Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.401.937 [Categoria DeCS]
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[PMID]:28707431
[Au] Autor:Steels E; Steele ML; Harold M; Coulson S
[Ad] Endereço:Sydney Medical School, The University of Sydney, Sydney, Australia.
[Ti] Título:Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study.
[So] Source:Phytother Res;31(9):1316-1322, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed). Active treatment was T. foenum-graecum de-husked seed extract, 600 mg per day for 12 weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p < 0.001); reflected by significant improvements in the vasomotor (p < 0.001), psychosocial (p < 0.001), physical (p < 0.001) and sexual symptoms (p < 0.001) domains. Vasomotor outcomes correlated with hot flushes, the active group reporting significantly less daytime hot flushes and night sweats at 12 weeks (p < 0.001). The average estradiol levels were similar in both the active group and placebo group after treatment. This study demonstrated that this proprietary T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Menopausa/efeitos dos fármacos
Extratos Vegetais/química
Trigonella/química
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Estradiol/sangue
Feminino
Fogachos/tratamento farmacológico
Seres Humanos
Meia-Idade
Qualidade de Vida
Inquéritos e Questionários
Sudorese/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts); 4TI98Z838E (Estradiol); 68990-15-8 (fenugreek seed meal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5856


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[PMID]:28679380
[Au] Autor:Kan J; Velliquette RA; Grann K; Burns CR; Scholten J; Tian F; Zhang Q; Gui M
[Ad] Endereço:Nutrilite Health Institute, 720 Cailun Road, Shanghai, 201203, China.
[Ti] Título:A novel botanical formula prevents diabetes by improving insulin resistance.
[So] Source:BMC Complement Altern Med;17(1):352, 2017 Jul 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigonella foenum graecum) seed, mulberry (Morus alba L.) leaf and American ginseng (Panax quinquefolius) root can improve glycemia in various animal models and humans with impaired glucose metabolism and T2DM. The aim of this study was to design an optimized botanical formula containing these herbal extracts as a nutritional strategy for the prevention of insulin resistance and T2DM. METHODS: Cell-free α-amylase and α-glucosidase enzyme assays were used to determine inhibitory potential of extracts. Glucose uptake was examined in differentiated human adipocytes using radiolabeled 2-deoxyglucose. Male Sprague Dawley rats were divided and glycemia balanced into 5 groups: two controls (naïve and model) and three doses of the botanical test formula containing standardized fenugreek seed, mulberry leaf and American ginseng extracts (42.33, 84.66 and 169.33 mg/kg BW). Insulin resistance and T2DM was induced by feeding animals a high fat diet and with an alloxan injection. Glucose tolerance was examined by measuring serum glucose levels following an oral glucose load. RESULTS: Fenugreek seed and mulberry leaf dose dependently inhibited α-amylase (IC50 = 73.2 µg/mL) and α-glucosidase (IC50 = 111.8 ng/mL), respectively. All three botanical extracts improved insulin sensitivity and glucose uptake in human adipocytes, which lead to the design of an optimized botanical test formula. In a rat model of insulin resistance and T2DM, the optimized botanical test formula improved fasting serum glucose levels, fasting insulin resistance and the development of impaired glucose tolerance. The reduction in epididymal adipose tissue GLUT4 and PDK1 expression induced by high fat diet and alloxan was blunted by the botanical test formula. CONCLUSIONS: A novel botanical formula containing standardized extracts of mulberry leaf, fenugreek seed and American ginseng at a ratio of 1:1.3:3.4 prevented the development of insulin resistance, impaired glucose tolerance and T2DM. Given the rising need for effective non-drug targeting of insulin resistance and progression to T2DM, complementary and alternative nutritional strategies without intolerable side effects could have meaningful impact on metabolic health and diabetes risks.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/prevenção & controle
Resistência à Insulina
Morus/química
Panax/química
Extratos Vegetais/administração & dosagem
Trigonella/química
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Diabetes Mellitus Tipo 2/genética
Diabetes Mellitus Tipo 2/metabolismo
Composição de Medicamentos
Transportador de Glucose Tipo 4/genética
Transportador de Glucose Tipo 4/metabolismo
Seres Humanos
Masculino
Extratos Vegetais/química
Folhas de Planta/química
Proteínas Serina-Treonina Quinases/genética
Proteínas Serina-Treonina Quinases/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Glucose Transporter Type 4); 0 (Plant Extracts); 68990-15-8 (fenugreek seed meal); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.2 (pyruvate dehydrogenase (acetyl-transferring) kinase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1848-3


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[PMID]:28625957
[Au] Autor:Malik A; Mehmood MH; Akhtar MS; Haider G; Gilani AH
[Ad] Endereço:Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan / Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan.
