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[PMID]:28119100
[Au] Autor:Desai S; Babaria P; Nakarani M; Shah K; Paranjape A
[Ad] Endereço:Department of Pharmacology, Baroda College of Pharmacy, Vadodara, Gujarat, India. Electronic address: sharadarva@gmail.com.
[Ti] Título:Antiosteoporotic effect of Hemidesmus indicus Linn. on ovariectomised rats.
[So] Source:J Ethnopharmacol;199:1-8, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:PHARMACOLOGICAL RELEVANCE: Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions. AIM OF THE STUDY: Lack of scientific data for potential use in bone loss, the present study was undertaken to investigate the effects of ethanol extract of Hemidesmus indicus root for osteoporosis in ovariectomised rats. MATERIALS AND METHODS: Thirty wistar female rats were randomly divided into five groups. One group was sham operated and other four groups were undergone dorsal ovariectomy (OVX). After four weeks of post-operative recovery, three OVX groups, viz. Group1, Group2 and Group3 were treated for ninety days with standard raloxifene (RLX) 1mg/kg/day, Hemidesmus indicus root extract (HIRE) 100mg/kg/day and HIRE 200mg/kg/day respectively. Sham and OVX control groups were fed with equal 1% vehicle volume. Serum and urine biochemistry (alkaline phosphatase, tartrate resistant acid phosphatase, triglyceride, total cholesterol, calcium, phosphorous and hydroxyproline), weight of body, uterus and vagina, femur parameters, three point bending of tibia and fourth lumbar vertebra compression were examined. Furthermore, bone architecture and uterine hypertrophy were examined by histopathological studies. RESULTS: Application of HIRE has increased bone strength and restored bone turnover markers such as alkaline phosphatase, tartrate resistant acid phosphatase and hydroxyproline moreover, improved femur parameters indicated mineralized bones, similar to the results observed with raloxifene treatment. Histopathology studies showed fibrocartilaginous proliferation of trabecular bone and absence of uterine hypertrophy. CONCLUSION: The results strongly suggest that HIRE prevents bone loss in OVX induced osteoporosis without estrogen like side effects. It might be a potential remedy like raloxifene for postmenopausal or estrogen deficiency caused osteoporosis.
[Mh] Termos MeSH primário: Densidade Óssea/efeitos dos fármacos
Hemidesmus
Osteoporose Pós-Menopausa/tratamento farmacológico
Ovariectomia/efeitos adversos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Densidade Óssea/fisiologia
Feminino
Seres Humanos
Osteoporose Pós-Menopausa/etiologia
Osteoporose Pós-Menopausa/patologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Raízes de Plantas
Distribuição Aleatória
Ratos
Ratos Sprague-Dawley
Ratos Wistar
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:25797527
[Au] Autor:Latha M; Sumathi M; Manikandan R; Arumugam A; Prabhu NM
[Ad] Endereço:Department of Animal Health and Management, Alagappa University, Karaikudi 630 004, Tamil Nadu, India.
[Ti] Título:Biocatalytic and antibacterial visualization of green synthesized silver nanoparticles using Hemidesmus indicus.
[So] Source:Microb Pathog;82:43-9, 2015 May.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present investigation, we described the green synthesis of silver nanoparticles using plant leaf extract of Hemidesmus indicus. The synthesized silver nanoparticles were characterized by UV-visible spectroscopy, fourier transform infra-red spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). TEM images proved that the synthesized silver nanoparticles were spherical in shape with an average particle size of 25.24 nm. To evaluate antibacterial efficacy, bacteria was isolated from poultry gut and subjected to 16S rRNA characterization and confirmed as Shigella sonnei. The in vitro antibacterial efficacy of synthesized silver nanoparticles was studied by agar bioassay, well diffusion and confocal laser scanning microscopy (CLSM) assay. The H. indicus mediated synthesis of silver nanoparticles shows rapid synthesis and higher inhibitory activity (34 ± 0.2 mm) against isolated bacteria S. sonnei at 40 µg/ml.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Hemidesmus/metabolismo
Nanopartículas/metabolismo
Shigella sonnei/efeitos dos fármacos
Prata/metabolismo
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Trato Gastrointestinal/microbiologia
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Transmissão
Nanopartículas/química
Nanopartículas/microbiologia
Extratos Vegetais/metabolismo
Folhas de Planta/metabolismo
Aves Domésticas
Shigella sonnei/isolamento & purificação
Prata/química
Prata/farmacologia
Análise Espectral
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150504
[Lr] Data última revisão:
150504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150324
[St] Status:MEDLINE


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[PMID]:25753739
[Au] Autor:Statti G; Marrelli M; Conforti F; Spagnoletti A; Tacchini M; Fimognari C; Brognara E; Gambari R; Sacchetti G; Guerrini A
[Ad] Endereço:Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy.
