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[PMID]:27987091
[Au] Autor:Villegas A; Arias JP; Aragón D; Ochoa S; Arias M
[Ad] Endereço:Research Group on Simulation, Design, Control and Optimization of Chemical Processes (SIDCOP), Faculty of Engineering, Universidad de Antioquia, Calle 67 No 53, 108, Medellín, Colombia. adriana.villegas@ucc.edu.co.
[Ti] Título:Structured model and parameter estimation in plant cell cultures of Thevetia peruviana.
[So] Source:Bioprocess Biosyst Eng;40(4):573-587, 2017 Apr.
[Is] ISSN:1615-7605
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this work, a mechanistic model for predicting the dynamic behavior of extracellular and intracellular nutrients, biomass production, and the main metabolites involved in the central carbon metabolism in plant cell cultures of Thevetia peruviana is presented. The proposed model is the first mechanistic model implemented for plant cell cultures of this species, and includes 28 metabolites, 33 metabolic reactions, and 61 parameters. Given the over-parametrization of the model, its nonlinear nature and the strong correlation among the effects of the parameters, a parameter estimation routine based on identifiability analysis was implemented. This routine reduces the parameter's search space by selecting the most sensitive and linearly independent parameters. Results have shown that only 19 parameters are identifiable. Finally, the model was used for analyzing the fluxes distribution in plant cell cultures of T. peruviana. This analysis shows high uptake of phosphates and parallel uptake of glucose and fructose. Furthermore, it has pointed out the main central carbon metabolism routes for promoting biomass production in this cell culture.
[Mh] Termos MeSH primário: Técnicas de Cultura de Células/métodos
Modelos Biológicos
Células Vegetais/metabolismo
Thevetia/citologia
Thevetia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE
[do] DOI:10.1007/s00449-016-1722-6


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[PMID]:28066105
[Au] Autor:Samanta J; Bhattacharya S; Rana AC
[Ad] Endereço:Rayat and Bahra Institute of Pharmacy, Mohali, Punjab, India.
[Ti] Título:Antifertility activity of (Pers.) K. Schum leaf in female Sprague-Dawley rat.
[So] Source:Indian J Pharmacol;48(6):669-674, 2016 Nov-Dec.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: (Pers.) K. Schum. ( ) is known to possess cardioactive glycoside such as thevetin A, thevetin B, neriifolin, peruvoside, thevetoxin, and ruvoside. Traditionally, leaves are used as abortifacient. The aim of the present study is to evaluate antifertility potential of leaves. SUBJECTS AND METHODS: Cardiac glycoside freed leaves of were extracted with methanol using maceration method. The dried cardiac glycoside-free methanolic extract of leaves (TPL-Me-G) was screened for phytoconstituents and evaluated for its effect on estrogen-primed female Sprague-Dawley rat uterus model. It was further studied for effects on the estrous cycle, implantation, and effect on estrogen and progesterone. STATISTICAL ANALYSIS USED: Statistical analysis was done by ANOVA followed by Dunnett's -test. RESULTS: Alkaloids, flavonoids, essential oils, carbohydrates, and amino acids were found to be present in the glycoside-free extract. Thin-layer chromatography (TLC) in n-butanol: acetone: water (4:1:5) revealed the presence of quercetin and kaempferol. The presence of flavonoids (quercetin 0.0326% and kaempferol 0.138% on dry weight basis) was reconfirmed by high-performance TLC analysis. The extract was able to induce uterine contractions (EC , 0.170 mg/ml) in a dose-dependent manner. Further investigation showed significant ( < 0.001) extension of estrous cycle and anti-implantation activity of the extract by reduction of the progesterone level. CONCLUSIONS: Methanolic extract of leaves (TPL-Me-G) containing quercetin 0.0326% and kaempferol 0.138% possesses a significant ( < 0.001) antifertility potential by virtue of decreasing the progesterone level.
[Mh] Termos MeSH primário: Anticoncepcionais Femininos/farmacologia
Fertilidade/efeitos dos fármacos
Extratos Vegetais/farmacologia
Folhas de Planta
Thevetia
Útero/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anticoncepcionais Femininos/isolamento & purificação
Estrogênios/sangue
Ciclo Estral/efeitos dos fármacos
Ciclo Estral/fisiologia
Feminino
Fertilidade/fisiologia
Técnicas de Cultura de Órgãos
Extratos Vegetais/isolamento & purificação
Gravidez
Progesterona/antagonistas & inibidores
Progesterona/sangue
Ratos
Ratos Sprague-Dawley
Testes de Toxicidade Aguda/métodos
Útero/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptive Agents, Female); 0 (Estrogens); 0 (Plant Extracts); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.194861