[Ti] Título:Studies on antihyperlipidemic and endothelium modulatory activities of polyherbal formulation (POL4) and its ingredients in high fat diet-fed rats.
[So] Source:Pak J Pharm Sci;30(1 Suppl):295-301, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:A compound herbal formulation (POL ) is used traditionally in interior parts (Distt. Badin) of Sindh, Pakistan, for the treatment of metabolic disorders like diabetes and hyperlipidemia. This study is aimed to determine the effectiveness of POL and its ingredients in hyperlipidemia and associated endothelial dysfunction and hypertension. POL is composed of equal proportion of Nigella sativa, Cichorium intybus, Trigonella foenum graecum and Gymnema sylvestre mixed in powdered form. Chronic (6 to 7 weeks) administration of POL and its ingredients mixed in diet caused a notable attenuation in total cholesterol, low density lipoprotein cholesterol, triglycerides, atherogenic index, C-reactive protein and glucose, while it has increased high density lipoprotein levels. POL4 intervention markedly (p<0.01) reduced systolic blood pressure in rats to 127±1.92 vs. 145.4±1.07 mm of Hg using tail-cuff method and significantly (p<0.05) improved endothelium-dependent relaxation (75±2.88 vs. 82.75±1.22%) to acetylcholine in isolated aortae of rats in treatment groups using force transducer and PowerLab system. Similar activities were assessed on the part of ingredients of POL . These findings indicate that POL4 and its ingredients possess antihyperlipidemic, endothelium-dependent modulatory and antihypertensive activities, thus providing an evidence to the vernacular use of POL in hyperlipidemia and hypertension.
[Mh] Termos MeSH primário: Dieta Hiperlipídica/efeitos adversos
Endotélio/efeitos dos fármacos
Hipolipemiantes/farmacologia
Extratos Vegetais/farmacologia
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Hipertensivos/farmacologia
Aorta/efeitos dos fármacos
Aorta/metabolismo
Pressão Sanguínea/efeitos dos fármacos
Proteína C-Reativa/metabolismo
Chicória/química
LDL-Colesterol/sangue
Endotélio/metabolismo
Feminino
Hiperlipidemias/tratamento farmacológico
Hiperlipidemias/metabolismo
Hipertensão/tratamento farmacológico
Hipertensão/metabolismo
Masculino
Nigella sativa/química
Paquistão
Ratos
Ratos Sprague-Dawley
Trigonella/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Cholesterol, LDL); 0 (Hypolipidemic Agents); 0 (Plant Extracts); 0 (Plant Preparations); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


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[PMID]:28581555
[Au] Autor:Repin N; Kay BA; Cui SW; Wright AJ; Duncan AM; Douglas Goff H
[Ad] Endereço:University of Guelph, Department of Food Science, Guelph, ON, CanadaN1G 2W1. dgoff@uoguelph.ca and Agriculture and Agri-Food Canada, Guelph Research and Development Centre, 93 Stone Rd. W., Guelph, ON, Canada N1G 5C9.
[Ti] Título:Investigation of mechanisms involved in postprandial glycemia and insulinemia attenuation with dietary fibre consumption.
