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Pesquisa : B01.650.940.800.575.912.250.456.500.411 [Categoria DeCS]
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[PMID]:28057569
[Au] Autor:Oliveira HP; Silva RG; Oliveira JT; Sousa DO; Pereira ML; Souza PF; Soares AA; Gomes VM; Monteiro-Moreira AC; Moreno FB; Vasconcelos IM
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Federal University of Ceara, 60440-900 Fortaleza, CE, Brazil; University of International Integration of the Afro-Brazilian Lusophony, 62790-000 Redençao, CE, Brazil.
[Ti] Título:A novel peroxidase purified from Marsdenia megalantha latex inhibits phytopathogenic fungi mediated by cell membrane permeabilization.
[So] Source:Int J Biol Macromol;96:743-753, 2017 Mar.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An antifungal class III peroxidase was purified from Marsdenia megalantha latex (named Mo-POX) using DEAE-cellulose and gel filtration chromatography on a Superose 12 HR 10/30 column. Mm-POX has an apparent molecular mass of 67.0kDa and a pI of 5.2, shares identity with other peroxidases, and follows Michaelis-Menten kinetics. It has a high affinity for guaiacol and hydrogen peroxide. The pH and temperature optima for Mm-POX were 5.0-7.0 and 60°C, respectively. The catalytic activity of Mm-POX was decreased in the presence of classic peroxidase inhibitors including azide, dithiothreitol, ethylenediamine tetraacetic acid, and sodium metabisulfite and high concentrations of Na , Mn , and salicylic acid. In contrast, Ca and Mg , even at low concentrations, enhanced the Mm-POX enzymatic activity. This protein inhibited the germination of the conidia of the phytopathogenic fungi Fusarium oxysporum and Fusarium solani by acting through a membrane permeabilization mechanism. Mm-POX also induced oxidative stress in F. solani. Mm-POX is the first enzyme to be isolated from the M. megalantha species and it has potential use in the control of plant disease caused by important phytopathogenic fungi. This adds biotechnological value to this enzyme.
[Mh] Termos MeSH primário: Permeabilidade da Membrana Celular/efeitos dos fármacos
Fusarium/efeitos dos fármacos
Látex/química
Marsdenia/química
Peroxidase/isolamento & purificação
Peroxidase/farmacologia
Plantas/microbiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Antifúngicos/química
Antifúngicos/isolamento & purificação
Antifúngicos/metabolismo
Antifúngicos/farmacologia
Inibidores Enzimáticos/farmacologia
Estabilidade Enzimática
Fusarium/citologia
Fusarium/metabolismo
Fusarium/fisiologia
Concentração de Íons de Hidrogênio
Cinética
Metais/farmacologia
Viabilidade Microbiana/efeitos dos fármacos
Peso Molecular
Peroxidase/antagonistas & inibidores
Peroxidase/química
Espécies Reativas de Oxigênio/metabolismo
Ácido Salicílico/farmacologia
Esporos Fúngicos/efeitos dos fármacos
Esporos Fúngicos/crescimento & desenvolvimento
Especificidade por Substrato
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Enzyme Inhibitors); 0 (Latex); 0 (Metals); 0 (Reactive Oxygen Species); EC 1.11.1.7 (Peroxidase); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE


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[PMID]:27756147
[Au] Autor:Gupta MR; Kumar A; Khare NK
[Ad] Endereço:a Department of Chemistry , University of Lucknow , Lucknow , India.
[Ti] Título:Isolation and identification of two novel compounds from Marsdenia roylei and their quantum chemical calculations.
[So] Source:Nat Prod Res;31(7):749-757, 2017 Apr.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new compounds 1 (Methyl 26-di-deoxy-6-methyl-ß-D-allohexopyranoside) and 3 (3, 11, 12, 20 tetra-O-acetyl-pregn-5-ene-14ß-ol) have been isolated from the chloroform-soluble extract of the whole plant of Marsdenia roylei (family: Asclepiadaceae) and their structures were determined by 1D, 2D NMR and ESI-MS as well as by chemical modification. We have calculated the molecular geometries, local reactivity descriptors by the density functional theory with B3LYP functional with basis set 6-311G+(d,2p) of 1, 3 and 4 (deacylated 3). The H and C NMR chemical shifts of 1, 3 and 4 were calculated using Gauge-Including Atomic Orbital approach and these values are correlated with the experimental observations.
[Mh] Termos MeSH primário: Marsdenia/química
[Mh] Termos MeSH secundário: Acilação
Clorofórmio/química
Glucosídeos
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Estrutura Molecular
Extratos Vegetais/química
Pregnenos
Teoria Quântica
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,11,12,20 tetra-O-acetyl-pregn-5-ene-14beta-ol); 0 (Glucosides); 0 (Plant Extracts); 0 (Pregnenes); 0 (methyl 26-di-deoxy-6-methyl-beta-D-allohexopyranoside); 7V31YC746X (Chloroform)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1241999