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[PMID]:27541569
[Au] Autor:Arias JP; Zapata K; Rojano B; Arias M
[Ad] Endereço:Escuela de Biociencias, Facultad de Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Antioquia, Colombia. Electronic address: jpariase@unal.edu.co.
[Ti] Título:Effect of light wavelength on cell growth, content of phenolic compounds and antioxidant activity in cell suspension cultures of Thevetia peruviana.
[So] Source:J Photochem Photobiol B;163:87-91, 2016 Oct.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Thevetia peruviana (T. peruviana) has been considered as a potentially important plant for industrial and pharmacological application. Among the number of compounds which are produced by T. peruviana, antioxidants and polyphenols are of particular interest due to their benefits on human health. Cell suspension cultures of T. peruviana were established under different conditions: 1) constant illumination (24h/day) at different light wavelengths (red, green, blue, yellow and white), 2) darkness and 3) control (12h/12h: day light/dark) to investigate their biomass, substrate uptake, polyphenols production and oxidizing activity. The results showed biomass concentrations between 17.1g dry weight (DW)/l (green light) and 18.2g DW/l (control) after 13days. The cultures that grew under green light conditions consumed completely all substrates after 10days, while other cultures required at least 13days or more. The total phenolic content was between 7.21 and 9.46mg gallic acid (GA)/g DW for all light conditions. In addition the ferric reducing antioxidant power and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid antioxidant activity ranged from 5.41-6.58mg ascorbic acid (AA)/g DW and 82.93-110.39µmol Trolox/g DW, respectively. Interestingly, the samples which grew under the darkness presented a higher phenolic content and antioxidant capacity when compared to the light conditions. All together, these results demonstrate the extraordinary effect of different lighting conditions on polyphenols production and antioxidant compounds by T. peruviana.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Antioxidantes/farmacologia
Luz
Polifenóis/metabolismo
Polifenóis/farmacologia
Thevetia/citologia
Thevetia/metabolismo
[Mh] Termos MeSH secundário: Transporte Biológico/efeitos da radiação
Proliferação Celular/efeitos da radiação
Células Cultivadas
Suspensões
Thevetia/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Polyphenols); 0 (Suspensions)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE


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[PMID]:27086856
[Au] Autor:Cheng HY; Tian DM; Tang JS; Shen WZ; Yao XS
[Ad] Endereço:a Department of Anatomy , Medical College, Jinan University , Guangzhou 510632 , China.
[Ti] Título:Cardiac glycosides from the seeds of Thevetia peruviana and their pro-apoptotic activity toward cancer cells.
[So] Source:J Asian Nat Prod Res;18(9):837-47, 2016 Sep.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the seeds of Thevetia peruviana resulted in the isolation of seven cardiac glycosides (1-7), including two new compounds (1 and 2). Cytotoxicity of them toward cancer cell lines P15 (human lung cancer cell), MGC-803 (human gastric cancer cells), SW1990 (human pancreatic cancer cells), and normal hepatocyte cell LO2 suggested that compound 1 could selectively inhibit the proliferation of cancer cell lines with IC50 from 0.05 to 0.15 µM. Pro-apoptotic activity revealed that it induced the apoptosis of MGC-803 cancer cells in a dose-dependent manner. Meanwhile, treatment of MGC-803 cancer cells with 1 resulted in diminution of pro-caspases 3 and 9 and activation of caspases 3 and 9, while it increased the Bax/Bcl-2 ratio in a dose-dependent manner. These meant that 1 induced the apoptosis of cancer cells by involving the intrinsic apoptotic pathway. In addition, the cell cycle distribution of MGC-803 cancer cells treated by 1 revealed that it could lead to cell cycle arrest at the G2/M phase. Altogether, this study suggested that compound 1 may exhibit anticancer activity by its capability of induction of intrinsic apoptosis and cell cycle arrest at G2/M phase.
[Mh] Termos MeSH primário: Glicosídeos Cardíacos/isolamento & purificação
Glicosídeos Cardíacos/farmacologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Sementes/química
Thevetia/química
[Mh] Termos MeSH secundário: Glicosídeos Cardíacos/química
Caspase 3/metabolismo
Caspases/metabolismo
Ciclo Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiac Glycosides); 0 (Drugs, Chinese Herbal); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1170814


