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[PMID]:28657530
[Au] Autor:Miranda AR; Albrecht C; Soria EA
[Ad] Endereço:Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, CONICET, FCM (Enrique Barros, Ciudad Universitaria, CP 5014), Córdoba, Argentina.
[Ti] Título:[Analysis of tissue bioavailability of total polyphenols by Folin Ciocalteu and Fast Blue BB techniques in organs of BALB/C/c mice].
[Ti] Título:Análisis de la biodisponibilidad tisular de polifenoles totales mediante las técnicas de Folin Ciocalteu y Fast Blue BB en órganos de ratones BALB/C..
[So] Source:Rev Fac Cien Med Univ Nac Cordoba;74(2):119-125, 2017.
[Is] ISSN:1853-0605
[Cp] País de publicação:Argentina
[La] Idioma:spa
[Ab] Resumo:Biomedical potential of polyphenols lies in their ability to modulate redox balance and the mechanisms involved in the development of chronic noncommunicable diseases. OBJECTIVE: The aim of this study was to determine the concentration of total polyphenols in different murine organs by assaying analytical techniques of Folin Ciocalteu (FC) and Fast Blue BB (FBBB). METHOD: Balb/c female mice (n≥3) received for 15 days 100 mg/kg/d of extract of Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB) or Ilex paraguariensis (IP) and control group (treated with water without extract). Polyphenolic concentrations were measured in telencephalon, diencephalon, midbrain, brainstem, cerebellum, spleen, thymus and cardiopulmonary tissue by FC and FBBB methods. Results were compared by ANOVA followed by Tukey test (p<0.05). RESULTS: FBBB method reported higher detections than FC (4.5 fold in telencephalon, 8.4 in midbrain, 5 in brainstem, 7.2 in spleen, 68.5 in thymus and 4 in cardiopulmonary tissue). Regarding the treatments, the group that received AQB showed to have increased polyphenolic bioavailability in brainstem (p<0.02). With FBBB, a decrease on thymic polyphenol content after treatment with IP was detected (p<0.005). In cerebellum of the groups treated with IP and telencephalon of the control group showed significant differences when these were analyzed with FC (p<0.05, p<0.0035 respectively). CONCLUSIONS: FBBB method showed higher estimations of polyphenolic bioavailability than FC, and this could be related to higher specificity of the technique to react with phenolic compounds.
[Mh] Termos MeSH primário: Aspidosperma/química
Extratos Vegetais/farmacocinética
Polifenóis/farmacocinética
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Encéfalo/metabolismo
Compostos de Diazônio
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Miocárdio/química
Baço/efeitos dos fármacos
Baço/metabolismo
Timo/efeitos dos fármacos
Timo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diazonium Compounds); 0 (Plant Extracts); 0 (Polyphenols); 15518-68-0 (Fast Blue BB)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28006917
[Au] Autor:Qu Y; Simonescu R; De Luca V
[Ad] Endereço:Department of Biological Sciences and ‡Department of Chemistry, Brock University , 1812 Sir Isaac Brock Way, St. Catharines, Ontario L2S 3A1, Canada.
[Ti] Título:Monoterpene Indole Alkaloids from the Fruit of Tabernaemontana litoralis and Differential Alkaloid Composition in Various Fruit Components.
[So] Source:J Nat Prod;79(12):3143-3147, 2016 Dec 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two new monoterpene indole alkaloids, isoakuammiline (1) and 18-hydroxypseudovincadifformine (2), and five known alkaloids, coronaridine (3), heyneanine (4), 3,19-oxidocoronaridine (5), tabersonine, and strictosidine, were identified from the fruit of Tabernaemontana litoralis. The structures of the alkaloids were determined using NMR and MS data analyses. While 18-hydroxypseudovincadifformine (2) showed a new hydroxylation pattern, isoakuammiline (1) revealed a novel skeleton for monoterpene indole alkaloids. In spite of the isolation of stemmadenine from the fruit tissues in other Tabernaemontana species, this vital biosynthetic precursor of iboga, aspidosperma, and pseudoaspidosperma skeletons was not found in T. litoralis.
[Mh] Termos MeSH primário: Frutas/química
Alcaloides de Triptamina e Secologanina/isolamento & purificação
Tabernaemontana/química
[Mh] Termos MeSH secundário: Aspidosperma/química
Hawaii
Alcaloides de Indol
Ressonância Magnética Nuclear Biomolecular
Quinolinas
Alcaloides de Triptamina e Secologanina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indole Alkaloids); 0 (Quinolines); 0 (Secologanin Tryptamine Alkaloids); 10012-73-4 (stemmadenine); 4429-63-4 (tabersonine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00405


