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[PMID]:29175017
[Au] Autor:Lim KT; Amanah A; Chear NJ; Zahari Z; Zainuddin Z; Adenan MI
[Ad] Endereço:Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Blok 5-A, Halaman Bukit Gambir, 11700 Penang, Malaysia.
[Ti] Título:Inhibitory effects of (+)-spectaline and iso-6-spectaline from Senna spectabilis on the growth and ultrastructure of human-infective species Trypanosoma brucei rhodesiense bloodstream form.
[So] Source:Exp Parasitol;184:57-66, 2018 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In our ongoing work searching for new trypanocidal lead compounds from Malaysian plants, two known piperidine alkaloids (+)-spectaline (1) and iso-6-spectaline (2) were isolated from the leaves of Senna spectabilis (sin. Cassia spectabilis). Analysis of the H and C NMR spectra showed that 1 and 2 presented analytical and spectroscopic data in full agreement with those published in the literature. All compounds were screened in vitro against Trypanosoma brucei rhodesiense in comparison to the standard drug pentamidine. Compound 1 and 2 inhibited growth of T. b. rhodesiense with an IC value of 0.41 ± 0.01 µM and 0.71 ± 0.01 µM, without toxic effect on L6 cells with associated a selectivity index of 134.92 and 123.74, respectively. These data show that piperidine alkaloids constitute a class of natural products that feature a broad spectrum of biological activities, and are potential templates for the development of new trypanocidal drugs. To our knowledge, the compounds are being reported for the first time to have inhibitory effects on T. b. rhodesiense. The ultrastructural alterations in the trypanosome induced by 1 and 2, leading to programmed cell death were characterized using electron microscopy. These alterations include wrinkling of the trypanosome surface, formation of autophagic vacuoles, disorganization of kinetoplast, and swelling of the mitochondria. These findings evidence a possible autophagic cell death.
[Mh] Termos MeSH primário: Piperidinas/farmacologia
Senna (Planta)/química
Tripanossomicidas/farmacologia
Trypanosoma brucei rhodesiense/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bioensaio
Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
Linhagem Celular
Seres Humanos
Concentração Inibidora 50
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Mioblastos Esqueléticos/efeitos dos fármacos
Piperidinas/isolamento & purificação
Piperidinas/toxicidade
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Extratos Vegetais/toxicidade
Folhas de Planta/química
Espectroscopia de Prótons por Ressonância Magnética
Ratos
Senna (Planta)/classificação
Tripanossomicidas/isolamento & purificação
Tripanossomicidas/toxicidade
Trypanosoma brucei rhodesiense/crescimento & desenvolvimento
Trypanosoma brucei rhodesiense/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Piperidines); 0 (Plant Extracts); 0 (Trypanocidal Agents); 0 (iso-6-spectaline); 0 (spectaline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28425292
[Au] Autor:Silva GH; Zeraik ML; de Oliveira CM; Teles HL; Trevisan HC; Pfenning LH; Nicolli CP; Young MCM; Mascarenhas YP; Abreu LM; Saraiva AC; Medeiros AI; Bolzani VDS; Araujo AR
[Ad] Endereço:Instituto de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa , Rio Paranaíba, Minas Gerais 38810-000, Brazil.
[Ti] Título:Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis.
[So] Source:J Nat Prod;80(5):1674-1678, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three new isoaigialones, A, B, and C (1-3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum. This is the first report of metabolites produced by an Phaeoacremonium sp., associated with S. spectabilis.
[Mh] Termos MeSH primário: Acetais/isolamento & purificação
Acetais/farmacologia
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Ascomicetos/química
Cladosporium/química
Cetonas/isolamento & purificação
Cetonas/farmacologia
Lactonas/isolamento & purificação
Folhas de Planta/química
Senna (Planta)/química
[Mh] Termos MeSH secundário: Acetais/química
Antifúngicos/química
Cetonas/química
Lactonas/química
Lactonas/metabolismo
Lactonas/farmacologia
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetals); 0 (Antifungal Agents); 0 (Ketones); 0 (Lactones); 0 (aigialone); 0 (isoaigialone A); 0 (isoaigialone B); 0 (isoaigialone C)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00828


  3 / 161 MEDLINE  
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[PMID]:28122565
[Au] Autor:Fidèle N; Joseph B; Emmanuel T; Théophile D
[Ad] Endereço:Department of Biological Sciences, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon. ntchapda71@yahoo.fr.