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[PMID]:27272399
[Au] Autor:Pang X; Kang LP; Fang XM; Zhao Y; Yu HS; Han LF; Li HT; Zhang LX; Guo BL; Yu LY; Ma BP
[Ad] Endereço:Beijing Institute of Radiation Medicine, Beijing, China.
[Ti] Título:Polyoxypregnane Glycosides from the Roots of Marsdenia tenacissima and Their Anti-HIV Activities.
[So] Source:Planta Med;83(1-02):126-134, 2017 Jan.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A continuous phytochemical study on the roots of led to the isolation and identification of 13 new polyoxypregnane glycosides named marstenacissides B10-B17 ( , and ) and marstenacissides A8-A12 ( , and ) in addition to two known polyoxypregnane glycosides marsdenosides M and L ( and ). Their structures were established by spectroscopic techniques and by comparison with the reported data in the literature. Moreover, the anti-HIV activities of these isolates and the previous isolated marstenacissides A1-A7 and B1-B9 were assessed, some of which exhibited slight or negligible effects against HIV-1.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/farmacologia
Medicamentos de Ervas Chinesas/química
Infecções por HIV/tratamento farmacológico
HIV-1/efeitos dos fármacos
Marsdenia/química
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/química
Fármacos Anti-HIV/isolamento & purificação
Infecções por HIV/virologia
Medicina Tradicional Chinesa
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Raízes de Plantas/química
Caules de Planta/química
Saponinas/química
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (12-0-benzoyl-8,11-ditigloyl-3,8,11,12-pentahydroxy-pregn-14-ol, 20-one 3-0-methyl-allopyranosyl(1-4)-thevetopyranoside); 0 (Anti-HIV Agents); 0 (Drugs, Chinese Herbal); 0 (Saponins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-108057


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[PMID]:28262119
[Au] Autor:Chen BY; Chen D; Lyu JX; Li KQ; Jiang MM; Zeng JJ; He XJ; Hao K; Tao HQ; Mou XZ; Ying YM; Zhang W; Zhu MH; Wang Z
[Ad] Endereço:Research Center of Blood Transfusion Medicine, Education Ministry Key Laboratory of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China; Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
[Ti] Título:Marsdeniae tenacissimae extract (MTE) suppresses cell proliferation by attenuating VEGF/VEGFR2 interactions and promotes apoptosis through regulating PKC pathway in human umbilical vein endothelial cells.
[So] Source:Chin J Nat Med;14(12):922-930, 2016 Dec.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Marsdeniae tenacissimae extract (MTE), commonly known as Xiao-Ai-Ping in China, is a traditional Chinese herb medicine capable of inhibiting proliferation and metastasis and boosting apoptosis in various cancer cells. However, little is known about the contribution of MTE towards tumor angiogenesis and the underlying mechanism. The present study aimed to evaluate the effects of MTE on the proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs) and the molecular mechanism. 3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium, inner salt (MTS) and PI-stained flow cytometry assays revealed that MTE dose-dependently reduced the proliferation of HUVECs by arresting cell cycle at S phase (P < 0.05). Annexin V-FITC/PI-stained flow cytometry confirmed that MTE (160 µL·L ) enhanced the apoptosis of HUVECs significantly (P < 0.001). Real-time quantitative RT-PCR and Western blot analyses showed an increase in Bax expression and a sharply decline in Bcl-2 expression; caspase-3 was activated simultaneously in a dose-dependent manner (P < 0.05). Further study observed the dose-dependent down-regulation of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2), P2Y6 receptor (P2Y6R), and chemokine (C-C motif) ligand 2 (CCL-2), along with the activation of PKC Δ and up-regulation of p53 in a dose-dependent manner in MTE-treated selected cells (P < 0.05). Collectively, the results from the present study suggested that MTE suppressed the proliferation by attenuating CCL-2-mediated VEGF/VEGFR2 interactions and promoted the apoptosis through PKCΔ-induced p53-dependent mitochondrial pathway in HUVECs, supporting that MTE may be developed as a potent anti-cancer medicine.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/citologia
Marsdenia/química
Extratos Vegetais/farmacologia
Transdução de Sinais
[Mh] Termos MeSH secundário: Ciclo Celular/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/metabolismo
Seres Humanos
Proteína Quinase C/genética
Proteína Quinase C/metabolismo
Transdução de Sinais/efeitos dos fármacos
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/genética
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Vascular Endothelial Growth Factor A); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); EC 2.7.11.13 (Protein Kinase C)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