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[PMID]:27759387
[Au] Autor:Nge CE; Sim KS; Lim SH; Thomas NF; Low YY; Kam TS
[Ad] Endereço:Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia.
[Ti] Título:A Hexacyclic, Iboga-Derived Monoterpenoid Indole with a Contracted Tetrahydroazepine C-Ring and Incorporation of an Isoxazolidine Moiety, a Seco-Corynanthean, an Aspidosperma-Aspidosperma Bisindole with Anticancer Properties, and the Absolute Configuration of the Pyridopyrimidine Indole Alkaloid, Vernavosine.
[So] Source:J Nat Prod;79(10):2709-2717, 2016 Oct 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Examination of the EtOH extract of the Malayan Tabernaemontana corymbosa resulted in the isolation of three new alkaloids, viz., cononuridine (1), an unusual hexacyclic, iboga-derived, monoterpenoid indole characterized by contraction of the tetrahydroazepine C-ring and incorporation of an additional isoxazolidine ring, taberisidine (2), a seco-corynanthean alkaloid, and conofolidine (3), an Aspidosperma-Aspidosperma bisindole that showed pronounced in vitro growth inhibitory activity against an array of human cancer cell lines, including KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, and HCT 116 cells. The structures and absolute configurations of 1 and 3 and the absolute configuration of the novel pyridopyrimidine indole alkaloid vernavosine (4) were confirmed by X-ray diffraction analysis. A reasonable biosynthesis route to cononuridine starting from an iboga precursor is presented.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos
Alcaloides de Indol
Monoterpenos
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Aspidosperma/química
Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais
Células HCT116
Células HT29
Seres Humanos
Alcaloides de Indol/química
Alcaloides de Indol/isolamento & purificação
Alcaloides de Indol/farmacologia
Células KB
Estrutura Molecular
Monoterpenos/isolamento & purificação
Monoterpenos/farmacologia
Tabernaemontana/química
Vincristina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Indole Alkaloids); 0 (Monoterpenes); 0 (corynanthean); 0 (vernavosine); 5J49Q6B70F (Vincristine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


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[PMID]:26926777
[Au] Autor:Wyler B; Brucelle F; Renaud P
[Ad] Endereço:Universität Bern , Departement für Chemie und Biochemie, Freiestrasse 3, CH-3012 Bern, Switzerland.
[Ti] Título:Preparation of the Core Structure of Aspidosperma and Strychnos Alkaloids from Aryl Azides by a Cascade Radical Cyclization.
[So] Source:Org Lett;18(6):1370-3, 2016 Mar 18.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel approach to prepare the core structure of Aspidosperma and Strychnos alkaloids is described. The strategy is based on a cyclization cascade involving the formation of quaternary carbon center followed by trapping of the radical intermediate by an aryl azide to build the 5-membered ring of the pyrrolocarbazole system. This reaction is run with triethylborane without the need for any hydrogen atom donor such as a tin hydride or tris(trimethylsilyl)silane, and it furnishes the tetracyclic framework as a single diastereomer. The influence of different N-protecting groups on the starting iodoacetamide has been examined.
[Mh] Termos MeSH primário: Alcaloides/síntese química
Aspidosperma/química
Azidas/química
Strychnos/química
[Mh] Termos MeSH secundário: Alcaloides/química
Catálise
Ciclização
Alcaloides de Indol/síntese química
Alcaloides de Indol/química
Iodoacetamida/química
Estrutura Molecular
Quinolinas/síntese química
Quinolinas/química
Estereoisomerismo
Estricnina/síntese química
Estricnina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Azides); 0 (Indole Alkaloids); 0 (Quinolines); 0 (aspidospermidine); H9Y79VD43J (Strychnine); ZRH8M27S79 (Iodoacetamide)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160318
[Lr] Data última revisão:
160318
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.6b00306