[Ti] Título:Hypolipidemic, antioxidant and anti-atherosclerogenic effect of aqueous extract leaves of Cassia. occidentalis Linn (Caesalpiniaceae) in diet-induced hypercholesterolemic rats.
[So] Source:BMC Complement Altern Med;17(1):76, 2017 Jan 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hyperlipidemia and oxidative stress are major risk factors for atherosclerosis, and all three are among the most important risk factors for cardiovascular diseases. Cassia occidentalis aqueous extract has been used in African traditional medicine for the treatment of hypertension and associated cardiovascular diseases. This study was undertaken to evaluate the hypolipidemic and anti-atherosclerotic properties of the aqueous extract of the leaves of C. occidentalis in rats with hypercholesterolemia (HC). Sixty Normocholesterolemic (NC) male rats were divided into six groups (n = 10) and fed a high-cholesterol (HC) diet for 30 days (5 groups), or normal rat chow (normal control group). The plant extract was administered to animals at the increasing dose of 240, 320 and 400 mg/kg. After 4 weeks of treatment 5 rats out of 10 were sacrificed, blood samples, aorta, liver, and fresh faecal were collected and processed for biochemical tests. The experiments were conducted under the same conditions with a group of rat treated with Atorvastatin (1 mg/kg), used positive control. The effects of C. occidentalis on weight gain, water and food consumptions, levels of serum lipids and lipoprotein lipid oxidation and stress markers in blood and liver were also examined. RESULTS: A significant body weight gain was observed in general in all the group of animals without any treatment after 4 weeks. During the treatment period, the C. occidentalis extract induced a significant increase (P < 0.01) in water consumption and food intakes. After 4 weeks of treatment with hypercholesterolemia, the body temperature and organ weights including the liver, kidney, heart and the testis did not present any significant change. The administration of C. occidentalis extract significantly (p < 0.05) prevented the elevation in TC, LDL-C, VLDL-C, hepatic and aortic TG and TC. The atherogenic, triglycerides, and lipid peroxidation (TBARS) index were also decreased in the rats treated with the plant extract. C. occidentalis favoured the performance of faecal cholesterol. It also significantly inhibited the changes and the formation of aortic atherosclerotic plaques. CONCLUSION: This study provides evidence of hypolipidemic and antiatherosclerotic effects of C. occidentalis extract. C. occidenntalis aqueous extract reduced bad cholesterols, triglycerides and increasing good cholesterols in rats subjected to a feeding regime enriched with cholesterol. The results support the traditional use of the extract of this plant in the treatment of hypertension and diabetes.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Aterosclerose/prevenção & controle
Hipercolesterolemia/tratamento farmacológico
Hipolipemiantes/uso terapêutico
Lipídeos/sangue
Fitoterapia
Senna (Planta)
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Aterosclerose/patologia
Colesterol na Dieta/efeitos adversos
Colesterol na Dieta/sangue
Dieta
Ingestão de Líquidos/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Hipercolesterolemia/sangue
Hipercolesterolemia/etiologia
Hipolipemiantes/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Masculino
Medicina Tradicional Africana
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Folhas de Planta
Placa Aterosclerótica/prevenção & controle
Ratos Wistar
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholesterol, Dietary); 0 (Hypolipidemic Agents); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1566-x


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[PMID]:28084505
[Au] Autor:Guo X; Li H; Chen H
[Ad] Endereço:Key Laboratory of Tropical Agro-Environment, Ministry of Agriculture, South China Agricultural University, Guangzhou, 510642, People's Republic of China.
[Ti] Título:The Effects of Biochar and Intercropping on the Cd, Cr and Zn Speciation in Soils and Plant Uptake by Machilus pauhoi.
[So] Source:Bull Environ Contam Toxicol;98(4):574-581, 2017 Apr.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A greenhouse pot experiment with biochar (BC) applied at 0%, 1%, 4% and 8% (w/w) in monoculture and intercropping settings was used to investigate Cd, Cr and Zn speciation in contaminated soils, the growth of two different plant types, and the heavy metal concentrations within these plants. The results showed that BC application increased the soil pH, decreased the bioavailability of Cd, Cr and Zn, significantly increased the dry biomass of Cassia occidentalis and Machilus pauhoi shoots and slightly increased the root biomass. Both BC addition and intercropping decreased the Cd, Cr and Zn contents in the M. pauhoi shoots and roots, but the effect of BC addition was more significant than the effect of intercropping. The Cd, Cr and Zn uptake by M. pauhoi shoots was reduced by up to 93.91%, 96.41% and 76.76%, respectively, when the concentration and bioavailability of Cd, Cr, and Zn were reduced by using the combination of intercropping and BC application. This treatment resulted in the greatest reduction efficiency, and resulted in a shoot biomass increase of M. pauhoi of up to 122.52% compared to the control (M. pauhoi monoculture). These results could be used as a reference for the promotion of M. pauhoi growth and the utilization of contaminated land.
