos de Ervas Chinesas/administração & dosagem
Células Epiteliais/patologia
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Fibrose
Citometria de Fluxo
Peróxido de Hidrogênio
Marcação In Situ das Extremidades Cortadas
Isoflavonas/administração & dosagem
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Rim/citologia
Rim/patologia
Túbulos Renais
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Proteínas Quinases Ativadas por Mitógeno
NADPH Oxidase 4
NADPH Oxidases/metabolismo
Estresse Oxidativo
Pueraria/química
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Isoflavones); BBX060AN9V (Hydrogen Peroxide); EC 1.6.3.- (NADPH Oxidase 4); EC 1.6.3.- (NADPH Oxidases); EC 1.6.3.- (Nox4 protein, mouse); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.4.22.- (Casp3 protein, mouse); EC 3.4.22.- (Caspase 3); Z9W8997416 (puerarin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1080/0886022X.2017.1305409


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[PMID]:28264481
[Au] Autor:Kim JH; Woo JH; Kim HM; Oh MS; Jang DS; Choi JH
[Ad] Endereço:Department of Life and Nanopharamceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea. hyemi586@gmail.com.
[Ti] Título:Anti-Endometriotic Effects of Pueraria Flower Extract  in Human Endometriotic Cells and Mice.
[So] Source:Nutrients;9(3), 2017 Feb 28.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Pueraria flowers have been used as a vegetable and an ingredient for tea and jelly. In this study, we investigated the effects of Pueraria flower extract (PFE) on endometriosis, a common gynaecological disease characterised by local sterile inflammation of peritoneal cavity. PFE suppressed the adhesion of human endometriotic cells 11Z and 12Z to human mesothelial Met5A cells. In addition, PFE significantly inhibited the migration of 11Z and 12Z cells as shown by woundhealing and transwell migration assays. PFE reduced the protein and mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 in endometriotic cells. Moreover, extracellular signalregulated kinase (ERK)1/2 was activated by PFE treatment, and an ERK1/2 inhibitor, PD98059, significantly inhibited PFE-inhibited cell migration in endometriotic cells. Furthermore, PFE significantly suppressed endometriotic lesion formation in a mouse model. These data suggest that Pueraria flower is a potential anti-endometriotic agent for the inhibition of endometriotic cell adhesion, migration, and MMP expression.
[Mh] Termos MeSH primário: Endometriose/tratamento farmacológico
Endométrio/efeitos dos fármacos
Flores/química
Extratos Vegetais/farmacologia
Pueraria/química
[Mh] Termos MeSH secundário: Animais
Adesão Celular/efeitos dos fármacos
Linhagem Celular
Movimento Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Regulação para Baixo
Endométrio/citologia
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/genética
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Feminino
Flavonoides/farmacologia
Seres Humanos
Metaloproteinase 2 da Matriz/genética
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/genética
Metaloproteinase 9 da Matriz/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one); 0 (Flavonoids); 0 (Plant Extracts); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 3.4.24.24 (MMP2 protein, human); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28254024
[Au] Autor:Huang Q; Zhang H; Xue D
[Ad] Endereço:Department of Pharmacognosy, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.
[Ti] Título:Enhancement of antioxidant activity of Radix Puerariae and red yeast rice by mixed fermentation with Monascus purpureus.
[So] Source:Food Chem;226:89-94, 2017 Jul 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, a new functional food combined Radix Puerariae and red yeast rice was explored. The pigment intensity, antioxidant activities and the main isoflavones of it were evaluated and compared with traditional red yeast rice and Radix Puerariae. The fermented mixture showed higher contents of isoflavones and pigment intensities than red yeast rice and Radix Puerariae. The DPPH, OH, FRAP and total antioxidant activity results of fermented mixture also showed higher antioxidant potential than those of Radix Puerariae and red yeast rice, owing to the higher pigment intensity and total phenolic contents. It is concluded that the fermented mixture of Radix Puerariae and rice could be widely used as a source of polyphenols with high antioxidative potential, thus introducing numerous health benefits for the consumer.
[Mh] Termos MeSH primário: Produtos Biológicos/química
Monascus/química
Raízes de Plantas/química
Pueraria/química
[Mh] Termos MeSH secundário: Antioxidantes
Fermentação
Isoflavonas
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biological Products); 0 (Isoflavones); 0 (red yeast rice)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


  10 / 557 MEDLINE  
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[PMID]:28243356
[Au] Autor:Anilkumar K; Reddy GV; Azad R; Yarla NS; Dharmapuri G; Srivastava A; Kamal MA; Pallu R
[Ad] Endereço:School of Life Sciences, University of Hyderabad, Hyderabad 500046, India; National Institute of Animal Biotechnology, Hyderabad 500049, India.
[Ti] Título:Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of .
[So] Source:Oxid Med Cell Longev;2017:5498054, 2017.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammation is the major causative factor of different diseases such as cardiovascular disease, diabetes, obesity, osteoporosis, rheumatoid arthritis, inflammatory bowel disease, and cancer. Anti-inflammatory drugs are often the first step of treatment in many of these diseases. The present study is aimed at evaluating the anti-inflammatory properties of isoorientin, a selective cyclooxygenase-2 (COX-2) inhibitor isolated from the tubers of , in vitro on mouse macrophage cell line (RAW 264.7) and in vivo on mouse paw edema and air pouch models of inflammation. Isoorientin reduced inflammation in RAW 264.7 cell line in vitro and carrageenan induced inflammatory animal model systems in vivo. Cellular infiltration into pouch tissue was reduced in isoorientin treated mice compared to carrageenan treated mice. Isoorientin treated RAW 264.7 cells and animals showed reduced expression of inflammatory proteins like COX-2, tumor necrosis factor- (TNF- ), interleukin-6 (IL-6), 5-lipoxygenase (5-LOX), and interleukin 1- (IL-1- ) both in vitro and in vivo. The antioxidant enzyme levels of catalase and GST were markedly increased in isoorientin treated mice compared to carrageenan treated mice. These results suggest that isoorientin, a selective inhibitor of COX-2, not only exerts anti-inflammatory effects in LPS induced RAW cells and carrageenan induced inflammatory model systems but also exhibits potent antioxidant properties.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Edema/tratamento farmacológico
Inflamação/tratamento farmacológico
Inflamação/patologia
Luteolina/farmacologia
Extratos Vegetais/farmacologia
Pueraria/química
[Mh] Termos MeSH secundário: Animais
Carragenina/toxicidade
Sobrevivência Celular/efeitos dos fármacos
Citocinas/metabolismo
Edema/induzido quimicamente
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos/metabolismo
Macrófagos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/metabolismo
Tubérculos/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 9000-07-1 (Carrageenan); A37342TIX1 (homoorientin); KUX1ZNC9J2 (Luteolin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1155/2017/5498054



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