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[PMID]:26827885
[Au] Autor:Kitajima M; Takayama H
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
[Ti] Título:Monoterpenoid Bisindole Alkaloids.
[So] Source:Alkaloids Chem Biol;76:259-310, 2016.
[Is] ISSN:1099-4831
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This chapter covers the literature on bisindole alkaloids consisting of monoterpenoid indoles, published up to June 2015. Bisindole alkaloids isolated from plants belonging to the families Apocynaceae and Loganiaceae, including Iboga-vobasine type, Aspidosperma-Aspidosperma type, eburnan-Aspidosperma type, Strychnos-Strychnos type, macroline-macroline type, and so on, are described. Some recent syntheses of monoterpenoid bisindole alkaloids are outlined as well.
[Mh] Termos MeSH primário: Alcaloides de Triptamina e Secologanina/metabolismo
[Mh] Termos MeSH secundário: Aspidosperma/química
Alcaloides de Indol/metabolismo
Tabernaemontana/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Indole Alkaloids); 0 (Secologanin Tryptamine Alkaloids); 0 (eburnan); 2134-83-0 (vobasine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE


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Ceravolo, Isabela Penna
PubMed Central Texto completo
Texto completo SciELO Brasil
[PMID]:26560981
[Au] Autor:Aguiar AC; Cunha AC; Ceravolo IP; Gonçalves RA; Oliveira AJ; Krettli AU
[Ad] Endereço:Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brasil.
[Ti] Título:Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part II: experimental studies withAspidosperma ramiflorum in vivo and in vitro.
[So] Source:Mem Inst Oswaldo Cruz;110(7):906-13, 2015 Nov.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Several species of Aspidosperma plants are used to treat diseases in the tropics, including Aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed. The species, known as guatambu-yellow, yellow peroba, coffee-peroba and matiambu, grows in the Atlantic Forest of Brazil in the South to the Southeast regions. Through a guided biofractionation of A. ramiflorum extracts, the plant activity against Plasmodium falciparum was evaluated in vitro for toxicity towards human hepatoma G2 cells, normal monkey kidney cells and nonimmortalised human monocytes isolated from peripheral blood. Six of the seven extracts tested were active at low doses (half-maximal drug inhibitory concentration < 3.8 µg/mL); the aqueous extract was inactive. Overall, the plant extracts and the purified compounds displayed low toxicity in vitro. A nonsoluble extract fraction and one purified alkaloid isositsirikine (compound 5) displayed high selectivity indexes (SI) (= 56 and 113, respectively), whereas compounds 2 and 3 were toxic (SI < 10). The structure, activity and low toxicity of isositsirikine in vitro are described here for the first time in A. ramiflorum, but only the neutral and precipitate plant fractions were tested for activity, which caused up to 53% parasitaemia inhibition of Plasmodium berghei in mice with blood-induced malaria. This plant species is likely to be useful in the further development of an antimalarial drug, but its pharmacological evaluation is still required.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Aspidosperma/química
Extratos Vegetais/farmacologia
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimaláricos/isolamento & purificação
Antimaláricos/toxicidade
Linhagem Celular
Relação Dose-Resposta a Droga
Seres Humanos
Camundongos
Testes de Sensibilidade Parasitária
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151128
[Lr] Data última revisão:
151128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151113
[St] Status:MEDLINE


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Texto completo SciELO Brasil
[PMID]:26465729
[Au] Autor:Rodrigues PM; Silva JO; Eisenlohr PV; Schaefer CE
[Ad] Endereço:Departamento Biologia Vegetal, Universidade Federal de Viçosa, Viçosa, MG, BR.
[Ti] Título:Climate change effects on the geographic distribution of specialist tree species of the Brazilian tropical dry forests.
[So] Source:Braz J Biol;75(3):679-84, 2015 Aug.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the ecological niche models (ENMs) for three specialist trees (Anadenanthera colubrina, Aspidosperma pyrifolium and Myracrodruon urundeuva) in seasonally dry tropical forests (SDTFs) in Brazil, considering present and future pessimist scenarios (2080) of climate change. These three species exhibit typical deciduousness and are widely distributed by SDTF in South America, being important in studies of the historical and evolutionary processes experienced by this ecosystem. The modeling of the potential geographic distribution of species was done by the method of maximum entropy (Maxent).We verified a general expansion of suitable areas for occurrence of the three species in future (c.a., 18%), although there was reduction of areas with high environmental suitability in Caatinga region. Precipitation of wettest quarter and temperature seasonality were the predictor variables that most contributed to our models. Climatic changes can provide more severe and longer dry season with increasing temperature and tree mortality in tropics. On this scenario, areas currently occupied by rainforest and savannas could become more suitable for occurrence of the SDTF specialist trees, whereas regions occupied by Caatinga could not support the future level of unsustainable (e.g., aridity). Long-term multidisciplinary studies are necessary to make reliable predictions of the plant's adaptation strategies and responses to climate changes in dry forest at community level. Based on the high deforestation rate, endemism and threat, public policies to minimize the effects of climate change on the biodiversity found within SDTFs must be undertaken rapidly.
[Mh] Termos MeSH primário: Mudança Climática
Ecossistema
Dispersão Vegetal
Árvores/fisiologia
[Mh] Termos MeSH secundário: Anacardiaceae/fisiologia
Aspidosperma/fisiologia
Brasil
Fabaceae/fisiologia
Florestas
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151015
[Lr] Data última revisão:
151015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151015
[St] Status:MEDLINE


