Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.500.833 [Categoria DeCS]
Referências encontradas : 8 [refinar]
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  1 / 8 MEDLINE  
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[PMID]:27416523
[Au] Autor:Knittel DN; Huber U; Stintzing FC; Kammerer DR
[Ad] Endereço:WALA Heilmittel GmbH, Department of Analytical Development & Research, Section Phytochemical Research, Dorfstr. 1, 73087 Bad Boll/Eckwälden, Germany.
[Ti] Título:Effect of extraction, microbial fermentation and storage on the cardenolide profile of Strophanthus kombé Oliv. seed preparations.
[So] Source:J Pharm Biomed Anal;129:96-104, 2016 Sep 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Strophanthus extracts containing cardioactive cardenolides are still applied in European complementary medicine for the treatment of heart diseases. However, the cardenolide profile and the fate of individual compounds during extraction and storage are not well understood. Therefore, the objective of the present study was to characterize the cardenolide compound pattern in extracts of different polarity and their structural changes upon storage in aqueous fermented preparations. For this purpose, individual cardenolides were quantitated by a UHPLC-DAD validated method using an internal standard. Three different extraction protocols were compared: hydroethanolic extraction under reflux with and without previous defatting of the seed material and ultrasonic-assisted extraction at ambient temperature. Reflux extraction of non-defatted seeds showed maximum cardenolide yields. Differences in the cardenolide contents of seeds of the different origins Zimbabwe and Malawi were observed. The cardenolide profile and metabolization of individual compounds upon fermentation and storage of S. kombé seed extracts revealed that predominant cardenolides, mainly strophanthidin glycosides, changed upon storage over 12 months. Cardenolides exhibiting two or three saccharide moieties were degraded presumably by ß-glucosidase activities, originating from the plant material or lactobacilli, releasing the corresponding monoglycosides. The latter were further degraded into the corresponding aglycones probably by acid hydrolysis as a result of lactic acid accumulation.
[Mh] Termos MeSH primário: Cardenolídeos/metabolismo
Fermentação/fisiologia
Extratos Vegetais/metabolismo
Sementes/metabolismo
Strophanthus
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Cardenolídeos/análise
Cromatografia Líquida de Alta Pressão/métodos
Armazenamento de Medicamentos/métodos
Extratos Vegetais/análise
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardenolides); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE


  2 / 8 MEDLINE  
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[PMID]:27032201
[Au] Autor:Uesugia D; Hamada H; Shimoda K
[Ti] Título:Glycosylation of trans-Resveratrol by Cultured Plant Cells under Illumination of LEDs.
[So] Source:Nat Prod Commun;11(2):199-200, 2016 Feb.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Incubation of cultured cells of Strophanthus gratus with trans-resveratrol gave its 4'-O-ß-D-glucoside as the major product in addition to its 3-O-ß-D-glucoside under white and red light-emitting diodes (LEDs). Use of blue LEDs as light sources for biotransformation of trans-resveratrol much improved the yield of its ß-D-glycosides and changed the composition of products, that is, 3-O-ß-D-glucoside was the major product and 4'-O-ß-D-glucoside was the minor one.
[Mh] Termos MeSH primário: Luz
Estilbenos/metabolismo
Strophanthus/citologia
Strophanthus/metabolismo
[Mh] Termos MeSH secundário: Biotransformação
Células Cultivadas
Glicosilação
Estereoisomerismo
Estilbenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Stilbenes); Q369O8926L (resveratrol)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160401
[Lr] Data última revisão:
160401
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