[Ti] Título:Inhibition of Cancer Cell Proliferation and Antiradical Effects of Decoction, Hydroalcoholic Extract, and Principal Constituents of Hemidesmus indicus R. Br.
[So] Source:Phytother Res;29(6):857-63, 2015 Jun.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In the present work, we explored the effects of decoction, traditional Ayurvedic preparation, and hydroalcoholic extract, a phytocomplex more traditionally studied and commercialized as food supplement in western medicine, from the roots as possible source of chemicals with new functional potential linked to their nutritional uses. The antiproliferative and antioxidant properties were assayed. To test antiproliferative affects, different cancer cell lines, growing both as monolayers (CaCo2, MCF-7, A549, K562, MDA-MB-231, Jurkat, HepG2, and LoVo) and in suspension (K562 and Jurkat) were used. The decoction showed strong activity on HepG2 cells, while the hydroalcoholic extracts were active on HepG2, LoVo, MCF-7, K562, and Jurkat cell lines. Weak inhibition of cancer cell proliferation was observed for the principal constituents of the preparations: 2-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-4-methoxybenzoic acid, and 3-hydroxy-4-methoxybenzaldehyde that were tested alone. The antiradical activity was tested with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt tests and inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Interesting result has also been obtained for hydroalcoholic extract regarding genoprotective potential (58.79% of inhibition at 37.5 µg/mL).
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Proliferação Celular/efeitos dos fármacos
Hemidesmus/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral/efeitos dos fármacos
Flavonoides/química
Seres Humanos
Macrófagos/efeitos dos fármacos
Medicina Ayurvédica
Camundongos
Extratos Vegetais/química
Raízes de Plantas/química
Polifenóis/química
Proantocianidinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Proanthocyanidins)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150609
[Lr] Data última revisão:
150609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150311
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5322


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[PMID]:25560668
[Au] Autor:Turrini E; Ferruzzi L; Guerrini A; Gotti R; Tacchini M; Teti G; Falconi M; Hrelia P; Fimognari C
[Ad] Endereço:Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.
[Ti] Título:In vitro anti-angiogenic effects of Hemidesmus indicus in hypoxic and normoxic conditions.