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[PMID]:26216513
[Au] Autor:Frausin G; Hidalgo Ade F; Lima RB; Kinupp VF; Ming LC; Pohlit AM; Milliken W
[Ad] Endereço:Coordenação de Tecnologia e Inovação, Instituto Nacional de Pesquisas da Amazônia, Avenida André Araújo, 2936, Petrópolis, CEP 69067-375 Manaus, Amazonas, Brazil. Electronic address: ginafrausin@gmail.com.
[Ti] Título:An ethnobotanical study of anti-malarial plants among indigenous people on the upper Negro River in the Brazilian Amazon.
[So] Source:J Ethnopharmacol;174:238-52, 2015 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this article we present the plants used for the treatment of malaria and associated symptoms in Santa Isabel do Rio Negro in the Brazilian Amazon. The region has important biological and cultural diversities including more than twenty indigenous ethnic groups and a strong history in traditional medicine. OBJECTIVE: The aims of this study are to survey information in the Baniwa, Baré, Desana, Piratapuia, Tariana, Tukano, Tuyuca and Yanomami ethnic communities and among caboclos (mixed-ethnicity) on (a) plant species used for the treatment of malaria and associated symptoms, (b) dosage forms and (c) distribution of these anti-malarial plants in the Amazon. METHODS: Information was obtained through classical ethnobotanical and ethnopharmacological methods from interviews with 146 informants in Santa Isabel municipality on the upper Negro River, Brazil. RESULTS: Fifty-five mainly native neotropical plant species from 34 families were in use. The detailed uses of these plants were documented. The result was 187 records (64.5%) of plants for the specific treatment of malaria, 51 records (17.6%) of plants used in the treatment of liver problems and 29 records (10.0%) of plants used in the control of fevers associated with malaria. Other uses described were blood fortification ('dar sangue'), headache and prophylaxis. Most of the therapeutic preparations were decoctions and infusions based on stem bark, root bark and leaves. These were administered by mouth. In some cases, remedies were prepared with up to three different plant species. Also, plants were used together with other ingredients such as insects, mammals, gunpowder and milk. CONCLUSION: This is the first study on the anti-malarial plants from this region of the Amazon. Aspidosperma spp. and Ampelozizyphus amazonicus Ducke were the most cited species in the communities surveyed. These species have experimental proof supporting their anti-malarial efficacy. The dosage of the therapeutic preparations depends on the kind of plant, quantity of plant material available, the patient's age (children and adults) and the local expert. The treatment time varies from a single dose to up to several weeks. Most anti-malarial plants are domesticated or grow spontaneously. They are grown in home gardens, open areas near the communities, clearings and secondary forests, and wild species grow in areas of seasonally flooded wetlands and terra firme ('solid ground') forest, in some cases in locations that are hard to access. Traditional knowledge of plants was found to be falling into disuse presumably as a consequence of the local official health services that treat malaria in the communities using commercial drugs. Despite this, some species are used in the prevention of this disease and also in the recovery after using conventional anti-malarial drugs.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Etnobotânica/métodos
Índios Sul-Americanos/etnologia
Malária/etnologia
Plantas Medicinais
Rios
[Mh] Termos MeSH secundário: Ampelopsis
Antimaláricos/isolamento & purificação
Aspidosperma
Brasil/etnologia
Feminino
Seres Humanos
Malária/tratamento farmacológico
Masculino
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151106
[Lr] Data última revisão:
151106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150729
[St] Status:MEDLINE