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[PMID]:26972464
[Au] Autor:Rincón-Pérez J; Rodríguez-Hernández L; Ruíz-Valdiviezo VM; Abud-Archila M; Luján-Hidalgo MC; Ruiz-Lau N; González-Mendoza D; Gutiérrez-Miceli FA
[Ad] Endereço:Tecnológico Nacional de México. Instituto Tecnológico de Tuxtla Gutiérrez, Laboratorio de Biotecnología vegetal.
[Ti] Título:Fatty Acids Profile, Phenolic Compounds and Antioxidant Capacity in Elicited Callus of Thevetia peruviana (Pers.) K. Schum.
[So] Source:J Oleo Sci;65(4):311-8, 2016.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The aim of this study was analyze the effect of jasmonic acid (JA) and abscisic acid (ABA) as elicitors on fatty acids profile (FAP), phenolic compounds (PC) and antioxidant capacity (AC) in callus of Thevetia peruviana. Schenk & Hildebrandt (SH) medium, supplemented with 2 mg/L 2, 4-dichlorophenoxyacetic (2, 4-D) and 0.5 mg/L kinetin (KIN) was used for callus induction. The effect of JA (50, 75 and 100 µM) and ABA (10, 55 and 100 µM) on FAP, PC and AC were analyzed using a response surface design. A maximum of 2.8 mg/g of TPC was obtained with 100 plus 10 µM JA and ABA, respectively, whereas AC maximum (2.17 µg/mL) was obtained with 75 plus 100 µM JA and ABA, respectively. The FAP was affected for JA but not for ABA. JA increased cis-9, cis-12-octadecadienoic acid and decreased dodecanoic acid. Eight fatty acids were identified by GC-MS analysis and cis-9-octadecenoic acid (18:1) was the principal fatty acid reaching 76 % in treatment with 50 µM JA plus 55 µM ABA. In conclusion, JA may be used in T. peruviana callus culture for obtain oil with different fatty acids profile.
[Mh] Termos MeSH primário: Ácido Abscísico/farmacologia
Antioxidantes/análise
Ciclopentanos/farmacologia
Ácidos Graxos/análise
Oxilipinas/farmacologia
Fenóis/análise
Thevetia/química
[Mh] Termos MeSH secundário: Acetatos
Ácidos Graxos/isolamento & purificação
Cromatografia Gasosa-Espectrometria de Massas
Cinetina
Ácidos Láuricos/análise
Ácidos Esteáricos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5-octadecenoic acid); 0 (Acetates); 0 (Antioxidants); 0 (Cyclopentanes); 0 (Fatty Acids); 0 (Lauric Acids); 0 (Oxylipins); 0 (Phenols); 0 (Stearic Acids); 1160N9NU9U (lauric acid); 6RI5N05OWW (jasmonic acid); 72S9A8J5GW (Abscisic Acid); P39Y9652YJ (Kinetin); YRC253429Q (phenoxyacetic acid)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess15254