[So] Source:Food Funct;8(6):2142-2154, 2017 Jun 01.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work examines the mechanisms involved in the attenuation of postprandial glycemic and insulinemic responses associated with soluble dietary fibre (SDF) consumption. The effect of SDF, including yellow mustard mucilage, soluble flaxseed gum and fenugreek gum on in vitro amylolysis and maltose transport was studied. Furthermore, a human clinical trial was conducted to investigate the effect of SDF consumption on postprandial glycemic and insulinemic responses and gastric emptying, as estimated based on the absorption of paracetamol. Participants (n = 15) at risk for type II diabetes consumed maltose syrup- and starch-based pudding treatments supplemented with each SDF, each at a concentration to match three times the apparent viscosity (18.54 mPa s at 60 s ) equivalent to the European Food Safety Authority (2011) glycemia control health claim for cereal ß-glucan, measured under simulated small intestinal conditions. The presence of each SDF delayed in vitro amylolysis to a similar extent, but had no effect on maltose transport. Generally, all SDF-containing treatments attenuated blood glucose and plasma insulin peak concentrations and plasma paracetamol 1 h incremental area under the curve values to a similar extent, relative to the controls, despite differences in the amounts at which each SDF was used (from 5.9 to 15.5 g). The postprandial attenuations were related to the ability of each SDF to modify digesta viscosity, perhaps through the delay of gastric emptying, as a delay of amylolysis and sugar transport under simulated upper intestinal conditions did not seem to have a substantial effect.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Diabetes Mellitus Tipo 2/dietoterapia
Fibras na Dieta/metabolismo
Insulina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Avena/química
Avena/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/fisiopatologia
Linho/química
Linho/metabolismo
Esvaziamento Gástrico
Índice Glicêmico
Seres Humanos
Masculino
Meia-Idade
Mostardeira/química
Mostardeira/metabolismo
Período Pós-Prandial
Trigonella/química
Trigonella/metabolismo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fiber); 0 (Insulin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00331e


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[PMID]:28566642
[Au] Autor:Hamden K; Keskes H; Elgomdi O; Feki A; Alouche N
[Ad] Endereço:Animal Ecophysiology, Faculty of Sciences, Universite de Sfax.
[Ti] Título:Modulatory Effect of an Isolated Triglyceride from Fenugreek Seed Oil on of α-Amylase, Lipase and ACE Activities, Liver-Kidney Functions and Metabolic Disorders of Diabetic Rats.
[So] Source:J Oleo Sci;66(6):633-645, 2017.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study was designed to examine physicochemical characteristics, chemical compositions and biological activities of fenugreek seed oil (FSO) and its pure triglyceride (TG). One fenugreek TG was purified using a bioassay-guided fractionation and administrated to surviving diabetic rats. The free fatty acids percentage as well as, the peroxide, the saponification and the iodine values were 2%, 12 mequiv. O /kg of oil, 189 (mg KOH/g) and 110 (g/100 g of oil), respectively. Linolenic acid (C 26.14%), Linoleic acid (C 41.13%) and Oleic acid (C 17.07%) were the dominant fatty acids in the FSO. ß-sitosterol was the major sterol (85.3%) in the FSO. LnLnO (17.1%), LLL (16.6%), OLL and OOLn (8.4%), were the abundant triglycerides. The hexane extract of fenugreek seed (exhibiting the powerful inhibitory activity against alpha-amylase) was purified using a bioassay-guided fractionation affording one fenugreek TG: (11Z)-11- eicosenoic acid 2, 3- bis[((9Z, 12Z, 15Z)-1-oxo-9, 12, 15-octadecatrien-1-yl)oxy] propyl ester. In diabetic rats, the administration of the fenugreek TG inhibited α-amylase activity in small intestine by 36% as compared to untreated diabetic rats. Moreover, fenugreek TG increased insulin sensibility which leads to decrease in blood glucose level by 43%. In addition, this study demonstrated that administration of pure fenugreek TG to diabetic rats ameliorated the glycogen rate in liver and muscle. In addition, the administration of fenugreek TG reverted back the activity of angiotensin converting enzyme respectively in kidney and plasma by 33 and 29%. Interestingly, the fenugreek TG inhibited lipase activity in small intestine by 33% which leads to the regulation of lipid profile. Moreover, the fenugreek TG protected liver-kidney function evidenced by histological study. In conclusion, our finding demonstrates that the administration of fenugreek TG to diabetic rats can make it a potential candidate for industrial application as a pharmacological agent for the treatment of hyperglycemia.