  3 / 8 MEDLINE  
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[PMID]:26974139
[Au] Autor:Knittel DN; Lorenz P; Huber U; Stintzing FC; Kammerer DR
[Ti] Título:Characterization of the cardiac glycoside and lipid profiles of Strophanthus kombé Oliv. seeds.
[So] Source:Z Naturforsch C;71(3-4):55-64, 2016 Mar.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The seeds of Strophanthus kombé Oliv. are known to contain high levels of cardioactive compounds. However, the therapeutic use of Strophanthus in the treatment of cardiopathy requires more detailed knowledge of the compound profile to profit from the full potential of Strophanthus preparations. Therefore, the objective was to characterize the cardenolide profile and lipophilic constituents in S. kombé seeds using methods applicable in routine quality control. Freshly prepared S. kombé seed extracts were analyzed without previous sample clean-up using a novel HPLC-DAD-MSn method. In addition, seed oils were analyzed by GC-MS following derivatization of the lipids. More than 20 cardenolides were tentatively assigned in the seed extracts including strophanthidin, strophanthidol, periplogenin and strophanthidinic acid aglycones, carrying various saccharide moieties. The findings revealed the presence of eight novel cardenolides, which have not been described for S. kombé so far. The occurrence of strophanthidinic acid derivatives was verified by comparison with synthesized strophanthidinic acid-cymaropyranoside. GC-MS characterization of the oils mainly revealed the presence of fatty acids, especially oleic acid and linoleic acid, as well as phytosterols, the latter representing intermediates of cardenolide biosynthesis. In summary, these findings broaden our knowledge on the secondary metabolism of Strophanthus.
[Mh] Termos MeSH primário: Glicosídeos Cardíacos/análise
Lipídeos/análise
Sementes/química
Strophanthus/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Digitoxigenina/análogos & derivados
Digitoxigenina/análise
Ácidos Graxos/análise
Cromatografia Gasosa-Espectrometria de Massas
Ácido Linoleico/análise
Espectrometria de Massas
Estrutura Molecular
Ácido Oleico/análise
Fitosteróis/análise
Extratos Vegetais/química
Estrofantidina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiac Glycosides); 0 (Fatty Acids); 0 (Lipids); 0 (Phytosterols); 0 (Plant Extracts); 143-62-4 (Digitoxigenin); 2UMI9U37CP (Oleic Acid); 66-28-4 (Strophanthidin); 9KJL21T0QJ (Linoleic Acid); B6808P7IY9 (periplogenin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE


  4 / 8 MEDLINE  
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[PMID]:23729560
[Au] Autor:Ishola IO; Awodele O; Oreagba IA; Murtala AA; Chijioke MC
[Ti] Título:Antinociceptive, anti-inflammatory and antiulcerogenic activities of ethanol root extract of Strophanthus hispidus DC (Apocynaceae).
[So] Source:J Basic Clin Physiol Pharmacol;24(4):277-86, 2013.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Strophanthus hispidus DC (Apocynaceae) is a medicinal plant widely used in traditional African medicine in the treatment of rheumatic afflictions, ulcer, conjunctivitis, leprosy and skin diseases. This study sought to investigate the antinociceptive, anti-inflammatory and antiulcer properties of the ethanol root extract of S. hispidus. METHODS: Antinociceptive activity was evaluated using acetic acid-induced writhing and formalin tests in mice. The carrageenan- and egg albumin-induced rat paw edema tests were used to investigate the anti-inflammatory actions, whereas the antiulcer activity was investigated using ethanol-, HCl- and pyloric ligation-induced gastric ulcer models in rats. RESULTS: S. hispidus [100-800 mg/kg orally (po)] produced significant (p<0.05) inhibition of writhing reflex with peak effect of 74.13% inhibition observed at 800 mg/kg. Similarly, S. hispidus significantly (p<0.05) attenuated formalin-induced early and late phase of nociception with peak effect of 61.84% and 89.43%, respectively, at 200 mg/kg. S. hispidus (25-800 mg/kg po) caused significant (p<0.05) inhibition of edema development in the carrageenan and egg albumin models with peak effect (93.40% and 90.10% inhibition of edema formation) observed at 50 mg/kg. With respect to antiulcer activity, S. hispidus (100-800 mg/kg) showed potent antiulcer activity with respective peak effects of 96% (ethanol-induced), 99% (HCl-induced) and 70.60% inhibition of ulcer. CONCLUSIONS: The findings in this study suggest that the ethanol root extract of S. hispidus possesses antinociceptive, anti-inflammatory and antiulcerogenic activities. This justifies the use of the extract in folklore medicine for the treatment of ulcer and inflammatory disorders.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Antiulcerosos/farmacologia
Extratos Vegetais/farmacologia
Strophanthus/química
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/uso terapêutico
Analgésicos/toxicidade
Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/uso terapêutico
Anti-Inflamatórios/toxicidade
Antiulcerosos/isolamento & purificação
Antiulcerosos/uso terapêutico
Antiulcerosos/toxicidade
Modelos Animais de Doenças
Edema/tratamento farmacológico
Etanol/química
Feminino
Dose Letal Mediana
Masculino
Medicina Tradicional Africana
Camundongos
Dor/tratamento farmacológico
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Extratos Vegetais/toxicidade
Raízes de Plantas/química
Ratos
Úlcera Gástrica/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Anti-Ulcer Agents); 0 (Plant Extracts); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:131104
[Lr] Data última revisão:
131104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130605
[St] Status:MEDLINE