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[PMID]:26794967
[Au] Autor:de Freitas CD; da Cruz WT; Silva MZ; Vasconcelos IM; Moreno FB; Moreira RA; Monteiro-Moreira AC; Alencar LM; Sousa JS; Rocha BA; Ramos MV
[Ad] Endereço:Departamento de Bioquímica e Biologia Molecular da Universidade Federal do Ceará, Campus do Pici, Cx. Postal 6033, Fortaleza, CE, CEP 60451-970, Brazil. cleversondiniz@hotmail.com.
[Ti] Título:Proteomic analysis and purification of an unusual germin-like protein with proteolytic activity in the latex of Thevetia peruviana.
[So] Source:Planta;243(5):1115-28, 2016 May.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: The latex from Thevetia peruviana is rich in plant defense proteins, including a 120 kDa cysteine peptidase with structural characteristics similar to germin-like proteins. More than 20,000 plant species produce latex, including Apocynaceae, Sapotaceae, Papaveraceae and Euphorbiaceae. To better understand the physiological role played by latex fluids, a proteomic analysis of Thevetia peruviana (Pers.) Schum latex was performed using two-dimensional gel electrophoresis and mass spectrometry. A total of 33 proteins (86 %) were identified, including storage proteins, a peptidase inhibitor, cysteine peptidases, peroxidases and osmotins. An unusual cysteine peptidase, termed peruvianin-I, was purified from the latex by a single chromatographic step involving gel filtration. The enzyme (glycoprotein) was inhibited by E-64 and iodoacetamide and exhibited high specific activity towards azocasein (K m 17.6 µM), with an optimal pH and temperature of 5.0-6.0 and 25-37 °C, respectively. Gel filtration chromatography, two-dimensional gel electrophoresis, and mass spectrometry revealed that peruvianin-I possesses 120 kDa, pI 4.0, and six subunits (20 kDa). A unique N-terminal amino acid sequence was obtained to oligomer and monomers of peruvianin-I (1ADPGPLQDFCLADLNSPLFINGYPCRNPALAISDDF36). High-resolution images from atomic force microscopy showed the homohexameric structure of peruvianin-I may be organized as a trimer of dimers that form a central channel similar to germin-like proteins. Peruvianin-I exhibited no oxalate oxidase and superoxide dismutase activity or antifungal effects. Peruvianin-I represents the first germin-like protein (GLP) with cysteine peptidase activity, an activity unknown in the GLP family so far.
[Mh] Termos MeSH primário: Látex/química
Proteínas de Plantas/metabolismo
Proteínas de Plantas/farmacologia
Thevetia/química
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Caseínas/metabolismo
Cisteína Proteases/isolamento & purificação
Cisteína Proteases/metabolismo
Cisteína Proteases/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Látex/metabolismo
Espectrometria de Massas/métodos
Proteínas de Plantas/isolamento & purificação
Proteômica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Caseins); 0 (Latex); 0 (Plant Proteins); 0 (azocasein); EC 3.4.- (Cysteine Proteases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-016-2468-8


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[PMID]:26714048
[Au] Autor:Tian DM; Cheng HY; Jiang MM; Shen WZ; Tang JS; Yao XS
[Ad] Endereço:College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
[Ti] Título:Cardiac Glycosides from the Seeds of Thevetia peruviana.
[So] Source:J Nat Prod;79(1):38-50, 2016 Jan 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Investigation of the seeds of Thevetia peruviana resulted in the isolation of 15 new (2-16) and 18 known (1 and 17-33) cardiac glycosides. Eight 19-nor-cardenolides (1-8), including two rare 19-nor-10-hydroperoxycardenolides, were obtained from T. peruviana for the first time. All the structures were characterized by NMR spectroscopy and chemical derivatization. The inhibitory effects of cardiac glycosides 1-33 against three cancer cell lines (human lung cancer cells, P15; human gastric cancer cells, MGC-803; and human pancreatic cancer cells, SW1990) and one normal hepatocyte cell line, LO2, were evaluated, and a preliminary structure-activity relationship is discussed. In addition, cardiac glycosides 1, 22, 26, and 28 were evaluated for their apoptosis-inducing activities in MGC-803 cells, showing IC50 values in the range 0.02-0.53 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Cardenolídeos/isolamento & purificação
Glicosídeos Cardíacos/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Sementes/química
Thevetia/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Cardenolídeos/química
Cardenolídeos/farmacologia
Glicosídeos Cardíacos/química
Glicosídeos Cardíacos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cardenolides); 0 (Cardiac Glycosides); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160122
[Lr] Data última revisão:
160122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151230
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00611


