Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.500.217 [Categoria DeCS]
Referências encontradas : 183 [refinar]
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[PMID]:29195214
[Au] Autor:Murugesan B; Sonamuthu J; Pandiyan N; Pandi B; Samayanan S; Mahalingam S
[Ad] Endereço:Advanced Green Chemistry Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.
[Ti] Título:Photoluminescent reduced graphene oxide quantum dots from latex of Calotropis gigantea for metal sensing, radical scavenging, cytotoxicity, and bioimaging in Artemia salina: A greener route.
[So] Source:J Photochem Photobiol B;178:371-379, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this work, we report the fabrication of green fluorescent reduced graphene oxide quantum dots (rGOQDs) from the latex of Calotropis gigantea by simple one-step microwave assisted greener route. The latex of Calotropis gigantea calcined at 300°C and its ethanolic extract is used for the synthesis of QDs, The rGOQDs showed particle size ranging from 2 to 8nm and it exhibited green fluorescent in longer UV region at 360-520nm. The rGOQDs graphitic nature was confirmed by RAMAN and XRD analysis. The FTIR, XPS demonstrate that presence of functional groups such as CO, COC, -OH, hence it's addressing them as rGOQDs. It is used to design the greener and economically adopted fluorescent probe for the detection of Pb ions. It provides simple and appropriate for the selective and sensitive detection of Pb ions in water purification process. It also trapped the free radicals and neutralized that and act as an excellent radical scavenger in DPPH radical scavenging assessment. These rGOQDs showed excellent biocompatibility on brine shrimp nauplii (Artemia salina) up to 160µg/mL for 24h incubation. Furthermore, rGOQDS were demonstrated as fluorescent bioimaging probe selectively in the inner digestion part of Artemia salina. In summary, stable, economically viable, highly biocompatible, greener method based rGOQDs were prepared for heavy metal ion detecting, radical scavenging, bioimaging applications which can play a vital role in the future nanotechnology-based biomedical field.
[Mh] Termos MeSH primário: Artemia/metabolismo
Calotropis/química
Depuradores de Radicais Livres/química
Grafite/química
Pontos Quânticos/química
[Mh] Termos MeSH secundário: Animais
Artemia/química
Artemia/efeitos dos fármacos
Materiais Biocompatíveis/química
Materiais Biocompatíveis/toxicidade
Calotropis/metabolismo
Técnicas Eletroquímicas
Corantes Fluorescentes/química
Íons/química
Látex/química
Chumbo/análise
Microscopia Eletrônica de Transmissão
Microscopia de Fluorescência
Micro-Ondas
Óxidos/química
Tamanho da Partícula
Pontos Quânticos/toxicidade
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Fluorescent Dyes); 0 (Free Radical Scavengers); 0 (Ions); 0 (Latex); 0 (Oxides); 2P299V784P (Lead); 7782-42-5 (Graphite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28817274
[Au] Autor:Yoneyama T; Arai MA; Akamine R; Koryudzu K; Tsuchiya A; Sadhu SK; Ahmed F; Itoh M; Okamoto R; Ishibashi M
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
[Ti] Título:Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.
[So] Source:J Nat Prod;80(9):2453-2461, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease occur due to loss of the structure and function of neurons. For the potential treatment of neurodegenerative diseases, accelerators of neuronal differentiation of neural stem cells (NSCs) have been focused on and a cell-based assay system for measuring Notch signaling pathway activity was constructed. Using this assay system, eight compounds isolated from Calotropis gigantea were identified as inhibitors of the Notch signaling pathway. Hes1 and Hes5 are target genes of the Notch signaling pathway, and compound 1, called uscharin, decreased the protein levels of Hes1 and Hes5 in assay cells and MEB5 cells (mouse NSCs). Furthermore, uscharin (1) enhanced the differentiation of MEB5 cells into neurons. The mechanism of uscharin (1) for the Notch signaling inhibitory activity would be acceleration of the degradation of the Notch intracellular domain (NICD) in the MEB5 cells.