[Mh] Termos MeSH primário: Agricultura/métodos
Cádmio/química
Carvão Vegetal/farmacologia
Cromo/química
Lauraceae/crescimento & desenvolvimento
Solo/química
Zinco/química
[Mh] Termos MeSH secundário: Biomassa
Cádmio/análise
Cromo/análise
Poluição Ambiental
Concentração de Íons de Hidrogênio/efeitos dos fármacos
Lauraceae/química
Senna (Planta)/química
Senna (Planta)/crescimento & desenvolvimento
Poluentes do Solo/análise
Zinco/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 0 (biochar); 00BH33GNGH (Cadmium); 0R0008Q3JB (Chromium); 16291-96-6 (Charcoal); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-016-2013-2


  5 / 161 MEDLINE  
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[PMID]:28001113
[Au] Autor:Rissi DR; L Barros CS
[Ti] Título:Pathology in Practice.
[So] Source:J Am Vet Med Assoc;250(1):51-53, 2017 Jan 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças dos Bovinos/patologia
Doenças Musculares/veterinária
Intoxicação por Plantas/veterinária
Senna (Planta)/toxicidade
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Músculo Esquelético/patologia
Doenças Musculares/patologia
Intoxicação por Plantas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.1.51


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[PMID]:27855501
[Au] Autor:Dhanani T; Singh R; Reddy N; Trivedi A; Kumar S
[Ad] Endereço:a Directorate of Medicinal and Aromatic Plants Research (Indian Council of Agricultural Research) , Anand , India.
[Ti] Título:Comparison on extraction yield of sennoside A and sennoside B from senna (Cassia angustifolia) using conventional and non conventional extraction techniques and their quantification using a validated HPLC-PDA detection method.
[So] Source:Nat Prod Res;31(9):1097-1101, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Senna is an important medicinal plant and is used in many Ayurvedic formulations. Dianthraquinone glucosides are the main bioactive phytochemicals present in leaves and pods of senna. The extraction efficiency in terms of yield and composition of the extract of senna prepared using both conventional (cold percolation at room temperature and refluxing) and non conventional (ultrasound and microwave assisted solvent extraction as well as supercritical fluid extraction) techniques were compared in the present study. Also a rapid reverse phase HPLC-PDA detection method was developed and validated for the simultaneous determination of sennoside A and sennoside B in the different extracts of senna leaves. Ultrasound and microwave assisted solvent extraction techniques were more effective in terms of yield and composition of the extracts compared to cold percolation at room temperature and refluxing methods of extraction.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Extrato de Sena/isolamento & purificação
Senna (Planta)/química
[Mh] Termos MeSH secundário: Cromatografia de Fase Reversa
Cromatografia com Fluido Supercrítico
Folhas de Planta/química
Extrato de Sena/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
8013-11-4 (Senna Extract); 9VK7V8762D (sennoside A&B)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1258562


  7 / 161 MEDLINE  
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[PMID]:27796545
[Au] Autor:Rezende JA; Camelo-García VM; Andrade SC; Buriolla JE; Kitajima EW; Duarte LM
[Ad] Endereço:Departamento de Fitopatologia e Nematologia, Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, Piracicaba, SP, Brazil. jrezende@usp.br.
[Ti] Título:Biological and molecular characterization of a putative new potexvirus infecting Senna occidentalis.
[So] Source:Arch Virol;162(2):529-533, 2017 Feb.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:In this work, we report the complete genome sequence of, production of polyclonal antibodies against, and development of biological assays for a putative new potexvirus, named senna mosaic virus (SenMV), found infecting Senna occidentalis in the state of São Paulo, Brazil. The complete genome sequence of SenMV comprises 6775 nucleotides excluding the poly(A) tail. The genome organization is similar to those of other potexviruses, with five open reading frames coding for RNA-dependent RNA polymerase (RdRp), the triple gene block (TGB 1, 2, and 3) proteins, and coat protein (CP). The virus was transmitted to S. occidentalis by mechanical inoculation and trimming scissors, but not by seeds.
