Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.898 [Categoria DeCS]
Referências encontradas : 7 [refinar]
Mostrando: 1 .. 7   no formato [Detalhado]

página 1 de 1

  1 / 7 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26003803
[Au] Autor:Kuate D; Kengne AP; Biapa CP; Azantsa BG; Abdul Manan Bin Wan Muda W
[Ad] Endereço:Program in Nutrition, School of Health Sciences Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia. kuatedie@msu.edu.
[Ti] Título:Tetrapleura tetraptera spice attenuates high-carbohydrate, high-fat diet-induced obese and type 2 diabetic rats with metabolic syndrome features.
[So] Source:Lipids Health Dis;14:50, 2015 May 24.
[Is] ISSN:1476-511X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tetrapleura tetraptera, a seasoning and nutritive spice is also used in western African folk medicine in the management of wide variety of diseases including diabetes, inflammation and hypertension. Flavonoids and saponins are some abundant secondary metabolic constituents in the fruits of this plant. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich hydroethanolic extract (HET) of this fruit in experimentally induced obese and type 2 diabetic rats (T2DM) with characteristic metabolic syndrome (MetS). METHODS: MetS was induced in rats by high-carbohydrate, high-fat diet and administration of low-dose streptozotocin. Then different oral doses of HET (200 and 400 mg/kg) were administered to T2DM rats for 28 days. A standard antidiabetic drug, metformin (300 mg/kg), was used for comparison. The body weight, systolic blood pressure, oxidative stress and metabolic parameters were then assessed to evaluate the effect of HET on MetS. RESULTS: HET reduced weight gain, fasting blood glucose and plasma insulin levels as well as homeostasis model assessment of insulin resistance (HOMA-IR) and alleviated obesity and T2DM associated oxidative stress and hypertension in rats. Moreover, a significantly hypolipidemic property and an attenuation of liver injury and tissue steatosis was observed after HET administration. HET further demonstrated its anti-inflammation effect via down regulation of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), leptin and an increase in adiponectin. The HET exhibited dose-dependent effects which were comparable to that of metformin. CONCLUSIONS: The present study thereby demonstrates the anti-insulin resistance, antilipidemic, anti-obesity, hypotensive and anti-inflammatory properties of HET; hence it has the potential to be further developed for the management of MetS such as obesity, T2DM and hypertension.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Frutas
Medicina Tradicional Africana/métodos
Síndrome Metabólica/tratamento farmacológico
Obesidade/tratamento farmacológico
Fitoterapia/métodos
Extratos Vegetais/uso terapêutico
Tetrapleura
[Mh] Termos MeSH secundário: Animais
Glicemia/análise
Glicemia/efeitos dos fármacos
Dieta Hiperlipídica/efeitos adversos
Hipoglicemiantes/uso terapêutico
Insulina/sangue
Masculino
Metformina/uso terapêutico
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 9100L32L2N (Metformin)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150525
[St] Status:MEDLINE
[do] DOI:10.1186/s12944-015-0051-0


  2 / 7 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:23175895
[Au] Autor:Odesanmi OS; Lawal RA; Ojokuku SA
[Ad] Endereço:Department of Biochemistry, College of Medicine, University of Lagos, Nigeria. loladot2001@yahoo.com
[Ti] Título:Effects of ethanolic extract of Tetrapleura tetraptera fruit on serum lipid profile and kidney function in male Dutch-white rabbits.
[So] Source:Nig Q J Hosp Med;21(4):299-302, 2011 Oct-Dec.
[Is] ISSN:0189-2657
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tetrapleura tetraptera fruit is widely used in Nigeria as a spice and for treatment of various medical ailments. Reports indicate that feeding of extracts to animals produced some toxic effects and pathological lesions in some organs. OBJECTIVE: This study was designed to investigate the effects of 10 days oral administration of the ethanolic extract of Tetrapleura tetraptera (TTE) on the lipid profile and kidney function in male rabbits. METHODS: Twenty healthy, acclimatized male rabbits weighing 1.4 - 1.6 kg were randomly divided into four groups. Group 1 served as control and received only water while groups 2, 3 and 4 were administered 50, 100 and 150 mg/kg bodyweight of TTE respectively. Fasting serum from all groups were analyzed for lipid profile and kidney function parameters using standard protocols. Data were analyzed using student's t-test and ANOVA. RESULTS: Tetrapleura tetraptera extract elicited reduction in serum triacylglycerols, elevation of LDL-cholesterol and alteration of kidney function parameters in male rabbits. CONCLUSION: Ethanolic extract of Tetrapleura tetraptera may predispose to hypertension and cardiovascular diseases.
[Mh] Termos MeSH primário: Lipídeos/sangue
Extratos Vegetais/farmacologia
Tetrapleura
[Mh] Termos MeSH secundário: Animais
LDL-Colesterol/sangue
Relação Dose-Resposta a Droga
Eletrólitos/sangue
Etanol
Rim/efeitos dos fármacos
Testes de Função Renal
Masculino
Extratos Vegetais/toxicidade
Coelhos
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholesterol, LDL); 0 (Electrolytes); 0 (Lipids); 0 (Plant Extracts); 0 (Triglycerides); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1212
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121127
[St] Status:MEDLINE