[Mh] Termos MeSH primário: Diabetes Mellitus/metabolismo
Diabetes Mellitus/fisiopatologia
Hiperglicemia/tratamento farmacológico
Rim/fisiopatologia
Lipase/metabolismo
Fígado/fisiopatologia
Fitoterapia
Óleos Vegetais/química
Sementes/química
Triglicerídeos/isolamento & purificação
Triglicerídeos/farmacologia
Trigonella/química
alfa-Amilases/metabolismo
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Diabetes Mellitus/tratamento farmacológico
Ácidos Graxos não Esterificados/análise
Glicogênio/metabolismo
Resistência à Insulina/fisiologia
Intestino Delgado/enzimologia
Rim/metabolismo
Fígado/metabolismo
Músculos/metabolismo
Peptidil Dipeptidase A/metabolismo
Ratos
Triglicerídeos/administração & dosagem
Triglicerídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Fatty Acids, Nonesterified); 0 (Plant Oils); 0 (Triglycerides); 9005-79-2 (Glycogen); EC 3.1.1.3 (Lipase); EC 3.2.1.1 (alpha-Amylases); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16254


  6 / 476 MEDLINE  
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[PMID]:28278666
[Au] Autor:Riasat M; Jafari AA; Bahmanzadegan A; Hatami A; Zareiyan F
[Ad] Endereço:a Department of Natural Resources , Researches and Education Center of Agriculture and Natural Resources of Fars Province , Shiraz , Iran.
[Ti] Título:The constituents of essential oil in leaves of Karaj accession of Trigonella foenum graecum.
[So] Source:Nat Prod Res;31(14):1709-1712, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the essential oils of Karaj accession of Trigonella foenum graecum leaves was detected by hydro-distillation and analysed by gas chromatography (GC-FID) and gas chromatography-mass spectroscopy (GC-MS) apparatuses for first time. Thirty-six compounds representing 95.3% of the total components were identified. The patterns of the main compounds were (2E)-Hexenal (26.61%), n-Hexadecanoic acid (10.14%) and (E)-b-Ionone (7.99%). Other notable constituents were Thymol (4.79%), 6,10,14-trimethyl-2-Pentadecanone (4.59%), Carvacrol (3.40%), (E)-Nerolidol (3.32%) and (2E,6Z)-Nonadienal (3.30%). (2E)-Hexenal was found as the most dominant component in this study.
[Mh] Termos MeSH primário: Óleos Voláteis/química
Folhas de Planta/química
Trigonella/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Hexobarbital/isolamento & purificação
Norisoprenoides/isolamento & purificação
Ácido Palmítico/isolamento & purificação
Extratos Vegetais/química
Sesquiterpenos/isolamento & purificação
Timol/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Norisoprenoids); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 2V16EO95H1 (Palmitic Acid); 3J50XA376E (Thymol); AL8Z8K3P6S (Hexobarbital); QR6IP857S6 (nerolidol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1286484


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[PMID]:28270141
[Au] Autor:Malik A; Mehmood MH; Channa H; Akhtar MS; Gilani AH
[Ad] Endereço:Natural Product Research Division, Department of Biological and Biomedical Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan.
[Ti] Título:Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents.