[So] Source:J Ethnopharmacol;162:261-9, 2015 Mar 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The decoction of the roots of Hemidesmus indicus is widely used in the Indian traditional medicine for many purposes and poly-herbal preparations containing Hemidesmus are often used by traditional medical practitioners for the treatment of cancer. In the context of anticancer pharmacology, anti-angiogenic therapy has become an effective strategy for inhibiting new vessel formation and contrast tumor growth. These considerations are supported by the evidence that most tumors originate in hypoxic conditions and limitation of oxygen diffusion stimulates the formation of tumor abnormal microvasculature. Aim of this study was to evaluate the in vitro anti-angiogenic potential of Hemidesmus indicus (0.31-0.93 mg/mL) on human umbilical vein endothelial cells and delineate the main molecular mechanisms involved in its anti-angiogenic activity both in normoxia and hypoxia. MATERIALS AND METHODS: The decoction of Hemidesmus indicus was subjected to an extensive HPLC phytochemical characterization. Its in vitro anti-angiogenic potential was investigated in normoxia and hypoxia. Cell proliferation, apoptosis induction, and inhibition of endothelial cell migration and invasion were analyzed by flow cytometry. The endothelial tube formation assay was evaluated in matrix gel. The capillary tube branch points formed were counted using a Motic AE21 microscope and a VisiCam videocamera. The regulation of key factors of the neovascularization process such as VEGF, HIF-1α and VEGFR-2 was explored at mRNA and protein level by real time PCR and flow cytometry, respectively. RESULTS: Treatment with Hemidesmus resulted in a significant inhibition of cell proliferation and tube formation in both normoxia and hypoxia. Hemidesmus differently regulated multiple molecular targets related to angiogenesis according to oxygen availability. In normoxia, the inhibition of VEGF was the main responsible for its anti-angiogenic effect; the angiogenesis inhibition induced in hypoxia was regulated by a more complex mechanism involving firstly HIF-1α inhibition, and then VEGF and VEGFR-2 down-regulation. Additionally, the inhibition of endothelial cell migration and invasion by Hemidesmus was more pronounced in normoxia than in hypoxia, possibly due to the physiological enhanced induction of invasion characteristic of hypoxia. CONCLUSIONS: Our results indicate that Hemidesmus might represent a promising therapeutic strategy for diseases in which the inhibition of angiogenesis could be beneficial, such as cancer. The antiangiogenic activity of Hemidesmus is based on multiple interactions with critical steps in the angiogenic cascade. VEGF expression stimulated by HIF-1α as well as endothelial cell migration and differentiation represent important targets of Hemidesmus action and might contribute to its cancer therapeutic efficacy that is presently emerging and offer a scientific basis for its use in traditional medicine.
[Mh] Termos MeSH primário: Células Endoteliais/efeitos dos fármacos
Hemidesmus/química
Neovascularização Fisiológica/efeitos dos fármacos
Oxigênio
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Células Endoteliais/fisiologia
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); S88TT14065 (Oxygen)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150217
[Lr] Data última revisão:
150217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150107
[St] Status:MEDLINE


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[PMID]:24786575
[Au] Autor:Di Pompo G; Poli F; Mandrone M; Lorenzi B; Roncuzzi L; Baldini N; Granchi D
[Ad] Endereço:Laboratory for Orthopedic Pathophysiology and Regenerative Medicine, Rizzoli Orthopedic Institute, via di Barbiano 1/10, 40136 Bologna, Italy. Electronic address: gemma.dipompo@ior.it.
[Ti] Título:Comparative "in vitro" evaluation of the antiresorptive activity residing in four Ayurvedic medicinal plants. Hemidesmus indicus emerges for its potential in the treatment of bone loss diseases.
[So] Source:J Ethnopharmacol;154(2):462-70, 2014 Jun 11.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Four Indian plants, traditionally used in Ayurvedic medicine: Asparagus racemosus Willd., Emblica officinalis Gaertn., Hemidesmus indicus R. Br., and Rubia cordifolia L. were selected on the basis of their ethnobotanical use and of scientific evidence that suggests a potential efficacy in the treatment of bone-loss diseases. The antiresorptive properties of the four plants have been investigated. The aim was to provide adequate evidence for the exploitation of natural compounds as alternative therapeutics for the treatment of diseases caused by increased osteoclast activity. MATERIALS AND METHODS: Decoctions were prepared from dried plant material according to the traditional procedure and standardization by HPLC was performed using marker compounds for each species. Total polyphenols, flavonoids and radical scavenging activity of the decoctions were also determined. The bioactivity of the plant decoctions was evaluated in subsequent phases. (1) A cytotoxicity screening was performed on the mouse monocytic RAW 264.7 cell line to define the concentrations that could be