  5 / 8 MEDLINE  
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[PMID]:22878209
[Au] Autor:Imai H; Kitagawa M; Ishihara K; Masuoka N; Shimoda K; Nakajima N; Hamada H
[Ad] Endereço:Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan.
[Ti] Título:Glycosylation of trans-resveratrol by plant-cultured cells.
[So] Source:Biosci Biotechnol Biochem;76(8):1552-4, 2012.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plant-cultured cells of Catharanthus roseus converted trans-resveratrol into its 3-O-ß-D-glucopyranoside, 4'-O-ß-D-glucopyranoside, 3-O-(6-O-ß-D-xylopyranosyl)-ß-D-glucopyranoside, and 3-O-(6-O-α-L-arabinopyranosyl)-ß-D-glucopyranoside. The 3-O-(6-O-ß-D-xylopyranosyl)-ß-D-glucopyranoside and 3-O-(6-O-α-L-arabinopyranosyl)-ß-D-glucopyranoside compounds of trans-resveratrol are both new. Incubation of plant-cultured cells of Ipomoea batatas and Strophanthus gratus with trans-resveratrol gave trans-resveratrol 3-O-ß-D-glucopyranoside and trans-resveratrol 4'-O-ß-D-glucopyranoside.
[Mh] Termos MeSH primário: Catharanthus/metabolismo
Ipomoea batatas/metabolismo
Células Vegetais/metabolismo
Estilbenos/metabolismo
Strophanthus/metabolismo
[Mh] Termos MeSH secundário: Biotransformação
Células Cultivadas
Glucose/análogos & derivados
Glucose/biossíntese
Glucosídeos/biossíntese
Glicosídeos/síntese química
Glicosilação
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside); 0 (3-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside); 0 (Glucosides); 0 (Glycosides); 0 (Stilbenes); 0 (resveratrol 3-O-glucopyranoside); 0 (trans-resveratrol-4'-O-beta-D-glucopyranoside); IY9XDZ35W2 (Glucose); Q369O8926L (resveratrol)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120811
[St] Status:MEDLINE