  3 / 7 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:19370941
[Au] Autor:Aboaba SA; Ogunwande IA; Walker TM; Setzer WN; Oladosu IA; Ekundayo O
[Ad] Endereço:Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
[Ti] Título:Essential oil composition, antibacterial activity and toxicity of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) taubert from Nigeria.
[So] Source:Nat Prod Commun;4(2):287-90, 2009 Feb.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The composition of the essential oil of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) Taubert. from Nigeria were analyzed by GC/MS. Forty-one compounds representing 89.5% of the essential oil were characterized. The essential oil was dominated by 1,8-cineole (19.4%), 6,10,14-trimethyl-2-pentadecanone (13.6%), phytol (9.1%), alpha-pinene (8.1%) and geranylacetone (6.7%). The oil exhibited moderate toxicity in the brine shrimp lethality assay (117.5 microg/mL), and displayed weak antibacterial activity against Bacillus subtilis.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Óleos Voláteis/química
Óleos Vegetais/química
Tetrapleura/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Bactérias/efeitos dos fármacos
Nigéria
Óleos Voláteis/farmacologia
Óleos Voláteis/toxicidade
Óleos Vegetais/farmacologia
Óleos Vegetais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:0906
[Cu] Atualização por classe:090417
[Lr] Data última revisão:
090417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090418
[St] Status:MEDLINE


  4 / 7 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:19153973
[Au] Autor:Noté OP; Mitaine-Offer AC; Miyamoto T; Paululat T; Pegnyemb DE; Lacaille-Dubois MA
[Ad] Endereço:Laboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon cedex, France.
[Ti] Título:Tetrapterosides A and B, two new oleanane-type saponins from Tetrapleura tetraptera.
[So] Source:Magn Reson Chem;47(3):277-82, 2009 Mar.
[Is] ISSN:1097-458X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the stem bark of Tetrapleura tetraptera, two new oleanane-type saponins, tetrapteroside A 3-O-{6-O-[(2E,6S)-2,6-dimethyl-6-hydroxyocta-2,7-dienoyl]-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl}-3,27-dihydroxyoleanolic acid (1), and tetrapteroside B 3-O-{ beta-D-glucopyranosyl-(1 --> 2)-6-O-[(E)-feruloyl]-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl}-3,27-dihydroxyoleanolic acid (2), were isolated. Further extractions from the roots led to the isolation of four known oleanane-type saponins. Their structures were elucidated by the combination of mass spectrometry (MS), one and two-dimensional NMR experiments.
[Mh] Termos MeSH primário: Saponinas/química
Tetrapleura/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); 0 (tetrapteroside A); 0 (tetrapteroside B)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:090204
[Lr] Data última revisão:
090204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090121
[St] Status:MEDLINE
[do] DOI:10.1002/mrc.2381


  5 / 7 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:17236733
[Au] Autor:Okokon JE; Udokpoh AE; Antia BS
[Ad] Endereço:Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
[Ti] Título:Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit.
[So] Source:J Ethnopharmacol;111(3):537-40, 2007 May 22.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The in vivo antiplasmodial activity of the ethanol fruit extract of Tetrapleura tetraptera used as spice and in the treatment of various ailment in Niger Delta region of Nigeria was evaluated in Plasmodium berghei infected mice. Tetrapleura tetraptera (300-900 mg/kg day) exhibited significant (P < 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg day. The fruit extract possesses significant (P < 0.05) antiplasmodial activity with may have contributed to the immune status of the Nigerians against malaria in addition to its nutritive value.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Malária/tratamento farmacológico
Extratos Vegetais/farmacologia
Plasmodium berghei/efeitos dos fármacos
Tetrapleura
[Mh] Termos MeSH secundário: Animais
Antimaláricos/administração & dosagem
Cloroquina/farmacologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Feminino
Frutas
Dose Letal Mediana
Malária/mortalidade
Masculino
Medicina Tradicional Africana
Camundongos
Fitoterapia
Extratos Vegetais/administração & dosagem
Taxa de Sobrevida
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:0707
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070124
[St] Status:MEDLINE