[Mh] Termos MeSH primário: Calotropis/química
Diferenciação Celular/fisiologia
Células-Tronco Neurais/citologia
Neurônios/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Seres Humanos
Camundongos
Estrutura Molecular
Células-Tronco Neurais/metabolismo
Neurônios/química
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00282


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[PMID]:28709944
[Au] Autor:Bezerra CF; Mota ÉF; Silva ACM; Tomé AR; Silva MZR; de Brito D; Porfírio CTMN; Oliveira AC; Lima-Filho JV; Ramos MV
[Ad] Endereço:Instituto Federal de Educação, Ciência e Tecnologia do Estado do Rio Grande do Norte, Pau dos Ferros, Rio Grande do Norte, Brazil. Electronic address: bfmila@yahoo.com.br.
[Ti] Título:Latex proteins from Calotropis procera: Toxicity and immunological tolerance revisited.
[So] Source:Chem Biol Interact;274:138-149, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Many thousands of plants are disseminated worldwide in traditional and folk medicines based on the belief that their leaves, roots, seeds, bark or secretions, when adequately handled, can treat, alleviate or ameliorate numerous disease symptoms. Calotropis procera (Apocynaceae) is a popular medicinal plant and the claims of this shrub's phytomedicinal properties have been scientifically validated. In this study, further prospects towards the in vivo toxicity and oral immunological tolerance of phytomodulatory proteins isolated from the latex of C. procera are reported. Acute toxicity was determined in mice by oral and intraperitoneal administration of latex proteins (LP) and was followed behavioral, hematological and histological analyses. Oral immunological tolerance to LP was assessed by intraperitoneal immunization in mice that had received LP orally before. Animals given 5000 mg/kg orally exhibited only discrete behavioral alterations and augmentation of monocytes. Death was not notified 14 days after exposure. However, all animals receiving LP 150 mg/kg by i.p. died in 1 h. Death (20%) was documented when LP (75 mg/kg) was given in the peritoneum and signs of harmful effects were observed in the survivors (80%). Oral immunological tolerance was observed in animals previously given LP orally, when they were further immunized/challenged with peritoneal exposure to different doses of LP. This was confirmed by the lowering of IgE and IgG in the serum, IL-4 and IFN-γ in spleen homogenates and the absence of anaphylaxis signs. It is therefore concluded that LP exhibited quite discrete adverse effects when orally administrated at higher concentrations and this route of administration did not stimulate adverse immunological reactions. Instead it was observed immunological tolerance. The present study contributes very important information concerning the safe use of C. procera as a phytotherapeutic agent.
[Mh] Termos MeSH primário: Calotropis/metabolismo
Tolerância Imunológica/efeitos dos fármacos
Látex/toxicidade
Proteínas de Plantas/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Anafilaxia/etiologia
Animais
Feminino
Hipersensibilidade Tardia/etiologia
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Infusões Parenterais
Interferon gama
Interleucina-4/metabolismo
Rim/efeitos dos fármacos
Rim/patologia
Látex/imunologia
Látex/metabolismo
Camundongos
Proteínas de Plantas/imunologia
Plantas Medicinais/metabolismo
Baço/efeitos dos fármacos
Baço/metabolismo
Baço/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Latex); 0 (Plant Proteins); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28495081
[Au] Autor:Nguyen KDH; Dang PH; Nguyen HX; Nguyen MTT; Awale S; Nguyen NT
[Ad] Endereço:Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Viet Nam.
[Ti] Título:Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea.
[So] Source:Bioorg Med Chem Lett;27(13):2902-2906, 2017 07 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new lignan, 9'-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4-12) have been isolated from the active fractions, CHCl (IC , 0.32µgmL ) and EtOAc (IC , 0.55µgmL ) fractions of the leaves of Calotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds 1 and 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC values of 3.7 and 3.3µM, respectively. 9'-Methoxypinoresinol (1) significantly inhibited the colony formation of PANC-1 cells in a concentration-dependent manner.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Calotropis/química
Lignanas/farmacologia
Compostos Fitoquímicos/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Lignanas/química
Lignanas/isolamento & purificação
Estrutura Molecular
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Lignans); 0 (Phytochemicals)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


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[PMID]:28490091
[Au] Autor:Rayanatou IA; Mahamadou EG; Garric G; Harel-Oger M; Leduc A; Jardin J; Briard-Bion V; Cauty C; Adakal H; Grongnet JF; Gaucheron F
[Ad] Endereço:STLO, UMR 1253, INRA, Agrocampus Ouest, 35000 Rennes, France; Agrocampus Ouest, 65 rue de St-Brieuc, 35042 Rennes Cedex, France; Faculté d'Agronomie et des Sciences de l'Environnement, Université Dandicko Dankoulodo de Maradi, BP 465 ADS Maradi, Niger.