[So] Source:BMC Complement Altern Med;17(1):142, 2017 Mar 07.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A compound herbal formulation (POL ) has been used in the indigenous system of medicine to treat cardiometabolic disorders like diabetes and associated hypertension. POL and most of its constituents have not been studied widely for its therapeutic use in hypertension. This study is aimed to determine the efficacy and possible insight into mechanism(s) for the medicinal use of POL and its ingredients in hypertension. METHODS: The aqueous methanolic extracts of POL (POL .Cr) and its components [Cichorium intybus (Ci.Cr), Gymnema sylvestre (Gs.Cr), Nigella sativa (Ns.Cr) and Trigonella foenum graecum (Tfg.Cr)] were tested for blood pressure lowering activity in anaesthetized Sprague-Dawley rats. To assess the vasomodulatory effect, isolated tissue experiments were performed on rat aortic strips using isometric force transducer coupled with PowerLab data acquisition system. RESULTS: Administration of POL to rats caused a dose-dependent (1-100 mg/kg) fall in mean arterial pressure (MAP) with maximum effect of 85.33 ± 1.76% at 100 mg/kg, similar to the effect of verapamil. All ingredients of POL also decreased blood pressure with varying efficacy in following order Ns.Cr ≅ Ci.Cr > Tfg.Cr > Gs.Cr. In rat aortic preparations, POL and its ingredients inhibited K (80 mM)-induced contractions, Ci.Cr was the most potent followed by Ns.Cr > Tfg.Cr > Gs.Cr ≅ POL . Against phenylephrine (P.E) contractions, Ci.Cr and Tfg.Cr exhibited complete relaxation, while POL .Cr, Gs.Cr and Ns.Cr showed vasomodulatory effect. The Ca antagonist activity was confirmed when POL and its ingredients shifted Ca concentrations-response curves to the right in a manner similar to that of verapamil. On baseline of rat aorta, the parent formulation and its ingredients (except Tfg.Cr) exhibited partially phentolamine (1 µM)-sensitive vasoconstriction. CONCLUSION: These data show that POL and its constituents possess blood pressure lowering activity mediated through inhibition of Ca influx via membranous Ca channels and receptor (α-adrenergic) operated pathways. Thus, this study provides a rationale to the medicinal use of POL and its constituents in hypertension.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/tratamento farmacológico
Chicória
Gymnema sylvestre
Hipertensão/tratamento farmacológico
Nigella sativa
Fitoterapia/métodos
Preparações de Plantas
Trigonella
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Modelos Animais de Doenças
Flavonoides/análise
Cobaias
Átrios do Coração/efeitos dos fármacos
Fenóis/análise
Preparações de Plantas/química
Preparações de Plantas/farmacologia
Preparações de Plantas/uso terapêutico
Ratos
Ratos Sprague-Dawley
Vasoconstrição/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Phenols); 0 (Plant Preparations)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1644-0


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[PMID]:28232283
[Au] Autor:Guardiola FA; Bahi A; Messina CM; Mahdhi A; Santulli A; Arena R; Bakhrouf A; Esteban MA
[Ad] Endereço:Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100, Murcia, Spain; Fish Nutrition & Immunobiology Group, Centro Interdisciplinar de Investigação Marinha e Am
[Ti] Título:Quality and antioxidant response of gilthead seabream (Sparus aurata L.) to dietary supplements of fenugreek (Trigonella foenum graecum) alone or combined with probiotic strains.
[So] Source:Fish Shellfish Immunol;63:277-284, 2017 Apr.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was conducted to determine the potential effect of the dietary intake of fenugreek (Trigonella foenum graecum) seeds alone or in combination with Bacillus licheniformis, Lactobacillus plantarum or B. subtilis on gilthead seabream quality and antioxidant response after 2 and 3 weeks of experimental feeding. The results showed that the supplements did not affect the percentage of the fatty acid profiles of muscle, demonstrating that all the additives tested can be administrated without any negative effect on biochemical composition and quality of gilthead seabream. The quantification of thiobarbituric acid reactive substances in muscle demonstrated the significant beneficial effect of the experimental diets compared with the control one. Besides, an increase in superoxide dismutase and catalase in liver was recorded after 3 weeks of administration of experimental diets. Furthermore, real time qPCR revealed that dietary supplementation with FEBS significantly enhances the expression of scavenging enzymes, such as cat and gr genes in the liver after 3 weeks. The findings suggest that the administration of fenugreek supplement alone or combined with probiotic strains could be considered as a good source of natural antioxidants and as a functional aquafeed ingredient for gilthead seabream.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Imunidade Inata
Extratos Vegetais/metabolismo
Probióticos
Dourada/imunologia
Trigonella/metabolismo
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/administração & dosagem
Ração Animal/análise
Animais
Bacillus licheniformis/química
Bacillus subtilis/química
Dieta/veterinária
Lactobacillus plantarum/química
Extratos Vegetais/administração & dosagem
Distribuição Aleatória
Dourada/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Plant Extracts); 68990-15-8 (fenugreek seed meal)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE


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[PMID]:28161815
[Au] Autor:Ciura J; Szeliga M; Grzesik M; Tyrka M
[Ad] Endereço:Department of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, al. Powstanców Warszawy 6, 35-959, Rzeszów, Poland.
[Ti] Título:Next-generation sequencing of representational difference analysis products for identification of genes involved in diosgenin biosynthesis in fenugreek (Trigonella foenum-graecum).
[So] Source:Planta;245(5):977-991, 2017 May.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: Representational difference analysis of cDNA was performed and differential products were sequenced and annotated. Candidate genes involved in biosynthesis of diosgenin in fenugreek were identified. Detailed mechanism of diosgenin synthesis was proposed. Fenugreek (Trigonella foenum-graecum L.) is a valuable medicinal and crop plant. It belongs to Fabaceae family and has a unique potential to synthesize valuable steroidal saponins, e.g., diosgenin. Elicitation (methyl jasmonate) and precursor feeding (cholesterol and squalene) were used to enhance the content of sterols and steroidal sapogenins in in vitro grown plants for representational difference analysis of cDNA (cDNA-RDA). To identify candidate genes involved in diosgenin biosynthesis, differential, factor-specific libraries were subject to the next-generation sequencing. Approximately 9.9 million reads were obtained, trimmed, and assembled into 31,491 unigenes with an average length of 291 bp. Then, functional annotation and gene ontogeny enrichment analysis was performed by aligning all-unigenes with public databases. Within the transcripts related to sterol and steroidal saponin biosynthesis, we discovered novel candidate genes of diosgenin biosynthesis and validated their expression using quantitative RT-PCR analysis. Based on these findings, we supported the idea that diosgenin is biosynthesized from cycloartenol via cholesterol. This is the first report on the next-generation sequencing of cDNA-RDA products. Analysis of the transcriptomes enriched in low copy sequences contributed substantially to our understanding of the biochemical pathways of steroid synthesis in fenugreek.
[Mh] Termos MeSH primário: Acetatos/metabolismo
Ciclopentanos/metabolismo
Diosgenina/metabolismo
Oxilipinas/metabolismo
Fitosteróis/metabolismo
Reguladores de Crescimento de Planta/metabolismo
Transcriptoma
Trigonella/genética
[Mh] Termos MeSH secundário: DNA Complementar/genética
Sequenciamento de Nucleotídeos em Larga Escala
Análise de Sequência de DNA
Trigonella/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Cyclopentanes); 0 (DNA, Complementary); 0 (Oxylipins); 0 (Phytosterols); 0 (Plant Growth Regulators); 900N171A0F (methyl jasmonate); K49P2K8WLX (Diosgenin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-017-2657-0


  10 / 476 MEDLINE  
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[PMID]:28157172
[Au] Autor:Gu LB; Liu XN; Liu HM; Pang HL; Qin GY
[Ad] Endereço:School of Physics and Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, Henan Province, China. gulingbiao@foxmail.com.
[Ti] Título:Extraction of Fenugreek (Trigonella foenum-graceum L.) Seed Oil Using Subcritical Butane: Characterization and Process Optimization.
[So] Source:Molecules;22(2), 2017 Feb 02.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this study, the subcritical butane extraction process of fenugreek seed oil was optimized using response surface methodology with a Box-Behnken design. The optimum conditions for extracted oil from fenugreek seed was as follows: extraction temperature of 43.24 °C , extraction time of 32.80 min, and particle size of 0.26 mm. No significant differences were found between the experimental and predicted values. The physical and chemical properties of the oil showed that the oil could be used as edible oil. Fatty acid composition of oils obtained by subcritical butane under the optimum conditions and by accelerated solvent extraction showed negligible difference. The oils were rich in linoleic acid (42.71%-42.80%), linolenic acid (26.03%-26.15%), and oleic acid (14.24%-14.40%). The results revealed that the proposed method was feasible, and this essay shows the way to exploit fenugreek seeds by subcritical butane extraction under the scope of edible oils.
[Mh] Termos MeSH primário: Butanos/química
Extração Líquido-Líquido
Extratos Vegetais/química
Óleos Vegetais/química
Sementes/química
Trigonella/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Ácidos Graxos/química
Extração Líquido-Líquido/métodos
Compostos Fitoquímicos/química
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanes); 0 (Fatty Acids); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Plant Oils); 6LV4FOR43R (butane)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE



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