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Texto completo
[PMID]:26166404
[Au] Autor:White KL; Mewald M; Movassaghi M
[Ad] Endereço:Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
[Ti] Título:Direct Observation of Intermediates Involved in the Interruption of the Bischler-Napieralski Reaction.
[So] Source:J Org Chem;80(15):7403-11, 2015 Aug 07.
[Is] ISSN:1520-6904
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first mechanistic investigation of electrophilic amide activation of α,α-disubstituted tertiary lactams and the direct observation of key intermediates by in situ FTIR, (1)H, (13)C, and (19)F NMR in our interrupted Bischler-Napieralski-based synthetic strategy to the aspidosperma alkaloids, including a complex tetracyclic diiminium ion, is discussed. The reactivity of a wide range of pyridines with trifluoromethanesulfonic anhydride was systematically examined, and characteristic IR absorption bands for the corresponding N-trifluoromethanesulfonylated pyridinium trifluoromethanesulfonates were assigned. The reversible formation of diiminium ether intermediates was studied, providing insight into divergent mechanistic pathways as a function of the steric environment of the amide substrate and stoichiometry of reagents. Importantly, when considering base additives during electrophilic amide activation, more hindered α-quaternary tertiary lactams require the use of non-nucleophilic pyridine additives in order to avoid deactivation via a competing desulfonylation reaction. The isolation and full characterization of a tetracyclic iminium trifluoromethanesulfonate provided additional correlation between in situ characterization of sensitive intermediates and isolable compounds involved in this synthetic transformation.
[Mh] Termos MeSH primário: Radioisótopos de Flúor/química
Lactamas/química
Mesilatos/química
Compostos de Piridínio/química
[Mh] Termos MeSH secundário: Alcaloides/química
Amidas/química
Aspidosperma/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amides); 0 (Fluorine Radioisotopes); 0 (Lactams); 0 (Mesylates); 0 (Pyridinium Compounds); JE2SY203E8 (trifluoromethanesulfonic acid)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150714
[St] Status:MEDLINE
[do] DOI:10.1021/acs.joc.5b01023


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[PMID]:25920261
[Au] Autor:Estrada O; González-Guzmán JM; Salazar-Bookman MM; Cardozo A; Lucena E; Alvarado-Castillo CP
[Ti] Título:Hypotensive and bradycardic effects of quinovic acid glycosides from Aspidosperma fendleri in spontaneously hypertensive rats.
[So] Source:Nat Prod Commun;10(2):281-4, 2015 Feb.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Aspidosperma genus (Apocynaceae) represents one of the largest sources of indole alkaloids widely associated with cardiovascular effects. Aspidosperma fendleri, a plant found mainly in Venezuela, has a single phytochemical report in which is revealed the presence of alkaloids in its seeds. This study explored the cardiovascular effects of an ethanolic extract of A. fendleri leaves (EEAF) in spontaneously hypertensive rats (SHR) and its potential bioactive compounds. Using bioguided fractionation, fractions and pure compounds were intravenously administered to SHR and their effects on mean arterial blood pressure (MABP) and heart rate (HR) monitored over time. EEAF induced hypotensive and bradycardic effects as shown by significant reductions in mean arterial blood pressure (MABP) and heart rate (HR), respectively. Bioactivity-guided fractionation led to the isolation of a mixture of two known isomeric triterpenoid glycosides identified by spectral evidence as quinovic acid 3-O-ß-rhamnopyranoside and quinovic acid 3-O-ß-fucopyranoside. This mixture of triterpenoid saponins induced reductions in MABP and HR similar to those induced by propranolol. Together, these findings indicate that the two quinovic acid glycosides are responsible for the hypotensive and bradycardic effects which suggest their potential use in cardiovascular therapy.
[Mh] Termos MeSH primário: Anti-Hipertensivos/farmacologia
Aspidosperma/química
Glicosídeos/farmacologia
Frequência Cardíaca/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Glicosídeos/química
Masculino
Estrutura Molecular
Ratos
Ratos Endogâmicos SHR
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Glycosides)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:150429
[Lr] Data última revisão:
150429
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150430
[St] Status:MEDLINE



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