[Mh] Termos MeSH primário: Genoma Viral
Vírus do Mosaico/genética
Potexvirus/genética
RNA Viral/genética
Senna (Planta)/virologia
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Brasil
Proteínas do Capsídeo/genética
Tamanho do Genoma
Vírus do Mosaico/classificação
Vírus do Mosaico/isolamento & purificação
Fases de Leitura Aberta
Filogenia
Doenças das Plantas/virologia
Potexvirus/classificação
Potexvirus/isolamento & purificação
RNA Replicase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (RNA, Viral); 0 (Viral Proteins); EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3114-2


  8 / 161 MEDLINE  
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[PMID]:27709374
[Au] Autor:Mehta RH; Ponnuchamy M; Kumar J; Reddy NR
[Ad] Endereço:ICAR-Directorate of Medicinal and Aromatic Plants Research (ICAR-DMAPR), Anand, 387310, Gujarat, India.
[Ti] Título:Exploring drought stress-regulated genes in senna (Cassia angustifolia Vahl.): a transcriptomic approach.
[So] Source:Funct Integr Genomics;17(1):1-25, 2017 Jan.
[Is] ISSN:1438-7948
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:De novo assembly of reads produced by next-generation sequencing (NGS) technologies offers a rapid approach to obtain expressed gene sequences for non-model organisms. Senna (Cassia angustifolia Vahl.) is a drought-tolerant annual undershrub of Caesalpiniaceae, a subfamily of Fabaceae. There are insufficient transcriptomic and genomic data in public databases for understanding the molecular mechanism underlying the drought tolerance of senna. Therefore, the main purpose of this study was to know the transcriptome profile of senna, with special reference to drought stress. RNA from two different stages of leaf development was extracted and sequenced separately using the Illumina technology. A total of 200 million reads were generated, and a de novo assembly of processed reads in the pooled transcriptome using Trinity yielded 43,413 transcripts which were further annotated using NCBI BLAST with "green plant database (txid 33090)," Swiss Prot, Kyoto Encyclopedia of Genes and Genomes (KEGG), Clusters of Orthologous Groups (COG), and Gene Ontology (GO). Out of the total transcripts, 42,280 (95.0 %) were annotated by BLASTX against the green plant database of NCBI. Senna transcriptome showed the highest similarity to Glycine max (41 %), followed by Phaseolus vulgaris (16 %), Cicer arietinum (15 %), and Medicago trancatula (5 %). The highest number of GO terms were enriched for the molecular functions category; of these "catalytic activity" (GO: 0003824) (25.10 %) and "binding activity" (GO: 0005488) (20.10 %) were most abundantly represented. We used InterProscan to see protein similarity at domain level; a total of 33,256 transcripts were annotated against the Pfam domains. The transcripts were assigned with various KEGG pathways. Coding DNA sequences (CDS) encoding various drought stress-regulated pathways such as signaling factors, protein-modifying/degrading enzymes, biosynthesis of phytohormone, phytohormone signaling, osmotically active compounds, free radical scavengers, chlorophyll metabolism, leaf cuticular wax, polyamines, and protective proteins were identified through BLASTX search. The lucine-rich repeat kinase family was the most abundantly found group of protein kinases. Orphan, bHLH, and bZIP family TFs were the most abundantly found in senna. Six genes encoding MYC2 transcription factor, 9-cis-epoxycarotenoid dioxygenase (NCED), l -ascorbate peroxidase (APX), aminocyclopropane carboxylate oxidase (ACO), abscisic acid 8'-hydroxylase (ABA), and WRKY transcription factor were confirmed through reverse transcriptase-PCR (RT-PCR) and Sanger sequencing for the first time in senna. The potential drought stress-related transcripts identified in this study provide a good start for further investigation into the drought adaptation in senna. Additionally, our transcriptome sequences are the valuable resource for accelerated genomics-assisted genetic improvement programs and facilitate manipulation of biochemical pathways for developing drought-tolerant genotypes of crop plants.