utilized in the following step. (2) The antiresorptive properties of plant decoctions were compared with that of a "gold standard" drug (alendronate) by measuring osteoclastogenesis inhibition and osteoclast apoptosis. (3) The toxic effect on bone forming cells was excluded by evaluating the impact on the proliferation of osteogenic precursors (mesenchymal stem cells, MSC). RESULTS: All the decoctions inhibited osteoclastogenesis similarly to alendronate at the highest doses, but Hemidesmus indicus and Rubia cordifolia were also effective at lower concentrations. Apoptosis increased significantly when cells were exposed to the highest concentration of Emblica officinalis, Hemidesmus indicus, and Rubia cordifolia. All concentrations of Emblica officinalis tested inhibited the proliferation of osteogenic precursors, while only the highest doses of Asparagus racemosus and Rubia cordifolia were toxic. On the contrary, Hemidesmus indicus did not affect osteogenic precursor growth at any concentration tested. CONCLUSION: Among the medicinal plants included in the study, Hemidesmus indicus showed the greatest antiosteoclastic activity without toxic effect on osteogenic precursors. Therefore, Hemidesmus indicus exhibits the properties of an antiresorptive drug and represents the ideal candidate for further clinical investigations.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Conservadores da Densidade Óssea/uso terapêutico
Reabsorção Óssea/prevenção & controle
Hemidesmus/química
Osteoclastos/efeitos dos fármacos
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Conservadores da Densidade Óssea/administração & dosagem
Conservadores da Densidade Óssea/isolamento & purificação
Conservadores da Densidade Óssea/toxicidade
Reabsorção Óssea/patologia
Técnicas de Cultura de Células
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Etnofarmacologia
Seres Humanos
Macrófagos/efeitos dos fármacos
Medicina Ayurvédica
Camundongos
Osteoclastos/patologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Extratos Vegetais/toxicidade
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140526
[Lr] Data última revisão:
140526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140503
[St] Status:MEDLINE


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[PMID]:24726843
[Au] Autor:Nair SA; Sabulal B; Radhika J; Arunkumar R; Subramoniam A
[Ad] Endereço:Phytochemistry and Phytopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Pacha-Palode, Thiruvananthapuram 695562, Kerala, India.
[Ti] Título:Promising anti-diabetes mellitus activity in rats of ß-amyrin palmitate isolated from Hemidesmus indicus roots.
[So] Source:Eur J Pharmacol;734:77-82, 2014 Jul 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:While evaluating the toxicity of the tuberous root extracts of Hemidesmus indicus, a traditional medicinal plant, the glucose lowering property of the root was observed by the investigators. Therefore, it was thought of interest to isolate the anti-hyperglycemic principle from the root and determine its utility to develop an anti-diabetes mellitus medicine. The active principle was isolated from H. indicus root extract by anti-hyperglycemic activity guided chromatographic techniques. Glucose tolerance test in rats was used to evaluate the anti-hyperglycenic property. Anti-diabetes mellitus property was evaluated in alloxan-induced diabetic rats as well as streptozotocin-induced (type-2 model) diabetic rats. The active principle was isolated and identified with spectral data as ß-amyrin palmitate. Although it is a known compound, its presence in H. indicus is not known previously. It was observed for the first time that ß-amyrin palmitate has remarkable anti-hyperglycemic activity in orally glucose loaded rats. Further, interestingly, it exhibited excellent anti-diabetes mellitus activity in both alloxan-diabetic and streptozotocin-diabetic rats at a very low concentration (50µg/kg body weight). One of the mechanisms of action of ß-amyrin palmitate appears to be blocking the entry of glucose from the intestine. ß-Amyrin palmitate is very promising to develop a medicine for diabetes for combination therapy and/or mono-therapy.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Hemidesmus/química
Hipoglicemiantes/farmacologia
Ácido Oleanólico/análogos & derivados
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Peso Corporal/efeitos dos fármacos
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/patologia
Teste de Tolerância a Glucose
Glicogênio/metabolismo
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/uso terapêutico
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Ácido Oleanólico/isolamento & purificação
Ácido Oleanólico/farmacologia
Ácido Oleanólico/uso terapêutico
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (beta-amyrin palmitate); 6SMK8R7TGJ (Oleanolic Acid); 9005-79-2 (Glycogen)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140526
[Lr] Data última revisão:
140526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140415
[St] Status:MEDLINE


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[PMID]:24682189
[Au] Autor:Senadheera SP; Ekanayake S; Wanigatunge C
[Ad] Endereço:Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka. sagarikae@hotmail.com.