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[PMID]:27468539
[Au] Autor:Zhang H; Zhang J; Ding H; Chen R; Liang F
[Ti] Título:[Clinical value of Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy in the treatment of advanced non-small cell lung cancer: a Meta-analysis].
[So] Source:J Tradit Chin Med;36(3):261-70, 2016 Jun.
[Is] ISSN:0255-2922
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the clinical efficacy and safety of Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy in the treatment of advanced non-small cell lung cancer (NCSLC) compared with chemotherapy alone. METHODS: Databases including Chinese National Knowledge Infrastructure, China Biology Medicine Disc, Wanfang, and MEDLINE were searched until April 1, 2014. Two assessors independently reviewed each trial. The primary outcome was the effective rate (ER) of Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy. The secondary outcomes included quality of life improvement rate (QOLIR) and adverse reactions. Statistical calculations were performed by using Cochrane Collaboration Review Manager 5.2. RESULTS: A total of 888 patients from 15 studies, 13 randomized controlled trials (RCT) and two controlled clinical trials, were included. Compared with chemotherapy alone, Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract plus chemotherapy significantly improved ER [Risk ratio (RR) = 1.32, 95% CI, (1.14, 1.54)] (based on 15 studies) and QOLIR [RR = 2.04, 95% CI, (1.69, 2.47)] (based on 13 studies). Compared with chemotherapy alone, Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract plus chemotherapy significantly inhibited chemotherapy-induced white blood cell decline [RR = 0.79, 95% CI, (0.70, 0.90) (based on 10 studies), chemotherapy-induced platelet decline [RR = 0.77, 95% CI, (0.60, 0.98)] (based on 8 studies), and significantly alleviated nausea and vomiting (NV) [RR = 0.83, 95% CI, (0.71, 0.97)] (based on 7 studies). There was no significant difference in hemoglobin decline between the two therapies [RR = 0.88, 95% CI, (0.70, 1.09)] (based on 6 studies). CONCLUSION: This Meta-analysis suggests that Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy may be more efficacious in the treatment of advanced NSCLC than chemotherapy alone. This effect includes enhancing ER and QOLIR, and weakening chemotherapy toxicity. However, large-scale RCTs are required to further investigate the short- and long-term effects of Tongguanteng (Radix seu Herba Marsdeniae Tenacissimae) extract.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Medicamentos de Ervas Chinesas/administração & dosagem
Neoplasias Pulmonares/tratamento farmacológico
Marsdenia/química
[Mh] Termos MeSH secundário: Seres Humanos
Qualidade de Vida
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE


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[PMID]:27106066
[Au] Autor:Zhao C; Han LY; Ren W; Zhao HY; Han SY; Zheng WX; Pang LN; Li XH; Li PP
[Ad] Endereço:Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing, 100142, People's Republic of China.
[Ti] Título:Metabolic profiling of tenacigenin B, tenacissoside H and tenacissoside I using UHPLC-ESI-Orbitrap MS/MS.
[So] Source:Biomed Chromatogr;30(11):1757-1765, 2016 Nov.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Marsdenia tenacissima, which is widely used as an anticancer herb in traditional Chinese medicine, has been shown to possess anticancer activity. However, its metabolic profile is poorly investigated. Tenacigenin B is the major steroidal skeleton of C-21 steroids in M. tenacissima. Tenacissoside H and Tenacissoside I are detected at relatively high levels in M. tenacissima. Therefore, we studied their metabolic characteristics in human liver microsomes by ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. Fourteen metabolites were tentatively identified by accurate mass measurement and MS/MS fragmentation behavior. It was found that hydroxylation reactions were the major metabolic pathway of Tenacissoside H and Tenacissoside I in human liver microsomes, whereas the metabolic pathway of Tenacigenin B involved dehydrogenation reactions. This is the first time that the metabolic profile of C-21 steroids from M. tenacissima has been explored in human liver microsomes, which is of great significance for subsequent pharmacokinetic and interaction research. Biotransformation in vivo or in vitro may influence the structure of a compound and change its activity. Identification of their fragmentation behaviors and metabolites provides valuable and new information for further understanding the anti-tumor activity of M. tenacissima. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/metabolismo
Microssomos Hepáticos/metabolismo
Fitosteróis/metabolismo
Saponinas/metabolismo
Esteroides/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Cromatografia Líquida de Alta Pressão/métodos
Seres Humanos
Marsdenia/química
Redes e Vias Metabólicas
Metabolômica/métodos
Fitosteróis/química
Saponinas/química
Esteroides/química
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Phytosterols); 0 (Saponins); 0 (Steroids); 0 (tenacigenin B)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3750