[Mh] Termos MeSH primário: Proteínas de Plantas/genética
Senna (Planta)/genética
Estresse Fisiológico/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Secas
Etiquetas de Sequências Expressas
Regulação da Expressão Gênica de Plantas
Genoma de Planta
Sequenciamento de Nucleotídeos em Larga Escala
Repetições de Microssatélites/genética
Anotação de Sequência Molecular
Proteínas de Plantas/biossíntese
Análise de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE
[do] DOI:10.1007/s10142-016-0523-y


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[PMID]:28699727
[Au] Autor:Gupta G; Sharma SB; Gupta R; Gupta S; Singh UR
[Ti] Título:Assessment of prophylactic effect of Senna auriculata (L.) Roxb. leaves on alcohol-induced pancreatitis in rat model.
[So] Source:Indian J Exp Biol;54(9):612-4, 2016 09.
[Is] ISSN:0019-5189
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Aqueous leaf extract of Senna auriculata (L.) Roxb. syn. Cassia auriculata (SLEx) is known to possess potential antidiabetic and antioxidant properties. Based on the known correlation between exocrine pancreatic function and endocrine secretary capacity, here, we studied the prophylactic effect of the SLEx on alcohol induced pancreatitis in rats. To induce chronic pancreatitis, the rats were fed with unsaturated fat i.e. corn oil (2.5 mL/kg) along with high dose of ethanol (10.2 g/kg) for 4 wk, and was increased 0.6 g/kg after every 2 days for 1 wk and then 0.6 g/kg after every 4 days for a period of 4 wk. SLEx was orally administered to rats at dose of 400 mg/kg/day for 4 wk. At the end of 4th wk, pancreatic enzymes i.e., α-amylase, lipase, serum and pancreatic MDA levels were estimated. Pancreatic histopathological studies were also performed. The SLEx significantly reduced the serum levels of α-amylase and lipase along with significant suppression in serum and pancreatic tissue lipid peroxidation. Histomorphological studies did not show any fatty vacoules in acinar cells of SLEx-treated rats. However, vacoulation was seen in acini of pathogenic control rats. With the results, we conclude that Senna auriculata aqueous leaf extract has potential to reduce the ethanol-induced pathogenecity, and it possesses prophylactic effect on alcohol-induced pancreatitis. However, a long term trial is needed to ascertain its therapeutic potential for pancreatitis.
[Mh] Termos MeSH primário: Pancreatite/prevenção & controle
Fitoterapia
Senna (Planta)
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Etanol/toxicidade
Lipase/sangue
Pancreatite/induzido quimicamente
Folhas de Planta
Ratos
alfa-Amilases/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3K9958V90M (Ethanol); EC 3.1.1.3 (Lipase); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:27803764
[Au] Autor:Campos JF; de Castro DT; Damião MJ; Vieira Torquato HF; Paredes-Gamero EJ; Carollo CA; Estevinho LM; de Picoli Souza K; Dos Santos EL
[Ad] Endereço:School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Itahum, Km 12, 79.804-970 Dourados, MS, Brazil.
[Ti] Título:The Chemical Profile of Leaves and Their Antioxidant and Cytotoxic Effects.
[So] Source:Oxid Med Cell Longev;2016:8405957, 2016.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes. In this context, this study aimed to analyze the chemical composition of an ethanol extract of leaves and to assess its antioxidant and cytotoxic activities in leukemic cells. The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract's inhibition of AAPH-induced lipid peroxidation in human erythrocytes. Its cytotoxicity and possible mechanisms of action were assessed in Jurkat and K562 leukemic cell lines. The ethanol extract contained flavonoids, such as epigallocatechin, epicatechin, kaempferol heteroside, rutin, and dimeric and trimeric proanthocyanidin derivatives. The extract exhibited antioxidant activity by scavenging free radicals and antihemolytic action, and it decreased malondialdehyde content in human erythrocytes. Furthermore, the extract also induced leukemic cell death by activating intracellular calcium and caspase-3, decreasing mitochondrial membrane potential, and arresting the cell cycle in S and G2 phases. Hence, leaf extract contains antioxidant and antileukemic biomolecules with potential applications in diseases associated with oxidative stress and in the inhibition of tumor cell proliferation.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Leucemia/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
Senna (Planta)/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Cálcio/metabolismo
Caspase 3/metabolismo
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Eritrócitos/efeitos dos fármacos
Eritrócitos/metabolismo
Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Células Jurkat
Células K562
Leucemia/metabolismo
Leucemia/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Compostos Fitoquímicos/isolamento & purificação
Fitoterapia
Picratos/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Pontos de Checagem da Fase S do Ciclo Celular/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Phytochemicals); 0 (Picrates); 0 (Plant Extracts); 4Y8F71G49Q (Malondialdehyde); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (Caspase 3); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE



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