[Ti] Título:Physico-chemical characterization of dairy gel obtained by a proteolytic extract from Calotropis procera - A comparison with chymosin.
[So] Source:Food Chem;232:405-412, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chymosin is the major enzyme used in cheesemaking but latex enzymes are also used. The aim of this work was to characterize the composition and the structure of dairy gel obtained by an extract of Calotropis procera leaves in comparison with those obtained by chymosin. The biochemical and mineral compositions of the curds and the cheese yields obtained by using Calotropis procera extract or chymosin were relatively similar. Quantitative and qualitative evaluations of proteolysis after milk coagulation, determined by the non-protein nitrogen content and chromatography coupled to mass spectrometry, indicated that Calotropis procera extract was more proteolytic than chymosin and that κ-casein was proteolyzed. The main consequence of proteolysis by Calotropis procera extract or chymosin was the formation of a similar and regular network with the presence of aggregates of casein micelles. These results support that Calotropis procera extract can be used as effective coagulant in cheesemaking.
[Mh] Termos MeSH primário: Calotropis
[Mh] Termos MeSH secundário: Animais
Caseínas
Queijo
Quimosina
Leite
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caseins); EC 3.4.23.4 (Chymosin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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Ramos, Marcio Viana
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[PMID]:28078650
[Au] Autor:Kumar VL; Guruprasad B; Fatmi SMA; Chaudhary P; Alencar NMN; Lima-Filho JVM; Ramos MV
[Ad] Endereço:Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India. kumarvl98@hotmail.com.
[Ti] Título:In Vivo Efficacy of Latex from Calotropis procera in Ameliorating Fever-Biochemical Characteristics and Plausible Mechanism.
[So] Source:Appl Biochem Biotechnol;182(3):1229-1239, 2017 Jul.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calotropis procera latex fractions possessing anti-inflammatory property were characterized for their biochemical properties, compared for their efficacy in ameliorating fever in rats and their mechanism of action was elucidated. Aqueous fraction and methanol extract (AqDL and MeDL) were derived from the dried latex (DL) and proteins were separated from the fresh latex (LP). Polyacrylamide gel electrophoresis carried out under denaturing conditions showed the presence of proteins with some similarity in LP and AqDL and both of these fractions exhibited proteinase activity by gelatin zymography. A further analysis revealed that only the LP fraction possesses cysteine proteinase activity. Oral administration of both AqDL and MeDL produced a dose-dependent reduction in body temperature in rats where fever was induced by yeast and their effect was comparable to that of standard drug paracetamol while intravenous administration of LP was not so effective. Both AqDL and MeDL produced a significant reduction in the levels of TNF-α, PGE , and immunoreactivity of COX-2 in the hypothalamus as compared to yeast control group. This study shows that both AqDL and MeDL, the orally effective anti-inflammatory fractions of latex, have therapeutic potential in treating various febrile conditions.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Calotropis/química
Febre/tratamento farmacológico
Látex/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Inflamatórios/química
Ciclo-Oxigenase 2/metabolismo
Dinoprostona/metabolismo
Relação Dose-Resposta a Droga
Febre/metabolismo
Febre/patologia
Hipotálamo/metabolismo
Hipotálamo/patologia
Extratos Vegetais/química
Proteínas de Plantas/química
Proteínas de Plantas/farmacologia
Ratos
Ratos Wistar
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Latex); 0 (Plant Extracts); 0 (Plant Proteins); 0 (Tumor Necrosis Factor-alpha); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (Ptgs2 protein, rat); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-016-2395-y


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[PMID]:28068637
[Au] Autor:Pradeepkumar P; Govindaraj D; Jeyaraj M; Munusamy MA; Rajan M
[Ad] Endereço:Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625021, Tamil Nadu, India.
[Ti] Título:Assembling of multifunctional latex-based hybrid nanocarriers from Calotropis gigantea for sustained (doxorubicin) DOX releases.
[So] Source:Biomed Pharmacother;87:461-470, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Natural rubber Latex (Lax) is a colloidal dispersion of polymer particles in liquid and shows good biodegradable, biocompatibility, and non-toxicity. Natural polymers are the most important materials used in food packaging, micro/nano-drug delivery, tissue engineering, agriculture, and coating. In the present study, natural compounds extracted from plant Lax were designed to function as drug carriers using various surfactants via emulation and solvent evaporation method. Calotropis gigantea belongs to the family Apocynaceae and has received considerable attention in modern medicine, ayurvedeic, siddha, and traditional medicine. Since, we were isolated biodegradable, non-toxic, and biocompatible materials as latex from Calotropis gigantea plant. The Lax was separated as per their solubility nature and it was designed as a carrier using surfactant namely; Sorbitanmonolaurate (Span-20), sodium lauryl sulfate (SLS), and cetyltrimethylammonium bromide (CTAB). The isolated compounds from Lax of Calotropis gigantea were analyzed using high-performance liquid chromatography. To confirm the encapsulation efficiency and in vitro drug release of the carriers, doxorubicin (DOX) was used as a model natural drug. The hybrid nanocarriers were successfully synthesized through simple solvent evaporation using three surfactants, and the morphology was characterized by SEM and TEM technique. The functionality and crystalline nature of the nanocarriers were confirmed using FTIR and XRD, respectively. Within 90min, the maximum amount of DOX was encapsulated in the carriers, and prolonged cumulative drug release by the nanocarriers was observed. The formulated natural carriers were found to have potentially effective cytotoxic effects on lung cancer cells.
[Mh] Termos MeSH primário: Calotropis/química
Preparações de Ação Retardada/química
Doxorrubicina/química
Portadores de Fármacos/química
Látex/química
Nanopartículas/química
[Mh] Termos MeSH secundário: Células A549
Linhagem Celular Tumoral
Compostos de Cetrimônio/química
Química Farmacêutica/métodos
Preparações de Ação Retardada/farmacologia
Doxorrubicina/farmacologia
Hexoses/química
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Extratos Vegetais/química
Dodecilsulfato de Sódio/química
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cetrimonium Compounds); 0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Hexoses); 0 (Latex); 0 (Plant Extracts); 368GB5141J (Sodium Dodecyl Sulfate); 6W9PS8B71J (sorbitan monolaurate); 80168379AG (Doxorubicin); Z7FF1XKL7A (cetrimonium)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


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[PMID]:28024207
[Au] Autor:Cao E; Duan W; Wang A; Zheng Y
[Ad] Endereço:Gansu Key Laboratory for Environmental Pollution Prediction and Control, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, 730000, China.
[Ti] Título:Oriented growth of poly(m-phenylenediamine) on Calotropis gigantea fiber for rapid adsorption of ciprofloxacin.
[So] Source:Chemosphere;171:223-230, 2017 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A facile polymerization of m-phenylenediamine (mPD) in methanol/water (50:50, v/v) was performed via conventional chemical oxidative method by using Calotropis gigantea fiber (CGF) as the natural biotemplate. The as-prepared CGF oriented poly(m-phenylenediamine) (PmPD), i.e. CGF-O-PmPD, exhibits a well defined fiber-oriented morphology. The presence of PmPD layer enables CGF-O-PmPD to present roughen surface with N-rich functional groups that can show high performance for the adsorption of ciprofloxacin. The variables affecting the adsorption capacity were systematically investigated, including contact time, initial concentration, initial pH, ion strength, and so forth. The experimental data reveal that with increasing the amount of mPD from 0.2, 0.5 to 2.0 g, the adsorption capacity for ciprofloxacin shows a monotonic decrease, while the adsorption kinetics show a monotonic increase, with the adsorption percentage from >50%, >60% to >70% within 10 s, demonstrating its superfast adsorption kinetics for ciprofloxacin. In addition, an increasing adsorption capacity is observed over the pH range studied, with the adsorption capacity from 0.73 to 6.7 mg g at pH 2.0 to 64.9-77.3 mg g at pH 10.0. After five adsorption-desorption cycles, the adsorption capacity of CGF-O-PmPD for ciprofloxacin shows no significant decrease, indicating its excellent reusability and potential application in treating antibiotic-containing wastewater.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Calotropis/metabolismo
Ciprofloxacino/isolamento & purificação
Fenilenodiaminas/química
[Mh] Termos MeSH secundário: Adsorção
Calotropis/crescimento & desenvolvimento
Concentração de Íons de Hidrogênio
Cinética
Concentração Osmolar
Oxirredução
Águas Residuais
Água
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Phenylenediamines); 0 (Waste Water); 0 (Water Pollutants, Chemical); 0 (poly(1,3-phenylenediamine)); 059QF0KO0R (Water); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


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[PMID]:27988899
[Au] Autor:Hussaan M; Iqbal N; Adeel S; Azeem M; Tariq Javed M; Raza A
[Ad] Endereço:Department of Botany, Faculty of Science and Technology, Government College University, Faisalabad, 38000, Pakistan.