[Ti] Título:Antioxidant potential of green leafy porridges.
[So] Source:Ceylon Med J;59(1):4-8, 2014 Mar.
[Is] ISSN:0009-0875
[Cp] País de publicação:Sri Lanka
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the antioxidant potential of porridges (kola kenda) made incorporating herbs. DESIGN: Experimental study. Main outcome measures Total phenolic content was estimated by Folin Ciocalteau method (GAEmg/g(FW) and the antioxidant potential by ABTS free radical scavenging activity (TEAC(µg)/100g (FW). RESULTS: Total phenolics and antioxidant potentials of porridges ranged from 5-73 TEAC(µg) /100g and 0.9- 34.2 GAEg/100g respectively. Significantly high (p ≤ 0.05) total phenolic contents were observed in C. auriculata ("Ranawara") [342 GAE mg/g (FW)] and in M. koenigii ("Karapincha") [199 GAEmg/g(FW)]. The highest antioxidant effect was in C. auriculata ("Ranawara") [73 TEAC(µg)/100g(FW)] followed by M. koenigi ("Karapincha") [26 TEAC(µg)/100g (FW)] and C. ternatea ("Ela Katarolu") [24 TEAC(µg)/100g (FW)]. Lowest antioxidant effect was in porridges made with rice and coconut milk both of which had comparable values. A positive correlation (correlation coefficient > 0.8) between total phenolics and the antioxidant potential was observed for all porridges except for Asparagus racemosus (Haathawariya) porridge which had a high antioxidant potential with a low phenolic content. CONCLUSIONS: This study provides evidence that green leafy porridges are a good source of antioxidants in addition to their reported low glycaemic indices.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Diabetes Mellitus/terapia
Depuradores de Radicais Livres/farmacologia
Fenóis/farmacologia
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Aegle
Amaranthaceae
Asparagus (Planta)
Cassia
Clitoria
Cocos
Hemidesmus
Seres Humanos
Medicina Tradicional
Murraya
Oryza
Fenóis/análise
Preparações de Plantas/química
Sapindaceae
Scoparia
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Plant Preparations)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140401
[St] Status:MEDLINE
[do] DOI:10.4038/cmj.v59i1.6731


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[PMID]:24395450
[Au] Autor:Guerrini A; Mancini I; Maietti S; Rossi D; Poli F; Sacchetti G; Gambari R; Borgatti M
[Ad] Endereço:Department of Life Sciences and Biotechnology, University of Ferrara, Italy.
[Ti] Título:Expression of pro-inflammatory interleukin-8 is reduced by ayurvedic decoctions.
[So] Source:Phytother Res;28(8):1173-81, 2014 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-α has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB. The chemical characterization of these 11 decoctions by spectrophotometric analysis and NMR fingerprinting highlighted that sugars and polyphenols seemed to be the main compounds. Our results demonstrated that Azadirachta indica, Terminalia bellerica, Terminalia chebula, Hemidesmus indicus, Emblica officinalis and Swertia chirata are the most active decoctions in inhibiting NF-kB/DNA interactions by EMSA assay and in reducing pro-inflammatory IL- 8 expression in CF cells at IC50 concentrations by Real-Time and Bio-plex analyses. Finally, we observed the increase of all inhibitory activities with the rise of total polyphenols, procyanidins and flavonoids, except for the levels of IL-8 mRNA accumulation, that were as high as flavonoid content grown up by the statistical multivariate analyses. In conclusion, these six decoctions might be interesting to explore new anti-inflammatory treatments for diseases, such as CF.
[Mh] Termos MeSH primário: Interleucina-8/metabolismo
Medicina Ayurvédica
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Azadirachta/química
Linhagem Celular
Fibrose Cística
Hemidesmus/química
Seres Humanos
NF-kappa B/metabolismo
Phyllanthus emblica/química
Extratos Vegetais/química
Polifenóis/química
Swertia/química
Terminalia/química
Fator de Necrose Tumoral alfa/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (IL8 protein, human); 0 (Interleukin-8); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140806
[Lr] Data última revisão:
140806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140108
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5109


  9 / 53 MEDLINE  
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[PMID]:24276235
[Au] Autor:Reddy MS; Kanakala S; Srinivas KP; Hema M; Malathi VG; Sreenivasulu P
[Ad] Endereço:Sri Venkateswara University, Tirupati, Andhra Pradesh, 517 502, India.
[Ti] Título:Complete genome sequence of a new begomovirus associated with yellow mosaic disease of Hemidesmus indicus in India.
[So] Source:Arch Virol;159(5):1223-8, 2014 May.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The complete DNA A genome of a virus isolate associated with yellow mosaic disease of a medicinal plant, Hemidesmus indicus, from India was cloned and sequenced. The length of DNA A was 2825 nucleotides, 35 nucleotides longer than the unit genome of monopartite begomoviruses. Comparison of the nucleotide sequence of DNA A of the virus isolate with those of other begomoviruses showed maximum sequence identity of 69 % to DNA A of ageratum yellow vein China virus (AYVCNV; AJ558120) and 68 % with tomato yellow leaf curl virus- LBa4 (TYLCV; EF185318), and it formed a distinct clade in phylogenetic analysis. The genome organization of the present virus isolate was found to be similar to that of Old World monopartite begomoviruses. The genome was considered to be monopartite, because association of DNA B and ß satellite DNA components was not detected. Based on its sequence identity (<70 %) to all other begomoviruses known to date and ICTV (International Committee on Taxonomy of Viruses) species demarcating criteria (<89 % identity), it is considered a member of a novel begomovirus species, and the tentative name "Hemidesmus yellow mosaic virus" (HeYMV) is proposed.
[Mh] Termos MeSH primário: Begomovirus/genética
Begomovirus/isolamento & purificação
Hemidesmus/virologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sequência de Bases
Genoma Viral
Índia
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1406
[Cu] Atualização por classe:140506
[Lr] Data última revisão:
140506
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131127
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-013-1811-7


  10 / 53 MEDLINE  
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[PMID]:23715789
[Au] Autor:Kundu A; Mitra A
[Ad] Endereço:Natural Product Biotechnology Group, Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur, India.
[Ti] Título:Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities.
[So] Source:Plant Foods Hum Nutr;68(3):247-53, 2013 Sep.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer's disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extracts of H. indicus and V. planifolia, respectively, produce fragrant phenolic compounds, 2-hydroxy-4-methoxybenzaldehyde (MBALD) and 4-hydroxy-3-methoxybenzaldehyde (vanillin). These methoxybenzaldehydes were shown to have inhibitory potential against acetylcholinesterase (AChE). Vanillin (IC50 = 0.037 mM) was detected as more efficient inhibitor than MBALD (IC50 = 0.047 mM). This finding was supported by kinetic analysis. Thus, plant-based food flavoring agents showed capacity in curing Alzheimer's disease and other neurological dysfunctions.
[Mh] Termos MeSH primário: Inibidores da Colinesterase/farmacologia
Aromatizantes/química
Hemidesmus/química
Extratos Vegetais/farmacologia
Vanilla/química
[Mh] Termos MeSH secundário: Doença de Alzheimer/tratamento farmacológico
Benzaldeídos/farmacologia
Aditivos Alimentares
Cinética
Doenças do Sistema Nervoso/tratamento farmacológico
Fitoterapia
Raízes de Plantas/química
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Cholinesterase Inhibitors); 0 (Flavoring Agents); 0 (Food Additives); 0 (Plant Extracts); 2N395P88LW (2-hydroxy-4-methoxybenzaldehyde); CHI530446X (vanillin)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130530
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-013-0363-z



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