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[PMID]:27025367
[Au] Autor:Lin SS; Li FF; Sun L; Fan W; Gu M; Zhang LY; Qin S; Yuan ST
[Ad] Endereço:New Drug Screen Center, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Marsdenia tenacissima extract suppresses A549 cell migration through regulation of CCR5-CCL5 axis, Rho C, and phosphorylated FAK.
[So] Source:Chin J Nat Med;14(3):203-9, 2016 Mar.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Marsdenia tenacissima, a traditional Chinese medicine, is long been used to treat various diseases including asthma, cancer, trachitis, tonsillitis, pharyngitis, cystitis, and pneumonia. Although Marsdenia tenacissima has been demonstrated to have strong anti-tumor effects against primary tumors, its effect on cancer metastasis remains to be defined, and the molecular mechanism underlying the anti-metastatic effect is unknown. In the present study, we investigated the effects of XAP (an extract of Marsdenia tenacissima) on A549 lung cancer cell migration and explored the role of CCR5-CCL5 axis in the anti-metastatic effects of XAP. Our resutls showed that XAP inhibited A549 lung cancer cell migration and invasion in a dose-dependent manner. The protein levels of CCR5, but not CCR9 and CXCR4, were decreased by XAP. The secretion of CCL5, the ligand of CCR5, was reduced by XAP. XAP down-regulated Rho C expression and FAK phosphorylation. In conclusion, XAP inhibited A549 cell migration and invasion through down-regulation of CCR5-CCL5 axis, Rho C, and FAK.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Movimento Celular/efeitos dos fármacos
Quimiocina CCL5/metabolismo
Marsdenia/química
Extratos Vegetais/farmacologia
Receptores CCR5/metabolismo
[Mh] Termos MeSH secundário: Células A549
Linhagem Celular Tumoral
Quinase 1 de Adesão Focal/metabolismo
Seres Humanos
Neoplasias Pulmonares
Fosforilação
Proteínas rho de Ligação ao GTP/metabolismo
Proteína de Ligação a GTP rhoC
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Chemokine CCL5); 0 (Plant Extracts); 0 (Receptors, CCR5); EC 2.7.10.2 (Focal Adhesion Kinase 1); EC 2.7.10.2 (PTK2 protein, human); EC 3.6.5.2 (RHOC protein, human); EC 3.6.5.2 (rho GTP-Binding Proteins); EC 3.6.5.2 (rhoC GTP-Binding Protein)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE


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[PMID]:26988729
[Au] Autor:Yao S; To KK; Ma L; Yin C; Tang C; Chai S; Ke CQ; Lin G; Ye Y
[Ad] Endereço:State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Joint Research Laboratory of Promoting Globalization of Traditional Chinese Medi
[Ti] Título:Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.
[So] Source:Phytochemistry;126:47-58, 2016 Jun.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A polyoxypregnane aglycone, 12ß-O-acetyl-11α-O-isobutyryltenacigenin B, and four polyoxypregnane glycosides with a pachybionic acid ester moiety, 12ß-O-acetyl-3-O-(6-deoxy-3-O-methyl-ß-D-allopyranosyl-(1→4)-ß-D-oleandronyl)-11α-O-isobutyryltenacigenin B, 12ß-O-acetyl-3-O-(6-deoxy-3-O-methyl-ß-D-allopyranosyl-(1→4)-ß-D-oleandronyl)-11α-O-tigloyltenacigenin B, 12ß-O-acetyl-3-O-(6-deoxy-3-O-methyl-ß-D-allopyranosyl-(1→4)-ß-D-oleandronyl)-11α-O-2-methylbutyryltenacigenin B, and 12ß-O-acetyl-3-O-(ß-D-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-ß-D-allopyranosyl-(1→4)-D-oleandronyl)-11α-O-tigloyltenacigenin B, were isolated from the canes of Marsdenia tenacissima, together with a disaccharide derivative. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations were further determined by X-ray crystallographic analysis. With the exception of the disaccharide derivative, all five compounds are unusual naturally occurring polyoxypregnane glycosides bearing an open-chain sugar moiety. Two of these exhibit a wide spectrum of chemoresistance reversal activity, and potential mechanisms were studied accordingly.
[Mh] Termos MeSH primário: Apocynaceae/química
Pregnanos/isolamento & purificação
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Marsdenia
Conformação Molecular
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Pregnanos/química
Pregnanos/farmacologia
Saponinas/química
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (12-0-benzoyl-8,11-ditigloyl-3,8,11,12-pentahydroxy-pregn-14-ol, 20-one 3-0-methyl-allopyranosyl(1-4)-thevetopyranoside); 0 (12beta-O-acetyl-11alpha-O-isobutyryltenacigenin B); 0 (Pregnanes); 0 (Saponins)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160412
[Lr] Data última revisão:
160412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE


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[PMID]:26686104
[Au] Autor:Jiang S; Qiu L; Li Y; Li L; Wang X; Liu Z; Guo Y; Wang H
[Ad] Endereço:College of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun 130117, Jilin, PR China. Electronic address: jiangshuang_2000@163.com.
[Ti] Título:Effects of Marsdenia tenacissima polysaccharide on the immune regulation and tumor growth in H22 tumor-bearing mice.
[So] Source:Carbohydr Polym;137:52-58, 2016 Feb 10.
[Is] ISSN:1879-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One water-soluble polysaccharide (Marsdenia tenacissima polysaccharide, MTP), with an average molecular weight of 4.9 × 10(4) Da, was isolated from the dried rattan of M. tenacissima. MTP contained 93.8% carbohydrates, 5.6% proteins and 21.3% uronic acid, and were composed of arabinose, mannose, galactose, xylose, glucuronic acid at a molar ratio of 9.1, 17.7, 30.2, 22.4 and 20.6. The experiments on the animals showed that MTP could increase the serum hemolysin, promote the formation of antibody-forming cells and improve the phagocytosis of mononuclear macrophage in normal mice. Meanwhile, MTP could also inhibit the growth of tumor in H22 tumor-bearing mice dose-dependently, and increase the spleen index, thymus index and serum albumin level in the mice. In addition, MTP could elevate the serum level of TNF-α and IL-2, increase the activity of GSH-Px, CAT and SOD in the liver tissue, and reduce the content of VEGF and MDA. These results suggest that MTP can regulate the immune function in mice and suppress the growth of tumor in H22 tumor-bearing mice, and its antitumor activity may be related to its antioxidant and immunomodulatory effects.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Neoplasias Hepáticas/tratamento farmacológico
Neoplasias Hepáticas/metabolismo
Marsdenia/química
Extratos Vegetais/uso terapêutico
Polissacarídeos/química
Polissacarídeos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Catalase/metabolismo
Glutationa/metabolismo
Interleucina-2/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Malondialdeído/metabolismo
Camundongos
Extratos Vegetais/química
Superóxido Dismutase/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Interleukin-2); 0 (Plant Extracts); 0 (Polysaccharides); 0 (Tumor Necrosis Factor-alpha); 0 (Vascular Endothelial Growth Factor A); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170625
[Lr] Data última revisão:
170625
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


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[PMID]:26618710
[Au] Autor:Mohd Nasuha NA; Choo YM
[Ad] Endereço:a Faculty of Science, Chemistry Department , University of Malaya , Kuala Lumpur , Malaysia.
[Ti] Título:A new flavone from Malaysia Borneo Marsdenia tinctoria.
[So] Source:Nat Prod Res;30(13):1532-6, 2016 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Marsdenia tinctoria is an indigo producing plant commonly found in Borneo, Malaysia. In this present study, one new flavone kapitone (1) and three known compounds, that is 3,2'-dihydroxyflavone (2), 1-methylcyclobutene (3) and dimethyl isatoate (4) were isolated from the Malaysia Borneo M. tinctoria R. Br. (Apocynaceae). These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods.
[Mh] Termos MeSH primário: Flavonas/isolamento & purificação
Marsdenia/química
[Mh] Termos MeSH secundário: Bornéu
Flavonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151201
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1118629



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