  6 / 7 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:16372367
[Au] Autor:Ojewole JA
[Ad] Endereço:Department of Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. ojewolej@ukzn.ac.za
[Ti] Título:Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
[So] Source:Phytother Res;19(12):1023-9, 2005 Dec.
[Is] ISSN:0951-418X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies in our laboratories and elsewhere have shown that the fruit of Tetrapleura tetraptera (Taub) (family: Fabaceae) is widely used in African traditional medicine for the management and/or control of an array of human ailments, including schistosomiasis, asthma, epilepsy, hypertension and so on. The present study was designed to investigate the analgesic and anticonvulsant effects of Tetrapleura tetraptera (Taub) fruit aqueous extract (TTE) in mice. Morphine (MPN, 10 mg/kg i.p.), diclofenac (DIC, 100 mg/kg i.p.), phenobarbitone (20 mg/kg i.p.) and diazepam (0.5 mg/kg i.p.) were used, respectively, as reference analgesic and anticonvulsant agents for comparison. T. tetraptera fruit aqueous extract (TTE, 50-800 mg/kg i.p.) produced dose-dependent, significant (p < 0.05-0.001) analgesic effects against thermally and chemically induced pain in mice. Like the standard anticonvulsant agents (phenobarbitone and diazepam) used, T. tetraptera fruit aqueous extract (TTE, 50-800 mg/kg i.p.) significantly (p < 0.05-0.001) delayed the onset of, and antagonized, pentylenetetrazole (PTZ)-induced seizures. Aqueous extract of the fruit (TTE, 50-800 mg/kg i.p.) also profoundly antagonized picrotoxin (PCT)-induced seizures, but only partially and weakly antagonized bicuculline (BCL)-induced seizures. However, the results of this experimental animal study indicate that Tetrapleura tetraptera (Taub) fruit aqueous extract (TTE) possesses analgesic and anticonvulsant properties. These findings lend pharmacological support to the suggested folkloric uses of the plant's fruit in the management and/or control of painful, arthritic inflammatory conditions, as well as for the management and/or control of epilepsy and childhood convulsions in some tropical African countries.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Anticonvulsivantes/uso terapêutico
Fitoterapia
Convulsões/tratamento farmacológico
Tetrapleura
[Mh] Termos MeSH secundário: Ácido Acético
Animais
Bicuculina
Feminino
Frutas
Temperatura Alta
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Dor/tratamento farmacológico
Dor/etiologia
Pentilenotetrazol
Picrotoxina
Extratos Vegetais/uso terapêutico
Convulsões/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anticonvulsants); 0 (Plant Extracts); 124-87-8 (Picrotoxin); Q40Q9N063P (Acetic Acid); WM5Z385K7T (Pentylenetetrazole); Y37615DVKC (Bicuculline)
[Em] Mês de entrada:0603
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051224
[St] Status:MEDLINE


  7 / 7 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:15507333
[Au] Autor:Ojewole JA; Adewunmi CO
[Ad] Endereço:Department of Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. ojewolej@ukzn.ac.za
[Ti] Título:Anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera (Taub) [Fabaceae] fruit aqueous extract in rats.
[So] Source:J Ethnopharmacol;95(2-3):177-82, 2004 Dec.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The fruit of Tetrapleura tetraptera (Taub) [Fabaceae] is frequently used in Tropical African traditional medicine for the management and/or control of an array of human ailments, including arthritis and other inflammatory conditions, asthma, diabetes mellitus, hypertension, epilepsy, schistosomiasis, and so on. The present study was undertaken to examine the anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera (Taub) fruit aqueous extract in rats. Fresh egg albumin-induced pedal oedema and streptozotocin (STZ)-induced diabetes mellitus were used as experimental test models of inflammation and diabetes. Diclofenac (DIC, 100mg/kg p.o.) and chlorpropamide (250 mg/kg p.o.) were employed as reference anti-inflammatory and hypoglycaemic agents, respectively, for comparison. Tetrapleura tetraptera (TTE, 50-800 mg/kg p.o.) produced dose-related, significant reductions (P < 0.05-0.001) of the fresh egg albumin-induced acute inflammation of the rat hind paw oedema. The plant extract (TTE, 50-800 mg/kg p.o.) also produced dose-dependent, significant reductions (P < 0.05-0.001) in the blood glucose concentrations of both fasted normal and fasted diabetic rats. The results of this experimental animal study indicate that T. tetraptera fruit aqueous extract possesses anti-inflammatory and hypoglycaemic properties. These findings lend pharmacological credence to the suggested folkloric uses of the plant's fruit in the management and/or control of arthritis and other inflammatory conditions, as well as in adult-onset, type-2 diabetes mellitus in some Yoruba-speaking communities of South-Western Nigeria.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Frutas
Hipoglicemiantes/uso terapêutico
Tetrapleura
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/isolamento & purificação
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/tratamento farmacológico
Edema/tratamento farmacológico
Hipoglicemiantes/isolamento & purificação
Masculino
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 059QF0KO0R (Water)
[Em] Mês de entrada:0502
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041028
[St] Status:MEDLINE



página 1 de 1
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde