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Pesquisa : B01.650.940.800.575.912.250.456 [Categoria DeCS]
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[Au] Autor:Bhuyan B; Paul A; Paul B; Dhar SS; Dutta P
[Ad] Endereço:Department of Chemistry, National Institute of Technology, Silchar, Silchar-788010, Assam, India.
[Ti] Título:Paederia foetida Linn. promoted biogenic gold and silver nanoparticles: Synthesis, characterization, photocatalytic and in vitro efficacy against clinically isolated pathogens.
[So] Source:J Photochem Photobiol B;173:210-215, 2017 Aug.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Development of newer improved therapeutic agents with efficient antimicrobial activities continues to draw attention of researchers till date. Moreover, abatement of polluting dyes released from industry with enhanced efficiency is currently being considered as challenging task for people working on material sciences. In the present study, we report a facile biogenic synthesis of gold and silver nanoparticles (NPs) in which aqueous extracts of Paederia foetida Linn. was used as reducing as well as stabilizing agent. The biosynthesized Au and Ag NPs were characterized by UV-visible spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction analysis (XRD) and transmission electron microscopy (TEM). The photocatalytic activity of these nanoparticles were tested against Rhodamine B (RhB). The antimicrobial activity of these biosynthesized NPs were investigated against four human pathogens viz. B. cereus, E. coli, S. aureus and A. niger. Biogenic silver nanoparticles presented a strong antimicrobial activity against B. cereus (26.13) followed by E. coli (26.02), S. aureus (25.43) and A. niger (22.69). Ag NPs owing to their small size (5-25nm) could have easily penetrate into the cell membrane, disturb the metabolism, cause irretrievable damage finally leading to the microbial cell death. Interestingly biogenic gold nanoparticles didn't show any antimicrobial activity.
[Mh] Termos MeSH primário: Gentianales/química
Nanopartículas Metálicas/química
Processos Fotoquímicos
[Mh] Termos MeSH secundário: Anti-Infecciosos/síntese química
Técnicas de Química Sintética
Seres Humanos
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 3M4G523W1G (Silver); 7440-57-5 (Gold)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE

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[Au] Autor:Huang XJ; Li J; Mei ZY; Chen G
[Ad] Endereço:a College of Pharmacy, South-Central University for Nationalities, Wuhan, P.R. China.
[Ti] Título:Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells.
[So] Source:Biochem Cell Biol;94(3):270-8, 2016 Jun.
[Is] ISSN:1208-6002
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The use of phytochemicals and herbal medicines has accompanied human history. Advances in modern biomedical sciences have allowed us to investigate the functional mechanisms of herbal medicines and phytochemicals. Veratrilla baillonii Franch. has long been used as a medicinal herb in southwestern China. Here, we analyzed the effects of an ethanol extract from V. baillonii (VBFE) on the expression levels of the cytosolic form of the phosphoenolpyruvate carboxykinase gene (Pck1) mRNA and components of the insulin signalling cascade in HL1C hepatoma cells. Compared with the insulin control, VBFE treatment inhibited the expression of Pck1 mRNA in a dose-dependent manner. This was associated with the phosphorylation of Akt and Erk1/2 in a time-dependent manner. Further analysis of the purified components of VBFE indicated that gentiopicroside and sweroside from VBFE, alone and in combination, suppressed Pck1 expression and induced Akt and Erk1/2 phosphorylation. In conclusion, gentiopicroside and sweroside suppress Pck1 expression and induce phosphorylation of components in the insulin signalling cascade. This is the first study to demonstrate that gentiopicroside and sweroside show insulin-mimicking effects on the regulation of Pck1 expression. Further studies are warranted to explore the potential of gentiopicroside and sweroside in the control of blood glucose in animals.
[Mh] Termos MeSH primário: Gentianales/química
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Glucosídeos Iridoides/farmacologia
Fosfoenolpiruvato Carboxiquinase (GTP)/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
[Mh] Termos MeSH secundário: Animais
Carcinoma Hepatocelular/metabolismo
Linhagem Celular Tumoral
Cromatografia Líquida de Alta Pressão
Relação Dose-Resposta a Droga
Peptídeos e Proteínas de Sinalização Intracelular/genética
Neoplasias Hepáticas/metabolismo
Proteína Quinase 3 Ativada por Mitógeno/metabolismo
Fosfoenolpiruvato Carboxiquinase (GTP)/genética
Fosforilação/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
RNA Mensageiro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); 0 (Intracellular Signaling Peptides and Proteins); 0 (Iridoid Glucosides); 0 (Plant Extracts); 0 (RNA, Messenger); 0WE09Z21RC (gentiopicroside); EC (Proto-Oncogene Proteins c-akt); EC (Mitogen-Activated Protein Kinase 3); EC (Phosphoenolpyruvate Carboxykinase (GTP)); EC (phosphoenolpyruvate carboxykinase 1 (soluble) protein, rat); I3YG76417O (sweroside)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1139/bcb-2015-0173

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