  6 / 8 MEDLINE  
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[PMID]:17988099
[Au] Autor:Karkare S; Adou E; Cao S; Brodie P; Miller JS; Andrianjafy NM; Razafitsalama J; Andriantsiferana R; Rasamison VE; Kingston DG
[Ad] Endereço:Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
[Ti] Título:Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest.
[So] Source:J Nat Prod;70(11):1766-70, 2007 Nov.
[Is] ISSN:0163-3864
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1-6, as well as the four known cardenolide glycosides digitoxigenin 3-O-[beta-D-glucopyrananosyl-(1-->4)-alpha-L-acofriopyranoside], corotoxigenin 3-O-beta-D-boivinoside, 17alpha-corotoxigenin 3-O-beta-D-sarmentoside, and uzarigenin 3-O-alpha-L-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC50 = 0.17 microM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Cardenolídeos/isolamento & purificação
Cardenolídeos/farmacologia
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Plantas Medicinais/química
Strophanthus/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Cardenolídeos/química
Ensaios de Seleção de Medicamentos Antitumorais
Feminino
Glicosídeos/química
Seres Humanos
Concentração Inibidora 50
Madagáscar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cardenolides); 0 (Glycosides)
[Em] Mês de entrada:0801
[Cu] Atualização por classe:161122
[Lr] Data última revisão:
161122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071109
[St] Status:MEDLINE


  7 / 8 MEDLINE  
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[PMID]:16209434
[Au] Autor:Mucaji P; Nagy M; Grancai D
[Ad] Endereço:Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmakognózie a botaniky, SR. mucaji@fpharm.uniba.sk
[Ti] Título:[Ouabain: from an arrow poison to a new steroidal hormone].
[Ti] Título:Ouabaín--od sípového jedu k novému steroidnému hormónu..
[So] Source:Ceska Slov Farm;54(5):207-10, 2005 Sep.
[Is] ISSN:1210-7816
[Cp] País de publicação:Czech Republic
[La] Idioma:slo
[Ab] Resumo:For more than 200 years, cardiotonic glycosides have been used for the treatment of congestive heart failure. Ouabain is a well-known arrow poison obtained from different Acokanthera or Strophanthus species. Much information has now accumulated that this plant toxin and its congeners are mammalian steroid hormones involved in the pathophysiology of cardiovascular diseases. There is an interesting fact that 50% patients with essential hypertension have elevated levels of endogenous ouabain. A better knowledge of the interactions of these compounds with the hormones of salt and water metabolism might help to improve the diagnosis and therapy of hypertension.
[Mh] Termos MeSH primário: Glicosídeos Cardíacos/uso terapêutico
Hormônios/fisiologia
Ouabaína/farmacologia
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Glicosídeos Cardíacos/farmacologia
Hormônios/farmacologia
Hormônios/uso terapêutico
Seres Humanos
Ouabaína/uso terapêutico
Esteroides/farmacologia
Esteroides/fisiologia
Strophanthus
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiac Glycosides); 0 (Hormones); 0 (Plant Extracts); 0 (Steroids); 5ACL011P69 (Ouabain)
[Em] Mês de entrada:0511
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051008
[St] Status:MEDLINE


  8 / 8 MEDLINE  
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[PMID]:12587992
[Au] Autor:Waldo R; Torres JL
[Ad] Endereço:Instituto de Física y Matemáticas, Universidad Michoacana, Morelia, Michoacán, México.
[Ti] Título:Mutual information and the homeopathic effect.
[So] Source:Homeopathy;92(1):30-4, 2003 Jan.
[Is] ISSN:1475-4916
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:We explore the feasibility of using mutual information to characterize the homeopathic effect. This quantity measures the information gained about a signal at time (t + tau), from its value at an earlier time t; it quantifies the predictability of data. We illustrate our method with an analysis of the homeopathic effect of Strophanthus hispidus on the cardiac rhythm of healthy human subjects, using data from a previous experiment. Our results allow an intuitively clear rendering and agree with the similitude principle applied to this case. They also show that the solvent has a significant effect on the signal; hence, it does not act as an ideal placebo and we discuss some therapeutic corollaries to this observation.
[Mh] Termos MeSH primário: Frequência Cardíaca/efeitos dos fármacos
Homeopatia/métodos
Plantas Medicinais
Strophanthus
[Mh] Termos MeSH secundário: Estudos de Viabilidade
Seres Humanos
Extratos Vegetais/farmacologia
Valores de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:0305
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030218
[St] Status:MEDLINE



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