[Ti] Título:Microwave-assisted enhancement of milkweed (Calotropis procera L.) leaves as an eco-friendly source of natural colorants for textile.
[So] Source:Environ Sci Pollut Res Int;24(5):5089-5094, 2017 Feb.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Application of natural colorants to textile fabrics has gained worldwide public acceptance due to the hazardous nature of synthetic dyes. Present study investigated the microwave's mediated extraction of natural colorants from leaves of milkweed (Calotropis procera L.) as well as their application to cotton fabrics assisted with biochemical mordants. Dye extraction from C. procera leaves was carried out in various mediums (alkali and aqueous), and the extracted dye as well as cotton fabrics was irradiated with microwaves for 2, 4, 6, 8, or 10 min. Effect of various temperature regimes and sodium chloride (NaCl) concentrations was also evaluated on the color strength of dyed cotton fabrics. The results revealed that extraction of natural colorants was enhanced when microwave radiations were applied for 4 min by using alkali as an extraction medium as compared to aqueous one. Optimum dyeing of cotton fabrics was achieved by using NaCl at a temperature of 55 °C. Among the chemical mordants, iron was effective for better color strength when used as pre- and post-mordant. Among the studied bio-mordants, extract of Acacia nilotica bark significantly improved the color strength and fastness properties as pre-mordant and Curcuma longa tuber as post-mordant. It was concluded that extract of C. procera leaves was a potential source of natural colorants and a high level of dye was obtained upon irradiation of alkali-solubilized extract for 4 min. Application of NaCl at concentration of 3 g/100 mL and temperature treatment of 55 °C significantly improved the color strength of dyed cotton fabrics.
[Mh] Termos MeSH primário: Calotropis
Corantes
Micro-Ondas
Têxteis
[Mh] Termos MeSH secundário: Cor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-8162-3


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Ramos, Marcio Viana
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[PMID]:27910140
[Au] Autor:de Alencar NM; da Silveira Bitencourt F; de Figueiredo IS; Luz PB; Lima-Júnior RC; Aragão KS; Magalhães PJ; de Castro Brito GA; Ribeiro RA; de Freitas AP; Ramos MV
[Ad] Endereço:Departamento de Fisiologia e Farmacologia/UFC, Coronel Nunes de Melo, 1127 Rodolfo Teófilo, 60430-270, Ceará, Brazil.
[Ti] Título:Side-Effects of Irinotecan (CPT-11), the Clinically Used Drug for Colon Cancer Therapy, Are Eliminated in Experimental Animals Treated with Latex Proteins from Calotropis procera (Apocynaceae).
[So] Source:Phytother Res;31(2):312-320, 2017 Feb.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Intestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for additional 6 days. Animal survival, body weight variation, and diarrhea were registered. After animal sacrifice (day 7 post first injection of CPT-11), intestinal samples were collected to study morphology and inflammatory parameters. Animals given LP exhibited improved parameters (survival, body weight, and absence of diarrhea) as compared with the CPT-11 control. The severity of IM observed in animals given CPT-11 was reduced in animals treated with LP. Treatment with LP also prevented the reduction in the villus/crypt ratio promoted by CPT-11. The rise in MPO activity and pro-inflammatory cytokines, over-contractility of the smooth muscle, and diarrhea were all abrogated in LP-treated mice. Markedly reduced immunostaining intensity for COX-2, TNF-α, IL-1ß, iNOS, and NF-κB was observed in the intestinal tissue of animals treated with LP. The side-effects of CPT-11 were eliminated by LP treatment in experimental animals and improved clinical parameters characteristic of IM All known biochemical pathogenesis. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Apocynaceae/química
Calotropis/química
Camptotecina/análogos & derivados
Neoplasias do Colo/tratamento farmacológico
Látex/farmacologia
[Mh] Termos MeSH secundário: Animais
Camptotecina/efeitos adversos
Neoplasias do Colo/patologia
Modelos Animais de Doenças
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Latex); 7673326042 (irinotecan); XT3Z54Z28A (Camptothecin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5752



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