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[PMID]:26456837
[Au] Autor:Kumar GN; Atreya A; Kanchan T
[Ad] Endereço:Department of Forensic Medicine and Toxicology, Mahatma Gandhi Medical College & Research Institute, Pillaiyarkuppam, India (Dr Pramod Kumar).
[Ti] Título:Thevetia peruviana.
[So] Source:Wilderness Environ Med;26(4):590-1, 2015 Dec.
[Is] ISSN:1545-1534
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Intoxicação por Plantas/etiologia
Plantas Tóxicas/envenenamento
Thevetia/envenenamento
[Mh] Termos MeSH secundário: Seres Humanos
Índia
Intoxicação por Plantas/terapia
Sri Lanka
Thevetia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151013
[St] Status:MEDLINE


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[PMID]:26081029
[Au] Autor:Haldar S; Karmakar I; Chakraborty M; Ahmad D; Haldar PK
[Ad] Endereço:Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India.
[Ti] Título:Antitumor Potential of Thevetia peruviana on Ehrlich's Ascites Carcinoma-Bearing Mice.
[So] Source:J Environ Pathol Toxicol Oncol;34(2):105-13, 2015.
[Is] ISSN:2162-6537
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12 ml, 2.88±0.23 ml, and 1.34±0.17 ml for the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. Nonviable cell counts were 4.44%±0.42%, 18.57%±3.07%, and 68.12%±5.32% in the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. METP-treated EAC cell-bearing mice had an increased life span (48.69% and 83.78%) compared to the EAC control group. Hematological and serum biochemical profiles were restored to normal levels in METP-treated mice compared to the EAC control group. METP significantly (P<0.001) decreased lipid peroxidation and recovered reduced glutathione, superoxide dismutase, and catalase toward normal levels compared to the EAC control group. In summary, METP exhibited remarkable antitumor activity in Swiss albino mice, which is plausibly attributable to its augmentation of endogenous antioxidant mechanisms.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Carcinoma de Ehrlich/tratamento farmacológico
Extratos Vegetais/farmacologia
Thevetia/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Análise Química do Sangue
Frutas/química
Testes Hematológicos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Camundongos
Fitoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150617
[Lr] Data última revisão:
150617
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150618
[St] Status:MEDLINE


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[PMID]:25301110
[Au] Autor:Durasnel P; Vanhuffel L; Blondé R; Lion F; Galas T; Mousset-Hovaere M; Balaÿ I; Viscardi G; Valyi L
[Ad] Endereço:Service de réanimation polyvalente, Centre hospitalier de Mayotte, BP04, 97600, Mamoudzou, Mayotte, France, p.durasnel@chmayotte.fr.
[Ti] Título:[Severe poisoning by plants used for traditional medicine in Mayotte].
[Ti] Título:Intoxications graves lors de traitements traditionnels par les plantes à Mayotte..
[So] Source:Bull Soc Pathol Exot;107(5):306-11, 2014 Dec.
[Is] ISSN:0037-9085
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The authors describe three cases of severe accidental poisoning by plants used as part of a traditional treatment in Mayotte. The established, or suspected, toxicity of Thevetia peruviana (Yellow oleander), Cinchona pubescens (Red quinine-tree), Melia azaderach (Persian lilac, also called china berry) and Azadirachta indica (Neem), is discussed. The clinical presentation is cardiac (atrioventricular block) and well known for Thevetia and Cinchona intoxications. Neurological signs and multi-organ failure are found for Azadirachta and Melia. The identification of the plants is never easy, nor is the evidence of their accountability. In the three cases reported, no other cause than the traditional treatment has been found to explain the clinical presentation. The outcome was favorable in all cases. The authors emphasize the difficulties to investigate these accidents, the poor medical knowledge of these practices in tropical areas, and in Mayotte particularly. The need for cooperation with local botanists, familiar with traditional medicine, is also underlined.
[Mh] Termos MeSH primário: Bloqueio Atrioventricular/induzido quimicamente
Azadirachta/envenenamento
Cinchona/envenenamento
Medicina Arábica
Fitoterapia/efeitos adversos
Thevetia/envenenamento
[Mh] Termos MeSH secundário: Adulto
Idoso
Bebidas/envenenamento
Bradicardia/induzido quimicamente
Comores
Feminino
Galactagogos/envenenamento
Seres Humanos
Hiperpotassemia/induzido quimicamente
Masculino
Farmacognosia
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Galactogogues)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141121
[Lr] Data última revisão:
141121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141011
[St] Status:MEDLINE
[do] DOI:10.1007/s13149-014-0400-7



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